"Protein Kinase C-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.
| Descriptor ID |
D051571
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.100
|
| Concept/Terms |
Protein Kinase C-alpha- Protein Kinase C-alpha
- Protein Kinase C(alpha)
- PKC-alpha Serine-Threonine Kinase
- PKC alpha Serine Threonine Kinase
- Serine-Threonine Kinase, PKC-alpha
- Protein Kinase C alpha
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-alpha".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-alpha".
This graph shows the total number of publications written about "Protein Kinase C-alpha" by people in this website by year, and whether "Protein Kinase C-alpha" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2013 | 0 | 2 | 2 |
| 2015 | 2 | 0 | 2 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C-alpha" by people in Profiles.
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Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Res. 2014 Sep 01; 74(17):4822-35.
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The protein phosphatase 2A regulatory subunit B55a is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. Biochim Biophys Acta. 2014 Sep; 1843(9):1969-77.
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Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCa invasive signaling axis. Sci Signal. 2012 Sep 11; 5(241):ra66.
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Antisense to protein kinase C-alpha and p47phox attenuates the pro-inflammatory effects of human C-reactive protein in macrophages of biobreeding diabetic rats. Diab Vasc Dis Res. 2012 Oct; 9(4):315-9.
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Long-term cellular and regional specificity of the photoreceptor toxin, iodoacetic acid (IAA), in the rabbit retina. Vis Neurosci. 2008 Mar-Apr; 25(2):167-77.
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Gbeta5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar cells. Eur J Neurosci. 2007 Nov; 26(10):2899-905.
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Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway. Mol Cell Biol. 2007 Oct; 27(19):6933-47.
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Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. Oncogene. 2006 Jun 01; 25(23):3286-95.
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Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}. Diabetes. 2005 Jan; 54(1):85-91.
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Heregulin-induced apoptosis. Apoptosis. 2002 Dec; 7(6):483-91.