"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Descriptor ID |
D017209
|
MeSH Number(s) |
G04.146.160
|
Concept/Terms |
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.
To see the data from this visualization as text,
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Year | Major Topic | Minor Topic | Total |
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1994 | 17 | 8 | 25 |
1995 | 30 | 14 | 44 |
1996 | 41 | 15 | 56 |
1997 | 47 | 25 | 72 |
1998 | 71 | 50 | 121 |
1999 | 54 | 45 | 99 |
2000 | 73 | 66 | 139 |
2001 | 75 | 80 | 155 |
2002 | 94 | 101 | 195 |
2003 | 97 | 104 | 201 |
2004 | 96 | 112 | 208 |
2005 | 101 | 120 | 221 |
2006 | 93 | 132 | 225 |
2007 | 85 | 135 | 220 |
2008 | 59 | 127 | 186 |
2009 | 64 | 131 | 195 |
2010 | 66 | 142 | 208 |
2011 | 72 | 132 | 204 |
2012 | 50 | 131 | 181 |
2013 | 40 | 152 | 192 |
2014 | 45 | 144 | 189 |
2015 | 43 | 119 | 162 |
2016 | 31 | 129 | 160 |
2017 | 33 | 99 | 132 |
2018 | 25 | 68 | 93 |
2019 | 21 | 90 | 111 |
2020 | 15 | 89 | 104 |
2021 | 7 | 81 | 88 |
2022 | 2 | 32 | 34 |
2023 | 2 | 41 | 43 |
2024 | 19 | 26 | 45 |
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Below are the most recent publications written about "Apoptosis" by people in Profiles.
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Low-Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer. Cancer Res. 2024 Nov 15; 84(22):3864-3880.
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Mechanism of Marinobufagenin-Induced Hyperpermeability of Human Brain Microvascular Endothelial Cell Monolayer: A Potential Pathogenesis of Seizure in Preeclampsia. Cells. 2024 Oct 30; 13(21).
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IFN-treated macrophage-derived exosomes prevents HBV-HCC migration and invasion via regulating miR-106b-3p/PCGF3/PI3K/AKT signaling axis. Front Cell Infect Microbiol. 2024; 14:1421195.
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Remyelination protects neurons from DLK-mediated neurodegeneration. Nat Commun. 2024 Oct 23; 15(1):9148.
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Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma. Br J Cancer. 2024 Dec; 131(11):1846-1857.
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The story behind the emergence of different forms of cell death. Dev Cell. 2024 Oct 07; 59(19):2519-2522.
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Selective inhibition of HDAC class IIA as therapeutic intervention for KMT2A-rearranged acute lymphoblastic leukemia. Commun Biol. 2024 Oct 04; 7(1):1257.
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PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer. Mol Cancer Ther. 2024 Oct 01; 23(10):1494-1510.
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WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma. Cancer Res. 2024 Sep 04; 84(17):2776-2791.
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Synergistic Cytotoxicity of Histone Deacetylase and Poly-ADP Ribose Polymerase Inhibitors and Decitabine in Breast and Ovarian Cancer Cells: Implications for Novel Therapeutic Combinations. Int J Mol Sci. 2024 Aug 26; 25(17).