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ALEJANDRO CONTRERAS

TitleAssistant Professor
InstitutionMD Anderson
DepartmentPathology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Thomas PS, Patel AB, Lee JJ, Liu DD, Hernandez M, Muzzio M, Contreras A, Sepeda V, Mays C, Weber D, Vornik LA, Khan SA, Dimond E, Heckman-Stoddard BM, Perloff M, Brown PH. Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer. Cancer Prev Res (Phila). 2023 01 04; 16(1):47-55. PMID: 36228112; PMCID: PMC10391360.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    2. Mazumdar A, Tahaney WM, Hill JL, Zhang Y, Ramachandran S, Kawedia J, Qian J, Contreras A, Savage MI, Vornik LA, Sei S, Mohammed A, Brown PH. Targeting the mTOR Pathway for the Prevention of ER-Negative Breast Cancer. Cancer Prev Res (Phila). 2022 12 01; 15(12):791-802. PMID: 35981902; PMCID: PMC9762336.
      Citations:    
    3. Kumar T, Hobbs E, Yang F, Chang JT, Contreras A, Cuentas ERP, Garber H, Lee S, Lu Y, Scoggins ME, Adrada BE, Whitman GJ, Arun BK, Mittendorf EA, Litton JK. Tumor Immune Microenvironment Changes by Multiplex Immunofluorescence Staining in a Pilot Study of Neoadjuvant Talazoparib for Early-Stage Breast Cancer Patients with a Hereditary BRCA Mutation. Clin Cancer Res. 2022 09 01; 28(17):3669-3676. PMID: 35736816; PMCID: PMC9444971.
      Citations:    Fields:    
    4. Liu X, Ge Z, Yang F, Contreras A, Lee S, White JB, Lu Y, Labrie M, Arun BK, Moulder SL, Mills GB, Piwnica-Worms H, Litton JK, Chang JT. Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment na?ve gBRCA+ breast cancers. NPJ Breast Cancer. 2022 May 10; 8(1):64. PMID: 35538088; PMCID: PMC9090765.
      Citations:    
    5. Sen A, Fowlkes NW, Kingsley CV, Kulp AM, Huynh T, Willis BJ, Brewer Savannah KJ, Bordes MCA, Hwang KP, McCulloch MM, Stafford RJ, Contreras A, Reece G, Brock KK. Technical Note: Histological validation of anatomical imaging for breast modeling using a novel cryo-microtome. Med Phys. 2021 Nov; 48(11):7323-7332. PMID: 34559413.
      Citations:    Fields:    Translation:Humans
    6. Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA. Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy. Cancers (Basel). 2019 May 24; 11(5). PMID: 31137625; PMCID: PMC6562947.
      Citations: 42     
    7. Middleton LP, Phipps R, Routbort M, Prieto V, Medeiros LJ, Riben M, Contreras A, Kelley J, Patel K, Bingham J, Wagar EA. Fifteen-Year Journey to High Reliability in Pathology and Laboratory Medicine. Am J Med Qual. 2018 Sep/Oct; 33(5):530-539. PMID: 29512395.
      Citations:    Fields:    
    8. Rimawi MF, De Angelis C, Contreras A, Pareja F, Geyer FC, Burke KA, Herrera S, Wang T, Mayer IA, Forero A, Nanda R, Goetz MP, Chang JC, Krop IE, Wolff AC, Pavlick AC, Fuqua SAW, Gutierrez C, Hilsenbeck SG, Li MM, Weigelt B, Reis-Filho JS, Kent Osborne C, Schiff R. Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer. Breast Cancer Res Treat. 2018 02; 167(3):731-740. PMID: 29110152; PMCID: PMC5821069.
      Citations: 32     Fields:    Translation:HumansCTClinical Trials
    9. Dogan BE, Black DM, Contreras A, Dryden MJ, Jimenez SM, Gilcrease MZ. Transection of Radioactive Seeds in Breast Specimens. Am J Surg Pathol. 2016 10; 40(10):1375-9. PMID: 27627744.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    10. Giuliano M, Hu H, Wang YC, Fu X, Nardone A, Herrera S, Mao S, Contreras A, Gutierrez C, Wang T, Hilsenbeck SG, De Angelis C, Wang NJ, Heiser LM, Gray JW, Pavlick AC, Trivedi MV, Chamness GC, Chang JC, Osborne CK, Rimawi MF, Schiff R, Lopez-Tarruella S. Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy. Clin Cancer Res. 2015 Sep 01; 21(17):3995-4003. PMID: 26015514; PMCID: PMC4558260.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    11. Suo J, Medina D, Herrera S, Zheng ZY, Jin L, Chamness GC, Contreras A, Gutierrez C, Hilsenbeck S, Umar A, Foekens JA, Hanash S, Schiff R, Zhang XH, Chang EC. Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells. Cell Biosci. 2015; 5:10. PMID: 25774287; PMCID: PMC4359526.
      Citations: 5     
    12. Giuliano M, Herrera S, Christiny P, Shaw C, Creighton CJ, Mitchell T, Bhat R, Zhang X, Mao S, Dobrolecki LE, Al-rawi A, Chen F, Veneziani BM, Zhang XH, Hilsenbeck SG, Contreras A, Gutierrez C, Jeselsohn RM, Rimawi MF, Osborne CK, Lewis MT, Schiff R, Trivedi MV. Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis. Breast Cancer Res. 2015 Jan 09; 17:3. PMID: 25572662; PMCID: PMC4318479.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    13. Niravath P, Eble T, Contreras A, Li M, Franco LM, Rimawi M. Breast adenocarcinoma recurring as small cell carcinoma in a patient with a germline BRCA2 mutation: clonal evolution unchecked. Exp Hematol Oncol. 2015; 4(1):1. PMID: 25671134; PMCID: PMC4323278.
      Citations: 1     
    14. Fu X, Creighton CJ, Biswal NC, Kumar V, Shea M, Herrera S, Contreras A, Gutierrez C, Wang T, Nanda S, Giuliano M, Morrison G, Nardone A, Karlin KL, Westbrook TF, Heiser LM, Anur P, Spellman P, Guichard SM, Smith PD, Davies BR, Klinowska T, Lee AV, Mills GB, Rimawi MF, Hilsenbeck SG, Gray JW, Joshi A, Osborne CK, Schiff R. Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase. Breast Cancer Res. 2014 Sep 11; 16(5):430. PMID: 25212826; PMCID: PMC4303114.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    15. Burstein MD, Tsimelzon A, Poage GM, Covington KR, Contreras A, Fuqua SA, Savage MI, Osborne CK, Hilsenbeck SG, Chang JC, Mills GB, Lau CC, Brown PH. Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer. Clin Cancer Res. 2015 Apr 01; 21(7):1688-98. PMID: 25208879; PMCID: PMC4362882.
      Citations: 448     Fields:    Translation:HumansCells
    16. Veeraraghavan J, Tan Y, Cao XX, Kim JA, Wang X, Chamness GC, Maiti SN, Cooper LJ, Edwards DP, Contreras A, Hilsenbeck SG, Chang EC, Schiff R, Wang XS. Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers. Nat Commun. 2014 Aug 07; 5:4577. PMID: 25099679; PMCID: PMC4130357.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    17. Tretiakova MS, Bond SD, Wheeler D, Contreras A, Kocherginsky M, Kroll TG, Hale TK. Heterochromatin protein 1 expression is reduced in human thyroid malignancy. Lab Invest. 2014 Jul; 94(7):788-95. PMID: 24840329.
      Citations: 6     Fields:    Translation:HumansCells
    18. Hatcher RJ, Dong J, Liu S, Bian G, Contreras A, Wang T, Hilsenbeck SG, Li Y, Zhang P. Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1008-13. PMID: 24395789; PMCID: PMC3903200.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    19. Mohammed S, Statz A, Lacross JS, Lassinger BK, Contreras A, Gutierrez C, Bonefas E, Liscum KR, Silberfein EJ. Granulomatous mastitis: a 10?year experience from a large inner city county hospital. J Surg Res. 2013 Sep; 184(1):299-303. PMID: 23890401.
      Citations: 8     Fields:    Translation:Humans
    20. Zhang X, Claerhout S, Prat A, Dobrolecki LE, Petrovic I, Lai Q, Landis MD, Wiechmann L, Schiff R, Giuliano M, Wong H, Fuqua SW, Contreras A, Gutierrez C, Huang J, Mao S, Pavlick AC, Froehlich AM, Wu MF, Tsimelzon A, Hilsenbeck SG, Chen ES, Zuloaga P, Shaw CA, Rimawi MF, Perou CM, Mills GB, Chang JC, Lewis MT. A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models. Cancer Res. 2013 Aug 01; 73(15):4885-97. PMID: 23737486; PMCID: PMC3732575.
      Citations: 223     Fields:    Translation:HumansAnimalsCells
    21. Gould DJ, Salmans JA, Lassinger BK, Contreras A, Gutierrez C, Bonefas E, Liscum KR, Silberfein EJ. Factors associated with phyllodes tumor of the breast after core needle biopsy identifies fibroepithelial neoplasm. J Surg Res. 2012 Nov; 178(1):299-303. PMID: 22524977.
      Citations: 8     Fields:    Translation:Humans
    22. Bardhan R, Chen W, Bartels M, Perez-Torres C, Botero MF, McAninch RW, Contreras A, Schiff R, Pautler RG, Halas NJ, Joshi A. Tracking of multimodal therapeutic nanocomplexes targeting breast cancer in vivo. Nano Lett. 2010 Dec 08; 10(12):4920-8. PMID: 21090693; PMCID: PMC4089981.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    23. Atkinson RL, Zhang M, Diagaradjane P, Peddibhotla S, Contreras A, Hilsenbeck SG, Woodward WA, Krishnan S, Chang JC, Rosen JM. Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy. Sci Transl Med. 2010 Oct 27; 2(55):55ra79. PMID: 20980696; PMCID: PMC4123313.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    24. Punar M, Tamboli P, Tu SM, Pisters L, Moran C, Czerniak BA, Guo CC, Contreras AL. Mediastinal germ cell tumors with an angiosarcomatous component: a report of 12 cases. Hum Pathol. 2010 Jun; 41(6):832-7. PMID: 20153508; PMCID: PMC4163004.
      Citations: 7     Fields:    Translation:Humans
    25. Contreras AL, Malpica A. Angiosarcoma arising in mature cystic teratoma of the ovary: a case report and review of the literature. Int J Gynecol Pathol. 2009 Sep; 28(5):453-7. PMID: 19696615.
      Citations: 14     Fields:    Translation:Humans
    26. Guo CC, Punar M, Tu SM, Pisters L, Tamboli P, Czerniak B, Contreras AL. Testicular germ cell tumors with sarcomatous components: an analysis of 33 cases. Am J Surg Pathol. 2009 Aug; 33(8):1173-8. PMID: 19561445; PMCID: PMC3812063.
      Citations: 19     Fields:    Translation:Humans
    27. Kau R, Tanna M, Misra S, Contreras AL. Nasopharyngeal angiofibroma. Ear Nose Throat J. 2008 May; 87(5):256. PMID: 18572778.
      Citations: 1     Fields:    Translation:Humans
    28. Hale TK, Contreras A, Morrison AJ, Herrera RE. Phosphorylation of the linker histone H1 by CDK regulates its binding to HP1alpha. Mol Cell. 2006 Jun 09; 22(5):693-9. PMID: 16762841.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    29. Cella N, Contreras A, Latha K, Rosen JM, Zhang M. Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. FASEB J. 2006 Jul; 20(9):1510-2. PMID: 16720730.
      Citations: 31     Fields:    Translation:HumansCells
    30. Ginger MR, Shore AN, Contreras A, Rijnkels M, Miller J, Gonzalez-Rimbau MF, Rosen JM. A noncoding RNA is a potential marker of cell fate during mammary gland development. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5781-6. PMID: 16574773; PMCID: PMC1420634.
      Citations: 89     Fields:    Translation:AnimalsCells
    31. Grimm SL, Contreras A, Barcellos-Hoff MH, Rosen JM. Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice. J Biol Chem. 2005 Oct 28; 280(43):36301-9. PMID: 16120603.
      Citations: 16     Fields:    Translation:AnimalsCells
    32. Contreras A, Hale TK, Stenoien DL, Rosen JM, Mancini MA, Herrera RE. The dynamic mobility of histone H1 is regulated by cyclin/CDK phosphorylation. Mol Cell Biol. 2003 Dec; 23(23):8626-36. PMID: 14612406; PMCID: PMC262667.
      Citations: 70     Fields:    Translation:HumansCells
    33. Medina D, Kittrell FS, Shepard A, Contreras A, Rosen JM, Lydon J. Hormone dependence in premalignant mammary progression. Cancer Res. 2003 Mar 01; 63(5):1067-72. PMID: 12615724.
      Citations: 37     Fields:    Translation:Animals
    34. Welm BE, Freeman KW, Chen M, Contreras A, Spencer DM, Rosen JM. Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland. J Cell Biol. 2002 May 13; 157(4):703-14. PMID: 12011115; PMCID: PMC2173854.
      Citations: 64     Fields:    Translation:AnimalsCells
    35. Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. Cell Growth Differ. 2000 Jul; 11(7):343-54. PMID: 10939588.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    36. Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with Anti-HER2 therapy. Clinical Cancer Research. 21:3995-4003.
    37. Transection of radioactive seeds in breast specimens. American Journal of Surgical Pathology. 40:1375-1379.
    38. Breast adenocarcinoma recurring as small cell carcinoma in a patient with a germline BRCA2 mutation. Experimental Hematology and Oncology. 4.
    39. Acute eosinophilic pneumonia. Pathology Case Reviews. 12:100-104.
    40. Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis. Breast Cancer Research. 17.
    41. Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells. Cell and Bioscience. 1-10.
    42. Nasopharyngeal angiofi broma. Ear, Nose and Throat Journal. 87.
    43. Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer. Clinical Cancer Research. 21:1688-1698.
    44. Pulmonary nodules in a patient with a history of squamous cell carcinoma. Pathology Case Reviews. 12:118-121.
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