InstitutionMD Anderson
DepartmentExperimental Radiation Oncology
Address7435 Fannin St
Houston TX 77054-1901
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abuhadra N, Sun R, Bassett RL, Huo L, Chang JT, Teshome M, Clayborn AR, White JB, Ravenberg EE, Adrada BE, Candelaria RP, Yang W, Ding Q, Symmans WF, Arun B, Damodaran S, Koenig KB, Layman RM, Lim B, Litton JK, Thompson A, Ueno NT, Piwnica-Worms H, Hortobagyi GN, Valero V, Tripathy D, Rauch GM, Moulder S, Yam C. Targeting chemotherapy resistance in mesenchymal triple-negative breast cancer: a phase II trial of neoadjuvant angiogenic and mTOR inhibition with chemotherapy. Invest New Drugs. 2023 Jun; 41(3):391-401. PMID: 37043123.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    2. Echeverria GV, Cai S, Tu Y, Shao J, Powell E, Redwood AB, Jiang Y, McCoy A, Rinkenbaugh AL, Lau R, Trevarton AJ, Fu C, Gould R, Ravenberg EE, Huo L, Candelaria R, Santiago L, Adrada BE, Lane DL, Rauch GM, Yang WT, White JB, Chang JT, Moulder SL, Symmans WF, Hilsenbeck SG, Piwnica-Worms H. Predictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer. NPJ Breast Cancer. 2023 Jan 10; 9(1):2. PMID: 36627285; PMCID: PMC9831981.
    3. Liu X, Ge Z, Yang F, Contreras A, Lee S, White JB, Lu Y, Labrie M, Arun BK, Moulder SL, Mills GB, Piwnica-Worms H, Litton JK, Chang JT. Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment na?ve gBRCA+ breast cancers. NPJ Breast Cancer. 2022 May 10; 8(1):64. PMID: 35538088; PMCID: PMC9090765.
    4. Redwood AB, Zhang X, Seth SB, Ge Z, Bindeman WE, Zhou X, Sinha VC, Heffernan TP, Piwnica-Worms H. The cytosolic iron-sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors. NPJ Breast Cancer. 2021 Dec 02; 7(1):152. PMID: 34857765; PMCID: PMC8639742.
    5. Acevedo Diaz AC, Kumari N, Govindaraju S, de la Cruz Bonilla M, San Lucas FA, Nguyen ND, Piwnica-Worms H, Maitra A, Taniguchi CM, Garc?a Garc?a CJ, Jim?nez Sacarello I. HIF2 Regulates Intestinal Wnt5a Expression. Front Oncol. 2021; 11:769385. PMID: 34900719; PMCID: PMC8656274.
      Citations: 1     
    6. Terranova CJ, Stemler KM, Barrodia P, Jeter-Jones SL, Ge Z, de la Cruz Bonilla M, Raman A, Cheng CW, Allton KL, Arslan E, Barton MC, Rai K, Piwnica-Worms H, Yilmaz ?H. Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine. Cell Rep. 2021 11 23; 37(8):110044. PMID: 34818540; PMCID: PMC8668154.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Jaggupilli A, Ly S, Nguyen K, Anand V, Yuan B, El-Dana F, Yan Y, Arvanitis Z, Piyarathna DWB, Putluri N, Piwnica-Worms H, Manning HC, Andreeff M, Battula VL. Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer. Br J Cancer. 2022 03; 126(4):615-627. PMID: 34811508; PMCID: PMC8854435.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Manu SM, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC. Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nat Commun. 2021 09 10; 12(1):5389. PMID: 34508101; PMCID: PMC8433435.
      Citations: 1     Fields:    Translation:HumansAnimals
    9. Sinha VC, Rinkenbaugh AL, Xu M, Zhou X, Zhang X, Jeter-Jones S, Shao J, Qi Y, Zebala JA, Maeda DY, McAllister F, Piwnica-Worms H. Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast. Nat Commun. 2021 08 18; 12(1):5024. PMID: 34408137; PMCID: PMC8373912.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Ly S, Anand V, El-Dana F, Nguyen K, Cai Y, Cai S, Piwnica-Worms H, Tripathy D, Sahin AA, Andreeff M, Battula VL. Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2+ breast cancer stem-like cells. J Immunother Cancer. 2021 03; 9(3). PMID: 33722905; PMCID: PMC7970220.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    11. Reddy TP, Rosato RR, Li X, Moulder S, Piwnica-Worms H, Chang JC. A comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations. Breast Cancer Res. 2020 11 04; 22(1):121. PMID: 33148288; PMCID: PMC7640663.
      Citations: 21     Fields:    Translation:HumansCells
    12. Powell RT, Redwood A, Liu X, Guo L, Cai S, Zhou X, Tu Y, Zhang X, Qi Y, Jiang Y, Echeverria G, Feng N, Ma X, Giuliani V, Marszalek JR, Heffernan TP, Vellano CP, White JB, Stephan C, Davies PJ, Moulder S, Symmans WF, Chang JT, Piwnica-Worms H. Pharmacologic profiling of patient-derived xenograft models of primary treatment-na?ve triple-negative breast cancer. Sci Rep. 2020 10 21; 10(1):17899. PMID: 33087803; PMCID: PMC7578025.
      Citations: 3     Fields:    Translation:HumansAnimals
    13. Hu X, Harvey SE, Zheng R, Lyu J, Grzeskowiak CL, Powell E, Piwnica-Worms H, Scott KL, Cheng C. The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing. Nat Commun. 2020 01 24; 11(1):486. PMID: 31980632; PMCID: PMC6981122.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    14. Litton JK, Scoggins ME, Hess KR, Adrada BE, Murthy RK, Damodaran S, DeSnyder SM, Brewster AM, Barcenas CH, Valero V, Whitman GJ, Schwartz-Gomez J, Mittendorf EA, Thompson AM, Helgason T, Ibrahim N, Piwnica-Worms H, Moulder SL, Arun BK. Neoadjuvant Talazoparib for Patients With Operable Breast Cancer With a Germline BRCA Pathogenic Variant. J Clin Oncol. 2020 02 10; 38(5):388-394. PMID: 31461380; PMCID: PMC7351336.
      Citations: 51     Fields:    Translation:HumansCTClinical Trials
    15. Cheng CW, Biton M, Haber AL, Gunduz N, Eng G, Gaynor LT, Tripathi S, Calibasi-Kocal G, Rickelt S, Butty VL, Moreno-Serrano M, Iqbal AM, Bauer-Rowe KE, Imada S, Ulutas MS, Mylonas C, Whary MT, Levine SS, Basbinar Y, Hynes RO, Mino-Kenudson M, Deshpande V, Boyer LA, Fox JG, Terranova C, Rai K, Piwnica-Worms H, Mihaylova MM, Regev A, Yilmaz ?H. Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet. Cell. 2019 08 22; 178(5):1115-1131.e15. PMID: 31442404; PMCID: PMC6732196.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    16. Yang H, Shu Z, Jiang Y, Mao W, Pang L, Redwood A, Jeter-Jones SL, Jennings NB, Ornelas A, Zhou J, Rodriguez-Aguayo C, Bartholomeusz G, Iles LR, Zacharias NM, Millward SW, Lopez-Berestein G, Le XF, Ahmed AA, Piwnica-Worms H, Sood AK, Bast RC, Lu Z. 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers. Clin Cancer Res. 2019 09 15; 25(18):5702-5716. PMID: 31391192; PMCID: PMC6744996.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    17. de la Cruz Bonilla M, Stemler KM, Jeter-Jones S, Fujimoto TN, Molkentine J, Asencio Torres GM, Zhang X, Broaddus RR, Taniguchi CM, Piwnica-Worms H. Fasting Reduces Intestinal Radiotoxicity, Enabling Dose-Escalated Radiation Therapy for Pancreatic Cancer. Int J Radiat Oncol Biol Phys. 2019 11 01; 105(3):537-547. PMID: 31271824; PMCID: PMC6754784.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    18. Acharya S, Yao J, Li P, Zhang C, Lowery FJ, Zhang Q, Guo H, Qu J, Yang F, Wistuba II, Piwnica-Worms H, Sahin AA, Yu D. Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer. Cancer Res. 2019 08 15; 79(16):4211-4226. PMID: 31239273; PMCID: PMC6697620.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    19. Fujimoto TN, Colbert LE, Huang Y, Molkentine JM, Deorukhkar A, Baseler L, Yu M, Lin D, Gupta S, Cabeceiras PK, Kingsley CV, Tailor RC, Sawakuchi GO, Koay EJ, Piwnica-Worms H, Maitra A, Taniguchi CM. Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer. Cancer Res. 2019 05 01; 79(9):2327-2338. PMID: 31043430; PMCID: PMC6666414.
      Citations: 13     Fields:    Translation:AnimalsPHPublic Health
    20. Li S, Lavagnino Z, Lemacon D, Kong L, Ustione A, Ng X, Zhang Y, Wang Y, Zheng B, Piwnica-Worms H, Vindigni A, Piston DW, You Z. Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Mol Cell. 2019 06 20; 74(6):1123-1137.e6. PMID: 31053472; PMCID: PMC6588484.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    21. Echeverria GV, Ge Z, Seth S, Zhang X, Jeter-Jones S, Zhou X, Cai S, Tu Y, McCoy A, Peoples M, Sun Y, Qiu H, Chang Q, Bristow C, Carugo A, Shao J, Ma X, Harris A, Mundi P, Lau R, Ramamoorthy V, Wu Y, Alvarez MJ, Califano A, Moulder SL, Symmans WF, Marszalek JR, Heffernan TP, Chang JT, Piwnica-Worms H. Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state. Sci Transl Med. 2019 04 17; 11(488). PMID: 30996079; PMCID: PMC6541393.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    22. Pisaneschi F, Gammon ST, Giambastiani G, Powell E, Piwnica-Worms H, Piwnica-Worms D, Biagiotti G, Machetti F, Ligi MC, Tuci G, Pranzini E, Paoli P, Cicchi S. Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study. J Mater Chem B. 2019 04 28; 7(16):2678-2687. PMID: 31073405; PMCID: PMC6501563.
      Citations: 3     Fields:    Translation:AnimalsCells
    23. Molkentine JM, Fujimoto TN, Horvath TD, Grossberg AJ, Garcia CJG, Deorukhkar A, de la Cruz Bonilla M, Lin D, Samuel ELG, Chan WK, Lorenzi PL, Piwnica-Worms H, Dantzer R, Tour JM, Mason KA, Taniguchi CM. Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation. Sci Rep. 2019 02 13; 9(1):1949. PMID: 30760738; PMCID: PMC6374382.
      Citations: 4     Fields:    Translation:Animals
    24. Echeverria GV, Powell E, Seth S, Ge Z, Carugo A, Bristow C, Peoples M, Robinson F, Qiu H, Shao J, Jeter-Jones SL, Zhang X, Ramamoorthy V, Cai S, Wu W, Draetta G, Moulder SL, Symmans WF, Chang JT, Heffernan TP, Piwnica-Worms H. High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer. Nat Commun. 2018 11 29; 9(1):5079. PMID: 30498242; PMCID: PMC6265294.
      Citations: 51     Fields:    Translation:HumansAnimals
    25. de la Cruz Bonilla M, Stemler KM, Taniguchi CM, Piwnica-Worms H. Stem cell enriched-epithelial spheroid cultures for rapidly assaying small intestinal radioprotectors and radiosensitizers in vitro. Sci Rep. 2018 10 18; 8(1):15410. PMID: 30337664; PMCID: PMC6194004.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    26. Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG, Livingston DM. BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1a activation. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):E9600-E9609. PMID: 30254159; PMCID: PMC6187201.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    27. Sinha VC, Piwnica-Worms H. Intratumoral Heterogeneity in Ductal Carcinoma In Situ: Chaos and Consequence. J Mammary Gland Biol Neoplasia. 2018 12; 23(4):191-205. PMID: 30194658; PMCID: PMC6934090.
      Citations: 6     Fields:    Translation:HumansAnimals
    28. Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, Khoo KH, Hung MC. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Mol Cell. 2018 08 16; 71(4):606-620.e7. PMID: 30118680; PMCID: PMC6786495.
      Citations: 177     Fields:    Translation:HumansAnimalsCells
    29. Murphy CI, Piwnica-Worms H, Romanow WG, Francis N, Fan HY, Marr S, Gr?nwald S. Expression and Purification of Recombinant Proteins Using the Baculovirus System. Curr Protoc Mol Biol. 2018 07; 123(1):e61. PMID: 29953734.
      Citations:    Fields:    Translation:AnimalsCells
    30. Powell E, Shao J, Picon HM, Bristow C, Ge Z, Peoples M, Robinson F, Jeter-Jones SL, Schlosberg C, Grzeskowiak CL, Yang F, Wu Y, Wistuba I, Moulder SL, Symmans WF, Scott KL, Edwards JR, Liang H, Heffernan TP, Piwnica-Worms H. A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis. NPJ Breast Cancer. 2018; 4:9. PMID: 29736411; PMCID: PMC5928229.
      Citations: 16     
    31. Ge Z, Leighton JS, Wang Y, Peng X, Chen Z, Chen H, Sun Y, Yao F, Li J, Zhang H, Liu J, Shriver CD, Hu H, Cancer Genome Atlas Research Network, Piwnica-Worms H, Ma L, Liang H. Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. Cell Rep. 2018 04 03; 23(1):213-226.e3. PMID: 29617661; PMCID: PMC5916807.
      Citations: 48     Fields:    Translation:HumansCells
    32. Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J, Hittelman WN, Udayakumar D, Pandita RK, Pandita TK, Pickering CR, Redwood AB, Piwnica-Worms H, Schlacher K, Frederick MJ, Myers JN. CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. Cancer Res. 2018 02 01; 78(3):781-797. PMID: 29229598; PMCID: PMC5811346.
      Citations: 21     Fields:    Translation:HumansCells
    33. Litton JK, Scoggins M, Ramirez DL, Murthy RK, Whitman GJ, Hess KR, Adrada BE, Moulder SL, Barcenas CH, Valero V, Gomez JS, Mittendorf EA, Thompson A, Helgason T, Mills GB, Piwnica-Worms H, Arun BK. A feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity. NPJ Breast Cancer. 2017; 3:49. PMID: 29238749; PMCID: PMC5719044.
      Citations: 24     
    34. Sen T, Tong P, Stewart CA, Cristea S, Valliani A, Shames DS, Redwood AB, Fan YH, Li L, Glisson BS, Minna JD, Sage J, Gibbons DL, Piwnica-Worms H, Heymach JV, Wang J, Byers LA. CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib. Cancer Res. 2017 07 15; 77(14):3870-3884. PMID: 28490518; PMCID: PMC5563854.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    35. Dobrolecki LE, Airhart SD, Alferez DG, Aparicio S, Behbod F, Bentires-Alj M, Bult CJ, Cai S, Clarke RB, Dowst H, Ellis MJ, Gonzalez-Suarez E, Kabos P, Li S, Lindeman GJ, Marangoni E, McCoy A, Meric-Bernstam F, Piwnica-Worms H, Poupon MF, Reis-Filho J, Sartorius CA, Tu Y, Visvader JE, Welm A, Wicha MS, Lewis MT, Brisken C, Iggo RD, Scabia V, Sflomos G, Vaillant F. Patient-derived xenograft (PDX) models in basic and translational breast cancer research. Cancer Metastasis Rev. 2016 12; 35(4):547-573. PMID: 28025748; PMCID: PMC5396460.
      Citations: 96     Fields:    Translation:HumansAnimals
    36. Werden SJ, Sphyris N, Sarkar TR, Paranjape AN, LaBaff AM, Taube JH, Hollier BG, Soundararajan R, den Hollander P, Powell E, Echeverria GV, Miura N, Chang JT, Piwnica-Worms H, Rosen JM, Mani SA, Ramirez-Pe?a EQ. Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene. 2016 11 17; 35(46):5977-5988. PMID: 27292262; PMCID: PMC5114155.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    37. Powell E, Shao J, Yuan Y, Chen HC, Cai S, Echeverria GV, Mistry N, Decker KF, Schlosberg C, Do KA, Edwards JR, Liang H, Piwnica-Worms D, Piwnica-Worms H. p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer. Breast Cancer Res. 2016 Jan 27; 18(1):13. PMID: 26818199; PMCID: PMC4728775.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    38. Tinkum KL, Stemler KM, White LS, Loza AJ, Jeter-Jones S, Michalski BM, Kuzmicki C, Pless R, Stappenbeck TS, Piwnica-Worms D, Piwnica-Worms H. Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):E7148-54. PMID: 26644583; PMCID: PMC4697381.
      Citations: 34     Fields:    Translation:AnimalsCells
    39. Cheruiyot A, Paudyal SC, Kim IK, Sparks M, Ellenberger T, Piwnica-Worms H, You Z. Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities. DNA Repair (Amst). 2015 Nov; 35:106-15. PMID: 26519824; PMCID: PMC4651717.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    40. Teasley DC, Parajuli S, Nguyen M, Moore HR, Alspach E, Lock YJ, Honaker Y, Saharia A, Piwnica-Worms H, Stewart SA. Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand. J Biol Chem. 2015 Jun 12; 290(24):15133-45. PMID: 25922071; PMCID: PMC4463456.
      Citations: 15     Fields:    Translation:HumansCells
    41. Chen X, Kim IK, Honaker Y, Paudyal SC, Koh WK, Sparks M, Li S, Piwnica-Worms H, Ellenberger T, You Z. 14-3-3 proteins restrain the Exo1 nuclease to prevent overresection. J Biol Chem. 2015 May 08; 290(19):12300-12. PMID: 25833945; PMCID: PMC4424361.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    42. Diamond MI, Cai S, Boudreau A, Carey CJ, Lyle N, Pappu RV, Swamidass SJ, Bissell M, Piwnica-Worms H, Shao J. Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1. J Biol Chem. 2015 Apr 03; 290(14):9075-86. PMID: 25681442; PMCID: PMC4423694.
      Citations: 13     Fields:    Translation:HumansCells
    43. Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS. Type I interferons link viral infection to enhanced epithelial turnover and repair. Cell Host Microbe. 2015 Jan 14; 17(1):85-97. PMID: 25482432; PMCID: PMC4297260.
      Citations: 47     Fields:    Translation:AnimalsCells
    44. Powell E, Piwnica-Worms D, Piwnica-Worms H. Contribution of p53 to metastasis. Cancer Discov. 2014 Apr; 4(4):405-14. PMID: 24658082; PMCID: PMC4063123.
      Citations: 145     Fields:    Translation:HumansCells
    45. Lewandowski KT, Piwnica-Worms H. Phosphorylation of the E3 ubiquitin ligase RNF41 by the kinase Par-1b is required for epithelial cell polarity. J Cell Sci. 2014 Jan 15; 127(Pt 2):315-27. PMID: 24259665; PMCID: PMC3889397.
      Citations: 12     Fields:    Translation:HumansCells
    46. Tinkum KL, White LS, Marpegan L, Herzog E, Piwnica-Worms D, Piwnica-Worms H. Forkhead box O1 (FOXO1) protein, but not p53, contributes to robust induction of p21 expression in fasted mice. J Biol Chem. 2013 Sep 27; 288(39):27999-8008. PMID: 23918930; PMCID: PMC3784713.
      Citations: 17     Fields:    Translation:AnimalsCells
    47. Ma CX, Ellis MJ, Petroni GR, Guo Z, Cai SR, Ryan CE, Craig Lockhart A, Naughton MJ, Pluard TJ, Brenin CM, Picus J, Creekmore AN, Mwandoro T, Yarde ER, Reed J, Ebbert M, Bernard PS, Watson M, Doyle LA, Dancey J, Piwnica-Worms H, Fracasso PM. A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer. Breast Cancer Res Treat. 2013 Jan; 137(2):483-92. PMID: 23242585; PMCID: PMC3539064.
      Citations: 43     Fields:    Translation:HumansCellsCTClinical Trials
    48. Huh J, Piwnica-Worms H. CRL4(CDT2) targets CHK1 for PCNA-independent destruction. Mol Cell Biol. 2013 Jan; 33(2):213-26. PMID: 23109433; PMCID: PMC3554108.
      Citations: 37     Fields:    Translation:HumansCells
    49. Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 2012 Jun 10; 486(7403):353-60. PMID: 22722193; PMCID: PMC3383766.
      Citations: 512     Fields:    Translation:HumansCells
    50. Duxin JP, Moore HR, Sidorova J, Karanja K, Honaker Y, Dao B, Piwnica-Worms H, Campbell JL, Monnat RJ, Stewart SA. Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem. 2012 Jun 22; 287(26):21980-91. PMID: 22570476; PMCID: PMC3381158.
      Citations: 37     Fields:    Translation:HumansCells
    51. Ma CX, Cai S, Li S, Ryan CE, Guo Z, Schaiff WT, Lin L, Hoog J, Goiffon RJ, Prat A, Aft RL, Ellis MJ, Piwnica-Worms H. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J Clin Invest. 2012 Apr; 122(4):1541-52. PMID: 22446188; PMCID: PMC3314455.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    52. Origanti S, Cai SR, Munir AZ, White LS, Piwnica-Worms H. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene. 2013 Jan 31; 32(5):577-88. PMID: 22430210; PMCID: PMC3381958.
      Citations: 35     Fields:    Translation:AnimalsCells
    53. Tinkum KL, Marpegan L, White LS, Sun J, Herzog ED, Piwnica-Worms D, Piwnica-Worms H. Bioluminescence imaging captures the expression and dynamics of endogenous p21 promoter activity in living mice and intact cells. Mol Cell Biol. 2011 Sep; 31(18):3759-72. PMID: 21791610; PMCID: PMC3165732.
      Citations: 14     Fields:    Translation:AnimalsCells
    54. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 01; 25(13):1426-38. PMID: 21724834; PMCID: PMC3134085.
      Citations: 29     Fields:    Translation:AnimalsCells
    55. Lee G, Origanti S, White LS, Sun J, Stappenbeck TS, Piwnica-Worms H. Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells. PLoS One. 2011 Jan 25; 6(1):e15561. PMID: 21283624; PMCID: PMC3026785.
      Citations: 12     Fields:    Translation:AnimalsCells
    56. Ma CX, Janetka JW, Piwnica-Worms H. Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. Trends Mol Med. 2011 Feb; 17(2):88-96. PMID: 21087899; PMCID: PMC6905465.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    57. Lennerz JK, Hurov JB, White LS, Lewandowski KT, Prior JL, Planer GJ, Gereau RW, Piwnica-Worms D, Schmidt RE, Piwnica-Worms H. Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. Mol Cell Biol. 2010 Nov; 30(21):5043-56. PMID: 20733003; PMCID: PMC2953066.
      Citations: 25     Fields:    Translation:AnimalsCells
    58. Fracasso PM, Williams KJ, Chen RC, Picus J, Ma CX, Ellis MJ, Tan BR, Pluard TJ, Adkins DR, Naughton MJ, Rader JS, Arquette MA, Fleshman JW, Creekmore AN, Goodner SA, Wright LP, Guo Z, Ryan CE, Tao Y, Soares EM, Cai SR, Lin L, Dancey J, Rudek MA, McLeod HL, Piwnica-Worms H. A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies. Cancer Chemother Pharmacol. 2011 Jun; 67(6):1225-37. PMID: 20694727; PMCID: PMC3102212.
      Citations: 23     Fields:    Translation:HumansCTClinical Trials
    59. Honaker Y, Piwnica-Worms H. Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction. Oncogene. 2010 Jun 10; 29(23):3324-34. PMID: 20348946; PMCID: PMC2883652.
      Citations: 37     Fields:    Translation:HumansCells
    60. Qian Z, Leung-Pineda V, Xuan B, Piwnica-Worms H, Yu D. Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. PLoS Pathog. 2010 Mar 19; 6(3):e1000814. PMID: 20333247; PMCID: PMC2841624.
      Citations: 26     Fields:    Translation:HumansCells
    61. Granot Z, Swisa A, Magenheim J, Stolovich-Rain M, Fujimoto W, Manduchi E, Miki T, Lennerz JK, Stoeckert CJ, Meyuhas O, Seino S, Permutt MA, Piwnica-Worms H, Bardeesy N, Dor Y. LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab. 2009 Oct; 10(4):296-308. PMID: 19808022; PMCID: PMC2790403.
      Citations: 89     Fields:    Translation:AnimalsCells
    62. Lin J, Hou KK, Piwnica-Worms H, Shaw AS. The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization. J Immunol. 2009 Jul 15; 183(2):1215-21. PMID: 19553522; PMCID: PMC2837933.
      Citations: 26     Fields:    Translation:HumansCells
    63. Leung-Pineda V, Huh J, Piwnica-Worms H. DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res. 2009 Mar 15; 69(6):2630-7. PMID: 19276361; PMCID: PMC2776040.
      Citations: 75     Fields:    Translation:HumansCells
    64. Lee G, White LS, Hurov KE, Stappenbeck TS, Piwnica-Worms H. Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4701-6. PMID: 19273838; PMCID: PMC2660721.
      Citations: 37     Fields:    Translation:AnimalsCells
    65. Watkins JL, Lewandowski KT, Meek SE, Storz P, Toker A, Piwnica-Worms H. Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18378-83. PMID: 19011111; PMCID: PMC2587537.
      Citations: 33     Fields:    Translation:HumansCells
    66. Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H. Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol Cell Biol. 2008 Oct; 28(19):5874-85. PMID: 18644861; PMCID: PMC2547006.
      Citations: 19     Fields:    Translation:HumansCells
    67. Nakajima H, Yonemura S, Murata M, Nakamura N, Piwnica-Worms H, Nishida E. Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit. J Cell Biol. 2008 Apr 07; 181(1):89-103. PMID: 18378775; PMCID: PMC2287290.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    68. Kang T, Wei Y, Honaker Y, Yamaguchi H, Appella E, Hung MC, Piwnica-Worms H. GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell. 2008 Jan; 13(1):36-47. PMID: 18167338; PMCID: PMC2276649.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    69. Tarakanova VL, Leung-Pineda V, Hwang S, Yang CW, Matatall K, Basson M, Sun R, Piwnica-Worms H, Sleckman BP, Virgin HW. Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe. 2007 Jun 14; 1(4):275-86. PMID: 18005708; PMCID: PMC2034359.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    70. Hurov J, Piwnica-Worms H. The Par-1/MARK family of protein kinases: from polarity to metabolism. Cell Cycle. 2007 Aug 15; 6(16):1966-9. PMID: 17721078.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    71. Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5680-5. PMID: 17372192; PMCID: PMC1838456.
      Citations: 39     Fields:    Translation:Animals
    72. King JB, Gross J, Lovly CM, Piwnica-Worms H, Townsend RR. Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom. 2007; 21(21):3443-51. PMID: 17918214.
      Citations: 6     Fields:    Translation:HumansCells
    73. Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol. 2006 Oct; 26(19):7086-102. PMID: 16980613; PMCID: PMC1592903.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    74. Leung-Pineda V, Ryan CE, Piwnica-Worms H. Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol Cell Biol. 2006 Oct; 26(20):7529-38. PMID: 17015476; PMCID: PMC1636880.
      Citations: 86     Fields:    Translation:HumansCells
    75. Chen YM, Wang QJ, Hu HS, Yu PC, Zhu J, Drewes G, Piwnica-Worms H, Luo ZG. Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8534-9. PMID: 16717194; PMCID: PMC1482526.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    76. King JB, Gross J, Lovly CM, Rohrs H, Piwnica-Worms H, Townsend RR. Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase. Anal Chem. 2006 Apr 01; 78(7):2171-81. PMID: 16579595.
      Citations: 17     Fields:    Translation:HumansCells
    77. Ferguson AM, White LS, Donovan PJ, Piwnica-Worms H. Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases. Mol Cell Biol. 2005 Apr; 25(7):2853-60. PMID: 15767688; PMCID: PMC1061644.
      Citations: 52     Fields:    Translation:AnimalsCells
    78. Puc J, Keniry M, Li HS, Pandita TK, Choudhury AD, Memeo L, Mansukhani M, Murty VV, Gaciong Z, Meek SE, Piwnica-Worms H, Hibshoosh H, Parsons R. Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell. 2005 Feb; 7(2):193-204. PMID: 15710331.
      Citations: 146     Fields:    Translation:HumansAnimalsCells
    79. Luker KE, Smith MC, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica-Worms D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12288-93. PMID: 15284440; PMCID: PMC514471.
      Citations: 195     Fields:    Translation:HumansAnimalsCells
    80. Meek SE, Lane WS, Piwnica-Worms H. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem. 2004 Jul 30; 279(31):32046-54. PMID: 15161933.
      Citations: 92     Fields:    Translation:HumansCells
    81. Hurov JB, Watkins JL, Piwnica-Worms H. Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity. Curr Biol. 2004 Apr 20; 14(8):736-41. PMID: 15084291.
      Citations: 130     Fields:    Translation:HumansCells
    82. Murphy CI, Piwnica-Worms H, Romanow WG, Francis N, Fan HY, Gr?nwald S. Maintenance of insect cell cultures and generation of recombinant baculoviruses. Curr Protoc Mol Biol. 2004 Feb; Chapter 16:Unit 16.10. PMID: 18265340.
      Citations: 3     Fields:    Translation:AnimalsCells
    83. Murphy CI, Piwnica-Worms H, Romanow WG, Francis N, Fan HY, Gr?nwald S. Expression and purification of recombinant proteins using the baculovirus system. Curr Protoc Mol Biol. 2004 Feb; Chapter 16:Unit 16.11. PMID: 18265341.
      Citations: 1     Fields:    Translation:AnimalsCells
    84. Murphy CI, Piwnica-Worms H, Romanow WG, Francis N, Fan HY, Gr?nwald S. Overview of the baculovirus expression system. Curr Protoc Mol Biol. 2004 Feb; Chapter 16:Unit 16.9. PMID: 18265342.
      Citations: 2     Fields:    Translation:AnimalsCells
    85. Chen MS, Ryan CE, Piwnica-Worms H. Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Mol Cell Biol. 2003 Nov; 23(21):7488-97. PMID: 14559997; PMCID: PMC207598.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    86. Neely KE, Piwnica-Worms H. Cdc25A regulation: to destroy or not to destroy--is that the only question? Cell Cycle. 2003 Sep-Oct; 2(5):455-7. PMID: 12963843.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    87. Bulavin DV, Higashimoto Y, Demidenko ZN, Meek S, Graves P, Phillips C, Zhao H, Moody SA, Appella E, Piwnica-Worms H, Fornace AJ. Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol. 2003 Jun; 5(6):545-51. PMID: 12766774.
      Citations: 65     Fields:    Translation:HumansCells
    88. Schwarz JK, Lovly CM, Piwnica-Worms H. Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation. Mol Cancer Res. 2003 Jun; 1(8):598-609. PMID: 12805407.
      Citations: 56     Fields:    Translation:HumansCells
    89. Luker GD, Sharma V, Pica CM, Dahlheimer JL, Li W, Ochesky J, Ryan CE, Piwnica-Worms H, Piwnica-Worms D. Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6961-6. PMID: 11997447; PMCID: PMC124511.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    90. Rothblum-Oviatt CJ, Ryan CE, Piwnica-Worms H. 14-3-3 binding regulates catalytic activity of human Wee1 kinase. Cell Growth Differ. 2001 Dec; 12(12):581-9. PMID: 11751453.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    91. Ory S, Copeland T, Piwnica-Worms H, Morrison DK, M?ller J. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol Cell. 2001 Nov; 8(5):983-93. PMID: 11741534.
      Citations: 119     Fields:    Translation:AnimalsCells
    92. Chen MS, Hurov J, White LS, Woodford-Thomas T, Piwnica-Worms H. Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase. Mol Cell Biol. 2001 Jun; 21(12):3853-61. PMID: 11359894; PMCID: PMC87049.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    93. Hurov JB, Stappenbeck TS, Zmasek CM, White LS, Ranganath SH, Russell JH, Chan AC, Murphy KM, Piwnica-Worms H. Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase. Mol Cell Biol. 2001 May; 21(9):3206-19. PMID: 11287624; PMCID: PMC86958.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    94. Murphy CI, Piwnica-Worms H. Overview of the baculovirus expression system. Curr Protoc Neurosci. 2001 May; Chapter 4:Unit 4.18. PMID: 18428479.
      Citations:    Fields:    Translation:AnimalsCells
    95. Murphy CI, Piwnica-Worms H. Overview of the baculovirus expression system. Curr Protoc Protein Sci. 2001 May; Chapter 5:Unit5.4. PMID: 18429185.
      Citations: 1     Fields:    Translation:Cells
    96. Graves PR, Lovly CM, Uy GL, Piwnica-Worms H. Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Oncogene. 2001 Apr 05; 20(15):1839-51. PMID: 11313932.
      Citations: 58     Fields:    Translation:HumansCells
    97. Ahn JY, Schwarz JK, Piwnica-Worms H, Canman CE. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res. 2000 Nov 01; 60(21):5934-6. PMID: 11085506.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    98. Graves PR, Yu L, Schwarz JK, Gales J, Sausville EA, O'Connor PM, Piwnica-Worms H. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem. 2000 Feb 25; 275(8):5600-5. PMID: 10681541.
      Citations: 129     Fields:    Translation:HumansCells
    99. Zeng Y, Piwnica-Worms H. DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding. Mol Cell Biol. 1999 Nov; 19(11):7410-9. PMID: 10523629; PMCID: PMC84734.
      Citations: 45     Fields:    Translation:AnimalsCells
    100. Piwnica-Worms H. Cell cycle. Fools rush in. Nature. 1999 Oct 07; 401(6753):535, 537. PMID: 10524615.
      Citations: 13     Fields:    Translation:HumansCells
    101. Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H. Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. Mol Cell Biol. 1999 Jul; 19(7):5113-23. PMID: 10373560; PMCID: PMC84354.
      Citations: 34     Fields:    Translation:HumansCells
    102. Brown AL, Lee CH, Schwarz JK, Mitiku N, Piwnica-Worms H, Chung JH. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3745-50. PMID: 10097108; PMCID: PMC22365.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    103. Yu L, Orlandi L, Wang P, Orr MS, Senderowicz AM, Sausville EA, Silvestrini R, Watanabe N, Piwnica-Worms H, O'Connor PM. UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase. J Biol Chem. 1998 Dec 11; 273(50):33455-64. PMID: 9837924.
      Citations: 16     Fields:    Translation:AnimalsCells
    104. Zeng Y, Forbes KC, Wu Z, Moreno S, Piwnica-Worms H, Enoch T. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature. 1998 Oct 01; 395(6701):507-10. PMID: 9774107.
      Citations: 128     Fields:    Translation:AnimalsCells
    105. Thorson JA, Yu LW, Hsu AL, Shih NY, Graves PR, Tanner JW, Allen PM, Piwnica-Worms H, Shaw AS. 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity. Mol Cell Biol. 1998 Sep; 18(9):5229-38. PMID: 9710607; PMCID: PMC109108.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    106. Fauman EB, Cogswell JP, Lovejoy B, Rocque WJ, Holmes W, Montana VG, Piwnica-Worms H, Rink MJ, Saper MA. Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. Cell. 1998 May 15; 93(4):617-25. PMID: 9604936.
      Citations: 54     Fields:    Translation:HumansCells
    107. Peng CY, Graves PR, Ogg S, Thoma RS, Byrnes MJ, Wu Z, Stephenson MT, Piwnica-Worms H. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ. 1998 Mar; 9(3):197-208. PMID: 9543386.
      Citations: 74     Fields:    Translation:HumansCells
    108. Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK. Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein. J Biol Chem. 1997 Oct 24; 272(43):27281-7. PMID: 9341175.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    109. Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science. 1997 Sep 05; 277(5331):1501-5. PMID: 9278512.
      Citations: 410     Fields:    Translation:HumansCells
    110. Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997 Sep 05; 277(5331):1497-501. PMID: 9278511.
      Citations: 408     Fields:    Translation:HumansAnimalsCells
    111. Liu F, Stanton JJ, Wu Z, Piwnica-Worms H. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol Cell Biol. 1997 Feb; 17(2):571-83. PMID: 9001210; PMCID: PMC231782.
      Citations: 109     Fields:    Translation:HumansCells
    112. Piwnica-Worms H. Reversible phosphorylation and mitotic control. J Lab Clin Med. 1996 Oct; 128(4):350-4. PMID: 8833882.
      Citations: 2     Fields:    Translation:HumansCells
    113. Parker LL, Sylvestre PJ, Byrnes MJ, Liu F, Piwnica-Worms H. Identification of a 95-kDa WEE1-like tyrosine kinase in HeLa cells. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9638-42. PMID: 7568188; PMCID: PMC40857.
      Citations: 24     Fields:    Translation:HumansCells
    114. Ogg S, Gabrielli B, Piwnica-Worms H. Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216. J Biol Chem. 1994 Dec 02; 269(48):30461-9. PMID: 7982962.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    115. Lee MS, Enoch T, Piwnica-Worms H. mik1+ encodes a tyrosine kinase that phosphorylates p34cdc2 on tyrosine 15. J Biol Chem. 1994 Dec 02; 269(48):30530-7. PMID: 7982971.
      Citations: 31     Fields:    Translation:AnimalsCells
    116. Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol. 1994 Dec; 14(12):8420-31. PMID: 7969176; PMCID: PMC359381.
      Citations: 95     Fields:    Translation:HumansCells
    117. Songyang Z, Blechner S, Hoagland N, Hoekstra MF, Piwnica-Worms H, Cantley LC. Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol. 1994 Nov 01; 4(11):973-82. PMID: 7874496.
      Citations: 248     Fields:    Translation:HumansAnimalsCells
    118. Atherton-Fessler S, Liu F, Gabrielli B, Lee MS, Peng CY, Piwnica-Worms H. Cell cycle regulation of the p34cdc2 inhibitory kinases. Mol Biol Cell. 1994 Sep; 5(9):989-1001. PMID: 7841526; PMCID: PMC301122.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    119. Baumann K, Mandelkow EM, Biernat J, Piwnica-Worms H, Mandelkow E. Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. FEBS Lett. 1993 Dec 28; 336(3):417-24. PMID: 8282104.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    120. Atherton-Fessler S, Hannig G, Piwnica-Worms H. Reversible tyrosine phosphorylation and cell cycle control. Semin Cell Biol. 1993 Dec; 4(6):433-42. PMID: 8305682.
      Citations: 22     Fields:    Translation:AnimalsCells
    121. Parker LL, Walter SA, Young PG, Piwnica-Worms H. Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase. Nature. 1993 Jun 24; 363(6431):736-8. PMID: 8515817.
      Citations: 63     Fields:    Translation:AnimalsCells
    122. Peeper DS, Parker LL, Ewen ME, Toebes M, Hall FL, Xu M, Zantema A, van der Eb AJ, Piwnica-Worms H. A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. EMBO J. 1993 May; 12(5):1947-54. PMID: 8491188; PMCID: PMC413416.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    123. Atherton-Fessler S, Parker LL, Geahlen RL, Piwnica-Worms H. Mechanisms of p34cdc2 regulation. Mol Cell Biol. 1993 Mar; 13(3):1675-85. PMID: 8441405; PMCID: PMC359480.
      Citations: 59     Fields:    Translation:HumansCells
    124. Lydon NB, Gay B, Mett H, Murray B, Liebetanz J, Gutzwiller A, Piwnica-Worms H, Roberts TM, McGlynn E. Purification and biochemical characterization of non-myristoylated recombinant pp60c-src kinase. Biochem J. 1992 Nov 01; 287 ( Pt 3):985-93. PMID: 1280108; PMCID: PMC1133104.
      Citations: 6     Fields:    Translation:AnimalsCells
    125. Parker LL, Piwnica-Worms H. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science. 1992 Sep 25; 257(5078):1955-7. PMID: 1384126.
      Citations: 255     Fields:    Translation:HumansCells
    126. Gabrielli BG, Lee MS, Walker DH, Piwnica-Worms H, Maller JL. Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex. J Biol Chem. 1992 Sep 05; 267(25):18040-6. PMID: 1517236.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    127. Parker LL, Atherton-Fessler S, Piwnica-Worms H. p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2917-21. PMID: 1372994; PMCID: PMC48774.
      Citations: 118     Fields:    Translation:AnimalsCells
    128. Auger KR, Carpenter CL, Shoelson SE, Piwnica-Worms H, Cantley LC. Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. J Biol Chem. 1992 Mar 15; 267(8):5408-15. PMID: 1372000.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    129. Lee MS, Ogg S, Xu M, Parker LL, Donoghue DJ, Maller JL, Piwnica-Worms H. cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2. Mol Biol Cell. 1992 Jan; 3(1):73-84. PMID: 1312880; PMCID: PMC275503.
      Citations: 65     Fields:    Translation:AnimalsCells
    130. Paris J, Swenson K, Piwnica-Worms H, Richter JD. Maturation-specific polyadenylation: in vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein. Genes Dev. 1991 Sep; 5(9):1697-708. PMID: 1653174.
      Citations: 46     Fields:    Translation:AnimalsCells
    131. Parker LL, Atherton-Fessler S, Lee MS, Ogg S, Falk JL, Swenson KI, Piwnica-Worms H. Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner. EMBO J. 1991 May; 10(5):1255-63. PMID: 1850698; PMCID: PMC452780.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    132. Roy LM, Swenson KI, Walker DH, Gabrielli BG, Li RS, Piwnica-Worms H, Maller JL. Activation of p34cdc2 kinase by cyclin A. J Cell Biol. 1991 May; 113(3):507-14. PMID: 1826688; PMCID: PMC2288969.
      Citations: 38     Fields:    Translation:AnimalsCells
    133. Mamon H, Williams N, Wood K, Frazier AL, Li P, Zmuidzinas A, Kremer N, D'Acangelo G, Qi H, Smith K, et al. New perspectives on Raf-1: the involvement of p21ras in the activation of Raf-1 and a potential role for Raf-1 in events occurring later in the cell cycle. Cold Spring Harb Symp Quant Biol. 1991; 56:251-63. PMID: 1819489.
      Citations:    Fields:    Translation:HumansAnimalsCells
    134. Piwnica-Worms H, Atherton-Fessler S, Lee MS, Ogg S, Swenson KI, Parker LL. p107wee1 is a serine/threonine and tyrosine kinase that promotes the tyrosine phosphorylation of the cyclin/p34cdc2 complex. Cold Spring Harb Symp Quant Biol. 1991; 56:567-76. PMID: 1840265.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    135. Swenson KI, Piwnica-Worms H, McNamee H, Paul DL. Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication. Cell Regul. 1990 Dec; 1(13):989-1002. PMID: 1966893; PMCID: PMC361697.
      Citations: 78     Fields:    Translation:AnimalsCells
    136. Furukawa Y, Piwnica-Worms H, Ernst TJ, Kanakura Y, Griffin JD. cdc2 gene expression at the G1 to S transition in human T lymphocytes. Science. 1990 Nov 09; 250(4982):805-8. PMID: 2237430.
      Citations: 61     Fields:    Translation:HumansCells
    137. Cohen B, Yoakim M, Piwnica-Worms H, Roberts TM, Schaffhausen BS. Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4458-62. PMID: 1693771; PMCID: PMC54134.
      Citations: 28     Fields:    Translation:AnimalsCells
    138. Piwnica-Worms H, Williams NG, Cheng SH, Roberts TM. Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells. J Virol. 1990 Jan; 64(1):61-8. PMID: 2152834; PMCID: PMC249044.
      Citations: 20     Fields:    Translation:AnimalsCells
    139. DeCaprio JA, Ludlow JW, Lynch D, Furukawa Y, Griffin J, Piwnica-Worms H, Huang CM, Livingston DM. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell. 1989 Sep 22; 58(6):1085-95. PMID: 2673542.
      Citations: 249     Fields:    Translation:HumansAnimalsCells
    140. Cheng SH, Harvey R, Piwnica-Worms H, Espino PC, Roberts TM, Smith AE. Mechanism of activation of complexed pp60c-src by the middle T antigen of polyomavirus. Curr Top Microbiol Immunol. 1989; 144:109-20. PMID: 2477197.
      Citations:    Fields:    Translation:Animals
    141. Draetta G, Piwnica-Worms H, Morrison D, Druker B, Roberts T, Beach D. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature. 1988 Dec 22-29; 336(6201):738-44. PMID: 2462672.
      Citations: 75     Fields:    Translation:Cells
    142. Murphy CI, Weiner B, Bikel I, Piwnica-Worms H, Bradley MK, Livingston DM. Purification and functional properties of simian virus 40 large and small T antigens overproduced in insect cells. J Virol. 1988 Aug; 62(8):2951-9. PMID: 2969056; PMCID: PMC253733.
      Citations: 19     Fields:    Translation:AnimalsCells
    143. Cheng SH, Piwnica-Worms H, Harvey RW, Roberts TM, Smith AE. The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus. Mol Cell Biol. 1988 Apr; 8(4):1736-47. PMID: 2454396; PMCID: PMC363334.
      Citations: 22     Fields:    Translation:AnimalsCells
    144. Roberts TM, Kaplan D, Morgan W, Keller T, Mamon H, Piwnica-Worms H, Druker B, Cohen B, Schaffhausen B, Whitman M, et al. Tyrosine phosphorylation in signal transduction. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:161-71. PMID: 2855480.
      Citations: 2     Fields:    Translation:AnimalsCells
    145. Piwnica-Worms H, Saunders KB, Roberts TM, Smith AE, Cheng SH. Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell. 1987 Apr 10; 49(1):75-82. PMID: 3103926.
      Citations: 207     Fields:    Translation:AnimalsCells
    146. Gee CE, Griffin J, Sastre L, Miller LJ, Springer TA, Piwnica-Worms H, Roberts TM. Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5131-5. PMID: 2425362; PMCID: PMC323904.
      Citations: 26     Fields:    Translation:HumansCells
    147. Piwnica-Worms H, Kaplan DR, Whitman M, Roberts TM. Retrovirus shuttle vector for study of kinase activities of pp60c-src synthesized in vitro and overproduced in vivo. Mol Cell Biol. 1986 Jun; 6(6):2033-40. PMID: 2431288; PMCID: PMC367743.
      Citations: 21     Fields:    Translation:AnimalsCells
    148. Piwnica-Worms H, Keene JD. Replication of the vesicular stomatitis virus genome in permissive and nonpermissive host cells. J Biol Chem. 1985 Sep 05; 260(19):10503-11. PMID: 2993276.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    149. Piwnica-Worms H, Keene JD. Sequential synthesis of small capped RNA transcripts in vitro by vesicular stomatitis virus. Virology. 1983 Feb; 125(1):206-18. PMID: 6299007.
      Citations: 13     Fields:    Translation:Cells
    150. Kurilla MG, Piwnica-Worms H, Keene JD. Rapid and transient localization of the leader RNA of vesicular stomatitis virus in the nuclei of infected cells. Proc Natl Acad Sci U S A. 1982 Sep; 79(17):5240-4. PMID: 6291035; PMCID: PMC346871.
      Citations: 28     Fields:    Translation:AnimalsCells
    151. Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities. DNA Repair. 35:106-115.
    152. Mitonc- and g2 checkpoint-control. FASEB Journal. 12.
    153. Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication. Molecular Biology of the Cell. 1:989-1002.
    154. Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival. Proceedings of the National Academy of Sciences of the United States of America. 112:E7148-E7154.
    155. The human myt1 kinask preferentially phosphorylates CDC2 on threonine 14 and localizes to the endoplasmic retlum and golgi complex. FASEB Journal. 11.
    156. p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer. Breast Cancer Research. 18.
    157. Patient-derived xenograft (PDX) models in basic and translational breast cancer research. Cancer and Metastasis Reviews. 35:547-573.
    158. Reversible phosphorylation and cell cycle control. FASEB Journal. 11.
    159. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models (Journal of Clinical Investigation (2012) 122, 4 (1541-1552) DOI. Journal of Clinical Investigation. 122:2702.
    160. Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene.
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