"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
| Descriptor ID |
D034622
|
| MeSH Number(s) |
G05.308.203.374.790
|
| Concept/Terms |
RNA Interference- RNA Interference
- Interference, RNA
- Gene Silencing, Post-Transcriptional
- Gene Silencing, Post Transcriptional
- RNA Silencing
- Post-Transcriptional Gene Silencing
- Post Transcriptional Gene Silencing
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- RNAi
- Posttranscriptional Gene Silencing
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
|
Below are MeSH descriptors whose meaning is more general than "RNA Interference".
Below are MeSH descriptors whose meaning is more specific than "RNA Interference".
This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2003 | 2 | 4 | 6 |
| 2004 | 3 | 19 | 22 |
| 2005 | 5 | 21 | 26 |
| 2006 | 5 | 21 | 26 |
| 2007 | 4 | 29 | 33 |
| 2008 | 5 | 31 | 36 |
| 2009 | 2 | 39 | 41 |
| 2010 | 4 | 54 | 58 |
| 2011 | 5 | 61 | 66 |
| 2012 | 6 | 64 | 70 |
| 2013 | 4 | 64 | 68 |
| 2014 | 4 | 66 | 70 |
| 2015 | 5 | 64 | 69 |
| 2016 | 5 | 49 | 54 |
| 2017 | 2 | 43 | 45 |
| 2018 | 2 | 25 | 27 |
| 2019 | 3 | 23 | 26 |
| 2020 | 1 | 17 | 18 |
| 2021 | 1 | 9 | 10 |
| 2022 | 1 | 2 | 3 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "RNA Interference" by people in Profiles.
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A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2a in Patients with Advanced Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2024 Jun 03; 30(11):2402-2411.
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Localization and RNA Interference-Driven Inhibition of a Brugia malayi-Encoded Interleukin-5 Receptor Binding Protein. Infect Immun. 2022 05 19; 90(5):e0031721.
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Protection of Quiescence and Longevity of IgG Memory B Cells by Mitochondrial Autophagy. J Immunol. 2022 03 01; 208(5):1085-1098.
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RNAi-based therapeutics and tumor targeted delivery in cancer. Adv Drug Deliv Rev. 2022 03; 182:114113.
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Phase 3 trial of lumasiran for primary hyperoxaluria type 1: A new RNAi therapeutic in infants and young children. Genet Med. 2022 03; 24(3):654-662.
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Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea. Nat Cell Biol. 2021 09; 23(9):939-952.
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PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nat Commun. 2021 07 30; 12(1):4626.
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Population scale nucleic acid delivery to Caenorhabditis elegans via electroporation. G3 (Bethesda). 2021 07 14; 11(7).
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Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions. Respir Res. 2021 Apr 06; 22(1):99.
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Prolyl Hydroxylase 3 Knockdown Accelerates VHL-Mutant Kidney Cancer Growth In Vivo. Int J Mol Sci. 2021 Mar 11; 22(6).