NICOLAS YOUNG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Precision Environmental Health
    DivisionCenter for Precision Env Health

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse Research 
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    F32CA139893     (YOUNG, NICOLAS L)Jul 1, 2010 - Jun 30, 2012
    NIH
    Investigation of the Histone Code in DNA Damage Response and Repair Mechanisms
    Role: Principal Investigator

    R01GM139295     (YOUNG, NICOLAS L)Sep 1, 2020 - May 31, 2025
    NIH
    Neutron encoded activity based probes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Murdaugh RL, Hoegenauer KA, Kitano A, Holt MV, Hill MC, Shi X, Tiessen JF, Chapple R, Hu T, Tseng YJ, Lin A, Martin JF, Young NL, Nakada D. The histone H3.3 chaperone HIRA restrains erythroid-biased differentiation of adult hematopoietic stem cells. Stem Cell Reports. 2021 Aug 10; 16(8):2014-2028. PMID: 34242617.
      Citations: 1     Fields:    
    2. Park KW, Wood CA, Li J, Taylor BC, Oh S, Young NL, Jankowsky JL. Gene therapy using Aß variants for amyloid reduction. Mol Ther. 2021 07 07; 29(7):2294-2307. PMID: 33647457.
      Citations:    Fields:    
    3. Young NL, Dere R. Mechanistic insights into KDM4A driven genomic instability. Biochem Soc Trans. 2021 02 26; 49(1):93-105. PMID: 33492339.
      Citations:    Fields:    
    4. Taylor BC, Young NL. Combinations of histone post-translational modifications. Biochem J. 2021 02 12; 478(3):511-532. PMID: 33567070.
      Citations: 2     Fields:    Translation:HumansCells
    5. Holt MV, Wang T, Young NL. Expeditious Extraction of Histones from Limited Cells or Tissue Samples and Quantitative Top-Down Proteomic Analysis. Curr Protoc. 2021 Feb; 1(2):e26. PMID: 33534192.
      Citations: 1     Translation:AnimalsCells
    6. Chang L, Campbell J, Raji IO, Guduru SKR, Kandel P, Nguyen M, Liu S, Tran K, Venugopal NK, Taylor BC, Holt MV, Young NL, Samuel ELG, Jain P, Santini C, Sankaran B, MacKenzie KR, Young DW. Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery. Sci Rep. 2021 01 13; 11(1):1121. PMID: 33441849.
      Citations: 2     Fields:    Translation:Cells
    7. Andrews AJ, Young NL. Methodological innovations drive conceptual innovations forward in chromatin biology. Methods. 2020 12 01; 184:1-3. PMID: 33069800.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Guo YR, Fan Y, Zhou Y, Jin M, Zhang JL, Jiang H, Holt MV, Wang T, Young NL, Wang D, Zhong W, Tao YJ. Orsay Virus CP-d Adopts a Novel ß-Bracelet Structural Fold and Incorporates into Virions as a Head Fiber. J Virol. 2020 10 14; 94(21). PMID: 32817218.
      Citations:    Fields:    Translation:AnimalsCells
    9. Srzentic K, Fornelli L, Tsybin YO, Loo JA, Seckler H, Agar JN, Anderson LC, Bai DL, Beck A, Brodbelt JS, van der Burgt YEM, Chamot-Rooke J, Chatterjee S, Chen Y, Clarke DJ, Danis PO, Diedrich JK, D'Ippolito RA, Dupré M, Gasilova N, Ge Y, Goo YA, Goodlett DR, Greer S, Haselmann KF, He L, Hendrickson CL, Hinkle JD, Holt MV, Hughes S, Hunt DF, Kelleher NL, Kozhinov AN, Lin Z, Malosse C, Marshall AG, Menin L, Millikin RJ, Nagornov KO, Nicolardi S, Paša-Tolic L, Pengelley S, Quebbemann NR, Resemann A, Sandoval W, Sarin R, Schmitt ND, Shabanowitz J, Shaw JB, Shortreed MR, Smith LM, Sobott F, Suckau D, Toby T, Weisbrod CR, Wildburger NC, Yates JR, Yoon SH, Young NL, Zhou M. Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry. J Am Soc Mass Spectrom. 2020 Sep 02; 31(9):1783-1802. PMID: 32812765.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    10. Dai S, Holt MV, Horton JR, Woodcock CB, Patel A, Zhang X, Young NL, Wilkinson AW, Cheng X. Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J Biol Chem. 2020 08 07; 295(32):10901-10910. PMID: 32503840.
      Citations: 2     Fields:    Translation:HumansCells
    11. Jiang Y, Hu T, Wang T, Shi X, Kitano A, Eagle K, Hoegenauer KA, Konopleva MY, Lin CY, Young NL, Nakada D. AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia. Blood. 2019 12 12; 134(24):2183-2194. PMID: 31697807.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    12. Holt MV, Wang T, Young NL. High-Throughput Quantitative Top-Down Proteomics: Histone H4. J Am Soc Mass Spectrom. 2019 Dec; 30(12):2548-2560. PMID: 31741267.
      Citations: 2     Fields:    Translation:HumansCells
    13. Holt MV, Wang T, Young NL. One-Pot Quantitative Top- and Middle-Down Analysis of GluC-Digested Histone H4. J Am Soc Mass Spectrom. 2019 Dec; 30(12):2514-2525. PMID: 31147891.
      Citations: 2     Fields:    Translation:HumansCells
    14. Wang T, Holt MV, Young NL. Early butyrate induced acetylation of histone H4 is proteoform specific and linked to methylation state. Epigenetics. 2018; 13(5):519-535. PMID: 29940793.
      Citations: 8     Fields:    Translation:HumansCells
    15. Wang T, Holt MV, Young NL. The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance. Epigenetics Chromatin. 2018 06 07; 11(1):29. PMID: 29880017.
      Citations: 7     Fields:    Translation:HumansCells
    16. Jiang T, Hoover ME, Holt MV, Freitas MA, Marshall AG, Young NL. Middle-Down Characterization of the Cell Cycle Dependence of Histone H4 Posttranslational Modifications and Proteoforms. Proteomics. 2018 06; 18(11):e1700442. PMID: 29667342.
      Citations: 6     Fields:    Translation:HumansCells
    17. Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. How many human proteoforms are there? Nat Chem Biol. 2018 02 14; 14(3):206-214. PMID: 29443976.
      Citations: 127     Fields:    Translation:HumansCells
    18. Fan Y, Guo YR, Yuan W, Zhou Y, Holt MV, Wang T, Demeler B, Young NL, Zhong W, Tao YJ. Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells. PLoS Pathog. 2017 02; 13(2):e1006231. PMID: 28241071.
      Citations: 6     Fields:    Translation:AnimalsCells
    19. Dang X, Singh A, Spetman BD, Nolan KD, Isaacs JS, Dennis JH, Dalton S, Marshall AG, Young NL. Label-Free Relative Quantitation of Isobaric and Isomeric Human Histone H2A and H2B Variants by Fourier Transform Ion Cyclotron Resonance Top-Down MS/MS. J Proteome Res. 2016 09 02; 15(9):3196-203. PMID: 27431976.
      Citations: 10     Fields:    Translation:HumansCells
    20. Chen Y, Hoover ME, Dang X, Shomo AA, Guan X, Marshall AG, Freitas MA, Young NL. Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence. Mol Cell Proteomics. 2016 Mar; 15(3):818-33. PMID: 26209608.
      Citations: 11     Fields:    Translation:HumansCells
    21. Dang X, Scotcher J, Wu S, Chu RK, Tolic N, Ntai I, Thomas PM, Fellers RT, Early BP, Zheng Y, Durbin KR, Leduc RD, Wolff JJ, Thompson CJ, Pan J, Han J, Shaw JB, Salisbury JP, Easterling M, Borchers CH, Brodbelt JS, Agar JN, Paša-Tolic L, Kelleher NL, Young NL. The first pilot project of the consortium for top-down proteomics: a status report. Proteomics. 2014 May; 14(10):1130-40. PMID: 24644084.
      Citations: 34     Fields:    Translation:HumansCells
    22. Ficarro SB, Biagi JM, Wang J, Scotcher J, Koleva RI, Card JD, Adelmant G, He H, Askenazi M, Marshall AG, Young NL, Gray NS, Marto JA. Protected amine labels: a versatile molecular scaffold for multiplexed nominal mass and sub-Da isotopologue quantitative proteomic reagents. J Am Soc Mass Spectrom. 2014 Apr; 25(4):636-50. PMID: 24496597.
      Citations: 1     Fields:    Translation:HumansCells
    23. Harshman SW, Young NL, Parthun MR, Freitas MA. H1 histones: current perspectives and challenges. Nucleic Acids Res. 2013 Nov; 41(21):9593-609. PMID: 23945933.
      Citations: 82     Fields:    Translation:Cells
    24. Zhang Q, Noble KA, Mao Y, Young NL, Sathe SK, Roux KH, Marshall AG. Rapid screening for potential epitopes reactive with a polycolonal antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry. J Am Soc Mass Spectrom. 2013 Jul; 24(7):1016-25. PMID: 23681851.
      Citations: 4     Fields:    Translation:AnimalsCells
    25. Voigt P, LeRoy G, Drury WJ, Zee BM, Son J, Beck DB, Young NL, Garcia BA, Reinberg D. Asymmetrically modified nucleosomes. Cell. 2012 Sep 28; 151(1):181-93. PMID: 23021224.
      Citations: 176     Fields:    Translation:HumansAnimalsCells
    26. Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 2012 Jul 05; 487(7405):114-8. PMID: 22722849.
      Citations: 199     Fields:    Translation:HumansAnimalsCells
    27. Green EM, Mas G, Young NL, Garcia BA, Gozani O. Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Nat Struct Mol Biol. 2012 Feb 19; 19(3):361-3. PMID: 22343720.
      Citations: 23     Fields:    Translation:AnimalsCells
    28. Torrente MP, Zee BM, Young NL, Baliban RC, LeRoy G, Floudas CA, Hake SB, Garcia BA. Proteomic interrogation of human chromatin. PLoS One. 2011; 6(9):e24747. PMID: 21935452.
      Citations: 16     Fields:    Translation:HumansCells
    29. Waldmann T, Izzo A, Kamieniarz K, Richter F, Vogler C, Sarg B, Lindner H, Young NL, Mittler G, Garcia BA, Schneider R. Methylation of H2AR29 is a novel repressive PRMT6 target. Epigenetics Chromatin. 2011 Jul 20; 4:11. PMID: 21774791.
      Citations: 33     Fields:    
    30. Yan K, Cao Q, Reilly CM, Young NL, Garcia BA, Mishra N. Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity. J Biol Chem. 2011 Aug 19; 286(33):28833-28843. PMID: 21708950.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    31. Young NL, Dimaggio PA, Garcia BA. The significance, development and progress of high-throughput combinatorial histone code analysis. Cell Mol Life Sci. 2010 Dec; 67(23):3983-4000. PMID: 20683756.
      Citations: 41     Fields:    Translation:HumansCells
    32. Plazas-Mayorca MD, Bloom JS, Zeissler U, Leroy G, Young NL, DiMaggio PA, Krugylak L, Schneider R, Garcia BA. Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown. Mol Biosyst. 2010 Sep; 6(9):1719-29. PMID: 20577673.
      Citations: 14     Fields:    Translation:HumansCells
    33. Young NL, Plazas-Mayorca MD, Garcia BA. Systems-wide proteomic characterization of combinatorial post-translational modification patterns. Expert Rev Proteomics. 2010 Feb; 7(1):79-92. PMID: 20121478.
      Citations: 21     Fields:    Translation:Cells
    34. Young NL, Plazas-Mayorca MD, DiMaggio PA, Flaniken IZ, Beltran AJ, Mishra N, LeRoy G, Floudas CA, Garcia BA. Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a. J Am Soc Mass Spectrom. 2010 Jun; 21(6):960-70. PMID: 20202861.
      Citations: 8     Fields:    Translation:HumansCells
    35. Baliban RC, DiMaggio PA, Plazas-Mayorca MD, Young NL, Garcia BA, Floudas CA. A novel approach for untargeted post-translational modification identification using integer linear optimization and tandem mass spectrometry. Mol Cell Proteomics. 2010 May; 9(5):764-79. PMID: 20103568.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    36. Plazas-Mayorca MD, Zee BM, Young NL, Fingerman IM, LeRoy G, Briggs SD, Garcia BA. One-pot shotgun quantitative mass spectrometry characterization of histones. J Proteome Res. 2009 Nov; 8(11):5367-74. PMID: 19764812.
      Citations: 75     Fields:    Translation:HumansCells
    37. DiMaggio PA, Young NL, Baliban RC, Garcia BA, Floudas CA. A mixed integer linear optimization framework for the identification and quantification of targeted post-translational modifications of highly modified proteins using multiplexed electron transfer dissociation tandem mass spectrometry. Mol Cell Proteomics. 2009 Nov; 8(11):2527-43. PMID: 19666874.
      Citations: 45     Fields:    Translation:HumansCells
    38. Young NL, DiMaggio PA, Plazas-Mayorca MD, Baliban RC, Floudas CA, Garcia BA. High throughput characterization of combinatorial histone codes. Mol Cell Proteomics. 2009 Oct; 8(10):2266-84. PMID: 19654425.
      Citations: 140     Fields:    Translation:HumansCells
    39. LeRoy G, Weston JT, Zee BM, Young NL, Plazas-Mayorca MD, Garcia BA. Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications. Mol Cell Proteomics. 2009 Nov; 8(11):2432-42. PMID: 19567367.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    40. Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M. Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol Cell. 2009 Feb 27; 33(4):417-27. PMID: 19250903.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    41. El Gazzar M, Yoza BK, Chen X, Garcia BA, Young NL, McCall CE. Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol Cell Biol. 2009 Apr; 29(7):1959-71. PMID: 19158276.
      Citations: 68     Fields:    Translation:HumansCells
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