"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
| Descriptor ID |
D034622
|
| MeSH Number(s) |
G05.308.203.374.790
|
| Concept/Terms |
RNA Interference- RNA Interference
- Interference, RNA
- Gene Silencing, Post-Transcriptional
- Gene Silencing, Post Transcriptional
- RNA Silencing
- Post-Transcriptional Gene Silencing
- Post Transcriptional Gene Silencing
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- RNAi
- Posttranscriptional Gene Silencing
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
|
Below are MeSH descriptors whose meaning is more general than "RNA Interference".
Below are MeSH descriptors whose meaning is more specific than "RNA Interference".
This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 2 | 4 | 6 |
| 2005 | 1 | 6 | 7 |
| 2006 | 3 | 8 | 11 |
| 2007 | 1 | 14 | 15 |
| 2008 | 1 | 14 | 15 |
| 2009 | 0 | 14 | 14 |
| 2010 | 1 | 25 | 26 |
| 2011 | 2 | 17 | 19 |
| 2012 | 4 | 22 | 26 |
| 2013 | 5 | 18 | 23 |
| 2014 | 3 | 25 | 28 |
| 2015 | 4 | 30 | 34 |
| 2016 | 1 | 17 | 18 |
| 2017 | 1 | 26 | 27 |
| 2018 | 3 | 18 | 21 |
| 2019 | 3 | 9 | 12 |
| 2020 | 1 | 11 | 12 |
| 2021 | 0 | 6 | 6 |
| 2022 | 0 | 3 | 3 |
| 2023 | 0 | 3 | 3 |
| 2024 | 0 | 2 | 2 |
| 2025 | 0 | 1 | 1 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "RNA Interference" by people in Profiles.
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Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation. EMBO J. 2022 11 02; 41(21):e112435.
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Protection of Quiescence and Longevity of IgG Memory B Cells by Mitochondrial Autophagy. J Immunol. 2022 03 01; 208(5):1085-1098.
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Phase 3 trial of lumasiran for primary hyperoxaluria type 1: A new RNAi therapeutic in infants and young children. Genet Med. 2022 03; 24(3):654-662.
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RNAi Screening to Identify Factors That Control Circular RNA Localization. Methods Mol Biol. 2021; 2209:321-332.
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Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus?. Biol Reprod. 2020 10 05; 103(4):760-768.
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STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity. Diabetes. 2020 12; 69(12):2630-2641.
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Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Sci Adv. 2019 10; 5(10):eaax6366.
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Expanded CUG Repeats Trigger Disease Phenotype and Expression Changes through the RNAi Machinery in C. elegans. J Mol Biol. 2019 04 19; 431(9):1711-1728.
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A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability. Mol Psychiatry. 2020 10; 25(10):2504-2516.
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A Druggable Genome Screen Identifies Modifiers of a-Synuclein Levels via a Tiered Cross-Species Validation Approach. J Neurosci. 2018 10 24; 38(43):9286-9301.