"Interleukin-12" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
| Descriptor ID |
D018664
|
| MeSH Number(s) |
D12.644.276.374.465.512 D12.776.467.374.465.512 D23.529.374.465.512
|
| Concept/Terms |
Interleukin-12- Interleukin-12
- Natural Killer Cell Stimulatory Factor
- IL-12
- Cytotoxic Lymphocyte Maturation Factor
- IL 12
- Edodekin Alfa
- IL-12 p70
- Interleukin-12 p70
- Interleukin 12 p70
- p70, Interleukin-12
- Interleukin 12
- IL12
|
Below are MeSH descriptors whose meaning is more general than "Interleukin-12".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-12".
This graph shows the total number of publications written about "Interleukin-12" by people in this website by year, and whether "Interleukin-12" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 2 | 1 | 3 |
| 1999 | 1 | 1 | 2 |
| 2000 | 2 | 2 | 4 |
| 2001 | 3 | 3 | 6 |
| 2002 | 3 | 3 | 6 |
| 2003 | 3 | 1 | 4 |
| 2004 | 4 | 4 | 8 |
| 2005 | 2 | 1 | 3 |
| 2006 | 0 | 3 | 3 |
| 2007 | 3 | 3 | 6 |
| 2008 | 2 | 4 | 6 |
| 2009 | 1 | 4 | 5 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 2 | 3 |
| 2012 | 0 | 3 | 3 |
| 2013 | 0 | 3 | 3 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
| 2017 | 0 | 5 | 5 |
| 2018 | 1 | 4 | 5 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Interleukin-12" by people in Profiles.
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Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol. 2018 09 25; 30(10):457-470.
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Adjuvant cationic liposomes presenting MPL and IL-12 induce cell death, suppress tumor growth, and alter the cellular phenotype of tumors in a murine model of breast cancer. Mol Pharm. 2014 Oct 06; 11(10):3484-91.
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CD8+T cell-specific induction of NKG2D receptor by doxorubicin plus interleukin-12 and its contribution to CD8+T cell accumulation in tumors. Mol Cancer. 2014 Feb 24; 13:34.
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Intricacies for posttranslational tumor-targeted cytokine gene therapy. Mediators Inflamm. 2013; 2013:378971.
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Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol. 2014 Jan; 34(1):34-43.
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Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes. PLoS One. 2013; 8(10):e76740.
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Protective immune responses to biolistic DNA vaccination of Brugia malayi abundant larval transcript-2. Vaccine. 2012 Oct 05; 30(45):6477-82.
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Interleukin-30: a novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury. Hepatology. 2012 Apr; 55(4):1204-14.
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Microbiota downregulates dendritic cell expression of miR-10a, which targets IL-12/IL-23p40. J Immunol. 2011 Dec 01; 187(11):5879-86.
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Tumor growth and metastasis suppression by Glipr1 gene-modified macrophages in a metastatic prostate cancer model. Gene Ther. 2011 Oct; 18(10):969-78.