DNA Breaks, Double-Stranded
"DNA Breaks, Double-Stranded" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently.
| Descriptor ID |
D053903
|
| MeSH Number(s) |
G05.200.210.220
|
| Concept/Terms |
DNA Breaks, Double-Stranded- DNA Breaks, Double-Stranded
- Break, Double-Stranded DNA
- Breaks, Double-Stranded DNA
- DNA Break, Double-Stranded
- DNA Breaks, Double Stranded
- Double-Stranded DNA Break
- Double Stranded DNA Break
- Double-Strand DNA Breaks
- Break, Double-Strand DNA
- Breaks, Double-Strand DNA
- DNA Break, Double-Strand
- DNA Breaks, Double-Strand
- Double Strand DNA Breaks
- Double-Strand DNA Break
- Double-Stranded DNA Breaks
- Double Stranded DNA Breaks
|
Below are MeSH descriptors whose meaning is more general than "DNA Breaks, Double-Stranded".
Below are MeSH descriptors whose meaning is more specific than "DNA Breaks, Double-Stranded".
This graph shows the total number of publications written about "DNA Breaks, Double-Stranded" by people in this website by year, and whether "DNA Breaks, Double-Stranded" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 2 | 1 | 3 |
| 2007 | 7 | 1 | 8 |
| 2008 | 3 | 3 | 6 |
| 2009 | 6 | 10 | 16 |
| 2010 | 17 | 6 | 23 |
| 2011 | 8 | 9 | 17 |
| 2012 | 8 | 8 | 16 |
| 2013 | 6 | 7 | 13 |
| 2014 | 8 | 8 | 16 |
| 2015 | 5 | 6 | 11 |
| 2016 | 5 | 12 | 17 |
| 2017 | 3 | 13 | 16 |
| 2018 | 6 | 4 | 10 |
| 2019 | 4 | 7 | 11 |
| 2020 | 2 | 5 | 7 |
| 2021 | 6 | 7 | 13 |
| 2022 | 4 | 3 | 7 |
| 2023 | 2 | 2 | 4 |
| 2024 | 2 | 3 | 5 |
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Below are the most recent publications written about "DNA Breaks, Double-Stranded" by people in Profiles.
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Direct and Indirect Effects for Radiosensitization of Gold Nanoparticles in Proton Therapy. Radiat Res. 2024 Nov 01; 202(5):795-806.
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Yeast EndoG prevents genome instability by degrading extranuclear DNA species. Nat Commun. 2024 Sep 03; 15(1):7653.
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Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. Proc Natl Acad Sci U S A. 2024 Jul 09; 121(28):e2322972121.
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ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma. Nat Commun. 2024 Jun 21; 15(1):5294.
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REV7-p53 interaction inhibits ATM-mediated DNA damage signaling. Cell Cycle. 2024 Feb; 23(4):339-352.
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Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration. Cell. 2023 09 28; 186(20):4404-4421.e20.
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Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs. Nat Struct Mol Biol. 2023 10; 30(10):1456-1467.
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Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma. Neuro Oncol. 2023 07 06; 25(7):1249-1261.
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Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells. Genome Biol. 2023 04 24; 24(1):89.
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Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration. Sci Adv. 2022 09 30; 8(39):eabo4662.