KEPING XIE

TitleProfessor
InstitutionMD Anderson
DepartmentGastroenterology Hepatology & Nutrition
Address7435 Fannin St
Houston TX 77054-1901
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang Y, Xiao B, Liu Y, Wu S, Xiang Q, Xiao Y, Zhao J, Yuan R, Xie K, Li L. Roles of PPAR activation in cancer therapeutic resistance: Implications for combination therapy and drug development. Eur J Pharmacol. 2024 Feb 05; 964:176304. PMID: 38142851.
      Citations:    Fields:    Translation:HumansCells
    2. Zhao T, Jiang T, Li X, Chang S, Sun Q, Kong F, Kong X, Wei F, He J, Hao J, Xie K, Zhao T, Jiang T, Li X, Chang S, Sun Q, Kong F, Kong X, Wei F, He J, Hao J, Xie K. Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2023 Dec 15; 29(24):5183-5195. PMID: 37819952.
      Citations:    Fields:    Translation:HumansAnimals
    3. Liang W, Liu M, Su Y, Wen Y, Wang L, Shan J, Zhao J, Xie K, Wang J. Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway. IUBMB Life. 2024 Mar; 76(3):140-160. PMID: 37728571.
      Citations:    Fields:    Translation:Humans
    4. Yang K, Li X, Xie K. Senescence program and its reprogramming in pancreatic premalignancy. Cell Death Dis. 2023 08 17; 14(8):528. PMID: 37591827; PMCID: PMC10435572.
      Citations: 2     Fields:    Translation:Humans
    5. Quan Y, He J, Zou Q, Zhang L, Sun Q, Huang H, Li W, Xie K, Wei F. Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer. J Immunother Cancer. 2023 08; 11(8). PMID: 37597850; PMCID: PMC10441131.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Yu S, He J, Xie K. Zonula Occludens Proteins Signaling in Inflammation and Tumorigenesis. Int J Biol Sci. 2023; 19(12):3804-3815. PMID: 37564207; PMCID: PMC10411466.
      Citations:    Fields:    
    7. Wei F, Su Y, Quan Y, Li X, Zou Q, Zhang L, Li S, Jiang M, Lin G, Liang P, He J, Xie K. Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor Infiltrates. Clin Cancer Res. 2023 07 05; 29(13):2525-2539. PMID: 36729148.
      Citations: 1     Fields:    Translation:Animals
    8. An J, Jiang T, Qi L, Xie K. Acinar cells and the development of pancreatic fibrosis. Cytokine Growth Factor Rev. 2023 Jun-Aug; 71-72:40-53. PMID: 37291030.
      Citations:    Fields:    
    9. He Z, He J, Xie K. KLF4 transcription factor in tumorigenesis. Cell Death Discov. 2023 Apr 08; 9(1):118. PMID: 37031197; PMCID: PMC10082813.
      Citations: 1     
    10. Nie X, Zhao C, Zhang Y, Huang W, Zhou Y, Liu H, Nie Y, Xie K, Jia L. Nucleolar protein treacle ribosome biogenesis factor 1 maintains gastric cancer cell proliferation by regulating R-loop associated DNA replication stress. J Gastroenterol Hepatol. 2023 Jul; 38(7):1170-1180. PMID: 36941105.
      Citations: 1     Fields:    Translation:HumansCells
    11. Zhang HQ, Kong F, Kong X, Jiang T, Ma M, Zheng S, Guo J, Xie K. Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression. Genes Dis. 2024 Mar; 11(2):921-934. PMID: 37692474; PMCID: PMC10491869.
      Citations: 1     
    12. Zhang W, Jiang T, Xie K. Epigenetic reprogramming in pancreatic premalignancy and clinical implications. Front Oncol. 2023; 13:1024151. PMID: 36874143; PMCID: PMC9978013.
      Citations:    
    13. Yue Y, Wu K, Qian W, Zhu Z, Zhang S, Zhang W, Zhang W, Wu S, Li L, Wu Z, Ma Q, Xie K, Wang Z. RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes malignant phenotypes of pancreatic ductal adenocarcinoma. Int J Biol Sci. 2022; 18(10):4245-4259. PMID: 35844783; PMCID: PMC9274491.
      Citations:    Fields:    Translation:HumansCells
    14. Jiang T, Wei F, Xie K. Clinical significance of pancreatic ductal metaplasia. J Pathol. 2022 06; 257(2):125-139. PMID: 35170758.
      Citations:    Fields:    Translation:Humans
    15. Li X, He J, Xie K. Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer. Cell Oncol (Dordr). 2022 Apr; 45(2):201-225. PMID: 35290607.
      Citations:    Fields:    Translation:HumansAnimals
    16. Li S, Xie K. Ductal metaplasia in pancreas. Biochim Biophys Acta Rev Cancer. 2022 03; 1877(2):188698. PMID: 35176433.
      Citations:    Fields:    Translation:HumansCells
    17. Wang L, Jia Z, Xie D, Zhao T, Tan Z, Zhang S, Kong F, Wei D, Xie K. Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics. Cancer Res. 2020 10 15; 80(20):4500-4513. PMID: 32699135.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    18. Xie VK, He J, Xie K. Protein arginine methylation promotes therapeutic resistance in human pancreatic cancer. Cytokine Growth Factor Rev. 2020 10; 55:58-69. PMID: 32739260.
      Citations: 2     Fields:    Translation:HumansCells
    19. Cui J, Quan M, Xie D, Gao Y, Guha S, Fallon MB, Chen J, Xie K. A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism. Oncogene. 2020 01; 39(5):1140-1151. PMID: 31641207.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    20. Huang C, Li Y, Li Z, Xu Y, Li N, Ge Y, Dong J, Chang A, Zhao T, Wang X, Wang H, Yang S, Xie K, Hao J, Ren H. LIMS1 Promotes Pancreatic Cancer Cell Survival under Oxygen-Glucose Deprivation Conditions by Enhancing HIF1A Protein Translation. Clin Cancer Res. 2019 07 01; 25(13):4091-4103. PMID: 30679163; PMCID: PMC6759834.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    21. Kong F, Deng X, Kong X, Du Y, Li L, Zhu H, Wang Y, Xie D, Guha S, Li Z, Guan M, Xie K. Correction: ZFPM2-AS1, a novel lncRNA, attenuates the p53 pathway and promotes gastric carcinogenesis by stabilizing MIF. Oncogene. 2018 11; 37(45):6010. PMID: 30108331.
      Citations: 2     Fields:    
    22. Zhang M, Zhao K, Xu X, Yang Y, Yan S, Wei P, Liu H, Xu J, Xiao F, Zhou H, Yang X, Huang N, Liu J, He K, Xie K, Zhang G, Huang S, Zhang N. A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Nat Commun. 2018 10 26; 9(1):4475. PMID: 30367041; PMCID: PMC6203777.
      Citations: 239     Fields:    Translation:HumansAnimalsCells
    23. Li Q, Wei P, Wu J, Zhang M, Li G, Li Y, Xu Y, Li X, Xie D, Cai S, Xie K, Li D. The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect. Oncogene. 2019 01; 38(4):483-496. PMID: 30171256.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    24. Chang G, Leu JS, Ma L, Xie K, Huang S. Methylation of RNA N6-methyladenosine in modulation of cytokine responses and tumorigenesis. Cytokine. 2019 06; 118:35-41. PMID: 30017390.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    25. Kong F, Deng X, Kong X, Du Y, Li L, Zhu H, Wang Y, Xie D, Guha S, Li Z, Guan M, Xie K. ZFPM2-AS1, a novel lncRNA, attenuates the p53 pathway and promotes gastric carcinogenesis by stabilizing MIF. Oncogene. 2018 11; 37(45):5982-5996. PMID: 29985481; PMCID: PMC6226322.
      Citations: 44     Fields:    Translation:HumansAnimals
    26. Kong F, Sun T, Kong X, Xie D, Li Z, Xie K. Kr?ppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition. Clin Cancer Res. 2018 05 15; 24(10):2440-2451. PMID: 29367428; PMCID: PMC6765216.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    27. Wang L, Zuo X, Xie K, Wei D. The Role of CD44 and Cancer Stem Cells. Methods Mol Biol. 2018; 1692:31-42. PMID: 28986884.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    28. Kong F, Kong X, Du Y, Chen Y, Deng X, Zhu J, Du J, Li L, Jia Z, Xie D, Li Z, Xie K. STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1a. Cancer Res. 2017 12 15; 77(24):6851-6862. PMID: 29038348.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    29. Xie VK, Li Z, Yan Y, Jia Z, Zuo X, Ju Z, Wang J, Du J, Xie D, Xie K, Wei D. DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Kr?ppel-Like Factor 4 Expression. Clin Cancer Res. 2017 Sep 15; 23(18):5585-5597. PMID: 28659310; PMCID: PMC5600846.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    30. Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, Majumder S, He C, Huang S, B?gler O. m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell. 2017 04 10; 31(4):591-606.e6. PMID: 28344040; PMCID: PMC5427719.
      Citations: 573     Fields:    Translation:AnimalsCells
    31. Zhao T, Jiang W, Wang X, Wang H, Zheng C, Li Y, Sun Y, Huang C, Han ZB, Yang S, Jia Z, Xie K, Ren H, Hao J. ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin. Cancer Res. 2017 02 15; 77(4):874-885. PMID: 27923832; PMCID: PMC5313376.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    32. Zhou A, Lin K, Zhang S, Chen Y, Zhang N, Xue J, Wang Z, Aldape KD, Xie K, Woodgett JR, Huang S. Nuclear GSK3? promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22. Nat Cell Biol. 2016 09; 18(9):954-966. PMID: 27501329; PMCID: PMC5026327.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    33. Guo K, Cui J, Quan M, Xie D, Jia Z, Wei D, Wang L, Gao Y, Ma Q, Xie K. The Novel KLF4/MSI2 Signaling Pathway Regulates Growth and Metastasis of Pancreatic Cancer. Clin Cancer Res. 2017 Feb 01; 23(3):687-696. PMID: 27449499; PMCID: PMC5253336.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    34. Xue J, Zhou A, Wu Y, Morris SA, Lin K, Amin S, Verhaak R, Fuller G, Xie K, Heimberger AB, Huang S. miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis. Cancer Res. 2016 07 15; 76(14):4293-304. PMID: 27246830; PMCID: PMC5033679.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    35. Wei D, Wang L, Yan Y, Jia Z, Gagea M, Li Z, Zuo X, Kong X, Huang S, Xie K. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell. 2016 Mar 14; 29(3):324-338. PMID: 26977883; PMCID: PMC4794756.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    36. Yan Y, Li Z, Kong X, Jia Z, Zuo X, Gagea M, Huang S, Wei D, Xie K. KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis. Cancer Res. 2016 04 15; 76(8):2419-31. PMID: 26880805; PMCID: PMC4876033.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    37. Guo J, Xie K, Zheng S. Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer. Int J Biol Sci. 2016; 12(3):292-301. PMID: 26929736; PMCID: PMC4753158.
      Citations: 12     Fields:    Translation:HumansAnimals
    38. Yu G, Yu W, Jin G, Xu D, Chen Y, Xia T, Yu A, Fang W, Zhang X, Li Z, Xie K. PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma. Mol Cancer. 2015 Nov 14; 14:193. PMID: 26576639; PMCID: PMC4650283.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    39. Xie D, Cui J, Xia T, Jia Z, Wang L, Wei W, Zhu A, Gao Y, Xie K, Quan M. Hippo transducer TAZ promotes epithelial mesenchymal transition and supports pancreatic cancer progression. Oncotarget. 2015 Nov 03; 6(34):35949-63. PMID: 26416426; PMCID: PMC4742153.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    40. Quan M, Cui J, Xia T, Jia Z, Xie D, Wei D, Huang S, Huang Q, Zheng S, Xie K. Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/?-Catenin Signaling. Cancer Res. 2015 Nov 15; 75(22):4778-4789. PMID: 26483206; PMCID: PMC4651817.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    41. Sun H, Tang H, Xie D, Jia Z, Ma Z, Wei D, Mishra L, Gao Y, Zheng S, Xie K, Peng Z. Kr?ppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6. Clin Cancer Res. 2016 Jan 15; 22(2):502-12. PMID: 26338995; PMCID: PMC4715982.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    42. Li F, Hu J, Xie K, He TC. Authentication of experimental materials: A remedy for the reproducibility crisis? Genes Dis. 2015 Dec; 2(4):283. PMID: 26900588; PMCID: PMC4758512.
      Citations: 2     
    43. Xue J, Zhou A, Tan C, Wu Y, Lee HT, Li W, Xie K, Huang S. Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression. J Biol Chem. 2015 Jul 24; 290(30):18662-70. PMID: 26085085; PMCID: PMC4513123.
      Citations: 14     Fields:    Translation:HumansCells
    44. Xie D, Xie K. Pancreatic cancer stromal biology and therapy. Genes Dis. 2015 Jun 01; 2(2):133-143. PMID: 26114155; PMCID: PMC4476547.
      Citations: 48     
    45. Yu G, Fang W, Xia T, Chen Y, Gao Y, Jiao X, Huang S, Wang J, Li Z, Xie K. Metformin potentiates rapamycin and cisplatin in gastric cancer in mice. Oncotarget. 2015 May 20; 6(14):12748-62. PMID: 25909163; PMCID: PMC4494971.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    46. Zhu M, Guo J, Li W, Lu Y, Fu S, Xie X, Xia H, Dong X, Chen Y, Quan M, Zheng S, Xie K, Li M. Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells. Oncotarget. 2015 May 20; 6(14):12196-208. PMID: 25682869; PMCID: PMC4494932.
      Citations: 35     Fields:    Translation:HumansCells
    47. Yu G, Zhou A, Xue J, Huang C, Zhang X, Kang SH, Chiu WT, Tan C, Xie K, Wang J, Huang S. FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway. Oncotarget. 2015 May 10; 6(13):11281-94. PMID: 25869208; PMCID: PMC4484456.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    48. Lee HT, Xue J, Chou PC, Zhou A, Yang P, Conrad CA, Aldape KD, Priebe W, Patterson C, Sawaya R, Xie K, Huang S. Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells. Oncotarget. 2015 Apr 30; 6(12):10016-29. PMID: 25881542; PMCID: PMC4496337.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    49. Phan AT, Hess K, Fogelman D, Jacobs C, Dagohoy C, Leary C, Xie K, Ng CS, Yao JC. Perfusion computed tomography as functional biomarker in randomized run-in study of bevacizumab and everolimus in well-differentiated neuroendocrine tumors. Pancreas. 2015 Mar; 44(2):190-7. PMID: 25426617; PMCID: PMC6063309.
      Citations: 20     Fields:    Translation:Humans
    50. Li Z, Guo J, Xie K, Zheng S. Vitamin D receptor signaling and pancreatic cancer cell EMT. Curr Pharm Des. 2015; 21(10):1262-7. PMID: 25506892; PMCID: PMC4880057.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    51. Li Z, Jia Z, Gao Y, Xie D, Wei D, Cui J, Mishra L, Huang S, Zhang Y, Xie K. Activation of vitamin D receptor signaling downregulates the expression of nuclear FOXM1 protein and suppresses pancreatic cancer cell stemness. Clin Cancer Res. 2015 Feb 15; 21(4):844-53. PMID: 25501129; PMCID: PMC4334671.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    52. Shi M, Cui J, Du J, Wei D, Jia Z, Zhang J, Zhu Z, Gao Y, Xie K. A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. Clin Cancer Res. 2014 Aug 15; 20(16):4370-80. PMID: 24947925; PMCID: PMC4134726.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    53. Li X, Wang Z, Ma Q, Xu Q, Liu H, Duan W, Lei J, Ma J, Wang X, Lv S, Han L, Li W, Guo J, Guo K, Zhang D, Wu E, Xie K. Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer. Clin Cancer Res. 2014 Aug 15; 20(16):4326-38. PMID: 24947933.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    54. Li L, Li Z, Kong X, Xie D, Jia Z, Jiang W, Cui J, Du Y, Wei D, Huang S, Xie K. Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and ?-catenin signaling in pancreatic ductal adenocarcinoma cells. Gastroenterology. 2014 Aug; 147(2):485-97.e18. PMID: 24859161.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    55. Cui J, Shi M, Xie D, Wei D, Jia Z, Zheng S, Gao Y, Huang S, Xie K. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clin Cancer Res. 2014 May 15; 20(10):2595-606. PMID: 24634381; PMCID: PMC4024335.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    56. Huang C, Xie D, Cui J, Li Q, Gao Y, Xie K. FOXM1c promotes pancreatic cancer epithelial-to-mesenchymal transition and metastasis via upregulation of expression of the urokinase plasminogen activator system. Clin Cancer Res. 2014 Mar 15; 20(6):1477-88. PMID: 24452790; PMCID: PMC3959252.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    57. Huang C, Du J, Xie K. FOXM1 and its oncogenic signaling in pancreatic cancer pathogenesis. Biochim Biophys Acta. 2014 Apr; 1845(2):104-16. PMID: 24418574; PMCID: PMC3995850.
      Citations: 30     Fields:    Translation:HumansCells
    58. Shi M, Xie D, Gaod Y, Xie K. Targeting miRNAs for pancreatic cancer therapy. Curr Pharm Des. 2014; 20(33):5279-86. PMID: 24479803; PMCID: PMC4113604.
      Citations: 9     Fields:    Translation:HumansCells
    59. Quan M, Wang P, Cui J, Gao Y, Xie K. The roles of FOXM1 in pancreatic stem cells and carcinogenesis. Mol Cancer. 2013 Dec 10; 12:159. PMID: 24325450; PMCID: PMC3924162.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    60. Cui J, Shi M, Quan M, Xie K. Regulation of EMT by KLF4 in gastrointestinal cancer. Curr Cancer Drug Targets. 2013 Nov; 13(9):986-95. PMID: 24168184; PMCID: PMC4127075.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    61. Cui J, Xie K, Shi M. Signaling of miRNAs-FOXM1 in cancer and potential targeted therapy. Curr Drug Targets. 2013 Sep; 14(10):1192-202. PMID: 23834153; PMCID: PMC4081534.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    62. Jiang Y, DiVittore NA, Young MM, Jia Z, Xie K, Ritty TM, Kester M, Fox TE. Altered sphingolipid metabolism in patients with metastatic pancreatic cancer. Biomolecules. 2013 Jul 25; 3(3):435-48. PMID: 24970174; PMCID: PMC4030952.
      Citations: 17     Fields:    
    63. Li L, Du Y, Kong X, Li Z, Jia Z, Cui J, Gao J, Wang G, Xie K. Lamin B1 is a novel therapeutic target of betulinic acid in pancreatic cancer. Clin Cancer Res. 2013 Sep 01; 19(17):4651-61. PMID: 23857605; PMCID: PMC3800003.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    64. Kong X, Li L, Li Z, Le X, Huang C, Jia Z, Cui J, Huang S, Wang L, Xie K. Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer. Cancer Res. 2013 Jul 01; 73(13):3987-96. PMID: 23598278; PMCID: PMC3702645.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    65. Guo K, Ma Q, Li J, Wang Z, Shan T, Li W, Xu Q, Xie K. Interaction of the sympathetic nerve with pancreatic cancer cells promotes perineural invasion through the activation of STAT3 signaling. Mol Cancer Ther. 2013 Mar; 12(3):264-73. PMID: 23288783.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    66. Huang C, Xie K. Analysis of the potential for pancreatic cancer metastasis in vitro and in vivo. Methods Mol Biol. 2013; 980:301-19. PMID: 23359162.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    67. Li D, Wei P, Peng Z, Huang C, Tang H, Jia Z, Cui J, Le X, Huang S, Xie K. The critical role of dysregulated FOXM1-PLAUR signaling in human colon cancer progression and metastasis. Clin Cancer Res. 2013 Jan 01; 19(1):62-72. PMID: 23136192; PMCID: PMC3537853.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    68. Wang L, Liu H, Chen X, Zhang M, Xie K, Ma Q. Immune sculpting of norepinephrine on MHC-I, B7-1, IDO and B7-H1 expression and regulation of proliferation and invasion in pancreatic carcinoma cells. PLoS One. 2012; 7(9):e45491. PMID: 23029049; PMCID: PMC3446877.
      Citations: 11     Fields:    Translation:HumansCells
    69. Kong X, Li L, Li Z, Xie K. Targeted destruction of the orchestration of the pancreatic stroma and tumor cells in pancreatic cancer cases: molecular basis for therapeutic implications. Cytokine Growth Factor Rev. 2012 Dec; 23(6):343-56. PMID: 22749856; PMCID: PMC3505269.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    70. Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K. Dysregulated Kr?ppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology. 2012 Sep; 143(3):799-810.e2. PMID: 22677193; PMCID: PMC3653768.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    71. Huang C, Xie K. Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. Cytokine Growth Factor Rev. 2012 Feb-Apr; 23(1-2):25-35. PMID: 22342309; PMCID: PMC3307878.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    72. Li W, Ma Q, Liu J, Han L, Ma G, Liu H, Shan T, Xie K, Wu E. Hyperglycemia as a mechanism of pancreatic cancer metastasis. Front Biosci (Landmark Ed). 2012 01 01; 17(5):1761-74. PMID: 22201834.
      Citations: 11     Fields:    Translation:Humans
    73. Jiang W, Wang S, Wang L, Xie K, Cui J. Role of Wnt/?-catenin signaling in drug resistance of pancreatic cancer. Curr Pharm Des. 2012; 18(17):2464-71. PMID: 22372504.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    74. Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon CD, Le X, Wei D, Huang S, Xie K. A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Res. 2012 Feb 01; 72(3):655-65. PMID: 22194465; PMCID: PMC3271134.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    75. Li Q, Jia Z, Wang L, Kong X, Li Q, Guo K, Tan D, Le X, Wei D, Huang S, Mishra L, Xie K. Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology. 2012 Mar; 142(3):531-42. PMID: 22155367; PMCID: PMC3477581.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    76. Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, He X, Huang S, Medema RH. FoxM1 promotes ?-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell. 2011 Oct 18; 20(4):427-42. PMID: 22014570; PMCID: PMC3199318.
      Citations: 282     Fields:    Translation:HumansAnimalsCells
    77. Gao Y, Jia Z, Kong X, Li Q, Chang DZ, Wei D, Le X, Suyun H, Huang S, Wang L, Xie K. Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Res. 2011 Aug 01; 71(15):5182-93. PMID: 21673052; PMCID: PMC3245664.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    78. Chiu WT, Lee HT, Huang FJ, Aldape KD, Yao J, Steeg PS, Chou CY, Lu Z, Xie K, Huang S. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res. 2011 Jul 15; 71(14):4932-43. PMID: 21622714; PMCID: PMC4170798.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    79. Li D, Peng Z, Tang H, Wei P, Kong X, Yan D, Huang F, Li Q, Le X, Li Q, Xie K. KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis. Clin Cancer Res. 2011 Jun 01; 17(11):3558-68. PMID: 21531817; PMCID: PMC3107880.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    80. Wei D, Wang L, Kanai M, Jia Z, Le X, Li Q, Wang H, Xie K. KLF4a up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer. Gastroenterology. 2010 Dec; 139(6):2135-45. PMID: 20727893; PMCID: PMC3245983.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    81. Dai B, Pieper RO, Li D, Wei P, Liu M, Woo SY, Aldape KD, Sawaya R, Xie K, Huang S. FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes. Cancer Res. 2010 Apr 01; 70(7):2951-61. PMID: 20332230; PMCID: PMC2848915.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    82. Jia Z, Gao Y, Wang L, Li Q, Zhang J, Le X, Wei D, Yao JC, Chang DZ, Huang S, Xie K. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Res. 2010 Feb 01; 70(3):1111-9. PMID: 20086170; PMCID: PMC2840649.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    83. Wang L, Xie K. Nitric oxide and pancreatic cancer pathogenesis, prevention, and treatment. Curr Pharm Des. 2010; 16(4):421-7. PMID: 20236070.
      Citations: 11     Fields:    Translation:HumansAnimals
    84. Hu HT, Ma QY, Zhang D, Shen SG, Han L, Ma YD, Li RF, Xie KP. HIF-1alpha links beta-adrenoceptor agonists and pancreatic cancer cells under normoxic condition. Acta Pharmacol Sin. 2010 Jan; 31(1):102-10. PMID: 20037603; PMCID: PMC4002695.
      Citations: 19     Fields:    Translation:HumansCells
    85. Li Q, Wei D, Wang L, Wang L, Jia Z, Le X, Gao Y, Huang S, Xie K. Modeling liver metastasis using a tumor cell line derived from an enhanced green fluorescent protein transgenic mouse. Clin Exp Metastasis. 2010; 27(1):11-8. PMID: 19882218.
      Citations: 1     Fields:    Translation:AnimalsCells
    86. Hu W, Hofstetter WL, Li H, Zhou Y, He Y, Pataer A, Wang L, Xie K, Swisher SG, Fang B. Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma. Clin Cancer Res. 2009 Sep 15; 15(18):5688-95. PMID: 19737957; PMCID: PMC2745510.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    87. Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell. 2009 Jul 10; 35(1):11-25. PMID: 19595712; PMCID: PMC2715139.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    88. Li Q, Zhang N, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Res. 2009 Apr 15; 69(8):3501-9. PMID: 19351851; PMCID: PMC4087044.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    89. Yu G, Wang J, Chen Y, Wang X, Pan J, Li G, Jia Z, Li Q, Yao JC, Xie K. Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer. Clin Cancer Res. 2009 Mar 01; 15(5):1821-9. PMID: 19223493.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    90. Truong CD, Feng W, Li W, Khoury T, Li Q, Alrawi S, Yu Y, Xie K, Yao J, Tan D. Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U.S.A. J Exp Clin Cancer Res. 2009 Feb 03; 28:14. PMID: 19192297; PMCID: PMC2642773.
      Citations: 30     Fields:    Translation:HumansCells
    91. Huang FJ, Steeg PS, Price JE, Chiu WT, Chou PC, Xie K, Sawaya R, Huang S. Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis. Cancer Res. 2008 Dec 01; 68(23):9634-42. PMID: 19047140; PMCID: PMC7418219.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    92. Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K, Huang S. FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. Cancer Res. 2008 Nov 01; 68(21):8733-42. PMID: 18974115; PMCID: PMC2597644.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    93. Peng Z, Tang H, Wang X, Zhou C, Fan J, Wang L, Jia Z, Li Q, Le X, Wei D, Xie K. Inhibition of the growth and metastasis of human colon cancer by restoration of RUNX3 expression in cancer cells. Int J Oncol. 2008 Nov; 33(5):979-84. PMID: 18949360.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    94. Fan J, Peng Z, Zhou C, Qiu G, Tang H, Sun Y, Wang X, Li Q, Le X, Xie K. Gene-expression profiling in Chinese patients with colon cancer by coupling experimental and bioinformatic genomewide gene-expression analyses: identification and validation of IFITM3 as a biomarker of early colon carcinogenesis. Cancer. 2008 Jul 15; 113(2):266-75. PMID: 18470904.
      Citations: 23     Fields:    Translation:HumansCells
    95. Wang L, Guan X, Zhang J, Jia Z, Wei D, Li Q, Yao J, Xie K. Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models. Int J Oncol. 2008 Jul; 33(1):161-7. PMID: 18575762.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    96. Wei D, Kanai M, Jia Z, Le X, Xie K. Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res. 2008 Jun 15; 68(12):4631-9. PMID: 18559508; PMCID: PMC2481517.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    97. Yu G, Wang J, Chen Y, Wang X, Pan J, Li Q, Xie K. Tissue microarray analysis reveals strong clinical evidence for a close association between loss of annexin A1 expression and nodal metastasis in gastric cancer. Clin Exp Metastasis. 2008; 25(7):695-702. PMID: 18535914.
      Citations: 35     Fields:    Translation:Humans
    98. Truong CD, Li W, Feng W, Cagle P, Khoury T, Alrawi S, Xie K, Yao J, Tan D. Alpha-methylacyl-CoA racemase expression is upregulated in gastric adenocarcinoma: a study of 249 cases. Int J Clin Exp Pathol. 2008 Apr 10; 1(6):518-23. PMID: 18787636; PMCID: PMC2480587.
      Citations: 3     Fields:    
    99. Yuan P, Wang L, Wei D, Zhang J, Jia Z, Li Q, Le X, Wang H, Yao J, Xie K. Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer. Cancer. 2007 Dec 15; 110(12):2682-90. PMID: 17973266.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    100. Lin EH, Hassan M, Li Y, Zhao H, Nooka A, Sorenson E, Xie K, Champlin R, Wu X, Li D. Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence. Cancer. 2007 Aug 01; 110(3):534-42. PMID: 17594720.
      Citations: 35     Fields:    Translation:HumansCells
    101. Jia Z, Zhang J, Wei D, Wang L, Yuan P, Le X, Li Q, Yao J, Xie K. Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A. Cancer Res. 2007 May 15; 67(10):4878-85. PMID: 17510417.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    102. Zhang J, Jia Z, Li Q, Wang L, Rashid A, Zhu Z, Evans DB, Vauthey JN, Xie K, Yao JC. Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors. Cancer. 2007 Apr 15; 109(8):1478-86. PMID: 17340592.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    103. Wang LW, Li Q, Hua ZL, Zhou F, Keping X, Daoyan W, Yao J, Ajani J. [Expression of transcription factor Sp1 in human gastric cancer tissue and its correlation with prognosis]. Zhonghua Zhong Liu Za Zhi. 2007 Feb; 29(2):107-11. PMID: 17645844.
      Citations: 3     Fields:    Translation:HumansCells
    104. Yao JC, Zhang JX, Rashid A, Yeung SC, Szklaruk J, Hess K, Xie K, Ellis L, Abbruzzese JL, Ajani JA. Clinical and in vitro studies of imatinib in advanced carcinoid tumors. Clin Cancer Res. 2007 Jan 01; 13(1):234-40. PMID: 17200360.
      Citations: 26     Fields:    Translation:HumansCellsCTClinical Trials
    105. Zhang J, Jiang Y, Jia Z, Li Q, Gong W, Wang L, Wei D, Yao J, Fang S, Xie K. Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer. Clin Exp Metastasis. 2006; 23(7-8):401-10. PMID: 17187227.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    106. Kanai M, Wei D, Li Q, Jia Z, Ajani J, Le X, Yao J, Xie K. Loss of Kr?ppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression. Clin Cancer Res. 2006 Nov 01; 12(21):6395-402. PMID: 17085651.
      Citations: 52     Fields:    Translation:HumansCells
    107. Peng Z, Wei D, Wang L, Tang H, Zhang J, Le X, Jia Z, Li Q, Xie K. RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer. Clin Cancer Res. 2006 Nov 01; 12(21):6386-94. PMID: 17085650.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    108. Lancaster JR, Xie K. Tumors face NO problems? Cancer Res. 2006 Jul 01; 66(13):6459-62. PMID: 16818612.
      Citations: 37     Fields:    Translation:HumansAnimals
    109. Liu M, Dai B, Kang SH, Ban K, Huang FJ, Lang FF, Aldape KD, Xie TX, Pelloski CE, Xie K, Sawaya R, Huang S. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res. 2006 Apr 01; 66(7):3593-602. PMID: 16585184.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    110. Xie TX, Huang FJ, Aldape KD, Kang SH, Liu M, Gershenwald JE, Xie K, Sawaya R, Huang S. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res. 2006 Mar 15; 66(6):3188-96. PMID: 16540670.
      Citations: 169     Fields:    Translation:HumansAnimals
    111. Xie K, Wei D, Huang S. Transcriptional anti-angiogenesis therapy of human pancreatic cancer. Cytokine Growth Factor Rev. 2006 Jun; 17(3):147-56. PMID: 16516532.
      Citations: 27     Fields:    Translation:HumansCells
    112. Wei D, Kanai M, Huang S, Xie K. Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis. 2006 Jan; 27(1):23-31. PMID: 16219632.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    113. Gong W, Jiang Y, Wang L, Wei D, Yao J, Huang S, Fang S, Xie K. Expression of autocrine motility factor correlates with the angiogenic phenotype of and poor prognosis for human gastric cancer. Clin Cancer Res. 2005 Aug 15; 11(16):5778-83. PMID: 16115916.
      Citations: 2     Fields:    Translation:Humans
    114. Le X, Wei D, Huang S, Lancaster JR, Xie K. Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8758-63. PMID: 15939886; PMCID: PMC1150810.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    115. Wei D, Gong W, Oh SC, Li Q, Kim WD, Wang L, Le X, Yao J, Wu TT, Huang S, Xie K. Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. Cancer Res. 2005 Jun 01; 65(11):4809-16. PMID: 15930301.
      Citations: 36     Fields:    Translation:HumansCells
    116. Yao JC, Tseng JF, Worah S, Hess KR, Mansfield PF, Crane CH, Schnirer II, Reddy S, Chiang SS, Najam A, Yu C, Giacco GG, Xie K, Wu TT, Feig BW, Pisters PW, Ajani JA. Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: analysis of a single institution's experience over 15 years. J Clin Oncol. 2005 May 01; 23(13):3094-103. PMID: 15860869.
      Citations: 32     Fields:    Translation:Humans
    117. Wei D, Gong W, Kanai M, Schlunk C, Wang L, Yao JC, Wu TT, Huang S, Xie K. Drastic down-regulation of Kr?ppel-like factor 4 expression is critical in human gastric cancer development and progression. Cancer Res. 2005 Apr 01; 65(7):2746-54. PMID: 15805274.
      Citations: 159     Fields:    Translation:HumansCells
    118. Gong W, Wang L, Yao JC, Ajani JA, Wei D, Aldape KD, Xie K, Sawaya R, Huang S. Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res. 2005 Feb 15; 11(4):1386-93. PMID: 15746037.
      Citations: 58     Fields:    Translation:HumansCells
    119. Peng Z, Zhang Y, Gu W, Wang Z, Li D, Zhang F, Qiu G, Xie K. Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: a key to the cell cycle and apoptosis. Int J Oncol. 2005 Feb; 26(2):467-73. PMID: 15645132.
      Citations: 24     Fields:    Translation:HumansCells
    120. An C, Choi IS, Yao JC, Worah S, Xie K, Mansfield PF, Ajani JA, Rashid A, Hamilton SR, Wu TT. Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):656-63. PMID: 15701853.
      Citations: 66     Fields:    Translation:HumansCells
    121. Wang L, Shi GG, Yao JC, Gong W, Wei D, Wu TT, Ajani JA, Huang S, Xie K. Expression of endothelial nitric oxide synthase correlates with the angiogenic phenotype of and predicts poor prognosis in human gastric cancer. Gastric Cancer. 2005; 8(1):18-28. PMID: 15747170.
      Citations: 15     Fields:    Translation:Humans
    122. Wang L, Guan X, Gong W, Yao J, Peng Z, Wei D, Wu TT, Huang S, Xie K. Altered expression of transcription factor Sp1 critically impacts the angiogenic phenotype of human gastric cancer. Clin Exp Metastasis. 2005; 22(3):205-13. PMID: 16158248.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    123. Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev. 2004 Oct; 15(5):297-324. PMID: 15450248.
      Citations: 44     Fields:    Translation:HumansCells
    124. Yao JC, Wang L, Wei D, Gong W, Hassan M, Wu TT, Mansfield P, Ajani J, Xie K. Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer. Clin Cancer Res. 2004 Jun 15; 10(12 Pt 1):4109-17. PMID: 15217947.
      Citations: 87     Fields:    Translation:HumansCells
    125. Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic cancer. Lancet. 2004 Mar 27; 363(9414):1049-57. PMID: 15051286.
      Citations: 782     Fields:    Translation:Humans
    126. Wei D, Wang L, He Y, Xiong HQ, Abbruzzese JL, Xie K. Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. Cancer Res. 2004 Mar 15; 64(6):2030-8. PMID: 15026340.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    127. Xiong HQ, Abbruzzese JL, Lin E, Wang L, Zheng L, Xie K. NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. Int J Cancer. 2004 Jan 10; 108(2):181-8. PMID: 14639600.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    128. Jiang Y, Wang L, Gong W, Wei D, Le X, Yao J, Ajani J, Abbruzzese JL, Huang S, Xie K. A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. Clin Exp Metastasis. 2004; 21(8):755-64. PMID: 16035620.
      Citations: 28     Fields:    Translation:HumansAnimals
    129. Zheng L, Wang L, Ajani J, Xie K. Molecular basis of gastric cancer development and progression. Gastric Cancer. 2004; 7(2):61-77. PMID: 15224192.
      Citations: 66     Fields:    Translation:Humans
    130. Wang L, Wei D, Huang S, Peng Z, Le X, Wu TT, Yao J, Ajani J, Xie K. Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer. Clin Cancer Res. 2003 Dec 15; 9(17):6371-80. PMID: 14695137.
      Citations: 150     Fields:    Translation:HumansCells
    131. Xie K, Abbruzzese JL. Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. Cancer Cell. 2003 Oct; 4(4):245-7. PMID: 14585350.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    132. Wei D, Richardson EL, Zhu K, Wang L, Le X, He Y, Huang S, Xie K. Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase. Cancer Res. 2003 Jul 15; 63(14):3855-9. PMID: 12873972.
      Citations: 14     Fields:    Translation:AnimalsCells
    133. Xie K, Huang S. Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency. Free Radic Biol Med. 2003 Apr 15; 34(8):969-86. PMID: 12684082.
      Citations: 24     Fields:    Translation:HumansAnimals
    134. Wang B, Wei D, Crum VE, Richardson EL, Xiong HH, Luo Y, Huang S, Abbruzzese JL, Xie K. A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis. Oncogene. 2003 Mar 27; 22(12):1771-82. PMID: 12660813.
      Citations: 19     Fields:    Translation:Animals
    135. Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene. 2003 Jan 23; 22(3):319-29. PMID: 12545153.
      Citations: 212     Fields:    Translation:HumansAnimalsCells
    136. Xie K, Huang S. Regulation of cancer metastasis by stress pathways. Clin Exp Metastasis. 2003; 20(1):31-43. PMID: 12650605.
      Citations: 28     Fields:    Translation:HumansCells
    137. Peng Z, Zhang F, Zhou C, Ling Y, Bai S, Liu W, Qiu G, He L, Wang L, Wei D, Lin E, Xie K. Genome-wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer. Int J Gastrointest Cancer. 2003; 34(1):39-48. PMID: 15235134.
      Citations: 7     Fields:    Translation:HumansCells
    138. Wei D, Xiong HQ, Abbruzzese JL, Xie K. Experimental animal models of pancreatic carcinogenesis and metastasis. Int J Gastrointest Cancer. 2003; 33(1):43-60. PMID: 12909737.
      Citations: 5     Fields:    Translation:HumansAnimals
    139. Yin S, Bailiang W, Xie K, Goodrich DW. Adenovirus-mediated N5 gene transfer inhibits tumor growth and metastasis of human carcinoma in nude mice. Cancer Gene Ther. 2002 Aug; 9(8):665-72. PMID: 12136427.
      Citations:    Fields:    Translation:HumansAnimalsCells
    140. Salnikow K, Kluz T, Costa M, Piquemal D, Demidenko ZN, Xie K, Blagosklonny MV. The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol. 2002 Mar; 22(6):1734-41. PMID: 11865053; PMCID: PMC135615.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    141. Yao JC, Schnirer II, Reddy S, Chiang S, Najam A, Yu C, Giacco G, Hess K, Rashid A, Xie K, Lynch P, Ajani JA. Effects of sex and racial/ethnic group on the pattern of gastric cancer localization. Gastric Cancer. 2002; 5(4):208-12. PMID: 12491078.
      Citations: 22     Fields:    Translation:Humans
    142. Xie K. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev. 2001 Dec; 12(4):375-91. PMID: 11544106.
      Citations: 249     Fields:    Translation:HumansAnimals
    143. Wang B, Xiong Q, Shi Q, Le X, Xie K. Genetic disruption of host interferon-gamma drastically enhances the metastasis of pancreatic adenocarcinoma through impaired expression of inducible nitric oxide synthase. Oncogene. 2001 Oct 18; 20(47):6930-7. PMID: 11687972.
      Citations: 4     Fields:    Translation:AnimalsCells
    144. Wen Y, Yan DH, Wang B, Spohn B, Ding Y, Shao R, Zou Y, Xie K, Hung MC. p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models. Cancer Res. 2001 Oct 01; 61(19):7142-7. PMID: 11585747.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    145. Shi Q, Xiong Q, Le X, Xie K. Regulation of interleukin-8 expression by tumor-associated stress factors. J Interferon Cytokine Res. 2001 Aug; 21(8):553-66. PMID: 11559433.
      Citations: 21     Fields:    Translation:HumansAnimals
    146. Xiong Q, Shi Q, Le X, Wang B, Xie K. Regulation of interleukin-8 expression by nitric oxide in human pancreatic adenocarcinoma. J Interferon Cytokine Res. 2001 Jul; 21(7):529-37. PMID: 11506748.
      Citations: 8     Fields:    Translation:HumansCells
    147. Shi Q, Le X, Wang B, Abbruzzese JL, Xiong Q, He Y, Xie K. Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. Oncogene. 2001 Jun 21; 20(28):3751-6. PMID: 11439338.
      Citations: 103     Fields:    Translation:HumansCells
    148. Shi Q, Le X, Abbruzzese JL, Peng Z, Qian CN, Tang H, Xiong Q, Wang B, Li XC, Xie K. Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res. 2001 May 15; 61(10):4143-54. PMID: 11358838.
      Citations: 120     Fields:    Translation:HumansCells
    149. Wang B, Xiong Q, Shi Q, Tan D, Le X, Xie K. Genetic disruption of host nitric oxide synthase II gene impairs melanoma-induced angiogenesis and suppresses pleural effusion. Int J Cancer. 2001 Mar 01; 91(5):607-11. PMID: 11267968.
      Citations: 16     Fields:    Translation:AnimalsCells
    150. Wang B, Xiong Q, Shi Q, Le X, Abbruzzese JL, Xie K. Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. Cancer Res. 2001 Jan 01; 61(1):71-5. PMID: 11196200.
      Citations: 19     Fields:    Translation:AnimalsCells
    151. Wang B, Shi Q, Abbruzzese JL, Xiong Q, Le X, Xie K. A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy. Int J Pancreatol. 2001; 29(1):37-46. PMID: 11558631.
      Citations: 11     Fields:    Translation:AnimalsCells
    152. Xie K, Wang B, Shi Q, Abbruzzese JL, Xiong Q, Le X. Mouse models of metastatic pancreatic adenocarcinoma. Int J Pancreatol. 2001; 29(1):25-35. PMID: 11558630.
      Citations: 1     Fields:    Translation:AnimalsCells
    153. Xie K, Wang B, Shi Q, Abbruzzese J, Xiong Q, Le X. Mouse Models of Metastatic Pancreatic Adenocarcinoma. Int J Gastrointest Cancer. 2001; 29(1):25-36. PMID: 12754402.
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    154. Wang B, Shi Q, Abbruzzese J, Xiong Q, Le X, Xie K. A Novel, Clinically Relevant Animal Model of Metastatic Pancreatic Adenocarcinoma Biology and Therapy. Int J Gastrointest Cancer. 2001; 29(1):37-46. PMID: 12754403.
      Citations: 7     Fields:    
    155. Le X, Shi Q, Wang B, Xiong Q, Qian C, Peng Z, Li XC, Tang H, Abbruzzese JL, Xie K. Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma. J Interferon Cytokine Res. 2000 Nov; 20(11):935-46. PMID: 11096450.
      Citations: 32     Fields:    Translation:HumansCells
    156. Shi Q, Le X, Wang B, Xiong Q, Abbruzzese JL, Xie K. Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells. J Interferon Cytokine Res. 2000 Nov; 20(11):1023-8. PMID: 11096460.
      Citations: 21     Fields:    Translation:HumansCells
    157. Shi Q, Xie K. Experimental animal models of pancreatic cancer (review). Int J Oncol. 2000 Aug; 17(2):217-25. PMID: 10891528.
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    158. Kumar R, Xie K, Eue I, Dong Z, Killion JJ, Fidler IJ. Differential regulation of type IV collagenases and metalloelastase in murine macrophages by the synthetic bacterial lipopeptide JBT 3002. Int J Immunopharmacol. 2000 Jun; 22(6):431-43. PMID: 10727754.
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    159. Shi Q, Le X, Abbruzzese JL, Wang B, Mujaida N, Matsushima K, Huang S, Xiong Q, Xie K. Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia. J Interferon Cytokine Res. 1999 Dec; 19(12):1363-71. PMID: 10638705.
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    160. Xu L, Xie K, Mukaida N, Matsushima K, Fidler IJ. Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells. Cancer Res. 1999 Nov 15; 59(22):5822-9. PMID: 10582705.
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    161. Shi Q, Abbruzzese JL, Huang S, Fidler IJ, Xiong Q, Xie K. Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res. 1999 Nov; 5(11):3711-21. PMID: 10589791.
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    162. Shi Q, Huang S, Jiang W, Kutach LS, Ananthaswamy HN, Xie K. Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53. Cancer Res. 1999 May 01; 59(9):2072-5. PMID: 10232590.
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    163. Xu L, Xie K, Fidler IJ. Therapy of human ovarian cancer by transfection with the murine interferon beta gene: role of macrophage-inducible nitric oxide synthase. Hum Gene Ther. 1998 Dec 10; 9(18):2699-708. PMID: 9874268.
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    164. Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM. Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res. 1998 Sep 01; 58(17):4008-14. PMID: 9731515.
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    165. Rodrigues-Lima F, Huang S, Xie K, Guillaume N, Bar-Eli M, Frade R. Procathepsin-L, a proteinase that cleaves human C3 (the third component of complement), confers high tumorigenic and metastatic properties to human melanoma cells. Cancer Res. 1998 Jul 01; 58(13):2733-6. PMID: 9661883.
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    166. Dong Z, Juang SH, Kumar R, Eue I, Xie K, Bielenberg D, Lu W, Bucana C, Yang X, Fidler IJ. Suppression of tumorigenicity and metastasis in murine UV-2237 fibrosarcoma cells by infection with a retroviral vector harboring the interferon-beta gene. Cancer Immunol Immunother. 1998 May; 46(3):137-46. PMID: 9625537.
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    167. Juang SH, Xie K, Xu L, Shi Q, Wang Y, Yoneda J, Fidler IJ. Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene. Hum Gene Ther. 1998 Apr 10; 9(6):845-54. PMID: 9581907.
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    168. Xie K, Fidler IJ. Therapy of cancer metastasis by activation of the inducible nitric oxide synthase. Cancer Metastasis Rev. 1998 Mar; 17(1):55-75. PMID: 9544423.
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    169. Ong C. The DNA repair capacity of melanoma cells. J Invest Dermatol. 1998 Feb; 110(2):187-8. PMID: 9457921.
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    170. Xie K, Bielenberg D, Huang S, Xu L, Salas T, Juang SH, Dong Z, Fidler IJ. Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide. Clin Cancer Res. 1997 Dec; 3(12 Pt 1):2283-94. PMID: 9815626.
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    171. Xie K, Wang Y, Huang S, Xu L, Bielenberg D, Salas T, McConkey DJ, Jiang W, Fidler IJ. Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2. Oncogene. 1997 Aug 14; 15(7):771-9. PMID: 9266963.
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    172. Juang SH, Xie K, Xu L, Wang Y, Yoneda J, Fidler IJ. Use of retroviral vectors encoding murine inducible nitric oxide synthase gene to suppress tumorigenicity and cancer metastasis of murine melanoma. Cancer Biother Radiopharm. 1997 Jun; 12(3):167-75. PMID: 10851463.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    173. Xie K, Huang S, Dong Z, Juang SH, Wang Y, Fidler IJ. Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene. J Natl Cancer Inst. 1997 Mar 19; 89(6):421-7. PMID: 9091643.
      Citations: 9     Fields:    Translation:AnimalsCells
    174. Wei Q, Cheng L, Xie K, Bucana CD, Dong Z. Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells. J Invest Dermatol. 1997 Jan; 108(1):3-6. PMID: 8980277.
      Citations: 8     Fields:    Translation:AnimalsCells
    175. Huang S, Xie K, Bucana CD, Ullrich SE, Bar-Eli M. Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis. Clin Cancer Res. 1996 Dec; 2(12):1969-79. PMID: 9816156.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    176. Xie K, Huang S, Wang Y, Beltran PJ, Juang SH, Dong Z, Reed JC, McDonnell TJ, McConkey DJ, Fidler IJ. Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis. Cancer Immunol Immunother. 1996 Oct; 43(2):109-15. PMID: 8954145.
      Citations: 2     Fields:    Translation:AnimalsCells
    177. Kitadai Y, Radinsky R, Bucana CD, Takahashi Y, Xie K, Tahara E, Fidler IJ. Regulation of carcinoembryonic antigen expression in human colon carcinoma cells by the organ microenvironment. Am J Pathol. 1996 Oct; 149(4):1157-66. PMID: 8863665; PMCID: PMC1865204.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    178. Xie K, Dong Z, Fidler IJ. Activation of nitric oxide synthase gene for inhibition of cancer metastasis. J Leukoc Biol. 1996 Jun; 59(6):797-803. PMID: 8691063.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    179. Bar-Eli M, Huang S, Xie K, Rodrigues-Lima F, Hermann J, Frade R, Jean D. A cysteine proteinase, which cleaves human C3, the third component of complement, is involved in tumorigenicity and metastasis of human melanoma. Cancer Res. 1996 Jan 15; 56(2):254-8. PMID: 8542576.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    180. Dong Z, Yang X, Xie K, Juang SH, Llansa N, Fidler IJ. Activation of inducible nitric oxide synthase gene in murine macrophages requires protein phosphatases 1 and 2A activities. J Leukoc Biol. 1995 Dec; 58(6):725-32. PMID: 7499972.
      Citations: 10     Fields:    Translation:AnimalsCells
    181. Xie K, Huang S, Dong Z, Gutman M, Fidler IJ. Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362. Cancer Res. 1995 Jul 15; 55(14):3123-31. PMID: 7541713.
      Citations: 19     Fields:    Translation:AnimalsCells
    182. Huang S, Xie K, Singh RK, Gutman M, Bar-Eli M. Suppression of tumor growth and metastasis of murine renal adenocarcinoma by syngeneic fibroblasts genetically engineered to secrete the JE/MCP-1 cytokine. J Interferon Cytokine Res. 1995 Jul; 15(7):655-65. PMID: 7553238.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    183. Gutman M, Singh RK, Xie K, Bucana CD, Fidler IJ. Regulation of interleukin-8 expression in human melanoma cells by the organ environment. Cancer Res. 1995 Jun 01; 55(11):2470-5. PMID: 7758001.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    184. Xie K, Huang S, Dong Z, Juang SH, Gutman M, Xie QW, Nathan C, Fidler IJ. Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J Exp Med. 1995 Apr 01; 181(4):1333-43. PMID: 7535333; PMCID: PMC2191958.
      Citations: 55     Fields:    Translation:AnimalsCells
    185. Huang S, Singh RK, Xie K, Gutman M, Berry KK, Bucana CD, Fidler IJ, Bar-Eli M. Expression of the JE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells. Cancer Immunol Immunother. 1994 Oct; 39(4):231-8. PMID: 7954525.
      Citations: 24     Fields:    Translation:AnimalsCells
    186. Dong Z, Staroselsky AH, Qi X, Xie K, Fidler IJ. Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells. Cancer Res. 1994 Feb 01; 54(3):789-93. PMID: 7508336.
      Citations: 36     Fields:    Translation:AnimalsCells
    187. Gutman M, Singh RK, Yoon S, Xie K, Bucana CD, Fidler IJ. Leukocyte-induced angiogenesis and subcutaneous growth of B16 melanoma. Cancer Biother. 1994; 9(2):163-70. PMID: 7529086.
      Citations: 3     Fields:    Translation:AnimalsCells
    188. Dong Z, Qi X, Xie K, Fidler IJ. Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages. J Immunol. 1993 Sep 01; 151(5):2717-24. PMID: 7689614.
      Citations: 24     Fields:    Translation:AnimalsCells
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    192. Merlin/NF2 suppresses pancreatic tumor growth and metastasis by attenuating the FOXM1-mediated Wnt/β-catenin signaling. Cancer Research. 75:4778-4789.
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