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XIANGSHENG ZUO

TitleAssistant Professor
InstitutionMD Anderson
DepartmentGI Medical Oncology
Address7435 Fannin St
Houston TX 77054-1901
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zuo X, Wang L, Liu Y, Wang H, Hafley M, Gagea M, Chen R, Xiong Y, Pan S, Shureiqi I, Bresalier RS, Wei D. Dysregulated KLF4 expression plays a pivotal role in the pathogenesis of pancreatic intraductal papillary mucinous neoplasms. Gut. 2024 Jul 05. PMID: 38969489.
      Citations: 1     Fields:    
    2. Kiyasu Y, Zuo X, Liu Y, Yao JC, Shureiqi I. EPA, DHA, and resolvin effects on cancer risk: The underexplored mechanisms. Prostaglandins Other Lipid Mediat. 2024 Oct; 174:106854. PMID: 38825147.
      Citations:    Fields:    Translation:HumansAnimals
    3. Yao Y, Shen Y, Yao JC, Zuo X. Editorial: New advancement in tumor microenvironment remodeling and cancer therapy. Front Cell Dev Biol. 2024; 12:1384567. PMID: 38516127; PMCID: PMC10955374.
      Citations:    
    4. Wei D, Wang L, Zuo X, Maitra A, Bresalier RS. A Small Molecule with Big Impact: MRTX1133 Targets the KRASG12D Mutation in Pancreatic Cancer. Clin Cancer Res. 2024 02 16; 30(4):655-662. PMID: 37831007; PMCID: PMC10922474.
      Citations:    Fields:    Translation:Humans
    5. Liu Y, Wei D, Deguchi Y, Xu W, Tian R, Liu F, Xu M, Mao F, Li D, Chen W, Valentin LA, Deguchi E, Yao JC, Shureiqi I, Zuo X. PPARd dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment. Gastric Cancer. 2023 11; 26(6):904-917. PMID: 37572185; PMCID: PMC10640489.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Tan TH, Wang H, Moniruzzaman R, Li L, Ji B, Liu Y, Zuo X, Abbasgholizadeh R, Zhao J, Liu G, Wang R, Tang H, Sun R, Su X, Maitra A, Wang H. Hematopoietic progenitor kinase 1 inhibits the development and progression of pancreatic intraepithelial neoplasia. J Clin Invest. 2023 06 15; 133(12). PMID: 37140994; PMCID: PMC10266776.
      Citations:    Fields:    Translation:Animals
    7. Wei D, Wang L, Liu Y, Hafley MA, Tan L, Lorenzi PL, Yang P, Zuo X, Bresalier RS. Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression. Dig Dis Sci. 2023 07; 68(7):3043-3058. PMID: 37071246.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Liu Y, Deguchi Y, Wei D, Liu F, Moussalli MJ, Deguchi E, Li D, Wang H, Valentin LA, Colby JK, Wang J, Zheng X, Ying H, Gagea M, Ji B, Shi J, Yao JC, Zuo X, Shureiqi I. Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARd. Nat Commun. 2022 05 13; 13(1):2665. PMID: 35562376; PMCID: PMC9106716.
      Citations:    Fields:    Translation:HumansAnimals
    9. Yang P, Zuo X, Advani S, Wei B, Malek J, Day RS, Shureiqi I. Celecoxib Colorectal Bioavailability and Chemopreventive Response in Patients with Familial Adenomatous Polyposis. Cancer Prev Res (Phila). 2022 04 01; 15(4):217-223. PMID: 34610992; PMCID: PMC8980107.
      Citations:    Fields:    Translation:Humans
    10. Maertzdorf J, Zuo X, Shureiqi I, Mollenkopf HJ, Meyer TF, Kapalczynska M, Lin M, Heuberger J, Muellerke S, Vidal R, Fischer AS, Sauer S, Berger H, Kidess E, Tacke F, Sigal M. BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation. Nat Commun. 2022 03 24; 13(1):1577. PMID: 35332152; PMCID: PMC8948225.
      Citations: 2     Fields:    Translation:AnimalsCells
    11. Pudakalakatti S, Titus M, Ramachandran S, Zacharias NM, Shureiqi I, Liu Y, Yao JC, Zuo X, Bhattacharya PK, Enriquez JS. Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors. Int J Mol Sci. 2022 Jan 31; 23(3). PMID: 35163565; PMCID: PMC8835946.
      Citations:    Fields:    Translation:AnimalsCells
    12. Wei D, Wang L, Zuo X, Bresalier RS. Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer. Cancers (Basel). 2021 May 31; 13(11). PMID: 34072725; PMCID: PMC8198176.
      Citations: 1     
    13. Liu F, Zuo X, Liu Y, Deguchi Y, Moussalli MJ, Chen W, Yang P, Wei B, Tan L, Lorenzi PL, Gao S, Jaoude JC, Mehdizadeh A, Valentin LA, Wei D, Shureiqi I. Suppression of Membranous LRP5 Recycling, Wnt/?-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P. Cell Rep. 2020 08 18; 32(7):108049. PMID: 32814052; PMCID: PMC8765570.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    14. Zuo X, Deguchi Y, Xu W, Liu Y, Li HS, Wei D, Tian R, Chen W, Xu M, Yang Y, Gao S, Jaoude JC, Liu F, Chrieki SP, Moussalli MJ, Gagea M, Sebastian MM, Zheng X, Tan D, Broaddus R, Wang J, Ajami NJ, Swennes AG, Watowich SS, Shureiqi I. PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice. Gastroenterology. 2019 07; 157(1):163-178. PMID: 30885780; PMCID: PMC6581611.
      Citations: 16     Fields:    Translation:AnimalsCells
    15. Liu Y, Deguchi Y, Tian R, Wei D, Wu L, Chen W, Xu W, Xu M, Liu F, Gao S, Jaoude JC, Chrieki SP, Moussalli MJ, Gagea M, Morris J, Broaddus RR, Zuo X, Shureiqi I. Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion. Cancer Res. 2019 03 01; 79(5):954-969. PMID: 30679176; PMCID: PMC6397663.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    16. Liu Y, Colby JK, Zuo X, Jaoude J, Wei D, Shureiqi I. The Role of PPAR-d in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor. Int J Mol Sci. 2018 Oct 26; 19(11). PMID: 30373124; PMCID: PMC6275063.
      Citations: 45     Fields:    Translation:HumansAnimals
    17. Wang L, Zuo X, Xie K, Wei D. The Role of CD44 and Cancer Stem Cells. Methods Mol Biol. 2018; 1692:31-42. PMID: 28986884.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    18. Xie VK, Li Z, Yan Y, Jia Z, Zuo X, Ju Z, Wang J, Du J, Xie D, Xie K, Wei D. DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Kr?ppel-Like Factor 4 Expression. Clin Cancer Res. 2017 Sep 15; 23(18):5585-5597. PMID: 28659310; PMCID: PMC5600846.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    19. Tian R, Zuo X, Jaoude J, Mao F, Colby J, Shureiqi I. ALOX15 as a suppressor of inflammation and cancer: Lost in the link. Prostaglandins Other Lipid Mediat. 2017 09; 132:77-83. PMID: 28089732; PMCID: PMC5509529.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    20. Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, Eng C, Kopetz S, Maru DM, Rashid A, Broaddus R, Wei D, Hung MC, Sood AK, Shureiqi I. Metastasis regulation by PPARD expression in cancer cells. JCI Insight. 2017 01 12; 2(1):e91419. PMID: 28097239; PMCID: PMC5214933.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    21. Wei D, Wang L, Yan Y, Jia Z, Gagea M, Li Z, Zuo X, Kong X, Huang S, Xie K. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell. 2016 Mar 14; 29(3):324-338. PMID: 26977883; PMCID: PMC4794756.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    22. Yan Y, Li Z, Kong X, Jia Z, Zuo X, Gagea M, Huang S, Wei D, Xie K. KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis. Cancer Res. 2016 04 15; 76(8):2419-31. PMID: 26880805; PMCID: PMC4876033.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    23. Yan Y, Zuo X, Wei D. Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target. Stem Cells Transl Med. 2015 Sep; 4(9):1033-43. PMID: 26136504; PMCID: PMC4542874.
      Citations: 232     Fields:    Translation:HumansCells
    24. Mao F, Xu M, Zuo X, Yu J, Xu W, Moussalli MJ, Elias E, Li HS, Watowich SS, Shureiqi I. 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. FASEB J. 2015 Jun; 29(6):2359-70. PMID: 25713055; PMCID: PMC4447220.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    25. Zuo X, Xu M, Yu J, Wu Y, Moussalli MJ, Manyam GC, Lee SI, Liang S, Gagea M, Morris JS, Broaddus RR, Shureiqi I. Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-d/? overexpression. J Natl Cancer Inst. 2014 Apr; 106(4):dju052. PMID: 24681603; PMCID: PMC3982893.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    26. Wu Y, Mao F, Zuo X, Moussalli MJ, Elias E, Xu W, Shureiqi I. 15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1a expression in human colon cancer cells. Cancer Med. 2014 Jun; 3(3):472-84. PMID: 24634093; PMCID: PMC4101738.
      Citations: 10     Fields:    Translation:HumansCells
    27. Xu M, Zuo X, Shureiqi I. Targeting peroxisome proliferator-activated receptor-?/d in colon cancer: how to aim? Biochem Pharmacol. 2013 Mar 01; 85(5):607-611. PMID: 23041232; PMCID: PMC3562563.
      Citations: 12     Fields:    Translation:Humans
    28. Zuo X, Shureiqi I. Eicosanoid profiling in colon cancer: emergence of a pattern. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug; 104-105:139-43. PMID: 22960430; PMCID: PMC3532570.
      Citations: 12     Fields:    Translation:HumansCells
    29. Zuo X, Peng Z, Wu Y, Moussalli MJ, Yang XL, Wang Y, Parker-Thornburg J, Morris JS, Broaddus RR, Fischer SM, Shureiqi I. Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice. J Natl Cancer Inst. 2012 May 02; 104(9):709-16. PMID: 22472308; PMCID: PMC3341308.
      Citations: 18     Fields:    Translation:AnimalsCells
    30. Il Lee S, Zuo X, Shureiqi I. 15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in? Cancer Metastasis Rev. 2011 Dec; 30(3-4):481-91. PMID: 22037943; PMCID: PMC3261081.
      Citations: 27     Fields:    Translation:HumansAnimals
    31. Moussalli MJ, Wu Y, Zuo X, Yang XL, Wistuba II, Raso MG, Morris JS, Bowser JL, Minna JD, Lotan R, Shureiqi I. Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion. Cancer Prev Res (Phila). 2011 Dec; 4(12):1961-72. PMID: 21881028; PMCID: PMC3232310.
      Citations: 17     Fields:    Translation:HumansCells
    32. Shureiqi I, Chen D, Day RS, Zuo X, Hochman FL, Ross WA, Cole RA, Moy O, Morris JS, Xiao L, Newman RA, Yang P, Lippman SM. Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesis. Cancer Prev Res (Phila). 2010 Jul; 3(7):829-38. PMID: 20570882; PMCID: PMC2900425.
      Citations: 32     Fields:    Translation:Humans
    33. Zuo X, Peng Z, Moussalli MJ, Morris JS, Broaddus RR, Fischer SM, Shureiqi I. Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis. J Natl Cancer Inst. 2009 May 20; 101(10):762-7. PMID: 19436036; PMCID: PMC2684551.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    34. Zuo X, Morris JS, Shureiqi I. Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells. J Biol Chem. 2008 Nov 14; 283(46):31341-7. PMID: 18799463; PMCID: PMC2581547.
      Citations: 12     Fields:    Translation:HumansCells
    35. Zuo X, Shen L, Issa JP, Moy O, Morris JS, Lippman SM, Shureiqi I. 15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation. FASEB J. 2008 Jun; 22(6):1981-92. PMID: 18198215; PMCID: PMC2410033.
      Citations: 13     Fields:    Translation:HumansCells
    36. Shureiqi I, Zuo X, Broaddus R, Wu Y, Guan B, Morris JS, Lippman SM. The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer. FASEB J. 2007 Mar; 21(3):743-53. PMID: 17167069; PMCID: PMC1847772.
      Citations: 31     Fields:    Translation:HumansCells
    37. Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9968-73. PMID: 12909723; PMCID: PMC187904.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    38. Zuo X, Li G, Luo T, Li J, Liu Y, Luo M. Differentiation of NIH3T3 fibroblasts into adipocytes induced by peroxisome proliferator activated receptor gamma 2 expression. Chin Med J (Engl). 2001 Sep; 114(9):916-20. PMID: 11780381.
      Citations: 3     Fields:    Translation:AnimalsCells
    39. Zuo X, Li G, Luo T, Li J, Liu Y, Sun W, Luo M. [Adipocytes differentiation of NIH3T3 cells induced by peroxisome proliferator activation receptor gamma 2 expression]. Zhonghua Nei Ke Za Zhi. 2001 Apr; 40(4):247-50. PMID: 11798586.
      Citations:    Fields:    Translation:AnimalsCells
    40. KLF4-mediated suppression of CD44 signaling negatively impacts pancreatic cancer stemness and metastasis. Cancer Research. 76:2419-2431.
    41. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell. 29:324-338.
    42. ALOX15 as a suppressor of inflammation and cancer. Prostaglandins and Other Lipid Mediators.
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