"Heat-Shock Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.
| Descriptor ID |
D006360
|
| MeSH Number(s) |
D12.776.580.216
|
| Concept/Terms |
Heat-Shock Proteins- Heat-Shock Proteins
- Heat Shock Proteins
- Stress Proteins
- Heat-Shock Protein
- Heat Shock Protein
|
Below are MeSH descriptors whose meaning is more general than "Heat-Shock Proteins".
Below are MeSH descriptors whose meaning is more specific than "Heat-Shock Proteins".
This graph shows the total number of publications written about "Heat-Shock Proteins" by people in this website by year, and whether "Heat-Shock Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 7 | 2 | 9 |
| 1995 | 3 | 0 | 3 |
| 1996 | 3 | 2 | 5 |
| 1997 | 6 | 1 | 7 |
| 1998 | 7 | 1 | 8 |
| 1999 | 8 | 2 | 10 |
| 2000 | 2 | 1 | 3 |
| 2001 | 3 | 2 | 5 |
| 2002 | 4 | 4 | 8 |
| 2003 | 8 | 5 | 13 |
| 2004 | 5 | 5 | 10 |
| 2005 | 2 | 12 | 14 |
| 2006 | 3 | 2 | 5 |
| 2007 | 4 | 3 | 7 |
| 2008 | 7 | 5 | 12 |
| 2009 | 4 | 1 | 5 |
| 2010 | 5 | 2 | 7 |
| 2011 | 5 | 4 | 9 |
| 2012 | 3 | 3 | 6 |
| 2013 | 4 | 4 | 8 |
| 2014 | 7 | 1 | 8 |
| 2015 | 2 | 4 | 6 |
| 2016 | 0 | 3 | 3 |
| 2017 | 3 | 0 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 2 | 2 |
| 2024 | 3 | 1 | 4 |
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Below are the most recent publications written about "Heat-Shock Proteins" by people in Profiles.
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BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection. PLoS Pathog. 2024 Oct; 20(10):e1012660.
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MaHsf24, a novel negative modulator, regulates cold tolerance in banana fruits by repressing the expression of HSPs and antioxidant enzyme genes. Plant Biotechnol J. 2024 Oct; 22(10):2873-2886.
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PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death. Neoplasia. 2024 08; 54:101008.
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HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker. Proc Natl Acad Sci U S A. 2024 Mar 26; 121(13):e2321606121.
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GRP78-CAR T?cell effector function against solid and brain tumors is controlled by GRP78 expression on T?cells. Cell Rep Med. 2023 11 21; 4(11):101297.
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Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. Circ Res. 2023 06 23; 133(1):e1-e16.
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Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria. Nat Commun. 2023 04 11; 14(1):2028.
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Deciphering the mechanism and function of Hsp100 unfoldases from protein structure. Biochem Soc Trans. 2022 12 16; 50(6):1725-1736.
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Disruption of DNA Repair and Survival Pathways through Heat Shock Protein Inhibition by Onalespib to Sensitize Malignant Gliomas to Chemoradiation Therapy. Clin Cancer Res. 2022 05 02; 28(9):1979-1990.
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Atomic structure of the Leishmania spp. Hsp100 N-domain. Proteins. 2022 06; 90(6):1242-1246.