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AMY B HEIMBERGER

TitleProfessor
InstitutionMD Anderson
DepartmentNeurosurgery
Address1400 Holcombe Blvd
Houston TX 77030-4008
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kim KS, Habashy K, Gould A, Zhao J, Najem H, Amidei C, Saganty R, Arrieta VA, Dmello C, Chen L, Zhang DY, Castro B, Billingham L, Levey D, Huber O, Marques M, Savitsky DA, Morin BM, Muzzio M, Canney M, Horbinski C, Zhang P, Miska J, Padney S, Zhang B, Rabadan R, Phillips JJ, Butowski N, Heimberger AB, Hu J, Stupp R, Chand D, Lee-Chang C, Sonabend AM, Kim KS, Habashy K, Gould A, Zhao J, Najem H, Amidei C, Saganty R, Arrieta VA, Dmello C, Chen L, Zhang DY, Castro B, Billingham L, Levey D, Huber O, Marques M, Savitsky DA, Morin BM, Muzzio M, Horbinski C, Zhang P, Miska J, Padney S, Zhang B, Rabadan R, Phillips JJ, Butowski N, Heimberger AB, Hu J, Stupp R, Chand D, Lee-Chang C, Sonabend AM. Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood-brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas. Neuro Oncol. 2024 Nov 04; 26(11):2044-2060. PMID: 39028616; PMCID: PMC11534315.
      Citations: 2     Fields:    Translation:HumansAnimals
    2. Du R, Zhang J, Lukas RV, Tripathi S, Ahrendsen JT, Curran MA, Dmello C, Zhang P, Stupp R, Rao G, Heimberger AB. Is modulation of immune checkpoints on glioblastoma-infiltrating myeloid cells a viable therapeutic strategy? Neuro Oncol. 2024 Oct 19. PMID: 39427326.
      Citations:    Fields:    
    3. Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Oberheim Bush NA, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EE, Raleigh DR. Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy. Cancer Discov. 2024 Oct 04; 14(10):1823-1837. PMID: 38742767; PMCID: PMC11452293.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    4. Hotchkiss KM, Karschnia P, Schreck KC, Geurts M, Cloughesy TF, Huse J, Duke ES, Lathia J, Ashley DM, Nduom EK, Long G, Singh K, Chalmers A, Ahluwalia MS, Heimberger A, Bagley S, Todo T, Verhaak R, Kelly PD, Hervey-Jumper S, de Groot J, Patel A, Fecci P, Parney I, Wykes V, Watts C, Burns TC, Sanai N, Preusser M, Tonn JC, Drummond KJ, Platten M, Das S, Tanner K, Vogelbaum MA, Weller M, Whittle JR, Berger MS, Khasraw M. A brave new framework for glioma drug development. Lancet Oncol. 2024 Oct; 25(10):e512-e519. PMID: 39362262.
      Citations:    Fields:    Translation:Humans
    5. Liu Y, Wu J, Najem H, Lin Y, Pang L, Khan F, Zhou F, Ali H, Heimberger AB, Chen P. Dual targeting macrophages and microglia is a therapeutic vulnerability in models of PTEN-deficient glioblastoma. J Clin Invest. 2024 Oct 01; 134(22). PMID: 39352749; PMCID: PMC11563674.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Wang S, Castro BA, Katz JL, Arrieta VA, Najem H, Vazquez-Cervantes GI, Wan H, Olson IE, Hou D, Dapash M, Billingham LK, Chia TY, Wei C, Rashidi A, Platanias LC, McCortney K, Horbinski CM, Stupp R, Zhang P, Ahmed AU, Sonabend AM, Heimberger AB, Lesniak MS, Riviere-Cazaux C, Burns TC, Miska J, Fischietti M, Lee-Chang C, Wang S, Castro BA, Katz JL, Arrieta V, Najem H, Vazquez-Cervantes GI, Wan H, Olson IE, Hou D, Dapash M, Billingham LK, Chia TY, Wei C, Rashidi A, Platanias LC, McCortney K, Horbinski CM, Stupp R, Zhang P, Ahmed AU, Sonabend AM, Heimberger AB, Lesniak MS, Riviere-Cazaux C, Burns T, Miska J, Fischietti M, Lee-Chang C. B cell-based therapy produces antibodies that inhibit glioblastoma growth. J Clin Invest. 2024 Aug 29; 134(20). PMID: 39207859; PMCID: PMC11473152.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Tripathi S, Najem H, Dussold C, Pacheco S, Du R, Sooreshjani M, Hurley LA, Chandler JP, Stupp R, Sonabend AM, Horbinski CM, Lukas RV, Xiu J, L?pez GY, Nicolaides TP, Brown V, Wadhwani NR, Lam SK, James CD, Rao G, Castro MG, Heimberger AB, DeCuypere M, Tripathi S, Najem H, Dussold C, Pacheco S, Du R, Sooreshjani M, Hurley L, Chandler JP, Stupp R, Sonabend AM, Horbinski CM, Lukas RV, Xiu J, Lopez G, Nicolaides TP, Brown V, Wadhwani NR, Lam SK, James CD, Rao G, Castro MG, Heimberger AB, DeCuypere M. Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma. J Clin Invest. 2024 Aug 13; 134(19). PMID: 39137048; PMCID: PMC11444160.
      Citations:    Fields:    Translation:HumansAnimals
    8. Gupta P, Dang M, Oberai S, Migliozzi S, Trivedi R, Kumar G, Peshoff M, Milam N, Ahmed A, Bojja K, Tran TM, Gumin J, Kamiya-Matsuoka C, Huse J, Cox K, Li J, Shehwana H, Sheth SA, Saxon R, Baohua S, Parker-Kerrigan B, Maheshwari A, Parra Cuentas ER, Navin NE, Heimberger AB, Lang FF, Iavarone A, Clise-Dwyer K, Wang L, Bhat KP. Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas. Neuro Oncol. 2024 Aug 10. PMID: 39126294.
      Citations: 2     Fields:    
    9. Najem H, Lea ST, Tripathi S, Hurley L, Chen CH, William I, Sooreshjani M, Bowie M, Hartley G, Dussold C, Pacheco S, Dmello C, Lee-Chang C, McCortney K, Steffens A, Walshon J, Ott M, Wei J, Marisetty A, Balyasnikova I, Stupp R, Lukas RV, Hu J, James CD, Horbinski CM, Lesniak MS, Ashley DM, Priebe W, Platanias LC, Curran MA, Heimberger AB. STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma. J Clin Invest. 2024 Jun 17; 134(12). PMID: 38941297; PMCID: PMC11178548.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Najem H, Pacheco S, Kowal J, Winkowski D, Burks JK, Heimberger AB. Protocol to quantify immune cell distribution from the vasculature to the glioma microenvironment on sequential immunofluorescence multiplex images. STAR Protoc. 2024 Jun 21; 5(2):103079. PMID: 38795354; PMCID: PMC11144811.
      Citations: 1     Fields:    Translation:HumansAnimals
    11. Lucas CG, Mirchia K, Seo K, Najem H, Chen WC, Zakimi N, Foster K, Eaton CD, Cady MA, Choudhury A, Liu SJ, Phillips JJ, Magill ST, Horbinski CM, Solomon DA, Perry A, Vasudevan HN, Heimberger AB, Raleigh DR. Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution. Nat Genet. 2024 Jun; 56(6):1121-1133. PMID: 38760638; PMCID: PMC11239374.
      Citations: 7     Fields:    Translation:HumansCells
    12. Du R, Tripathi S, Najem H, Brat DJ, Lukas RV, Zhang P, Heimberger AB. Glioblastoma Phagocytic Cell Death: Balancing the Opportunities for Therapeutic Manipulation. Cells. 2024 May 11; 13(10). PMID: 38786045; PMCID: PMC11119757.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    13. Ene CI, Abi Faraj C, Beckham TH, Weinberg JS, Andersen CR, Haider AS, Rao G, Ferguson SD, Alvarez-Brenkenridge CA, Kim BYS, Heimberger AB, McCutcheon IE, Prabhu SS, Wang CM, Ghia AJ, McGovern SL, Chung C, McAleer MF, Tom MC, Perni S, Swanson TA, Yeboa DN, Briere TM, Huse JT, Fuller GN, Lang FF, Li J, Suki D, Sawaya RE. Response of treatment-naive brain metastases to stereotactic radiosurgery. Nat Commun. 2024 May 02; 15(1):3728. PMID: 38697991; PMCID: PMC11066027.
      Citations: 2     Fields:    Translation:Humans
    14. Humphries W, Wang Y, Qiao W, Reina-Ortiz C, Abou-Ghazal MK, Crutcher LM, Wei J, Kong LY, Sawaya R, Rao G, Weinberg J, Prabhu SS, Fuller GN, Heimberger AB. Correction: Detecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients. J Transl Med. 2024 Mar 21; 22(1):296. PMID: 38515188; PMCID: PMC10958894.
      Citations:    Fields:    
    15. Tripathi S, Najem H, Dussold C, Pacheco S, Miska J, McCortney K, Steffens A, Walshon J, Winkowski D, Cloney M, Ordon M, Gibson W, Kemeny H, Youngblood M, Du R, Mossner J, Texakalidis P, Sprau A, Tate M, James CD, Horbinski CM, Wadhwani NR, Lesniak MS, Lam S, Sati A, Aghi M, DeCuypere M, Heimberger AB. Cancer-associated fibroblast-secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas. J Clin Invest. 2024 Feb 15; 134(4). PMID: 38357919; PMCID: PMC10866651.
      Citations: 1     Fields:    Translation:HumansCells
    16. Kudruk S, Forsyth CM, Dion MZ, Hedlund Orbeck JK, Luo J, Klein RS, Kim AH, Heimberger AB, Mirkin CA, Stegh AH, Artzi N. Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy. Proc Natl Acad Sci U S A. 2024 Feb 20; 121(8):e2306973121. PMID: 38346200; PMCID: PMC10895370.
      Citations: 4     Fields:    Translation:Humans
    17. Najem H, Arrieta VA, Duffy J, Tripathi S, Zannikou M, Dhiantravan S, Miska J, McCortney K, Steffens A, Walshon J, Lee Chang C, Dahdaleh NS, Sonabend AM, Smith Z, Horbinski CM, Chandler J, Heimberger AB, Balyasnikova IV. Prohibitin Expression in Antigen-Presenting Cells: Implications for Inciting Trigger in CNS IgG4-Related Disease. Ann Case Rep. 2024; 9(1). PMID: 38606301; PMCID: PMC11008565.
      Citations:    
    18. Hou D, Wan H, Katz JL, Wang S, Castro BA, Vazquez-Cervantes GI, Arrieta VA, Dhiantravan S, Najem H, Rashidi A, Chia TY, Arjmandi T, Collado J, Billingham L, Lopez-Rosas A, Han Y, Sonabend AM, Heimberger AB, Zhang P, Miska J, Lee-Chang C. Antigen-presenting B cells promote TCF-1+ PD1- stem-like CD8+ T-cell proliferation in glioblastoma. Front Immunol. 2023; 14:1295218. PMID: 38268923; PMCID: PMC10806106.
      Citations: 1     Fields:    Translation:HumansCells
    19. Tripathi S, Nathan CL, Tate MC, Horbinski CM, Templer JW, Rosenow JM, Sita TL, James CD, Deneen B, Miller SD, Heimberger AB. The immune system and metabolic products in epilepsy and glioma-associated epilepsy: emerging therapeutic directions. JCI Insight. 2024 Jan 09; 9(1). PMID: 38193532; PMCID: PMC10906461.
      Citations: 2     Fields:    Translation:HumansAnimals
    20. Fares J, Petrosyan E, Kanojia D, Dmello C, Cordero A, Duffy JT, Yeeravalli R, Sahani MH, Zhang P, Rashidi A, Arrieta VA, Ulasov I, Ahmed AU, Miska J, Balyasnikova IV, James CD, Sonabend AM, Heimberger AB, Lesniak MS. Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases. J Clin Invest. 2023 12 15; 133(24). PMID: 37847564; PMCID: PMC10721147.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. McCord M, Jamshidi P, Thirunavu V, Santana-Santos L, Vormittag-Nocito E, Dittman D, Parker S, Baczkowski J, Jennings L, Walshon J, McCortney K, Galbraith K, Zhang H, Lukas RV, Stupp R, Dixit K, Kumthekar P, Heimberger AB, Snuderl M, Horbinski C. Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results. Acta Neuropathol Commun. 2023 11 02; 11(1):175. PMID: 37919784; PMCID: PMC10623846.
      Citations:    Fields:    Translation:HumansCells
    22. Youngblood MW, Erson-Omay Z, Li C, Najem H, Co?kun S, Tyrtova E, Montejo JD, Miyagishima DF, Barak T, Nishimura S, Harmanci AS, Clark VE, Duran D, Huttner A, Avsar T, Bayri Y, Schramm J, Boetto J, Peyre M, Riche M, Goldbrunner R, Amankulor N, Louvi A, Bilg?var K, Pamir MN, ?zduman K, Kilic T, Knight JR, Simon M, Horbinski C, Kalamarides M, Timmer M, Heimberger AB, Mishra-Gorur K, Moliterno J, Yasuno K, G?nel M. Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas. Nat Commun. 2023 10 07; 14(1):6279. PMID: 37805627; PMCID: PMC10560290.
      Citations: 2     Fields:    Translation:HumansCells
    23. Sim HW, Wachsmuth L, Barnes EH, Yip S, Koh ES, Hall M, Jennens R, Ashley DM, Verhaak RG, Heimberger AB, Rosenthal MA, Hovey EJ, Ellingson BM, Tognela A, Gan HK, Wheeler H, Back M, McDonald KL, Long A, Cuff K, Begbie S, Gedye C, Mislang A, Le H, Johnson MO, Kong BY, Simes JR, Lwin Z, Khasraw M. NUTMEG: A randomized phase II study of nivolumab and temozolomide versus temozolomide alone in newly diagnosed older patients with glioblastoma. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad124. PMID: 37841696; PMCID: PMC10576515.
      Citations: 1     
    24. Chen CH, Chin RL, Hartley GP, Lea ST, Engel BJ, Hsieh CE, Prasad R, Roszik J, Shingu T, Lizee GA, Heimberger AB, Millward SW, Hu J, Hong DS, Curran MA. Novel murine glioblastoma models that reflect the immunotherapy resistance profile of a human disease. Neuro Oncol. 2023 08 03; 25(8):1415-1427. PMID: 36705543; PMCID: PMC10398813.
      Citations:    Fields:    Translation:HumansAnimalsCells
    25. Drumm MR, Wang W, Sears TK, Bell-Burdett K, Javier R, Cotton KY, Webb B, Byrne K, Unruh D, Thirunavu V, Walshon J, Steffens A, McCortney K, Lukas RV, Phillips JJ, Mohamed E, Finan JD, Santana-Santos L, Heimberger AB, Franz CK, Kurz J, Templer JW, Swanson GT, Horbinski C. Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors. J Clin Invest. 2023 06 15; 133(12). PMID: 37104042; PMCID: PMC10266777.
      Citations:    Fields:    Translation:Humans
    26. Goethe EA, Heimberger AB, Rao G. Aspirin and immunotherapy: a Faustian bargain? J Clin Invest. 2023 05 01; 133(9). PMID: 37115694; PMCID: PMC10145917.
      Citations:    Fields:    Translation:Humans
    27. Petrosyan E, Fares J, Fernandez LG, Yeeravalli R, Dmello C, Duffy JT, Zhang P, Lee-Chang C, Miska J, Ahmed AU, Sonabend AM, Balyasnikova IV, Heimberger AB, Lesniak MS. Endoplasmic Reticulum Stress in the Brain Tumor Immune Microenvironment. Mol Cancer Res. 2023 05 01; 21(5):389-396. PMID: 36652630; PMCID: PMC10159901.
      Citations: 1     Fields:    Translation:Humans
    28. Gould A, Gonzales VAA, Dmello CC, Saganty R, Lukas RV, Zhang DY, Heimberger AB, Canney M, Carpentier A, Desseaux C, Bouchoux G, Stupp R, Sonabend AM. Advances in Blood-Brain Barrier Disruption to Facilitate Drug Delivery for Infiltrative Gliomas. Adv Oncol. 2023 May; 3(1):77-86. PMID: 37860079; PMCID: PMC10583833.
      Citations:    
    29. Dmello C, Zhao J, Chen L, Gould A, Castro B, Arrieta VA, Zhang DY, Kim KS, Kanojia D, Zhang P, Miska J, Yeeravalli R, Habashy K, Saganty R, Kang SJ, Fares J, Liu C, Dunn G, Bartom E, Schipma MJ, Hsu PD, Alghamri MS, Lesniak MS, Heimberger AB, Rabadan R, Lee-Chang C, Sonabend AM. Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade. Nat Commun. 2023 03 22; 14(1):1566. PMID: 36949040; PMCID: PMC10033639.
      Citations:    Fields:    Translation:HumansAnimalsCells
    30. Burdett KB, Unruh D, Drumm M, Steffens A, Lamano J, Judkins J, Schwartz M, Javier R, Amidei C, Lipp ES, Peters KB, Lai A, Eldred BSC, Heimberger AB, McCortney K, Scholtens DM, Horbinski C. Determining venous thromboembolism risk in patients with adult-type diffuse glioma. Blood. 2023 03 16; 141(11):1322-1336. PMID: 36399711; PMCID: PMC10082363.
      Citations: 1     Fields:    Translation:Humans
    31. Sahm F, Youngblood MW, Tran AN, Wang W, An S, Scholtens D, Zhang L, O'Shea K, Pokorny JL, Magill ST, Sachdev S, Lukas RV, Ahmed A, Unruh D, Walshon J, McCortney K, Wang Y, Baran A, Aldape K, Chandler JP, David James C, Heimberger AB, Horbinski C. Docetaxel targets aggressive methylation profiles and serves as a radiosensitizer in high-risk meningiomas. Neuro Oncol. 2023 03 14; 25(3):508-519. PMID: 35976058; PMCID: PMC10013641.
      Citations:    
    32. Pang L, Dunterman M, Xuan W, Gonzalez A, Lin Y, Hsu WH, Khan F, Hagan RS, Muller WA, Heimberger AB, Chen P. Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma. Cell Rep. 2023 02 28; 42(2):112127. PMID: 36795563; PMCID: PMC10423747.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    33. Zhao Q, Hu J, Kong L, Jiang S, Tian X, Wang J, Hashizume R, Jia Z, Fowlkes NW, Yan J, Xia X, Yi SF, Dao LH, Masopust D, Heimberger AB, Li S. FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells. Nat Commun. 2023 02 10; 14(1):735. PMID: 36759517; PMCID: PMC9911733.
      Citations: 1     Fields:    Translation:AnimalsCells
    34. Liang J, Fang D, Gumin J, Najem H, Sooreshjani M, Song R, Sabbagh A, Kong LY, Duffy J, Balyasnikova IV, Pollack SM, Puduvalli VK, Heimberger AB. A Case Study of Chimeric Antigen Receptor T Cell Function: Donor Therapeutic Differences in Activity and Modulation with Verteporfin. Cancers (Basel). 2023 Feb 08; 15(4). PMID: 36831427; PMCID: PMC9953964.
      Citations: 1     
    35. Arrieta VA, Dmello C, McGrail DJ, Brat DJ, Lee-Chang C, Heimberger AB, Chand D, Stupp R, Sonabend AM. Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized treatment. J Clin Invest. 2023 01 17; 133(2). PMID: 36647828; PMCID: PMC9843050.
      Citations: 7     Fields:    Translation:Humans
    36. Khan F, Pang L, Dunterman M, Lesniak MS, Heimberger AB, Chen P. Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy. J Clin Invest. 2023 01 03; 133(1). PMID: 36594466; PMCID: PMC9797335.
      Citations: 11     Fields:    Translation:HumansCells
    37. Khan AB, Lee S, Harmanci AS, Patel R, Latha K, Yang Y, Marisetty A, Lee HK, Heimberger AB, Fuller GN, Deneen B, Rao G. CXCR4 expression is associated with proneural-to-mesenchymal transition in glioblastoma. Int J Cancer. 2023 02 15; 152(4):713-724. PMID: 36250346; PMCID: PMC10071545.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    38. Tripathi S, Najem H, Mahajan AS, Zhang P, Low JT, Stegh AH, Curran MA, Ashley DM, James CD, Heimberger AB. cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma. F1000Res. 2022; 11:1010. PMID: 36324813; PMCID: PMC9597127.
      Citations:    Fields:    Translation:Humans
    39. Zhang S, Rao G, Heimberger A, Li S. Fibrinogen-like protein 2: Its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors. Cytokine Growth Factor Rev. 2023 02; 69:73-79. PMID: 36085259; PMCID: PMC10204071.
      Citations:    
    40. Cao TQ, Wainwright DA, Lee-Chang C, Miska J, Sonabend AM, Heimberger AB, Lukas RV. Next Steps for Immunotherapy in Glioblastoma. Cancers (Basel). 2022 Aug 20; 14(16). PMID: 36011015; PMCID: PMC9406905.
      Citations:    
    41. Zamler DB, Shingu T, Kahn LM, Huntoon K, Kassab C, Ott M, Tomczak K, Liu J, Li Y, Lai I, Zorilla-Veloz R, Yee C, Rai K, Kim BY, Watowich SS, Heimberger AB, Draetta GF, Hu J. Immune landscape of a genetically engineered murine model of glioma compared with human glioma. JCI Insight. 2022 06 22; 7(12). PMID: 35653194; PMCID: PMC9309065.
      Citations:    Fields:    Translation:HumansAnimalsCells
    42. Larkin CJ, Najem H, Li G, Zhang P, Miska J, Chen P, James CD, Sonabend AM, Heimberger AB, Arrieta VA. Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era. Front Immunol. 2022; 13:907605. PMID: 35784281; PMCID: PMC9244707.
      Citations:    Fields:    Translation:HumansCells
    43. Xuan W, Hsu WH, Khan F, Dunterman M, Pang L, Wainwright DA, Ahmed AU, Heimberger AB, Lesniak MS, Chen P. Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma. Cancer Immunol Res. 2022 06 03; 10(6):770-784. PMID: 35413115; PMCID: PMC9177794.
      Citations:    Fields:    Translation:HumansAnimalsCells
    44. Pang L, Khan F, Heimberger AB, Chen P. Mechanism and therapeutic potential of tumor-immune symbiosis in glioblastoma. Trends Cancer. 2022 10; 8(10):839-854. PMID: 35624002; PMCID: PMC9492629.
      Citations:    Fields:    
    45. Groot J, Ott M, Wei J, Kassab C, Fang D, O'Brien B, Weathers SP, Matsouka CK, Majd NK, Harrison RA, Fuller GN, Huse JT, Long JP, Sawaya R, Rao G, MacDonald TJ, Priebe W, Najem H, DeCuypere M, Heimberger AB. A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma. CNS Oncol. 2022 06 01; 11(2):CNS87. PMID: 35575067; PMCID: PMC9134932.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    46. Najem H, Ott M, Kassab C, Rao A, Rao G, Marisetty A, Sonabend AM, Horbinski C, Verhaak R, Shankar A, Krishnan SN, Varn FS, Gupta P, Ferguson SD, Huse JT, Fuller GN, Long JP, Winkowski DE, Freiberg BA, James CD, Platanias LC, Lesniak MS, Burks JK, Heimberger AB, Arrieta VA. Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression. JCI Insight. 2022 05 09; 7(9). PMID: 35316217; PMCID: PMC9090258.
      Citations: 1     Fields:    Translation:HumansCells
    47. Low JT, Chandramohan V, Bowie ML, Brown MC, Waitkus MS, Briley A, Stevenson K, Fuller R, Reitman ZJ, Muscat AM, Hariharan S, Hostettler J, Danehower S, Baker A, Khasraw M, Wong NC, Gregory S, Nair SK, Heimberger A, Gromeier M, Bigner DD, Ashley DM. Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition. Cancer Cell. 2022 05 09; 40(5):439-440. PMID: 35487217.
      Citations: 1     Fields:    Translation:Humans
    48. Wei J, Song R, Sabbagh A, Marisetty A, Shukla N, Fang D, Najem H, Ott M, Long J, Zhai L, Lesniak MS, James CD, Platanias L, Curran M, Heimberger AB. Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system. Oncoimmunology. 2022; 11(1):2062827. PMID: 35433114; PMCID: PMC9009928.
      Citations:    Fields:    Translation:Humans
    49. Vogelbaum MA, Li G, Heimberger AB, Lang FF, Fueyo J, Gomez-Manzano C, Sanai N. A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology. Am Soc Clin Oncol Educ Book. 2022 Apr; 42:1-8. PMID: 35580289.
      Citations:    Fields:    Translation:Humans
    50. Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C, Shilati J, Jaishankar D, Chen L, Gould A, Zhang D, Yuan J, Zhao W, Ling X, Burks JK, Amidei C, Bruce JN, Lukas RV, Yamaguchi JT, Cieremans D, Rothschild G, Basu U, McCord M, Brat DJ, Zhang H, Cooper LAD, Zhang B, Sims P, Cloughesy TF, Prins R, Canoll P, Stupp R, Heimberger AB, Horbinski C, Iwamoto FM, Rabadan R, Sonabend AM, Arrieta VA, Laffleur B. Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nat Cancer. 2022 Mar; 3(3):373. PMID: 35149861.
      Citations:    
    51. Singh K, Batich KA, Wen PY, Tan AC, Bagley SJ, Lim M, Platten M, Colman H, Ashley DM, Chang SM, Rahman R, Galanis E, Mansouri A, Puduvalli VK, Reardon DA, Sahebjam S, Sampson JH, Simes J, Berry DA, Zadeh G, Cloughesy TF, Mehta MP, Piantadosi S, Heimberger AB, Khasraw M, Weller M. Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma. Clin Cancer Res. 2022 02 15; 28(4):585-593. PMID: 34561270; PMCID: PMC9306329.
      Citations: 2     Fields:    Translation:Humans
    52. Najem H, Petrosyan E, Lee-Chang C, Chen P, Sonabend AM, Heimberger AB, Arrieta VA. The Eclectic Nature of Glioma-Infiltrating Macrophages and Microglia. Int J Mol Sci. 2021 Dec 13; 22(24). PMID: 34948178; PMCID: PMC8705822.
      Citations: 3     Fields:    Translation:HumansCells
    53. Chen AX, Kane JR, Kang SJ, Kassab C, Dmello C, Zhao J, Burdett KB, Upadhyayula PS, Lee-Chang C, Shilati J, Jaishankar D, Chen L, Gould A, Zhang D, Yuan J, Zhao W, Ling X, Burks JK, Amidei C, Bruce JN, Lukas RV, Yamaguchi JT, Cieremans D, Rothschild G, Basu U, McCord M, Brat DJ, Zhang H, Cooper LAD, Zhang B, Sims P, Cloughesy TF, Prins R, Canoll P, Stupp R, Heimberger AB, Horbinski C, Iwamoto FM, Rabadan R, Sonabend AM, Arrieta VA, Laffleur B. ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma. Nat Cancer. 2021 12; 2(12):1372-1386. PMID: 35121903; PMCID: PMC8818262.
      Citations: 6     Translation:HumansCells
    54. McGrail DJ, Dai H, Lam TNA, Liang Y, Voorwerk L, Kok M, Zhang XH, Rosen JM, Heimberger AB, Peterson CB, Jonasch E, Lin SY, Pili? PG. Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers. Sci Transl Med. 2021 Oct 27; 13(617):eabe6201. PMID: 34705519; PMCID: PMC8577990.
      Citations: 2     Fields:    Translation:Humans
    55. Khasraw M, Fujita Y, Lee-Chang C, Balyasnikova IV, Najem H, Heimberger AB. New Approaches to Glioblastoma. Annu Rev Med. 2022 01 27; 73:279-292. PMID: 34665646; PMCID: PMC9479165.
      Citations: 1     Fields:    Translation:Humans
    56. Najem H, Marisetty A, Horbinski C, Long J, Huse JT, Glitza Oliva IC, Ferguson SD, Kumthekar PU, Wainwright DA, Chen P, Lesniak MS, Burks JK, Heimberger AB. CD11c+CD163+ Cells and Signal Transducer and Activator of Transcription 3 (STAT3) Expression Are Common in Melanoma Leptomeningeal Disease. Front Immunol. 2021; 12:745893. PMID: 34691054; PMCID: PMC8531809.
      Citations: 1     Fields:    Translation:HumansCells
    57. Pudakalakatti S, Audia A, Mukhopadhyay A, Enriquez JS, Bourgeois D, Tayob N, Zacharias NM, Millward SW, Carson D, Farach-Carson MC, Lang FF, Heimberger AB, Bhat KP, Bhattacharya PK. NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors. Reports (MDPI). 2021 Dec; 4(4). PMID: 35937580; PMCID: PMC9352435.
      Citations:    
    58. Wei J, Gilboa E, Calin GA, Heimberger AB. Immune Modulatory Short Noncoding RNAs Targeting the Glioblastoma Microenvironment. Front Oncol. 2021; 11:682129. PMID: 34532286; PMCID: PMC8438301.
      Citations: 1     
    59. Boudreau CE, Najem H, Ott M, Horbinski C, Fang D, DeRay CM, Levine JM, Curran MA, Heimberger AB. Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma. Clin Cancer Res. 2021 10 15; 27(20):5528-5535. PMID: 34433652; PMCID: PMC8989401.
      Citations: 2     Fields:    Translation:Animals
    60. Najem H, Khasraw M, Heimberger AB. Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy. Cells. 2021 08 09; 10(8). PMID: 34440802; PMCID: PMC8393758.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    61. Brown PD, Chung C, Liu DD, McAvoy S, Grosshans D, Al Feghali K, Mahajan A, Li J, McGovern SL, McAleer MF, Ghia AJ, Sulman EP, Penas-Prado M, de Groot JF, Heimberger AB, Wang J, Armstrong TS, Gilbert MR, Guha-Thakurta N, Wefel JS. A prospective phase II randomized trial of proton radiotherapy vs intensity-modulated radiotherapy for patients with newly diagnosed glioblastoma. Neuro Oncol. 2021 08 02; 23(8):1337-1347. PMID: 33647972; PMCID: PMC8328012.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    62. Shaim H, Shanley M, Basar R, Daher M, Gumin J, Zamler DB, Uprety N, Wang F, Huang Y, Gabrusiewicz K, Miao Q, Dou J, Alsuliman A, Kerbauy LN, Acharya S, Mohanty V, Mendt M, Li S, Lu J, Wei J, Fowlkes NW, Gokdemir E, Ensley EL, Kaplan M, Kassab C, Li L, Ozcan G, Banerjee PP, Shen Y, Gilbert AL, Jones CM, Bdiwi M, Nunez-Cortes AK, Liu E, Yu J, Imahashi N, Muniz-Feliciano L, Li Y, Hu J, Draetta G, Marin D, Yu D, Champlin RE, Chen K, Lang FF, Shpall EJ, Heimberger AB, Rezvani K, Mielke S, Eyrich M. Targeting the av integrin/TGF-? axis improves natural killer cell function against glioblastoma stem cells. J Clin Invest. 2021 07 15; 131(14). PMID: 34138753; PMCID: PMC8279586.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    63. Dardis C, Donner D, Sanai N, Xiu J, Mittal S, Michelhaugh SK, Pandey M, Kesari S, Heimberger AB, Gatalica Z, Korn MW, Sumrall AL, Phuphanich S. Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling. BMC Neurol. 2021 Jun 23; 21(1):231. PMID: 34162346; PMCID: PMC8220715.
      Citations: 2     Fields:    Translation:Humans
    64. Ott M, Prins RM, Heimberger AB. The immune landscape of common CNS malignancies: implications for immunotherapy. Nat Rev Clin Oncol. 2021 11; 18(11):729-744. PMID: 34117475; PMCID: PMC11090136.
      Citations: 12     Fields:    Translation:Humans
    65. Al Feghali KA, Randall JW, Liu DD, Wefel JS, Brown PD, Grosshans DR, McAvoy SA, Farhat MA, Li J, McGovern SL, McAleer MF, Ghia AJ, Paulino AC, Sulman EP, Penas-Prado M, Wang J, de Groot J, Heimberger AB, Armstrong TS, Gilbert MR, Mahajan A, Guha-Thakurta N, Chung C. Phase II trial of proton therapy versus photon IMRT for GBM: secondary analysis comparison of progression-free survival between RANO versus clinical assessment. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab073. PMID: 34337411; PMCID: PMC8320688.
      Citations:    
    66. Sabbagh A, Beccaria K, Ling X, Marisetty A, Ott M, Caruso H, Barton E, Kong LY, Fang D, Latha K, Zhang DY, Wei J, DeGroot J, Curran MA, Rao G, Hu J, Carpentier A, Heimberger AB, Desseaux C, Bouchoux G, Canney M. Opening of the Blood-Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models. Clin Cancer Res. 2021 08 01; 27(15):4325-4337. PMID: 34031054; PMCID: PMC9012394.
      Citations: 10     Fields:    Translation:Animals
    67. Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown CE, Chen Y, Fecci PE, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H. Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. PMID: 33367885; PMCID: PMC7992879.
      Citations: 22     Fields:    Translation:Humans
    68. Yan J, Zhao Q, Wang J, Tian X, Wang J, Xia X, Ott M, Rao G, Heimberger AB, Li S. FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells. Cancer Lett. 2021 05 28; 506:83-94. PMID: 33676940; PMCID: PMC8009861.
      Citations: 4     Fields:    Translation:AnimalsCells
    69. Xuan W, Lesniak MS, James CD, Heimberger AB, Chen P. Context-Dependent Glioblastoma-Macrophage/Microglia Symbiosis and Associated Mechanisms. Trends Immunol. 2021 04; 42(4):280-292. PMID: 33663953; PMCID: PMC8005482.
      Citations: 7     Fields:    Translation:HumansCells
    70. Mohan R, Liu AY, Brown PD, Mahajan A, Dinh J, Chung C, McAvoy S, McAleer MF, Lin SH, Li J, Ghia AJ, Zhu C, Sulman EP, de Groot JF, Heimberger AB, McGovern SL, Grassberger C, Shih H, Ellsworth S, Grosshans DR. Proton therapy reduces the likelihood of high-grade radiation-induced lymphopenia in glioblastoma patients: phase II randomized study of protons vs photons. Neuro Oncol. 2021 02 25; 23(2):284-294. PMID: 32750703; PMCID: PMC7906048.
      Citations: 17     Fields:    Translation:HumansCTClinical Trials
    71. Hu J, Zhao Q, Kong LY, Wang J, Yan J, Xia X, Jia Z, Heimberger AB, Li S. Regulation of tumor immune suppression and cancer cell survival by CXCL1/2 elevation in glioblastoma multiforme. Sci Adv. 2021 01; 7(5). PMID: 33571109; PMCID: PMC7840139.
      Citations: 12     Fields:    Translation:HumansCells
    72. Ou A, Ott M, Fang D, Heimberger AB. The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma. Cancers (Basel). 2021 Jan 24; 13(3). PMID: 33498872; PMCID: PMC7865703.
      Citations: 14     
    73. Ren J, Dai C, Zhou X, Barnes JA, Chen X, Wang Y, Yuan L, Shingu T, Heimberger AB, Chen Y, Hu J. Qki is an essential regulator of microglial phagocytosis in demyelination. J Exp Med. 2021 01 04; 218(1). PMID: 33045062; PMCID: PMC7543092.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    74. Marisetty A, Wei J, Kong LY, Ott M, Fang D, Sabbagh A, Heimberger AB. MiR-181 Family Modulates Osteopontin in Glioblastoma Multiforme. Cancers (Basel). 2020 Dec 17; 12(12). PMID: 33348707; PMCID: PMC7765845.
      Citations: 3     
    75. Khasraw M, Walsh KM, Heimberger AB, Ashley DM. What is the Burden of Proof for Tumor Mutational Burden in gliomas? Neuro Oncol. 2020 Nov 30. PMID: 33252666; PMCID: PMC7849945.
      Citations: 7     Fields:    
    76. Ferguson SD, Hodges TR, Majd NK, Alfaro-Munoz K, Al-Holou WN, Suki D, de Groot JF, Fuller GN, Xue L, Li M, Jacobs C, Rao G, Colen RR, Xiu J, Verhaak R, Spetzler D, Khasraw M, Sawaya R, Long JP, Heimberger AB. A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdaa146. PMID: 33426529; PMCID: PMC7780842.
      Citations: 1     
    77. Giridharan N, Glitza Oliva IC, O'Brien BJ, Parker Kerrigan BC, Heimberger AB, Ferguson SD. Targeting the Tumor Microenvironment in Brain Metastasis. Neurosurg Clin N Am. 2020 Oct; 31(4):641-649. PMID: 32921358.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    78. Wang M, Jain P, Chi TL, Chen SE, Heimberger A, Weathers SP, Zheng L, Rao AV, Rossi JM. Management of a patient with mantle cell lymphoma who developed severe neurotoxicity after chimeric antigen receptor T-cell therapy in ZUMA-2. J Immunother Cancer. 2020 10; 8(2). PMID: 33067318; PMCID: PMC7570235.
      Citations: 2     Fields:    Translation:Humans
    79. Ott M, Tomaszowski KH, Marisetty A, Kong LY, Wei J, Duna M, Blumberg K, Ji X, Jacobs C, Fuller GN, Langford LA, Huse JT, Long JP, Hu J, Li S, Weinberg JS, Prabhu SS, Sawaya R, Ferguson S, Rao G, Lang FF, Curran MA, Heimberger AB. Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration. JCI Insight. 2020 09 03; 5(17). PMID: 32721947; PMCID: PMC7526457.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    80. Sa JK, Chang N, Lee HW, Cho HJ, Ceccarelli M, Cerulo L, Yin J, Kim SS, Caruso FP, Lee M, Kim D, Oh YT, Lee Y, Her NG, Min B, Kim HJ, Jeong DE, Kim HM, Kim H, Chung S, Woo HG, Lee J, Kong DS, Seol HJ, Lee JI, Kim J, Park WY, Wang Q, Sulman EP, Heimberger AB, Lim M, Park JB, Iavarone A, Verhaak RGW, Nam DH. Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma. Genome Biol. 2020 08 26; 21(1):216. PMID: 32847614; PMCID: PMC7448990.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    81. Ott M, Kassab C, Marisetty A, Hashimoto Y, Wei J, Zamler D, Leu JS, Tomaszowski KH, Sabbagh A, Fang D, Gupta P, Priebe W, Zielinski RJ, Burks JK, Long JP, Kong LY, Fuller GN, DeGroot J, Sulman EP, Heimberger AB. Radiation with STAT3 Blockade Triggers Dendritic Cell-T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy. Clin Cancer Res. 2020 09 15; 26(18):4983-4994. PMID: 32605912; PMCID: PMC9341321.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    82. Dumas AA, Pomella N, Rosser G, Guglielmi L, Vinel C, Millner TO, Rees J, Aley N, Sheer D, Wei J, Marisetty A, Heimberger AB, Bowman RL, Brandner S, Joyce JA, Marino S. Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment. EMBO J. 2020 08 03; 39(15):e103790. PMID: 32567735; PMCID: PMC7396846.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    83. Rao G, Latha K, Ott M, Sabbagh A, Marisetty A, Ling X, Zamler D, Doucette TA, Yang Y, Kong LY, Wei J, Fuller GN, Benavides F, Sonabend AM, Long J, Li S, Curran M, Heimberger AB. Anti-PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells. Clin Cancer Res. 2020 09 01; 26(17):4699-4712. PMID: 32554515; PMCID: PMC7483850.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    84. Kane JR, Zhao J, Tsujiuchi T, Laffleur B, Mahajan A, Rao G, Mela A, Dmello C, Chen L, Zhang DY, Lee-Chang C, Xiao T, Rothschild G, Basu U, Horbinski C, Lesniak MS, Heimberger AB, Rabadan R, Canoll P, Sonabend AM, Arrieta VA, Gonz?lez-Buendia E. CD8+ T-cell-Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas. Clin Cancer Res. 2020 08 15; 26(16):4390-4401. PMID: 32430477; PMCID: PMC7442699.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    85. Rao G, Sonabend A, Heimberger AB. Are radiation and response biomarkers the missing elements for efficacious immunotherapy for glioma patients? Neuro Oncol. 2020 05 15; 22(5):590-591. PMID: 31967642; PMCID: PMC7229240.
      Citations:    Fields:    Translation:HumansCells
    86. Zhou X, He C, Ren J, Dai C, Stevens SR, Wang Q, Zamler D, Shingu T, Yuan L, Chandregowda CR, Wang Y, Ravikumar V, Rao AU, Zhou F, Zheng H, Rasband MN, Chen Y, Lan F, Heimberger AB, Segal BM, Hu J. Mature myelin maintenance requires Qki to coactivate PPAR?-RXRa-mediated lipid metabolism. J Clin Invest. 2020 05 01; 130(5):2220-2236. PMID: 32202512; PMCID: PMC7191000.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    87. Weathers SP, Penas-Prado M, Pei BL, Ling X, Kassab C, Banerjee P, Bdiwi M, Shaim H, Alsuliman A, Shanley M, de Groot JF, O'Brien BJ, Harrison R, Majd N, Kamiya-Matsuoka C, Fuller GN, Huse JT, Chi L, Rao G, Weinberg JS, Lang FF, Sawaya R, Shpall EJ, Rezvani K, Heimberger AB. Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial. Clin Cancer Res. 2020 07 15; 26(14):3565-3577. PMID: 32299815; PMCID: PMC9347965.
      Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
    88. de Groot J, Penas-Prado M, Alfaro-Munoz K, Hunter K, Pei BL, O'Brien B, Weathers SP, Loghin M, Kamiya Matsouka C, Yung WKA, Mandel J, Wu J, Yuan Y, Zhou S, Fuller GN, Huse J, Rao G, Weinberg JS, Prabhu SS, McCutcheon IE, Lang FF, Ferguson SD, Sawaya R, Colen R, Yadav SS, Blando J, Vence L, Allison J, Sharma P, Heimberger AB. Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages. Neuro Oncol. 2020 04 15; 22(4):539-549. PMID: 31755915; PMCID: PMC7158647.
      Citations: 41     Fields:    Translation:HumansCells
    89. Liang J, Wang L, Wang C, Shen J, Su B, Marisetty AL, Fang D, Kassab C, Jeong KJ, Zhao W, Lu Y, Jain AK, Zhou Z, Liang H, Sun SC, Lu C, Xu ZX, Yu Q, Shao S, Chen X, Gao M, Claret FX, Ding Z, Chen J, Chen P, Barton MC, Peng G, Mills GB, Heimberger AB. Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy. Cancer Immunol Res. 2020 07; 8(7):952-965. PMID: 32265228; PMCID: PMC8204534.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    90. Beccaria K, Sabbagh A, de Groot J, Heimberger AB, Canney M, Carpentier A. Blood-brain barrier opening with low intensity pulsed ultrasound for immune modulation and immune therapeutic delivery to CNS tumors. J Neurooncol. 2021 Jan; 151(1):65-73. PMID: 32112296.
      Citations: 15     Fields:    Translation:Humans
    91. Wei J, Chen P, Gupta P, Ott M, Zamler D, Kassab C, Bhat KP, Curran MA, de Groot JF, Heimberger AB. Immune biology of glioma-associated macrophages and microglia: functional and therapeutic implications. Neuro Oncol. 2020 02 20; 22(2):180-194. PMID: 31679017; PMCID: PMC7442334.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    92. Ou A, Sumrall A, Phuphanich S, Spetzler D, Gatalica Z, Xiu J, Michelhaugh S, Brenner A, Pandey M, Kesari S, Korn WM, Mittal S, Westin J, Heimberger AB. Primary CNS lymphoma commonly expresses immune response biomarkers. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa018. PMID: 32201861; PMCID: PMC7067145.
      Citations: 13     
    93. Amin SB, Anderson KJ, Boudreau CE, Martinez-Ledesma E, Kocakavuk E, Johnson KC, Barthel FP, Varn FS, Kassab C, Ling X, Kim H, Barter M, Lau CC, Ngan CY, Chapman M, Koehler JW, Long JP, Miller AD, Miller CR, Porter BF, Rissi DR, Mazcko C, LeBlanc AK, Dickinson PJ, Packer RA, Taylor AR, Rossmeisl JH, Woolard KD, Heimberger AB, Levine JM, Verhaak RGW. Comparative Molecular Life History of Spontaneous Canine and Human Gliomas. Cancer Cell. 2020 02 10; 37(2):243-257.e7. PMID: 32049048; PMCID: PMC7132629.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    94. Al-Holou WN, Hodges TR, Everson RG, Freeman J, Zhou S, Suki D, Rao G, Ferguson SD, Heimberger AB, McCutcheon IE, Prabhu SS, Lang FF, Weinberg JS, Wildrick DM, Sawaya R. Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes. Neurosurgery. 2020 01 01; 86(1):112-121. PMID: 30799490; PMCID: PMC8253299.
      Citations: 10     Fields:    Translation:Humans
    95. Goswami S, Walle T, Cornish AE, Basu S, Anandhan S, Fernandez I, Vence L, Blando J, Zhao H, Yadav SS, Ott M, Kong LY, Heimberger AB, de Groot J, Sepesi B, Overman M, Kopetz S, Allison JP, Pe'er D, Sharma P. Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma. Nat Med. 2020 01; 26(1):39-46. PMID: 31873309; PMCID: PMC7182038.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    96. Caruso HG, Tanaka R, Liang J, Ling X, Sabbagh A, Henry VK, Collier TL, Heimberger AB. Shortened ex vivo manufacturing time of EGFRvIII-specific chimeric antigen receptor (CAR) T cells reduces immune exhaustion and enhances antiglioma therapeutic function. J Neurooncol. 2019 Dec; 145(3):429-439. PMID: 31686330.
      Citations: 14     Fields:    Translation:HumansAnimals
    97. Kassab C, Zamler D, Kamiya-Matsuoka C, Gatalica Z, Xiu J, Spetzler D, Heimberger AB. Genetic and immune profiling for potential therapeutic targets in adult human craniopharyngioma. Clin Oncol Res. 2019; 2(3):2-8. PMID: 31712784; PMCID: PMC6844364.
      Citations: 2     
    98. Patel R, Traylor JI, Latha K, Heimberger AB, Li S, Rao G. Fibrinogen-like protein 2: a potential molecular target for glioblastoma treatment. Expert Opin Ther Targets. 2019 08; 23(8):647-649. PMID: 31167575; PMCID: PMC6635074.
      Citations: 2     Fields:    Translation:HumansAnimals
    99. Ferguson SD, Bindal S, Bassett RL, Haydu LE, McCutcheon IE, Heimberger AB, Li J, O'Brien BJ, Guha-Thakurta N, Tetzlaff MT, Tawbi H, Davies MA, Glitza IC. Predictors of survival in metastatic melanoma patients with leptomeningeal disease (LMD). J Neurooncol. 2019 May; 142(3):499-509. PMID: 30847840.
      Citations: 8     Fields:    Translation:Humans
    100. Latha K, Yan J, Yang Y, Gressot LV, Kong LY, Manyam G, Ezhilarasan R, Wang Q, Sulman EP, Eric Davis R, Huang S, Fuller GN, Rao A, Heimberger AB, Li S, Rao G. The Role of Fibrinogen-Like Protein 2 on Immunosuppression and Malignant Progression in Glioma. J Natl Cancer Inst. 2019 03 01; 111(3):292-300. PMID: 29947810; PMCID: PMC6410946.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    101. Yan J, Zhao Q, Gabrusiewicz K, Kong LY, Xia X, Wang J, Ott M, Xu J, Davis RE, Huo L, Rao G, Sun SC, Watowich SS, Heimberger AB, Li S. Author Correction: FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nat Commun. 2019 02 15; 10(1):862. PMID: 30770835; PMCID: PMC6377651.
      Citations: 5     Fields:    
    102. Yan J, Zhao Q, Gabrusiewicz K, Kong LY, Xia X, Wang J, Ott M, Xu J, Davis RE, Huo L, Rao G, Sun SC, Watowich SS, Heimberger AB, Li S. FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nat Commun. 2019 01 25; 10(1):448. PMID: 30683885; PMCID: PMC6347641.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    103. Wei J, Marisetty A, Schrand B, Gabrusiewicz K, Hashimoto Y, Ott M, Grami Z, Kong LY, Ling X, Caruso H, Zhou S, Wang YA, Fuller GN, Huse J, Gilboa E, Kang N, Huang X, Verhaak R, Li S, Heimberger AB. Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target. J Clin Invest. 2019 01 02; 129(1):137-149. PMID: 30307407; PMCID: PMC6307970.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    104. Ferguson SD, Zheng S, Xiu J, Zhou S, Khasraw M, Brastianos PK, Kesari S, Hu J, Rudnick J, Salacz ME, Piccioni D, Huang S, Davies MA, Glitza IC, Heymach JV, Zhang J, Ibrahim NK, DeGroot JF, McCarty J, O'Brien BJ, Sawaya R, Verhaak RGW, Reddy SK, Priebe W, Gatalica Z, Spetzler D, Heimberger AB. Profiles of brain metastases: Prioritization of therapeutic targets. Int J Cancer. 2018 12 01; 143(11):3019-3026. PMID: 29923182; PMCID: PMC6235694.
      Citations: 15     Fields:    Translation:Humans
    105. Caruso HG, Heimberger AB, Cooper LJN. Steering CAR T cells to distinguish friend from foe. Oncoimmunology. 2019; 8(10):e1271857. PMID: 31646067; PMCID: PMC6791456.
      Citations: 12     Fields:    
    106. Noh H, Zhao Q, Yan J, Kong LY, Gabrusiewicz K, Hong S, Xia X, Heimberger AB, Li S. Cell surface vimentin-targeted monoclonal antibody 86C increases sensitivity to temozolomide in glioma stem cells. Cancer Lett. 2018 10 01; 433:176-185. PMID: 29991446; PMCID: PMC6086585.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    107. Caruso H, Heimberger AB. Comment on "Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma". Neuro Oncol. 2018 06 18; 20(7):1003-1004. PMID: 29648659; PMCID: PMC6007451.
      Citations: 6     Fields:    Translation:HumansCells
    108. Hashimoto Y, Penas-Prado M, Zhou S, Wei J, Khatua S, Hodges TR, Sanai N, Xiu J, Gatalica Z, Kim L, Kesari S, Rao G, Spetzler D, Heimberger A. Rethinking medulloblastoma from a targeted therapeutics perspective. J Neurooncol. 2018 Sep; 139(3):713-720. PMID: 29869738; PMCID: PMC6132970.
      Citations: 7     Fields:    Translation:Humans
    109. Ferguson SD, Zhou S, Huse JT, de Groot JF, Xiu J, Subramaniam DS, Mehta S, Gatalica Z, Swensen J, Sanai N, Spetzler D, Heimberger AB. Targetable Gene Fusions Associate With the IDH Wild-Type Astrocytic Lineage in Adult Gliomas. J Neuropathol Exp Neurol. 2018 06 01; 77(6):437-442. PMID: 29718398; PMCID: PMC5961205.
      Citations: 22     Fields:    Translation:HumansCells
    110. Everson RG, Hashimoto Y, Freeman JL, Hodges TR, Huse J, Zhou S, Xiu J, Spetzler D, Sanai N, Kim L, Kesari S, Brenner A, De Monte F, Heimberger A, Raza SM. Multiplatform profiling of meningioma provides molecular insight and prioritization of drug targets for rational clinical trial design. J Neurooncol. 2018 Sep; 139(2):469-478. PMID: 29846894.
      Citations: 7     Fields:    Translation:Humans
    111. Shen J, Song R, Hodges TR, Heimberger AB, Zhao H. Identification of metabolites in plasma for predicting survival in glioblastoma. Mol Carcinog. 2018 08; 57(8):1078-1084. PMID: 29603794.
      Citations: 8     Fields:    Translation:Humans
    112. Domenyuk V, Gatalica Z, Santhanam R, Wei X, Stark A, Kennedy P, Toussaint B, Levenberg S, Wang J, Xiao N, Heimberger AB, Berry DA, Barker A, Quackenbush J, Marshall JL, Poste G, Vacirca JL, Vidal GA, Schwartzberg LS, Halbert DD, Voss A, Magee D, Miglarese MR, Famulok M, Spetzler D, Greil R, Rinnerthaler G, Gampenrieder SP, Mayer G. Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes. Nat Commun. 2018 03 23; 9(1):1219. PMID: 29572535; PMCID: PMC5865185.
      Citations: 10     Fields:    Translation:HumansCells
    113. Glitza IC, Rohlfs M, Guha-Thakurta N, Bassett RL, Bernatchez C, Diab A, Woodman SE, Yee C, Amaria RN, Patel SP, Tawbi H, Wong M, Hwu WJ, Hwu P, Heimberger A, McCutcheon IE, Papadopoulos N, Davies MA. Retrospective review of metastatic melanoma patients with leptomeningeal disease treated with intrathecal interleukin-2. ESMO Open. 2018; 3(1):e000283. PMID: 29387478; PMCID: PMC5786950.
      Citations: 12     
    114. Gabrusiewicz K, Li X, Wei J, Hashimoto Y, Marisetty AL, Ott M, Wang F, Hawke D, Yu J, Healy LM, Hossain A, Akers JC, Maiti SN, Yamashita S, Shimizu Y, Dunner K, Zal MA, Burks JK, Gumin J, Nwajei F, Rezavanian A, Zhou S, Rao G, Sawaya R, Fuller GN, Huse JT, Antel JP, Li S, Cooper L, Sulman EP, Chen C, Geula C, Kalluri R, Zal T, Heimberger AB. Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes. Oncoimmunology. 2018; 7(4):e1412909. PMID: 29632728; PMCID: PMC5889290.
      Citations: 122     Fields:    
    115. Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW, Gabriel Sauv? CE. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2018 01 08; 33(1):152. PMID: 29316430; PMCID: PMC5892424.
      Citations: 78     Fields:    
    116. Ferguson SD, Zhou S, Xiu J, Hashimoto Y, Sanai N, Kim L, Kesari S, de Groot J, Spetzler D, Heimberger AB. Ependymomas overexpress chemoresistance and DNA repair-related proteins. Oncotarget. 2018 Jan 30; 9(8):7822-7831. PMID: 29487694; PMCID: PMC5814261.
      Citations: 4     Fields:    
    117. Shen J, Hodges TR, Song R, Gong Y, Calin GA, Heimberger AB, Zhao H. Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma. Mol Carcinog. 2018 Jan; 57(1):137-141. PMID: 28926136.
      Citations: 36     Fields:    Translation:Humans
    118. Jacobs DI, Liu Y, Gabrusiewicz K, Tsavachidis S, Armstrong GN, Zhou R, Wei J, Ivan C, Calin G, Molinaro AM, Rice T, Bracci PM, Hansen HM, Wiencke JK, Wrensch MR, Heimberger AB, Bondy ML. Germline polymorphisms in myeloid-associated genes are not associated with survival in glioma patients. J Neurooncol. 2018 Jan; 136(1):33-39. PMID: 28965162; PMCID: PMC5756111.
      Citations: 2     Fields:    Translation:HumansCells
    119. Narang S, Kim D, Aithala S, Heimberger AB, Ahmed S, Rao D, Rao G, Rao A. Tumor image-derived texture features are associated with CD3 T-cell infiltration status in glioblastoma. Oncotarget. 2017 Nov 24; 8(60):101244-101254. PMID: 29254160; PMCID: PMC5731870.
      Citations: 11     Fields:    
    120. Hodges TR, Ott M, Xiu J, Gatalica Z, Swensen J, Zhou S, Huse JT, de Groot J, Li S, Overwijk WW, Spetzler D, Heimberger AB. Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy. Neuro Oncol. 2017 Aug 01; 19(8):1047-1057. PMID: 28371827; PMCID: PMC5570198.
      Citations: 165     Fields:    Translation:HumansCells
    121. Wang Q, Hu B, Hu X, Kim H, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW, Squatrito M, Sauv? CG. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2017 07 10; 32(1):42-56.e6. PMID: 28697342; PMCID: PMC5599156.
      Citations: 549     Fields:    Translation:HumansCells
    122. Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G. Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial. Lancet Oncol. 2017 08; 18(8):1040-1048. PMID: 28687375; PMCID: PMC5560102.
      Citations: 148     Fields:    Translation:HumansCTClinical Trials
    123. Tan AC, Heimberger AB, Menzies AM, Pavlakis N, Khasraw M. Immune Checkpoint Inhibitors for Brain Metastases. Curr Oncol Rep. 2017 Jun; 19(6):38. PMID: 28417311.
      Citations: 8     Fields:    Translation:Humans
    124. Srinivasan VM, Ferguson SD, Lee S, Weathers SP, Kerrigan BCP, Heimberger AB. Tumor Vaccines for Malignant Gliomas. Neurotherapeutics. 2017 04; 14(2):345-357. PMID: 28389997; PMCID: PMC5398993.
      Citations: 21     Fields:    Translation:HumansAnimals
    125. Zhao H, Shen J, Hodges TR, Song R, Fuller GN, Heimberger AB. Serum microRNA profiling in patients with glioblastoma: a survival analysis. Mol Cancer. 2017 03 11; 16(1):59. PMID: 28284220; PMCID: PMC5346242.
      Citations: 36     Fields:    Translation:Humans
    126. Yaghi NK, Wei J, Hashimoto Y, Kong LY, Gabrusiewicz K, Nduom EK, Ling X, Huang N, Zhou S, Kerrigan BC, Levine JM, Fajt VR, Levine G, Porter BF, Marcusson EG, Tachikawa K, Chivukula P, Webb DC, Payne JE, Heimberger AB. Immune modulatory nanoparticle therapeutics for intracerebral glioma. Neuro Oncol. 2017 03 01; 19(3):372-382. PMID: 27765835; PMCID: PMC5464307.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    127. Shingu T, Ho AL, Yuan L, Zhou X, Dai C, Zheng S, Wang Q, Zhong Y, Chang Q, Horner JW, Liebelt BD, Yao Y, Hu B, Chen Y, Fuller GN, Verhaak RG, Heimberger AB, Hu J. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet. 2017 01; 49(1):75-86. PMID: 27841882; PMCID: PMC5453714.
      Citations: 39     Fields:    Translation:AnimalsCells
    128. Salzillo TC, Hu J, Nguyen L, Whiting N, Lee J, Weygand J, Dutta P, Pudakalakatti S, Millward NZ, Gammon ST, Lang FF, Heimberger AB, Bhattacharya PK. Interrogating Metabolism in Brain Cancer. Magn Reson Imaging Clin N Am. 2016 Nov; 24(4):687-703. PMID: 27742110; PMCID: PMC5091807.
      Citations: 5     Fields:    Translation:Humans
    129. Noh H, Yan J, Hong S, Kong LY, Gabrusiewicz K, Xia X, Heimberger AB, Li S. Discovery of cell surface vimentin targeting mAb for direct disruption of GBM tumor initiating cells. Oncotarget. 2016 Nov 01; 7(44):72021-72032. PMID: 27713131; PMCID: PMC5342141.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    130. Ferguson SD, Xiu J, Weathers SP, Zhou S, Kesari S, Weiss SE, Verhaak RG, Hohl RJ, Barger GR, Reddy SK, Heimberger AB. GBM-associated mutations and altered protein expression are more common in young patients. Oncotarget. 2016 Oct 25; 7(43):69466-69478. PMID: 27579614; PMCID: PMC5342491.
      Citations: 9     Fields:    Translation:HumansCells
    131. Garber ST, Hashimoto Y, Weathers SP, Xiu J, Gatalica Z, Verhaak RG, Zhou S, Fuller GN, Khasraw M, de Groot J, Reddy SK, Spetzler D, Heimberger AB. Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies. Neuro Oncol. 2016 10; 18(10):1357-66. PMID: 27370400; PMCID: PMC5035527.
      Citations: 76     Fields:    Translation:HumansCells
    132. Torikai H, Zhang L, Maiti S, Dai J, Do KA, Singh H, Huls H, Lee DA, Champlin RE, Heimberger AB, Cooper LJ, Caruso HG. Redirecting T-Cell Specificity to EGFR Using mRNA to Self-limit Expression of Chimeric Antigen Receptor. J Immunother. 2016 06; 39(5):205-17. PMID: 27163741; PMCID: PMC5847343.
      Citations: 17     Fields:    Translation:HumansCells
    133. Xue J, Zhou A, Wu Y, Morris SA, Lin K, Amin S, Verhaak R, Fuller G, Xie K, Heimberger AB, Huang S. miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis. Cancer Res. 2016 07 15; 76(14):4293-304. PMID: 27246830; PMCID: PMC5033679.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    134. Hodges TR, Ferguson SD, Heimberger AB. Immunotherapy in glioblastoma: emerging options in precision medicine. CNS Oncol. 2016 07; 5(3):175-86. PMID: 27225028; PMCID: PMC4926530.
      Citations: 6     Fields:    Translation:Humans
    135. Zhao H, Heimberger AB, Lu Z, Wu X, Hodges TR, Song R, Shen J. Metabolomics profiling in plasma samples from glioma patients correlates with tumor phenotypes. Oncotarget. 2016 Apr 12; 7(15):20486-95. PMID: 26967252; PMCID: PMC4991469.
      Citations: 17     Fields:    Translation:Humans
    136. Gabrusiewicz K, Rodriguez B, Wei J, Hashimoto Y, Healy LM, Maiti SN, Thomas G, Zhou S, Wang Q, Elakkad A, Liebelt BD, Yaghi NK, Ezhilarasan R, Huang N, Weinberg JS, Prabhu SS, Rao G, Sawaya R, Langford LA, Bruner JM, Fuller GN, Bar-Or A, Li W, Colen RR, Curran MA, Bhat KP, Antel JP, Cooper LJ, Sulman EP, Heimberger AB. Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype. JCI Insight. 2016; 1(2). PMID: 26973881; PMCID: PMC4784261.
      Citations: 194     Fields:    
    137. Hodges TR, Ferguson SD, Caruso HG, Kohanbash G, Zhou S, Cloughesy TF, Berger MS, Poste GH, Khasraw M, Ba S, Jiang T, Mikkelson T, Yung WK, de Groot JF, Fine H, Cantley LC, Mellinghoff IK, Mitchell DA, Okada H, Heimberger AB. Prioritization schema for immunotherapy clinical trials in glioblastoma. Oncoimmunology. 2016 Jun; 5(6):e1145332. PMID: 27471611; PMCID: PMC4938323.
      Citations: 10     Fields:    
    138. Lin J, Xu K, Wei J, Heimberger AB, Roth JA, Ji L. MicroRNA-124 suppresses tumor cell proliferation and invasion by targeting CD164 signaling pathway in non-small cell lung cancer. J Gene Ther. 2016 Feb; 2(1). PMID: 27376157; PMCID: PMC4927004.
      Citations: 16     
    139. Ferguson SD, Srinivasan VM, Ghali MG, Heimberger AB. Cytomegalovirus-targeted immunotherapy and glioblastoma: hype or hope? Immunotherapy. 2016; 8(4):413-23. PMID: 26973123.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    140. Liebelt BD, Finocchiaro G, Heimberger AB. Principles of immunotherapy. Handb Clin Neurol. 2016; 134:163-81. PMID: 26948354.
      Citations: 4     Fields:    Translation:Humans
    141. Kong LY, Wei J, Fuller GN, Schrand B, Gabrusiewicz K, Zhou S, Rao G, Calin G, Gilboa E, Heimberger AB. Tipping a favorable CNS intratumoral immune response using immune stimulation combined with inhibition of tumor-mediated immune suppression. Oncoimmunology. 2016 May; 5(5):e1117739. PMID: 27467917; PMCID: PMC4910740.
      Citations: 5     Fields:    
    142. Wei J, Nduom EK, Kong LY, Hashimoto Y, Xu S, Gabrusiewicz K, Ling X, Huang N, Qiao W, Zhou S, Ivan C, Fuller GN, Gilbert MR, Overwijk W, Calin GA, Heimberger AB. MiR-138 exerts anti-glioma efficacy by targeting immune checkpoints. Neuro Oncol. 2016 05; 18(5):639-48. PMID: 26658052; PMCID: PMC4827047.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    143. Nduom EK, Weller M, Heimberger AB. Immunosuppressive mechanisms in glioblastoma. Neuro Oncol. 2015 Nov; 17 Suppl 7:vii9-vii14. PMID: 26516226; PMCID: PMC4625890.
      Citations: 144     Fields:    Translation:HumansAnimals
    144. Caruso HG, Hurton LV, Najjar A, Rushworth D, Ang S, Olivares S, Mi T, Switzer K, Singh H, Huls H, Lee DA, Heimberger AB, Champlin RE, Cooper LJ. Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity. Cancer Res. 2015 Sep 01; 75(17):3505-18. PMID: 26330164; PMCID: PMC4624228.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    145. Nduom EK, Wei J, Yaghi NK, Huang N, Kong LY, Gabrusiewicz K, Ling X, Zhou S, Ivan C, Chen JQ, Burks JK, Fuller GN, Calin GA, Conrad CA, Creasy C, Ritthipichai K, Radvanyi L, Heimberger AB. PD-L1 expression and prognostic impact in glioblastoma. Neuro Oncol. 2016 Feb; 18(2):195-205. PMID: 26323609; PMCID: PMC4724183.
      Citations: 235     Fields:    Translation:HumansAnimalsCells
    146. Yan J, Kong LY, Hu J, Gabrusiewicz K, Dibra D, Xia X, Heimberger AB, Li S. FGL2 as a Multimodality Regulator of Tumor-Mediated Immune Suppression and Therapeutic Target in Gliomas. J Natl Cancer Inst. 2015 Aug; 107(8). PMID: 25971300; PMCID: PMC4554195.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    147. Gong AH, Wei P, Zhang S, Yao J, Yuan Y, Zhou AD, Lang FF, Heimberger AB, Rao G, Huang S. FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. Cancer Res. 2015 Jun 01; 75(11):2337-48. PMID: 25832656; PMCID: PMC4452436.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    148. Ferguson SD, Srinivasan VM, Heimberger AB. The role of STAT3 in tumor-mediated immune suppression. J Neurooncol. 2015 Jul; 123(3):385-94. PMID: 25700834.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    149. Schuster J, Lai RK, Recht LD, Reardon DA, Paleologos NA, Groves MD, Mrugala MM, Jensen R, Baehring JM, Sloan A, Archer GE, Bigner DD, Cruickshank S, Green JA, Keler T, Davis TA, Heimberger AB, Sampson JH. A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study. Neuro Oncol. 2015 Jun; 17(6):854-61. PMID: 25586468; PMCID: PMC4483122.
      Citations: 164     Fields:    Translation:HumansCTClinical Trials
    150. Fecci PE, Heimberger AB, Sampson JH. Immunotherapy for primary brain tumors: no longer a matter of privilege. Clin Cancer Res. 2014 Nov 15; 20(22):5620-9. PMID: 25398845; PMCID: PMC4235630.
      Citations: 50     Fields:    Translation:Humans
    151. Kong LY, Wei J, Haider AS, Liebelt BD, Ling X, Conrad CA, Fuller GN, Levine NB, Priebe W, Sawaya R, Heimberger AB. Therapeutic targets in subependymoma. J Neuroimmunol. 2014 Dec 15; 277(1-2):168-75. PMID: 25465288.
      Citations: 6     Fields:    Translation:HumansCells
    152. Gressot LV, Doucette TA, Yang Y, Fuller GN, Heimberger AB, Rao A, Latha K, Rao G, B?gler O. Signal transducer and activator of transcription 5b drives malignant progression in a PDGFB-dependent proneural glioma model by suppressing apoptosis. Int J Cancer. 2015 May 01; 136(9):2047-54. PMID: 25302990; PMCID: PMC4331224.
      Citations: 7     Fields:    Translation:Animals
    153. Congdon KL, Gedeon PC, Suryadevara CM, Caruso HG, Cooper LJ, Heimberger AB, Sampson JH. Epidermal growth factor receptor and variant III targeted immunotherapy. Neuro Oncol. 2014 Oct; 16 Suppl 8:viii20-5. PMID: 25342601; PMCID: PMC4207138.
      Citations: 12     Fields:    Translation:HumansAnimals
    154. Hu J, Yan J, Rao G, Latha K, Overwijk WW, Heimberger AB, Li S. The Duality of Fgl2 - Secreted Immune Checkpoint Regulator Versus Membrane-Associated Procoagulant: Therapeutic Potential and Implications. Int Rev Immunol. 2016 07 03; 35(4):325-339. PMID: 25259408; PMCID: PMC5257246.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    155. Xu S, Wei J, Wang F, Kong LY, Ling XY, Nduom E, Gabrusiewicz K, Doucette T, Yang Y, Yaghi NK, Fajt V, Levine JM, Qiao W, Li XG, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB. Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma. J Natl Cancer Inst. 2014 Aug; 106(8). PMID: 24974128; PMCID: PMC4271080.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    156. Schrand B, Berezhnoy A, Brenneman R, Williams A, Levay A, Kong LY, Rao G, Zhou S, Heimberger AB, Gilboa E. Targeting 4-1BB costimulation to the tumor stroma with bispecific aptamer conjugates enhances the therapeutic index of tumor immunotherapy. Cancer Immunol Res. 2014 Sep; 2(9):867-77. PMID: 24938283; PMCID: PMC5502823.
      Citations: 48     Fields:    Translation:AnimalsCells
    157. Bhat KPL, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WFA, Boddeke HWGM, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K. Mesenchymal differentiation mediated by NF-?B promotes radiation resistance in glioblastoma. Cancer Cell. 2013 Sep 09; 24(3):331-46. PMID: 23993863; PMCID: PMC3817560.
      Citations: 479     Fields:    Translation:HumansAnimalsCells
    158. Doucette T, Rao G, Rao A, Shen L, Aldape K, Wei J, Dziurzynski K, Gilbert M, Heimberger AB. Immune heterogeneity of glioblastoma subtypes: extrapolation from the cancer genome atlas. Cancer Immunol Res. 2013 Aug; 1(2):112-22. PMID: 24409449; PMCID: PMC3881271.
      Citations: 121     Fields:    Translation:Humans
    159. Wei J, Gabrusiewicz K, Heimberger A. The controversial role of microglia in malignant gliomas. Clin Dev Immunol. 2013; 2013:285246. PMID: 23983766; PMCID: PMC3741958.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    160. Heimberger AB, Gilbert M, Rao G, Wei J. MicroRNAs as novel immunotherapeutics. Oncoimmunology. 2013 Aug 01; 2(8):e25124. PMID: 24083077; PMCID: PMC3782519.
      Citations: 1     Fields:    
    161. Wei J, Wang F, Kong LY, Xu S, Doucette T, Ferguson SD, Yang Y, McEnery K, Jethwa K, Gjyshi O, Qiao W, Levine NB, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB. miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma. Cancer Res. 2013 Jul 01; 73(13):3913-26. PMID: 23636127; PMCID: PMC3780786.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    162. Sanchez-Perez L, Choi BD, Reap EA, Sayour EJ, Norberg P, Schmittling RJ, Archer GE, Herndon JE, Mitchell DA, Heimberger AB, Bigner DD, Sampson JH. BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide. Cancer Immunol Immunother. 2013 Jun; 62(6):983-7. PMID: 23591978; PMCID: PMC3665719.
      Citations: 10     Fields:    Translation:Humans
    163. Wu AS, Trinh VT, Suki D, Graham S, Forman A, Weinberg JS, McCutcheon IE, Prabhu SS, Heimberger AB, Sawaya R, Wang X, Qiao W, Hess K, Lang FF. A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. J Neurosurg. 2013 Apr; 118(4):873-883. PMID: 23394340; PMCID: PMC4083773.
      Citations: 39     Fields:    Translation:Humans
    164. de Groot J, Liang J, Kong LY, Wei J, Piao Y, Fuller G, Qiao W, Heimberger AB. Modulating antiangiogenic resistance by inhibiting the signal transducer and activator of transcription 3 pathway in glioblastoma. Oncotarget. 2012 Sep; 3(9):1036-48. PMID: 23013619; PMCID: PMC3660053.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    165. Doucette TA, Kong LY, Yang Y, Ferguson SD, Yang J, Wei J, Qiao W, Fuller GN, Bhat KP, Aldape K, Priebe W, Heimberger AB, Rao G, B?gler O. Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma. Neuro Oncol. 2012 Sep; 14(9):1136-45. PMID: 22753228; PMCID: PMC3424209.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    166. Lee I, Fox PS, Ferguson SD, Bassett R, Kong LY, Schacherer CW, Gershenwald JE, Grimm EA, Fuller GN, Heimberger AB. The expression of p-STAT3 in stage IV melanoma: risk of CNS metastasis and survival. Oncotarget. 2012 Mar; 3(3):336-44. PMID: 22488042; PMCID: PMC3359889.
      Citations: 12     Fields:    Translation:HumansCells
    167. Dziurzynski K, Chang SM, Heimberger AB, Kalejta RF, McGregor Dallas SR, Smit M, Soroceanu L, Cobbs CS, HCMV and Gliomas Symposium. Consensus on the role of human cytomegalovirus in glioblastoma. Neuro Oncol. 2012 Mar; 14(3):246-55. PMID: 22319219; PMCID: PMC3280809.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    168. Vogelbaum MA, Jost S, Aghi MK, Heimberger AB, Sampson JH, Wen PY, Macdonald DR, Van den Bent MJ, Chang SM. Application of novel response/progression measures for surgically delivered therapies for gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group. Neurosurgery. 2012 Jan; 70(1):234-43; discussion 243-4. PMID: 21593697.
      Citations: 89     Fields:    Translation:Humans
    169. Jethwa K, Wei J, McEnery K, Heimberger AB. miRNA-mediated immune regulation and immunotherapeutic potential in glioblastoma. Clin Investig (Lond). 2011 Dec; 1(12):1637-1650. PMID: 22468222; PMCID: PMC3314429.
      Citations: 5     
    170. Hatiboglu MA, Kong LY, Wei J, Wang Y, McEnery KA, Fuller GN, Qiao W, Davies MA, Priebe W, Heimberger AB. The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models. Int J Cancer. 2012 Jul 01; 131(1):8-17. PMID: 21792892; PMCID: PMC3319790.
      Citations: 13     Fields:    Translation:AnimalsCells
    171. Dziurzynski K, Wei J, Qiao W, Hatiboglu MA, Kong LY, Wu A, Wang Y, Cahill D, Levine N, Prabhu S, Rao G, Sawaya R, Heimberger AB. Glioma-associated cytomegalovirus mediates subversion of the monocyte lineage to a tumor propagating phenotype. Clin Cancer Res. 2011 Jul 15; 17(14):4642-9. PMID: 21490182; PMCID: PMC3139801.
      Citations: 72     Fields:    Translation:HumansCells
    172. Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W, Heimberger AB. Hypoxia potentiates glioma-mediated immunosuppression. PLoS One. 2011 Jan 20; 6(1):e16195. PMID: 21283755; PMCID: PMC3024401.
      Citations: 94     Fields:    Translation:HumansCells
    173. Heimberger AB, Sampson JH. Immunotherapy coming of age: what will it take to make it standard of care for glioblastoma? Neuro Oncol. 2011 Jan; 13(1):3-13. PMID: 21149252; PMCID: PMC3018912.
      Citations: 56     Fields:    Translation:Humans
    174. Sampson JH, Aldape KD, Archer GE, Coan A, Desjardins A, Friedman AH, Friedman HS, Gilbert MR, Herndon JE, McLendon RE, Mitchell DA, Reardon DA, Sawaya R, Schmittling R, Shi W, Vredenburgh JJ, Bigner DD, Heimberger AB. Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma. Neuro Oncol. 2011 Mar; 13(3):324-33. PMID: 21149254; PMCID: PMC3064599.
      Citations: 166     Fields:    Translation:HumansCellsCTClinical Trials
    175. Kong LY, Wu AS, Doucette T, Wei J, Priebe W, Fuller GN, Qiao W, Sawaya R, Rao G, Heimberger AB. Intratumoral mediated immunosuppression is prognostic in genetically engineered murine models of glioma and correlates to immunotherapeutic responses. Clin Cancer Res. 2010 Dec 01; 16(23):5722-33. PMID: 20921210; PMCID: PMC2999668.
      Citations: 44     Fields:    Translation:HumansAnimals
    176. Sampson JH, Heimberger AB, Archer GE, Aldape KD, Friedman AH, Friedman HS, Gilbert MR, Herndon JE, McLendon RE, Mitchell DA, Reardon DA, Sawaya R, Schmittling RJ, Shi W, Vredenburgh JJ, Bigner DD. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol. 2010 Nov 01; 28(31):4722-9. PMID: 20921459; PMCID: PMC3020702.
      Citations: 363     Fields:    Translation:HumansCellsCTClinical Trials
    177. Hatiboglu MA, Wei J, Wu AS, Heimberger AB. Immune therapeutic targeting of glioma cancer stem cells. Target Oncol. 2010 Sep; 5(3):217-27. PMID: 20737294; PMCID: PMC4262967.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    178. Wu A, Wei J, Kong LY, Wang Y, Priebe W, Qiao W, Sawaya R, Heimberger AB. Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro Oncol. 2010 Nov; 12(11):1113-25. PMID: 20667896; PMCID: PMC3098021.
      Citations: 312     Fields:    Translation:HumansCells
    179. Kong LY, Gelbard A, Wei J, Reina-Ortiz C, Wang Y, Yang EC, Hailemichael Y, Fokt I, Jayakumar A, Qiao W, Fuller GN, Overwijk WW, Priebe W, Heimberger AB. Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model. Clin Cancer Res. 2010 May 01; 16(9):2550-61. PMID: 20388845; PMCID: PMC2936966.
      Citations: 23     Fields:    Translation:AnimalsCells
    180. Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Sawaya R, Lang FF, Heimberger AB. Glioma-associated cancer-initiating cells induce immunosuppression. Clin Cancer Res. 2010 Jan 15; 16(2):461-73. PMID: 20068105; PMCID: PMC2943842.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    181. Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Priebe W, Sawaya R, Lang FF, Heimberger AB. Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway. Mol Cancer Ther. 2010 Jan; 9(1):67-78. PMID: 20053772; PMCID: PMC2939737.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    182. Kanaly CW, Ding D, Heimberger AB, Sampson JH. Clinical applications of a peptide-based vaccine for glioblastoma. Neurosurg Clin N Am. 2010 Jan; 21(1):95-109. PMID: 19944970; PMCID: PMC2824535.
      Citations: 12     Fields:    Translation:HumansAnimalsPHPublic Health
    183. Humphries W, Wei J, Sampson JH, Heimberger AB. The role of tregs in glioma-mediated immunosuppression: potential target for intervention. Neurosurg Clin N Am. 2010 Jan; 21(1):125-37. PMID: 19944972; PMCID: PMC2786818.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    184. Humphries W, Wang Y, Qiao W, Reina-Ortiz C, Abou-Ghazal MK, Crutcher LM, Wei J, Kong LY, Sawaya R, Rao G, Weinberg J, Prabhu SS, Fuller GN, Heimberger AB. yuDetecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients. J Transl Med. 2009 Nov 09; 7:92. PMID: 19900287; PMCID: PMC2777138.
      Citations: 4     Fields:    Translation:HumansCells
    185. Choi BD, Archer GE, Mitchell DA, Heimberger AB, McLendon RE, Bigner DD, Sampson JH. EGFRvIII-targeted vaccination therapy of malignant glioma. Brain Pathol. 2009 Oct; 19(4):713-23. PMID: 19744042; PMCID: PMC2846812.
      Citations: 60     Fields:    Translation:Humans
    186. Sampson JH, Archer GE, Mitchell DA, Heimberger AB, Herndon JE, Lally-Goss D, McGehee-Norman S, Paolino A, Reardon DA, Friedman AH, Friedman HS, Bigner DD. An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme. Mol Cancer Ther. 2009 Oct; 8(10):2773-9. PMID: 19825799; PMCID: PMC2991139.
      Citations: 122     Fields:    Translation:HumansCTClinical Trials
    187. Wiemels JL, Wilson D, Patil C, Patoka J, McCoy L, Rice T, Schwartzbaum J, Heimberger A, Sampson JH, Chang S, Prados M, Wiencke JK, Wrensch M. IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era. Int J Cancer. 2009 Aug 01; 125(3):680-7. PMID: 19408307; PMCID: PMC2861569.
      Citations: 41     Fields:    Translation:Humans
    188. Heimberger AB, Sampson JH. The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients. Expert Opin Biol Ther. 2009 Aug; 9(8):1087-98. PMID: 19591631; PMCID: PMC2793529.
      Citations: 41     Fields:    Translation:HumansAnimals
    189. Murat A, Migliavacca E, Hussain SF, Heimberger AB, Desbaillets I, Hamou MF, Stupp R, Delorenzi M, Hegi ME, R?egg C. Modulation of angiogenic and inflammatory response in glioblastoma by hypoxia. PLoS One. 2009 Jun 17; 4(6):e5947. PMID: 19536297; PMCID: PMC2694268.
      Citations: 60     Fields:    Translation:HumansCells
    190. Kim SS, McCutcheon IE, Suki D, Weinberg JS, Sawaya R, Lang FF, Ferson D, Heimberger AB, DeMonte F, Prabhu SS. Awake craniotomy for brain tumors near eloquent cortex: correlation of intraoperative cortical mapping with neurological outcomes in 309 consecutive patients. Neurosurgery. 2009 May; 64(5):836-45; discussion 345-6. PMID: 19404147.
      Citations: 48     Fields:    Translation:HumansCTClinical Trials
    191. Heimberger AB, Kong LY, Abou-Ghazal M, Reina-Ortiz C, Yang DS, Wei J, Qiao W, Schmittling RJ, Archer GE, Sampson JH, Hiraoka N, Priebe W, Fuller GN, Sawaya R. The role of tregs in human glioma patients and their inhibition with a novel STAT-3 inhibitor. Clin Neurosurg. 2009; 56:98-106. PMID: 20214040.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    192. Abou-Ghazal M, Yang DS, Qiao W, Reina-Ortiz C, Wei J, Kong LY, Fuller GN, Hiraoka N, Priebe W, Sawaya R, Heimberger AB. The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas. Clin Cancer Res. 2008 Dec 15; 14(24):8228-35. PMID: 19088040; PMCID: PMC2605668.
      Citations: 97     Fields:    Translation:HumansCells
    193. Kong LY, Wei J, Sharma AK, Barr J, Abou-Ghazal MK, Fokt I, Weinberg J, Rao G, Grimm E, Priebe W, Heimberger AB. A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells. Cancer Immunol Immunother. 2009 Jul; 58(7):1023-32. PMID: 19002459; PMCID: PMC2674523.
      Citations: 42     Fields:    Translation:HumansCells
    194. Heimberger AB, Priebe W. Small molecular inhibitors of p-STAT3: novel agents for treatment of primary and metastatic CNS cancers. Recent Pat CNS Drug Discov. 2008 Nov; 3(3):179-88. PMID: 18991807.
      Citations: 11     Fields:    Translation:HumansCells
    195. Kong LY, Abou-Ghazal MK, Wei J, Chakraborty A, Sun W, Qiao W, Fuller GN, Fokt I, Grimm EA, Schmittling RJ, Archer GE, Sampson JH, Priebe W, Heimberger AB. A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. Clin Cancer Res. 2008 Sep 15; 14(18):5759-68. PMID: 18794085; PMCID: PMC2583362.
      Citations: 68     Fields:    Translation:AnimalsCells
    196. Schmittling RJ, Archer GE, Mitchell DA, Heimberger A, Pegram C, Herndon JE, Friedman HS, Bigner DD, Sampson JH. Detection of humoral response in patients with glioblastoma receiving EGFRvIII-KLH vaccines. J Immunol Methods. 2008 Nov 30; 339(1):74-81. PMID: 18775433.
      Citations: 25     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    197. Heimberger AB, Abou-Ghazal M, Reina-Ortiz C, Yang DS, Sun W, Qiao W, Hiraoka N, Fuller GN. Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas. Clin Cancer Res. 2008 Aug 15; 14(16):5166-72. PMID: 18698034.
      Citations: 160     Fields:    Translation:HumansCells
    198. Wei J, DeAngulo G, Sun W, Hussain SF, Vasquez H, Jordan J, Weinberg J, Wolff J, Koshkina N, Heimberger AB. Topotecan enhances immune clearance of gliomas. Cancer Immunol Immunother. 2009 Feb; 58(2):259-70. PMID: 18594817; PMCID: PMC11030728.
      Citations: 9     Fields:    Translation:HumansCells
    199. Sampson JH, Archer GE, Mitchell DA, Heimberger AB, Bigner DD. Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma. Semin Immunol. 2008 Oct; 20(5):267-75. PMID: 18539480; PMCID: PMC2633865.
      Citations: 81     Fields:    Translation:HumansAnimals
    200. Brem SS, Bierman PJ, Black P, Brem H, Chamberlain MC, Chiocca EA, DeAngelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Glass J, Grossman SA, Heimberger AB, Junck L, Linette GP, Loeffler JJ, Maor MH, Moots P, Mrugala M, Nabors LB, Newton HB, Olivi A, Portnow J, Prados M, Raizer JJ, Shrieve DC, Sills AK. Central nervous system cancers. J Natl Compr Canc Netw. 2008 May; 6(5):456-504. PMID: 18492461.
      Citations: 8     Fields:    Translation:Humans
    201. Heimberger AB, Sun W, Hussain SF, Dey M, Crutcher L, Aldape K, Gilbert M, Hassenbusch SJ, Sawaya R, Schmittling B, Archer GE, Mitchell DA, Bigner DD, Sampson JH. Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study. Neuro Oncol. 2008 Feb; 10(1):98-103. PMID: 18079360; PMCID: PMC2600844.
      Citations: 61     Fields:    Translation:HumansCells
    202. Hussain SF, Kong LY, Jordan J, Conrad C, Madden T, Fokt I, Priebe W, Heimberger AB. A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res. 2007 Oct 15; 67(20):9630-6. PMID: 17942891.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    203. Paz N, Levanon EY, Amariglio N, Heimberger AB, Ram Z, Constantini S, Barbash ZS, Adamsky K, Safran M, Hirschberg A, Krupsky M, Ben-Dov I, Cazacu S, Mikkelsen T, Brodie C, Eisenberg E, Rechavi G. Altered adenosine-to-inosine RNA editing in human cancer. Genome Res. 2007 Nov; 17(11):1586-95. PMID: 17908822; PMCID: PMC2045141.
      Citations: 156     Fields:    Translation:HumansAnimalsCells
    204. Barnett JA, Urbauer DL, Murray GI, Fuller GN, Heimberger AB. Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target. Clin Cancer Res. 2007 Jun 15; 13(12):3559-67. PMID: 17575219.
      Citations: 10     Fields:    Translation:Humans
    205. Pelloski CE, Ballman KV, Furth AF, Zhang L, Lin E, Sulman EP, Bhat K, McDonald JM, Yung WK, Colman H, Woo SY, Heimberger AB, Suki D, Prados MD, Chang SM, Barker FG, Buckner JC, James CD, Aldape K. Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma. J Clin Oncol. 2007 Jun 01; 25(16):2288-94. PMID: 17538175.
      Citations: 121     Fields:    Translation:Humans
    206. Jordan JT, Sun W, Hussain SF, DeAngulo G, Prabhu SS, Heimberger AB. Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy. Cancer Immunol Immunother. 2008 Jan; 57(1):123-31. PMID: 17522861; PMCID: PMC11030978.
      Citations: 117     Fields:    Translation:HumansCells
    207. Pelloski CE, Lin E, Zhang L, Yung WK, Colman H, Liu JL, Woo SY, Heimberger AB, Suki D, Prados M, Chang S, Barker FG, Fuller GN, Aldape KD. Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma. Clin Cancer Res. 2006 Jul 01; 12(13):3935-41. PMID: 16818690.
      Citations: 79     Fields:    Translation:HumansCells
    208. Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB. The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro Oncol. 2006 Jul; 8(3):261-79. PMID: 16775224; PMCID: PMC1871955.
      Citations: 277     Fields:    Translation:HumansCells
    209. Hussain SF, Yang D, Suki D, Grimm E, Heimberger AB. Innate immune functions of microglia isolated from human glioma patients. J Transl Med. 2006 Mar 30; 4:15. PMID: 16573834; PMCID: PMC1501057.
      Citations: 39     Fields:    
    210. Heimberger AB, Suki D, Yang D, Shi W, Aldape K. The natural history of EGFR and EGFRvIII in glioblastoma patients. J Transl Med. 2005 Oct 19; 3:38. PMID: 16236164; PMCID: PMC1298339.
      Citations: 96     Fields:    
    211. Hussain SF, Heimberger AB. Immunotherapy for human glioma: innovative approaches and recent results. Expert Rev Anticancer Ther. 2005 Oct; 5(5):777-90. PMID: 16221048.
      Citations: 14     Fields:    Translation:HumansCells
    212. Brem SS, Bierman PJ, Black P, Blumenthal DT, Brem H, Chamberlain MC, Chiocca EA, DeAngelis LM, Fenstermaker RA, Fine HA, Friedman A, Glass J, Grossman SA, Heimberger AB, Junck L, Levin V, Loeffler JJ, Maor MH, Narayana A, Newton HB, Olivi A, Portnow J, Prados M, Raizer JJ, Rosenfeld SS, Shrieve DC, Sills AK, Spence AM, Vrionis FD, National Comprehensive Cancer Network. Central nervous system cancers: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2005 Sep; 3(5):644-90. PMID: 16194456.
      Citations: 20     Fields:    Translation:Humans
    213. Heimberger AB, Hlatky R, Suki D, Yang D, Weinberg J, Gilbert M, Sawaya R, Aldape K. Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients. Clin Cancer Res. 2005 Feb 15; 11(4):1462-6. PMID: 15746047.
      Citations: 216     Fields:    Translation:Humans
    214. Heimberger AB, McGary EC, Suki D, Ruiz M, Wang H, Fuller GN, Bar-Eli M. Loss of the AP-2alpha transcription factor is associated with the grade of human gliomas. Clin Cancer Res. 2005 Jan 01; 11(1):267-72. PMID: 15671555.
      Citations: 26     Fields:    Translation:HumansCells
    215. Heimberger AB, Wang E, McGary EC, Hess KR, Henry VK, Shono T, Cohen Z, Gumin J, Sawaya R, Conrad CA, Lang FF. Mechanisms of action of rapamycin in gliomas. Neuro Oncol. 2005 Jan; 7(1):1-11. PMID: 15701277; PMCID: PMC1871627.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    216. McGary EC, Onn A, Mills L, Heimberger A, Eton O, Thomas GW, Shtivelband M, Bar-Eli M. Imatinib mesylate inhibits platelet-derived growth factor receptor phosphorylation of melanoma cells but does not affect tumorigenicity in vivo. J Invest Dermatol. 2004 Feb; 122(2):400-5. PMID: 15009722.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    217. McGary EC, Heimberger A, Mills L, Weber K, Thomas GW, Shtivelband M, Lev DC, Bar-Eli M. A fully human antimelanoma cellular adhesion molecule/MUC18 antibody inhibits spontaneous pulmonary metastasis of osteosarcoma cells in vivo. Clin Cancer Res. 2003 Dec 15; 9(17):6560-6. PMID: 14695161.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    218. Heimberger AB, Crotty LE, Archer GE, Hess KR, Wikstrand CJ, Friedman AH, Friedman HS, Bigner DD, Sampson JH. Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors. Clin Cancer Res. 2003 Sep 15; 9(11):4247-54. PMID: 14519652.
      Citations: 115     Fields:    Translation:AnimalsCells
    219. Heimberger AB, Learn CA, Archer GE, McLendon RE, Chewning TA, Tuck FL, Pracyk JB, Friedman AH, Friedman HS, Bigner DD, Sampson JH. Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa). Clin Cancer Res. 2002 Nov; 8(11):3496-502. PMID: 12429640.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    220. Heimberger AB, Wiltshire RN, Bronec R, McLendon RE, Cummings TJ. Biphasic malignant meningioma: a comparative genomic hybridization study. Clin Neuropathol. 2002 Nov-Dec; 21(6):258-64. PMID: 12489674.
      Citations: 1     Fields:    Translation:HumansCells
    221. Heimberger AB, Archer GE, Crotty LE, McLendon RE, Friedman AH, Friedman HS, Bigner DD, Sampson JH. Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. Neurosurgery. 2002 Jan; 50(1):158-64; discussion 164-6. PMID: 11844246.
      Citations: 40     Fields:    Translation:AnimalsCells
    222. Hsieh CS, Heimberger AB, Gold JS, O'Garra A, Murphy KM. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):6065-9. PMID: 1385868; PMCID: PMC49438.
      Citations: 202     Fields:    Translation:AnimalsCellsPHPublic Health
    223. Murphy KM, Heimberger AB, Loh DY. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science. 1990 Dec 21; 250(4988):1720-3. PMID: 2125367.
      Citations: 464     Fields:    Translation:AnimalsCells
    224. Heimberger A, Eisenstark A, Lev?n S. Catalase HPI influences membrane permeability in Escherichia coli following near-UV stress. Biochem Biophys Res Commun. 1990 Sep 28; 171(3):1224-8. PMID: 2222441.
      Citations: 3     Fields:    Translation:Cells
    225. Heimberger A, Eisenstark A. Compartmentalization of catalases in Escherichia coli. Biochem Biophys Res Commun. 1988 Jul 15; 154(1):392-7. PMID: 3293564.
      Citations: 14     Fields:    Translation:Cells
    226. Reply to M.C. Chamberlain. Journal of Clinical Oncology. 29.
    227. PD-L1 expression and prognostic impact in glioblastoma. Neuro-Oncology. 18:195-205.
    228. MicroRNAs as novel immunotherapeutics. OncoImmunology. 2.
    229. MiR-138 exerts anti-glioma efficacy by targeting immune checkpoints. Neuro-Oncology. 18:639-648.
    230. The Duality of Fgl2 - Secreted Immune Checkpoint Regulator Versus Membrane-Associated Procoagulant. International Reviews of Immunology.
    231. Tipping a favorable CNS intratumoral immune response using immune stimulation combined with inhibition of tumor-mediated immune suppression. OncoImmunology.
    232. Discovery of cell surface vimentin targeting mAb for direct disruption of GBM tumor initiating cells. Oncotarget. 7:72021-72032.
    233. Synergistic effect of immunotherapy and chemotherapy in cancers. Letters in Drug Design and Discovery. 3:513-523.
    234. Cytomegalovirus-targeted immunotherapy and glioblastoma. Immunotherapy. 8:413-423.
    235. Principles of immunotherapy. 163-181.
    236. The natural history of EGFR and EGFRvIII in glioblastoma patients. Journal of Translational Medicine. 3.
    237. Reply to J.W. Locasale et al. Journal of Clinical Oncology. 30:338-339.
    238. Redirecting T-cell specificity to EGFR using mRNA to self-limit expression of chimeric antigen receptor. Journal of Immunotherapy. 39:205-217.
    239. Reply to M.S. Lesniak. Journal of Clinical Oncology. 29:3105-3106.
    240. The role of STAT3 in tumor-mediated immune suppression. Journal of Neuro-Oncology. 123:385-394.
    241. Metabolomics profiling in plasma samples from glioma patients correlates with tumor phenotypes. Oncotarget. 7:20486-20495.
    242. Prioritization schema for immunotherapy clinical trials in glioblastoma. OncoImmunology.
    243. Interrogating Metabolism in Brain Cancer. Magnetic Resonance Imaging Clinics of North America. 24:687-703.
    244. GBM-associated mutations and altered protein expression are more common in young patients. Oncotarget. 7:69466-69478.
    245. The role of glioma microenvironment in immune modulation. Letters in Drug Design and Discovery. 3:443-453.
    246. Erratum. Cancer Immunology, Immunotherapy. 57:133.
    247. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nature Genetics. 49:75-86.
    248. miR-182-5p induced by STAT3 activation promotes glioma tumorigenesis. Cancer Research. 76:4293-4304.
    249. Innate immune functions of microglia isolated from human glioma patients. Journal of Translational Medicine. 4.
    250. Immune checkpoint blockade as a potential therapeutic target. Neuro-Oncology. 18:1357-1366.
    251. A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma. Neuro-Oncology. 17:854-861.
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