"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Descriptor ID |
D017209
|
MeSH Number(s) |
G04.146.160
|
Concept/Terms |
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1994 | 16 | 8 | 24 |
1995 | 30 | 14 | 44 |
1996 | 36 | 12 | 48 |
1997 | 45 | 23 | 68 |
1998 | 61 | 46 | 107 |
1999 | 48 | 40 | 88 |
2000 | 66 | 63 | 129 |
2001 | 60 | 74 | 134 |
2002 | 97 | 106 | 203 |
2003 | 98 | 108 | 206 |
2004 | 96 | 119 | 215 |
2005 | 103 | 127 | 230 |
2006 | 94 | 135 | 229 |
2007 | 86 | 141 | 227 |
2008 | 58 | 130 | 188 |
2009 | 66 | 135 | 201 |
2010 | 65 | 145 | 210 |
2011 | 75 | 133 | 208 |
2012 | 50 | 134 | 184 |
2013 | 37 | 158 | 195 |
2014 | 46 | 148 | 194 |
2015 | 45 | 120 | 165 |
2016 | 31 | 128 | 159 |
2017 | 33 | 98 | 131 |
2018 | 26 | 68 | 94 |
2019 | 21 | 90 | 111 |
2020 | 15 | 94 | 109 |
2021 | 7 | 83 | 90 |
2022 | 2 | 31 | 33 |
2023 | 2 | 42 | 44 |
2024 | 16 | 18 | 34 |
To return to the timeline,
click here.
Below are the most recent publications written about "Apoptosis" by people in Profiles.
-
PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer. Mol Cancer Ther. 2024 Oct 01; 23(10):1494-1510.
-
WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma. Cancer Res. 2024 Sep 04; 84(17):2776-2791.
-
TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions. Nat Commun. 2024 Aug 14; 15(1):6971.
-
Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia. Sci Adv. 2024 Aug 02; 10(31):eadj3145.
-
Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer. Nat Commun. 2024 Aug 02; 15(1):6538.
-
Mechanism and rational combinations with GP-2250, a novel oxathiazine derivative, in ovarian cancer. Cancer Med. 2024 Aug; 13(15):e70031.
-
N-Myc and STAT Interactor is an Endometriosis Suppressor. Int J Mol Sci. 2024 Jul 26; 25(15).
-
SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion. Oncoimmunology. 2024; 13(1):2376264.
-
Transcriptional coactivation of NRF2 signaling in cardiac fibroblasts promotes resistance to oxidative stress. J Mol Cell Cardiol. 2024 Sep; 194:70-84.
-
Study on the mechanism of glucocorticoid receptor mitochondrial translocation and glucocorticoid-induced apoptosis in macrophages. Immunopharmacol Immunotoxicol. 2024 Aug; 46(4):482-495.