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GIULIO DRAETTA

TitleProfessor
InstitutionMD Anderson
DepartmentGenomic Medicine
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ho IL, Li CY, Wang F, Zhao L, Liu J, Yen EY, Dyke CA, Shah R, Liu Z, ?etin AO, Chu Y, Citron F, Attanasio S, Corti D, Darbaniyan F, Del Poggetto E, Loponte S, Liu J, Soeung M, Chen Z, Jiang S, Jiang H, Inoue A, Gao S, Deem A, Feng N, Ying H, Kim M, Giuliani V, Genovese G, Zhang J, Futreal A, Maitra A, Heffernan T, Wang L, Do KA, Gargiulo G, Draetta G, Carugo A, Lin R, Viale A. Clonal dominance defines metastatic dissemination in pancreatic cancer. Sci Adv. 2024 Mar 15; 10(11):eadd9342. PMID: 38478609.
      Citations:    Fields:    Translation:HumansCells
    2. Perelli L, Zhang L, Mangiameli S, Russell AJC, Giannese F, Peng F, Carbone F, Le C, Khan H, Citron F, Soeung M, Lam TNA, Lundgren S, Zhu C, Catania D, Feng N, Gurreri E, Sgambato A, Tortora G, Draetta GF, Tonon G, Futreal A, Giuliani V, Carugo A, Viale A, Heffernan TP, Wang L, Cittaro D, Chen F, Genovese G. Evolutionary fingerprints of EMT in pancreatic cancers. bioRxiv. 2023 Sep 19. PMID: 37786705; PMCID: PMC10541589.
      Citations:    
    3. Perelli L, Carbone F, Zhang L, Huang JK, Le C, Khan H, Citron F, Del Poggetto E, Gutschner T, Tomihara H, Soeung M, Minelli R, Srinivasan S, Peoples M, Lam TNA, Lundgren S, Xia R, Zhu C, Mohamed AMT, Zhang J, Sircar K, Sgambato A, Gao J, Jonasch E, Draetta GF, Futreal A, Bakouny Z, Van Allen EM, Choueiri T, Signoretti S, Msaouel P, Litchfield K, Turajlic S, Wang L, Chen YB, Di Natale RG, Hakimi AA, Giuliani V, Heffernan TP, Viale A, Bristow CA, Tannir NM, Carugo A, Genovese G. Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer. Nat Cancer. 2023 07; 4(7):984-1000. PMID: 37365326; PMCID: PMC10368532.
      Citations: 1     Fields:    Translation:Humans
    4. Soeung M, Perelli L, Chen Z, Dondossola E, Ho IL, Carbone F, Zhang L, Khan H, Le CN, Zhu C, Peoples MD, Feng N, Jiang S, Zacharias NM, Minelli R, Shapiro DD, Deem AK, Gao S, Cheng EH, Lucchetti D, Walker CL, Carugo A, Giuliani V, Heffernan TP, Viale A, Tannir NM, Draetta GF, Msaouel P, Genovese G. SMARCB1 regulates the hypoxic stress response in sickle cell trait. Proc Natl Acad Sci U S A. 2023 05 23; 120(21):e2209639120. PMID: 37186844; PMCID: PMC10214195.
      Citations: 2     Fields:    Translation:HumansAnimals
    5. Chen Z, Ho IL, Soeung M, Yen EY, Liu J, Yan L, Rose JL, Srinivasan S, Jiang S, Edward Chang Q, Feng N, Gay JP, Wang Q, Wang J, Lorenzi PL, Veillon LJ, Wei B, Weinstein JN, Deem AK, Gao S, Genovese G, Viale A, Yao W, Lyssiotis CA, Marszalek JR, Draetta GF, Ying H. Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis. Nat Commun. 2023 04 17; 14(1):2194. PMID: 37069167; PMCID: PMC10110566.
      Citations: 1     Fields:    Translation:HumansCells
    6. Zhang ZY, Ding Y, Ezhilarasan R, Lhakhang T, Wang Q, Yang J, Modrek AS, Zhang H, Tsirigos A, Futreal A, Draetta GF, Verhaak RGW, Sulman EP. Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma. Cell Discov. 2022 Oct 06; 8(1):102. PMID: 36202798; PMCID: PMC9537441.
      Citations:    
    7. Zamler DB, Shingu T, Kahn LM, Huntoon K, Kassab C, Ott M, Tomczak K, Liu J, Li Y, Lai I, Zorilla-Veloz R, Yee C, Rai K, Kim BY, Watowich SS, Heimberger AB, Draetta GF, Hu J. Immune landscape of a genetically engineered murine model of glioma compared with human glioma. JCI Insight. 2022 06 22; 7(12). PMID: 35653194; PMCID: PMC9309065.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Ghilardi C, Moreira-Barbosa C, Brunelli L, Ostano P, Lupi M, Anastasia A, Fiordaliso F, Salio M, Formenti L, Russo M, Arrigoni E, Chiaradonna F, Chiorino G, Draetta G, Marszalek JR, Vellano CP, Pastorelli R, Bani M, Decio A, Giavazzi R, Panini N. PGC1a/? Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer. Cancer Res. 2022 04 01; 82(7):1423-1434. PMID: 35131872.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Shapiro DD, Soeung M, Perelli L, Dondossola E, Surasi DS, Tripathi DN, Bertocchio JP, Carbone F, Starbuck MW, Van Alstine ML, Rao P, Katz MHG, Parker NH, Shah AY, Carugo A, Heffernan TP, Schadler KL, Logothetis C, Walker CL, Wood CG, Karam JA, Draetta GF, Tannir NM, Genovese G, Msaouel P. Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies. Cancers (Basel). 2021 Nov 30; 13(23). PMID: 34885132; PMCID: PMC8656882.
      Citations: 2     
    10. Donati G, Filipuzzi M, Nicoli P, Cassina L, Verrecchia A, Doni M, Rodighiero S, Parodi F, Boletta A, Vellano CP, Marszalek JR, Draetta GF, Amati B, Rav? M. Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma. Mol Oncol. 2022 03; 16(5):1132-1152. PMID: 34632715; PMCID: PMC8895457.
      Citations:    Fields:    Translation:Humans
    11. Czako B, Sun Y, McAfoos T, Cross JB, Leonard PG, Burke JP, Carroll CL, Feng N, Harris AL, Jiang Y, Kang Z, Kovacs JJ, Mandal P, Meyers BA, Mseeh F, Parker CA, Yu SS, Williams CC, Wu Q, Di Francesco ME, Draetta G, Heffernan T, Marszalek JR, Kohl NE, Jones P. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 10 28; 64(20):15141-15169. PMID: 34643390.
      Citations:    Fields:    Translation:HumansAnimalsCells
    12. Del Poggetto E, Ho IL, Balestrieri C, Yen EY, Zhang S, Citron F, Shah R, Corti D, Diaferia GR, Li CY, Loponte S, Carbone F, Hayakawa Y, Valenti G, Jiang S, Sapio L, Jiang H, Dey P, Gao S, Deem AK, Yao W, Ying H, Rhim AD, Genovese G, Heffernan TP, Maitra A, Wang TC, Wang L, Draetta GF, Carugo A, Natoli G, Viale A, Rose-John S. Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science. 2021 Sep 17; 373(6561):eabj0486. PMID: 34529467; PMCID: PMC9733946.
      Citations: 9     Fields:    Translation:AnimalsCells
    13. Evans KW, Yuca E, Scott SS, Zhao M, Paez Arango N, Cruz Pico CX, Saridogan T, Shariati M, Class CA, Bristow CA, Vellano CP, Zheng X, Gonzalez-Angulo AM, Su X, Tapia C, Chen K, Akcakanat A, Lim B, Tripathy D, Yap TA, Francesco MED, Draetta GF, Jones P, Heffernan TP, Marszalek JR, Meric-Bernstam F. Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer. Cancer Res. 2021 11 01; 81(21):5572-5581. PMID: 34518211; PMCID: PMC8563442.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    14. Giuliani V, Miller MA, Liu CY, Hartono SR, Class CA, Bristow CA, Suzuki E, Sanz LA, Gao G, Gay JP, Feng N, Rose JL, Tomihara H, Daniele JR, Peoples MD, Bardenhagen JP, Geck Do MK, Chang QE, Vangamudi B, Vellano C, Ying H, Deem AK, Do KA, Genovese G, Marszalek JR, Kovacs JJ, Kim M, Fleming JB, Guccione E, Viale A, Maitra A, Emilia Di Francesco M, Yap TA, Jones P, Draetta G, Carugo A, Chedin F, Heffernan TP. PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nat Commun. 2021 07 30; 12(1):4626. PMID: 34330913; PMCID: PMC8324870.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    15. Invrea F, Punzi S, Petti C, Minelli R, Peoples MD, Bristow CA, Vurchio V, Corrado A, Bragoni A, Bertotti A, Trusolino L, Bardelli A, Isella C, Carugo A, Draetta GF, Medico E, Marchi? C. Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways. Cancers (Basel). 2021 Jul 28; 13(15). PMID: 34359705; PMCID: PMC8345131.
      Citations: 1     
    16. Shaim H, Shanley M, Basar R, Daher M, Gumin J, Zamler DB, Uprety N, Wang F, Huang Y, Gabrusiewicz K, Miao Q, Dou J, Alsuliman A, Kerbauy LN, Acharya S, Mohanty V, Mendt M, Li S, Lu J, Wei J, Fowlkes NW, Gokdemir E, Ensley EL, Kaplan M, Kassab C, Li L, Ozcan G, Banerjee PP, Shen Y, Gilbert AL, Jones CM, Bdiwi M, Nunez-Cortes AK, Liu E, Yu J, Imahashi N, Muniz-Feliciano L, Li Y, Hu J, Draetta G, Marin D, Yu D, Champlin RE, Chen K, Lang FF, Shpall EJ, Heimberger AB, Rezvani K, Mielke S, Eyrich M. Targeting the av integrin/TGF-? axis improves natural killer cell function against glioblastoma stem cells. J Clin Invest. 2021 07 15; 131(14). PMID: 34138753; PMCID: PMC8279586.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    17. Citron F, Segatto I, Musco L, Pellarin I, Rampioni Vinciguerra GL, Franchin G, Fanetti G, Giacomarra V, Lupato V, Favero A, Concina I, Srinivasan S, Avanzo M, Castiglioni I, Barzan L, Sulfaro S, Viale A, Draetta GF, Vecchione A, Belletti B, Baldassarre G, Miccich? F, Petrone G. miR-9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC. EMBO Mol Med. 2021 07 07; 13(7):e12872. PMID: 34062049; PMCID: PMC8261495.
      Citations: 3     Fields:    Translation:HumansCells
    18. Puca F, Yu F, Bartolacci C, Pettazzoni P, Carugo A, Huang-Hobbs E, Liu J, Zanca C, Carbone F, Del Poggetto E, Gumin J, Dasgupta P, Seth S, Srinivasan S, Lang FF, Sulman EP, Lorenzi PL, Tan L, Shan M, Tolstyka ZP, Kachman M, Zhang L, Gao S, Deem AK, Genovese G, Scaglioni PP, Lyssiotis CA, Viale A, Draetta GF. Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma. Cancer Discov. 2021 11; 11(11):2904-2923. PMID: 34039636; PMCID: PMC8711129.
      Citations: 1     Fields:    Translation:HumansCells
    19. Inoue A, Robinson FS, Minelli R, Tomihara H, Rizi BS, Rose JL, Kodama T, Srinivasan S, Harris AL, Zuniga AM, Mullinax RA, Ma X, Seth S, Daniele JR, Peoples MD, Loponte S, Akdemir KC, Khor TO, Feng N, Roszik J, Sobieski MM, Brunell D, Stephan C, Giuliani V, Deem AK, Shingu T, Deribe YL, Menter DG, Heffernan TP, Viale A, Bristow CA, Kopetz S, Draetta GF, Genovese G, Carugo A. Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer. Gastroenterology. 2021 07; 161(1):196-210. PMID: 33745946; PMCID: PMC8238881.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    20. Tomihara H, Carbone F, Perelli L, Huang JK, Soeung M, Rose JL, Robinson FS, Lissanu Deribe Y, Feng N, Takeda M, Inoue A, Poggetto ED, Deem AK, Maitra A, Msaouel P, Tannir NM, Draetta GF, Viale A, Heffernan TP, Bristow CA, Carugo A, Genovese G. Loss of ARID1A Promotes Epithelial-Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress. Cancer Res. 2021 01 15; 81(2):332-343. PMID: 33158812; PMCID: PMC8728103.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    21. Soth MJ, Le K, Di Francesco ME, Hamilton MM, Liu G, Burke JP, Carroll CL, Kovacs JJ, Bardenhagen JP, Bristow CA, Cardozo M, Czako B, de Stanchina E, Feng N, Garvey JR, Gay JP, Do MKG, Greer J, Han M, Harris A, Herrera Z, Huang S, Giuliani V, Jiang Y, Johnson SB, Johnson TA, Kang Z, Leonard PG, Liu Z, McAfoos T, Miller M, Morlacchi P, Mullinax RA, Palmer WS, Pang J, Rogers N, Rudin CM, Shepard HE, Spencer ND, Theroff J, Wu Q, Xu A, Yau JA, Draetta G, Toniatti C, Heffernan TP, Jones P. Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties. J Med Chem. 2020 11 12; 63(21):12957-12977. PMID: 33118821; PMCID: PMC9007139.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    22. Sun Y, Meyers BA, Czako B, Leonard P, Mseeh F, Harris AL, Wu Q, Johnson S, Parker CA, Cross JB, Di Francesco ME, Bivona BJ, Bristow CA, Burke JP, Carrillo CC, Carroll CL, Chang Q, Feng N, Gao G, Gera S, Giuliani V, Huang JK, Jiang Y, Kang Z, Kovacs JJ, Liu CY, Lopez AM, Ma X, Mandal PK, McAfoos T, Miller MA, Mullinax RA, Peoples M, Ramamoorthy V, Seth S, Spencer ND, Suzuki E, Williams CC, Yu SS, Zuniga AM, Draetta GF, Marszalek JR, Heffernan TP, Kohl NE, Jones P. Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res. 2020 11 01; 80(21):4840-4853. PMID: 32928921.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    23. Czako B, Marszalek JR, Burke JP, Mandal P, Leonard PG, Cross JB, Mseeh F, Jiang Y, Chang EQ, Suzuki E, Kovacs JJ, Feng N, Gera S, Harris AL, Liu Z, Mullinax RA, Pang J, Parker CA, Spencer ND, Yu SS, Wu Q, Tremblay MR, Mikule K, Wilcoxen K, Heffernan TP, Draetta GF, Jones P. Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R. J Med Chem. 2020 09 10; 63(17):9888-9911. PMID: 32787110.
      Citations: 2     Fields:    Translation:HumansCells
    24. Manzo T, Prentice BM, Anderson KG, Raman A, Schalck A, Codreanu GS, Nava Lauson CB, Tiberti S, Raimondi A, Jones MA, Reyzer M, Bates BM, Spraggins JM, Patterson NH, McLean JA, Rai K, Tacchetti C, Tucci S, Wargo JA, Rodighiero S, Clise-Dwyer K, Sherrod SD, Kim M, Navin NE, Caprioli RM, Greenberg PD, Draetta G, Nezi L. Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells. J Exp Med. 2020 08 03; 217(8). PMID: 32491160; PMCID: PMC7398173.
      Citations: 30     Fields:    Translation:AnimalsCells
    25. Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer. Cell. 2019 Nov 14; 179(5):1239. PMID: 31730860; PMCID: PMC6941747.
      Citations: 9     Fields:    
    26. Tu B, Yao J, Ferri-Borgogno S, Zhao J, Chen S, Wang Q, Yan L, Zhou X, Zhu C, Bang S, Chang Q, Bristow CA, Kang Y, Zheng H, Wang H, Fleming JB, Kim M, Heffernan TP, Draetta GF, Pan D, Maitra A, Yao W, Gupta S, Ying H. YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma. JCI Insight. 2019 11 01; 4(21). PMID: 31557131; PMCID: PMC6948828.
      Citations: 24     Fields:    Translation:Humans
    27. Inoue A, Deem AK, Kopetz S, Heffernan TP, Draetta GF, Carugo A. Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research. Cancers (Basel). 2019 Sep 06; 11(9). PMID: 31500168; PMCID: PMC6770280.
      Citations: 15     
    28. Mottini C, Tomihara H, Carrella D, Lamolinara A, Iezzi M, Huang JK, Amoreo CA, Buglioni S, Manni I, Robinson FS, Minelli R, Kang Y, Fleming JB, Kim MP, Bristow CA, Trisciuoglio D, Iuliano A, Del Bufalo D, Di Bernardo D, Melisi D, Draetta GF, Ciliberto G, Carugo A, Cardone L. Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma. Cancer Res. 2019 Nov 01; 79(21):5612-5625. PMID: 31492820.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    29. Liu J, Srinivasan S, Li CY, Ho IL, Rose J, Shaheen M, Wang G, Yao W, Deem A, Bristow C, Hart T, Draetta G. Pooled library screening with multiplexed Cpf1 library. Nat Commun. 2019 Jul 17; 10(1):3144. PMID: 31316073; PMCID: PMC6637147.
      Citations: 17     Fields:    Translation:HumansCells
    30. Zhang L, Yao Y, Zhang S, Liu Y, Guo H, Ahmed M, Bell T, Zhang H, Han G, Lorence E, Badillo M, Zhou S, Sun Y, Di Francesco ME, Feng N, Haun R, Lan R, Mackintosh SG, Mao X, Song X, Zhang J, Pham LV, Lorenzi PL, Marszalek J, Heffernan T, Draetta G, Jones P, Futreal A, Nomie K, Wang L, Wang M. Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma. Sci Transl Med. 2019 05 08; 11(491). PMID: 31068440.
      Citations: 61     Fields:    Translation:AnimalsCells
    31. Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature. 2019 04; 568(7752):410-414. PMID: 30918400; PMCID: PMC6661074.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    32. Bast RC, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z, Mills GB, Modugno F, Nelson BH, Odunsi K, Pilsworth JA, Rottapel RK, Powell DJ, Shen L, Shih IM, Spriggs DR, Walton J, Zhang K, Zhang R, Zou L. Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer. 2019 06 15; 125(12):1963-1972. PMID: 30835824; PMCID: PMC6557260.
      Citations: 17     Fields:    Translation:Humans
    33. Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G, Malouf GG, Sgambato A. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019 02 11; 35(2):204-220.e9. PMID: 30753823; PMCID: PMC7876656.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    34. Seth S, Li CY, Ho IL, Corti D, Loponte S, Sapio L, Del Poggetto E, Yen EY, Robinson FS, Peoples M, Karpinets T, Deem AK, Kumar T, Song X, Jiang S, Kang Y, Fleming J, Kim M, Zhang J, Maitra A, Heffernan TP, Giuliani V, Genovese G, Futreal A, Draetta GF, Carugo A, Viale A. Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors. Cell Rep. 2019 02 05; 26(6):1518-1532.e9. PMID: 30726735.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    35. Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, Miao L, Ma X, Feng N, Giuliani V, Geck Do M, Czako B, Palmer WS, Mseeh F, Asara JM, Jiang Y, Morlacchi P, Zhao S, Peoples M, Tieu TN, Warmoes MO, Lorenzi PL, Muller FL, DePinho RA, Draetta GF, Toniatti C, Jones P, Heffernan TP, Marszalek JR. Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Rep. 2019 01 08; 26(2):469-482.e5. PMID: 30625329.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    36. Echeverria GV, Powell E, Seth S, Ge Z, Carugo A, Bristow C, Peoples M, Robinson F, Qiu H, Shao J, Jeter-Jones SL, Zhang X, Ramamoorthy V, Cai S, Wu W, Draetta G, Moulder SL, Symmans WF, Chang JT, Heffernan TP, Piwnica-Worms H. High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer. Nat Commun. 2018 11 29; 9(1):5079. PMID: 30498242; PMCID: PMC6265294.
      Citations: 51     Fields:    Translation:HumansAnimals
    37. Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, Chang E, Ciurea S, Cross JB, Czako B, Deem A, Daver N, de Groot JF, Dong JW, Feng N, Gao G, Gay J, Do MG, Greer J, Giuliani V, Han J, Han L, Henry VK, Hirst J, Huang S, Jiang Y, Kang Z, Khor T, Konoplev S, Lin YH, Liu G, Lodi A, Lofton T, Ma H, Mahendra M, Matre P, Mullinax R, Peoples M, Petrocchi A, Rodriguez-Canale J, Serreli R, Shi T, Smith M, Tabe Y, Theroff J, Tiziani S, Xu Q, Zhang Q, Muller F, DePinho RA, Toniatti C, Draetta GF, Heffernan TP, Konopleva M, Jones P, Di Francesco ME, Marszalek JR. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med. 2018 07; 24(7):1036-1046. PMID: 29892070.
      Citations: 261     Fields:    Translation:HumansAnimalsCells
    38. Carugo A, Draetta GF. Collapsing the Tumor Ecosystem: Preventing Adaptive Response to Treatment by Inhibiting Transcription. Cancer Discov. 2018 01; 8(1):17-19. PMID: 29311224.
      Citations: 1     Fields:    Translation:Humans
    39. Jaffee EM, Dang CV, Agus DB, Alexander BM, Anderson KC, Ashworth A, Barker AD, Bastani R, Bhatia S, Bluestone JA, Brawley O, Butte AJ, Coit DG, Davidson NE, Davis M, DePinho RA, Diasio RB, Draetta G, Frazier AL, Futreal A, Gambhir SS, Ganz PA, Garraway L, Gerson S, Gupta S, Heath J, Hoffman RI, Hudis C, Hughes-Halbert C, Ibrahim R, Jadvar H, Kavanagh B, Kittles R, Le QT, Lippman SM, Mankoff D, Mardis ER, Mayer DK, McMasters K, Meropol NJ, Mitchell B, Naredi P, Ornish D, Pawlik TM, Peppercorn J, Pomper MG, Raghavan D, Ritchie C, Schwarz SW, Sullivan R, Wahl R, Wolchok JD, Wong SL, Yung A. Future cancer research priorities in the USA: a Lancet Oncology Commission. Lancet Oncol. 2017 11; 18(11):e653-e706. PMID: 29208398; PMCID: PMC6178838.
      Citations: 52     Fields:    Translation:Humans
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      Citations: 38     Fields:    Translation:HumansAnimalsCells
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      Citations: 51     Fields:    Translation:HumansCells
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      Citations: 25     Fields:    Translation:HumansAnimalsCells
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      Citations: 53     Fields:    Translation:HumansAnimalsCells
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      Citations: 96     Fields:    Translation:HumansAnimalsCells
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      Citations: 41     Fields:    Translation:HumansAnimalsCells
    56. Vangamudi B, Paul TA, Shah PK, Kost-Alimova M, Nottebaum L, Shi X, Zhan Y, Leo E, Mahadeshwar HS, Protopopov A, Futreal A, Tieu TN, Peoples M, Heffernan TP, Marszalek JR, Toniatti C, Petrocchi A, Verhelle D, Owen DR, Draetta G, Jones P, Palmer WS, Sharma S, Andersen JN. The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies. Cancer Res. 2015 Sep 15; 75(18):3865-3878. PMID: 26139243; PMCID: PMC4755107.
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      Citations: 3     Fields:    Translation:HumansCells
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    63. Draetta GF, Depinho RA. Cancer drug discovery faces the FACT. Sci Transl Med. 2011 Aug 10; 3(95):95ps34. PMID: 21832237.
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    65. Benedettini E, Sholl LM, Peyton M, Reilly J, Ware C, Davis L, Vena N, Bailey D, Yeap BY, Fiorentino M, Ligon AH, Pan BS, Richon V, Minna JD, Gazdar AF, Draetta G, Bosari S, Chirieac LR, Lutterbach B, Loda M. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am J Pathol. 2010 Jul; 177(1):415-23. PMID: 20489150; PMCID: PMC2893683.
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    66. Efferson CL, Winkelmann CT, Ware C, Sullivan T, Giampaoli S, Tammam J, Patel S, Mesiti G, Reilly JF, Gibson RE, Buser C, Yeatman T, Coppola D, Winter C, Clark EA, Draetta GF, Strack PR, Majumder PK. Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. Cancer Res. 2010 Mar 15; 70(6):2476-84. PMID: 20197467.
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    67. Tammam J, Ware C, Efferson C, O'Neil J, Rao S, Qu X, Gorenstein J, Angagaw M, Kim H, Kenific C, Kunii K, Leach KJ, Nikov G, Zhao J, Dai X, Hardwick J, Scott M, Winter C, Bristow L, Elbi C, Reilly JF, Look T, Draetta G, Van der Ploeg L, Kohl NE, Strack PR, Majumder PK. Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia. Br J Pharmacol. 2009 Nov; 158(5):1183-95. PMID: 19775282; PMCID: PMC2782329.
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    68. Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG. Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells. Cancer Res. 2009 Apr 01; 69(7):3060-8. PMID: 19318552.
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    69. O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, Hardwick J, Welcker M, Meijerink JP, Pieters R, Draetta G, Sears R, Clurman BE, Look AT. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med. 2007 Aug 06; 204(8):1813-24. PMID: 17646409; PMCID: PMC2118656.
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    70. Senese S, Zaragoza K, Minardi S, Muradore I, Ronzoni S, Passafaro A, Bernard L, Draetta GF, Alcalay M, Seiser C, Chiocca S. Role for histone deacetylase 1 in human tumor cell proliferation. Mol Cell Biol. 2007 Jul; 27(13):4784-95. PMID: 17470557; PMCID: PMC1951481.
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    71. Busino L, Bassermann F, Maiolica A, Lee C, Nolan PM, Godinho SI, Draetta GF, Pagano M. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science. 2007 May 11; 316(5826):900-4. PMID: 17463251.
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    72. Lewis HD, Leveridge M, Strack PR, Haldon CD, O'neil J, Kim H, Madin A, Hannam JC, Look AT, Kohl N, Draetta G, Harrison T, Kerby JA, Shearman MS, Beher D. Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling. Chem Biol. 2007 Feb; 14(2):209-19. PMID: 17317574.
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    73. Capra M, Nuciforo PG, Confalonieri S, Quarto M, Bianchi M, Nebuloni M, Boldorini R, Pallotti F, Viale G, Gishizky ML, Draetta GF, Di Fiore PP. Frequent alterations in the expression of serine/threonine kinases in human cancers. Cancer Res. 2006 Aug 15; 66(16):8147-54. PMID: 16912193.
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    74. Squatrito M, Mancino M, Sala L, Draetta GF. Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation. Biochem Biophys Res Commun. 2006 Jun 09; 344(3):859-68. PMID: 16631606.
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    75. Draetta GF. Commentary on "A new cancer diagnostic system based on a CDK profiling technology" [Biochim. Biophys. Acta Molecular Basis of Disease 1741 (2005) 226-233]. Biochim Biophys Acta. 2005 Sep 25; 1741(3):225. PMID: 16183014.
      Citations:    Fields:    Translation:HumansCells
    76. Ray D, Terao Y, Nimbalkar D, Chu LH, Donzelli M, Tsutsui T, Zou X, Ghosh AK, Varga J, Draetta GF, Kiyokawa H. Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner. Mol Cell Biol. 2005 Apr; 25(8):3338-47. PMID: 15798217; PMCID: PMC1069597.
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    77. Boggio R, Colombo R, Hay RT, Draetta GF, Chiocca S. A mechanism for inhibiting the SUMO pathway. Mol Cell. 2004 Nov 19; 16(4):549-61. PMID: 15546615.
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    78. Masciadri B, Areces LB, Carpinelli P, Foiani M, Draetta G, Fiore F. Characterization of the BUD31 gene of Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2004 Aug 06; 320(4):1342-50. PMID: 15303280.
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    79. Squatrito M, Mancino M, Donzelli M, Areces LB, Draetta GF. EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes. Oncogene. 2004 May 27; 23(25):4454-65. PMID: 15064750.
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    80. Donzelli M, Busino L, Chiesa M, Ganoth D, Hershko A, Draetta GF. Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation. Cell Cycle. 2004 Apr; 3(4):469-71. PMID: 14752276.
      Citations: 19     Fields:    Translation:HumansCells
    81. Busino L, Chiesa M, Draetta GF, Donzelli M. Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis. Oncogene. 2004 Mar 15; 23(11):2050-6. PMID: 15021892.
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    82. Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF. Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature. 2003 Nov 06; 426(6962):87-91. PMID: 14603323.
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    83. Donzelli M, Draetta GF. Regulating mammalian checkpoints through Cdc25 inactivation. EMBO Rep. 2003 Jul; 4(7):671-7. PMID: 12835754; PMCID: PMC1326326.
      Citations: 158     Fields:    Translation:Animals
    84. Colombo R, Draetta GF, Chiocca S. Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein. Oncogene. 2003 May 01; 22(17):2541-7. PMID: 12730668.
      Citations: 6     Fields:    Translation:HumansCells
    85. Donzelli M, Squatrito M, Ganoth D, Hershko A, Pagano M, Draetta GF. Dual mode of degradation of Cdc25 A phosphatase. EMBO J. 2002 Sep 16; 21(18):4875-84. PMID: 12234927; PMCID: PMC126287.
      Citations: 84     Fields:    Translation:HumansCells
    86. Chiocca S, Kurtev V, Colombo R, Boggio R, Sciurpi MT, Brosch G, Seiser C, Draetta GF, Cotten M. Histone deacetylase 1 inactivation by an adenovirus early gene product. Curr Biol. 2002 Apr 02; 12(7):594-8. PMID: 11937030.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    87. Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, Meloche S, Rodier G. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 2001 Dec 03; 20(23):6672-82. PMID: 11726503; PMCID: PMC125773.
      Citations: 109     Fields:    Translation:AnimalsCells
    88. Soncini C, Berdo I, Draetta G. Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. Oncogene. 2001 Jun 28; 20(29):3869-79. PMID: 11439350.
      Citations: 93     Fields:    Translation:HumansCells
    89. Molinari M, Mercurio C, Dominguez J, Goubin F, Draetta GF. Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Rep. 2000 Jul; 1(1):71-9. PMID: 11256629; PMCID: PMC1083693.
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    90. Piva R, Cancelli I, Cavalla P, Bortolotto S, Dominguez J, Draetta GF, Schiffer D. Proteasome-dependent degradation of p27/kip1 in gliomas. J Neuropathol Exp Neurol. 1999 Jul; 58(7):691-6. PMID: 10411338.
      Citations: 21     Fields:    Translation:Humans
    91. Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, Pagano M. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 1999 May 01; 13(9):1181-9. PMID: 10323868; PMCID: PMC316946.
      Citations: 193     Fields:    Translation:HumansCells
    92. Thomas GV, Szigeti K, Murphy M, Draetta G, Pagano M, Loda M. Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases. Am J Pathol. 1998 Sep; 153(3):681-7. PMID: 9736017; PMCID: PMC1853015.
      Citations: 32     Fields:    Translation:HumansCells
    93. Naviglio S, Mattecucci C, Matoskova B, Nagase T, Nomura N, Di Fiore PP, Draetta GF. UBPY: a growth-regulated human ubiquitin isopeptidase. EMBO J. 1998 Jun 15; 17(12):3241-50. PMID: 9628861; PMCID: PMC1170662.
      Citations: 61     Fields:    Translation:HumansAnimals
    94. Draetta GF. 11th European Cell Cycle Conference: April 23-26, 1997, Gardone Riviera (Italy) and Symposium on Cell Cycle Regulation (17th International Congress of Biochemistry and Molecular Biology): August 24-29, 1997, San Francisco, CA. Biochim Biophys Acta. 1998 Feb 20; 1377(1):R11-20. PMID: 9540812.
      Citations:    Fields:    Translation:HumansAnimalsCells
    95. Lamphere L, Fiore F, Xu X, Brizuela L, Keezer S, Sardet C, Draetta GF, Gyuris J. Interaction between Cdc37 and Cdk4 in human cells. Oncogene. 1997 Apr 24; 14(16):1999-2004. PMID: 9150368.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    96. Draetta G, Eckstein J. Cdc25 protein phosphatases in cell proliferation. Biochim Biophys Acta. 1997 Apr 18; 1332(2):M53-63. PMID: 9141461.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    97. Tan P, Cady B, Wanner M, Worland P, Cukor B, Magi-Galluzzi C, Lavin P, Draetta G, Pagano M, Loda M. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res. 1997 Apr 01; 57(7):1259-63. PMID: 9102210.
      Citations: 76     Fields:    Translation:Humans
    98. Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM, Pagano M. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med. 1997 Feb; 3(2):231-4. PMID: 9018245.
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    99. Draetta GF. Cell cycle: will the real Cdk-activating kinase please stand up. Curr Biol. 1997 Jan 01; 7(1):R50-2. PMID: 9072172.
      Citations: 6     Fields:    Translation:Animals
    100. Galaktionov K, Lee AK, Eckstein J, Draetta G, Meckler J, Loda M, Beach D. CDC25 phosphatases as potential human oncogenes. Science. 1995 Sep 15; 269(5230):1575-7. PMID: 7667636.
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    101. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995 Aug 04; 269(5224):682-5. PMID: 7624798.
      Citations: 453     Fields:    Translation:HumansAnimalsCells
    102. Rolfe M, Beer-Romero P, Glass S, Eckstein J, Berdo I, Theodoras A, Pagano M, Draetta G. Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP). Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3264-8. PMID: 7724550; PMCID: PMC42146.
      Citations: 32     Fields:    Translation:HumansCells
    103. Basi G, Draetta G. p13suc1 of Schizosaccharomyces pombe regulates two distinct forms of the mitotic cdc2 kinase. Mol Cell Biol. 1995 Apr; 15(4):2028-36. PMID: 7891698; PMCID: PMC230430.
      Citations: 14     Fields:    Translation:AnimalsCells
    104. Draetta GF. Mammalian G1 cyclins. Curr Opin Cell Biol. 1994 Dec; 6(6):842-6. PMID: 7880531.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    105. Brambilla R, Draetta G. Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. Oncogene. 1994 Oct; 9(10):3037-41. PMID: 8084611.
      Citations: 12     Fields:    Translation:HumansCells
    106. O'Connor PM, Ferris DK, Hoffmann I, Jackman J, Draetta G, Kohn KW. Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9480-4. PMID: 7937793; PMCID: PMC44836.
      Citations: 16     Fields:    Translation:HumansCells
    107. Hoffmann I, Draetta G, Karsenti E. Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J. 1994 Sep 15; 13(18):4302-10. PMID: 7523110; PMCID: PMC395357.
      Citations: 121     Fields:    Translation:HumansCells
    108. Tam SW, Theodoras AM, Shay JW, Draetta GF, Pagano M. Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression. Oncogene. 1994 Sep; 9(9):2663-74. PMID: 8058330.
      Citations: 67     Fields:    Translation:HumansCells
    109. Pagano M, Theodoras AM, Tam SW, Draetta GF. Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev. 1994 Jul 15; 8(14):1627-39. PMID: 7958844.
      Citations: 98     Fields:    Translation:HumansCells
    110. Lukas J, Pagano M, Staskova Z, Draetta G, Bartek J. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene. 1994 Mar; 9(3):707-18. PMID: 8108113.
      Citations: 71     Fields:    Translation:HumansCells
    111. Roussou I, Draetta G. The Schizosaccharomyces pombe casein kinase II alpha and beta subunits: evolutionary conservation and positive role of the beta subunit. Mol Cell Biol. 1994 Jan; 14(1):576-86. PMID: 8264625; PMCID: PMC358407.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    112. Draetta G. Cdc2 activation: the interplay of cyclin binding and Thr161 phosphorylation. Trends Cell Biol. 1993 Sep; 3(9):287-9. PMID: 14731844.
      Citations: 20     Fields:    
    113. Marcote MJ, Knighton DR, Basi G, Sowadski JM, Brambilla P, Draetta G, Taylor SS. A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites. Mol Cell Biol. 1993 Aug; 13(8):5122-31. PMID: 8336738; PMCID: PMC360168.
      Citations: 19     Fields:    Translation:AnimalsCells
    114. Roussou I, Draetta G. Phosphorylation in yeast cell processes. Cell Signal. 1993 Jul; 5(4):381-7. PMID: 8373722.
      Citations:    Fields:    Translation:AnimalsCells
    115. Superti-Furga G, Fumagalli S, Koegl M, Courtneidge SA, Draetta G. Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. EMBO J. 1993 Jul; 12(7):2625-34. PMID: 7687537; PMCID: PMC413509.
      Citations: 68     Fields:    Translation:AnimalsCells
    116. Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev. 1993 May; 7(5):812-21. PMID: 8491378.
      Citations: 545     Fields:    Translation:HumansCells
    117. Draetta G, B?rtek J, Staskov? Z, Luk?s J. Molecular pathology of the cell cycle in human cancer cells. Stem Cells. 1993 May; 11 Suppl 1:51-8. PMID: 8318919.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    118. O'Connor PM, Ferris DK, Pagano M, Draetta G, Pines J, Hunter T, Longo DL, Kohn KW. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15; 268(11):8298-308. PMID: 8463339.
      Citations: 26     Fields:    Translation:HumansCells
    119. Meichle A, Steiner P, Pagano M, Finke K, Botz J, Wessbecher J, Draetta G, Eilers M, Jansen-D?rr P. Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3685-9. PMID: 8386381; PMCID: PMC46366.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    120. Clarke PR, Hoffmann I, Draetta G, Karsenti E. Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts. Mol Biol Cell. 1993 Apr; 4(4):397-411. PMID: 8389619; PMCID: PMC300941.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    121. Pagano M, Pepperkok R, Lukas J, Baldin V, Ansorge W, Bartek J, Draetta G. Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol. 1993 Apr; 121(1):101-11. PMID: 8458862; PMCID: PMC2119764.
      Citations: 89     Fields:    Translation:HumansCells
    122. Hoffmann I, Clarke PR, Marcote MJ, Karsenti E, Draetta G. Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J. 1993 Jan; 12(1):53-63. PMID: 8428594; PMCID: PMC413175.
      Citations: 189     Fields:    Translation:HumansAnimalsCells
    123. Pagano M, Joswig S, Draetta G, D?rst M, Jansen-D?rr P. Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells. Oncogene. 1992 Sep; 7(9):1681-6. PMID: 1323816.
      Citations: 38     Fields:    Translation:HumansCells
    124. Landesman Y, Pagano M, Draetta G, Rotter V, Fusenig NE, Kimchi A. Modifications of cell cycle controlling nuclear proteins by transforming growth factor beta in the HaCaT keratinocyte cell line. Oncogene. 1992 Aug; 7(8):1661-5. PMID: 1385861.
      Citations: 8     Fields:    Translation:Cells
    125. Draetta G, Bartek J, Luk?s J. Distinct forms of human CDC2 identified by novel monoclonal antibodies. Eur J Biochem. 1992 Jul 01; 207(1):169-76. PMID: 1628647.
      Citations: 2     Fields:    Translation:HumansAnimals
    126. Meggio F, Draetta G, Pinna LA, Marin O. The consensus sequences for cdc2 kinase and for casein kinase-2 are mutually incompatible. A study with peptides derived from the beta-subunit of casein kinase-2. FEBS Lett. 1992 Apr 13; 301(1):111-4. PMID: 1451779.
      Citations: 31     Fields:    Translation:Cells
    127. Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G. Cyclin A is required at two points in the human cell cycle. EMBO J. 1992 Mar; 11(3):961-71. PMID: 1312467; PMCID: PMC556537.
      Citations: 457     Fields:    Translation:HumansCells
    128. Buendia B, Draetta G, Karsenti E. Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinase. J Cell Biol. 1992 Mar; 116(6):1431-42. PMID: 1531830; PMCID: PMC2289368.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    129. Pagano M, Draetta G, Jansen-D?rr P. Association of cdk2 kinase with the transcription factor E2F during S phase. Science. 1992 Feb 28; 255(5048):1144-7. PMID: 1312258.
      Citations: 70     Fields:    Translation:HumansCells
    130. Marcote MJ, Pagano M, Draetta G. cdc2 protein kinase: structure-function relationships. Ciba Found Symp. 1992; 170:30-41; discussion 41-9. PMID: 1483349.
      Citations: 1     Fields:    Translation:Humans
    131. Ducommun B, Brambilla P, Draetta G. Mutations at sites involved in Suc1 binding inactivate Cdc2. Mol Cell Biol. 1991 Dec; 11(12):6177-84. PMID: 1944283; PMCID: PMC361799.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    132. Ducommun B, Brambilla P, Franza BR, Karsenti E, Draetta G, F?lix MA. cdc2 phosphorylation is required for its interaction with cyclin. EMBO J. 1991 Nov; 10(11):3311-9. PMID: 1833185; PMCID: PMC453057.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    133. Roth SY, Collini MP, Draetta G, Beach D, Allis CD. A cdc2-like kinase phosphorylates histone H1 in the amitotic macronucleus of Tetrahymena. EMBO J. 1991 Aug; 10(8):2069-75. PMID: 2065655; PMCID: PMC452890.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    134. Wang HG, Draetta G, Moran E. E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products. Mol Cell Biol. 1991 Aug; 11(8):4253-65. PMID: 1830128; PMCID: PMC361255.
      Citations: 39     Fields:    Translation:AnimalsCells
    135. Howe PH, Draetta G, Leof EB. Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest. Mol Cell Biol. 1991 Mar; 11(3):1185-94. PMID: 1996085; PMCID: PMC369389.
      Citations: 45     Fields:    Translation:AnimalsCells
    136. Pagano M, Draetta G. Cyclin A, cell cycle control and oncogenesis. Prog Growth Factor Res. 1991; 3(4):267-77. PMID: 1839823.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    137. Brambilla P, Ducommun B, Draetta G. cdc2 protein kinase: interactions with cyclins and suc1. Cold Spring Harb Symp Quant Biol. 1991; 56:515-21. PMID: 1840262.
      Citations: 1     Fields:    Translation:HumansCells
    138. Draetta G. Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends Biochem Sci. 1990 Oct; 15(10):378-83. PMID: 2147521.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    139. Ducommun B, Draetta G, Young P, Beach D. Fission yeast cdc25 is a cell-cycle regulated protein. Biochem Biophys Res Commun. 1990 Feb 28; 167(1):301-9. PMID: 2178610.
      Citations: 25     Fields:    Translation:AnimalsCells
    140. Giordano A, Whyte P, Harlow E, Franza BR, Beach D, Draetta G. A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell. 1989 Sep 08; 58(5):981-90. PMID: 2570639.
      Citations: 86     Fields:    Translation:HumansCells
    141. Morla AO, Draetta G, Beach D, Wang JY. Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell. 1989 Jul 14; 58(1):193-203. PMID: 2473839.
      Citations: 136     Fields:    Translation:AnimalsCells
    142. Brizuela L, Draetta G, Beach D. Activation of human CDC2 protein as a histone H1 kinase is associated with complex formation with the p62 subunit. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4362-6. PMID: 2543971; PMCID: PMC287269.
      Citations: 43     Fields:    Translation:HumansCells
    143. Riabowol K, Draetta G, Brizuela L, Vandre D, Beach D. The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell. 1989 May 05; 57(3):393-401. PMID: 2541912.
      Citations: 120     Fields:    Translation:HumansAnimalsCells
    144. Draetta G, Luca F, Westendorf J, Brizuela L, Ruderman J, Beach D. Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell. 1989 Mar 10; 56(5):829-38. PMID: 2538242.
      Citations: 171     Fields:    Translation:AnimalsCells
    145. Draetta G, Beach D. The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle. J Cell Sci Suppl. 1989; 12:21-7. PMID: 2699735.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    146. Draetta G, Piwnica-Worms H, Morrison D, Druker B, Roberts T, Beach D. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature. 1988 Dec 22-29; 336(6201):738-44. PMID: 2462672.
      Citations: 75     Fields:    Translation:Cells
    147. Heppel LA, Newton DL, Klee CB, Draetta GF. The phosphorylation of calmodulin and calmodulin fragments by kinase fractions from bovine brain. Biochim Biophys Acta. 1988 Oct 28; 972(1):69-78. PMID: 2846073.
      Citations: 2     Fields:    Translation:AnimalsCells
    148. Draetta G, Beach D. Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell. 1988 Jul 01; 54(1):17-26. PMID: 3289755.
      Citations: 216     Fields:    Translation:HumansCells
    149. Draetta G, Beach D, Moran E. Synthesis of p34, the mammalian homolog of the yeast cdc2+/CDC28 protein kinase, is stimulated during adenovirus-induced proliferation of primary baby rat kidney cells. Oncogene. 1988 Jun; 2(6):553-7. PMID: 2838787.
      Citations: 17     Fields:    Translation:AnimalsCells
    150. Draetta G, Brizuela L, Moran B, Beach D. Regulation of the vertebrate cell cycle by the cdc2 protein kinase. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:195-201. PMID: 3076080.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    151. Draetta G, Brizuela L, Beach D. p34, a protein kinase involved in cell cycle regulation in eukaryotic cells. Adv Exp Med Biol. 1988; 231:453-7. PMID: 3046250.
      Citations:    Fields:    Translation:HumansAnimals
    152. Draetta G, Klee CB. Purification of calmodulin-stimulated phosphodiesterase by affinity chromatography on calmodulin fragment 1-77 linked to sepharose. Methods Enzymol. 1988; 159:573-81. PMID: 2842620.
      Citations:    Fields:    Translation:Animals
    153. Klee CB, Draetta GF, Hubbard MJ. Calcineurin. Adv Enzymol Relat Areas Mol Biol. 1988; 61:149-200. PMID: 2833077.
      Citations: 102     Fields:    Translation:Cells
    154. Brizuela L, Draetta G, Beach D. p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J. 1987 Nov; 6(11):3507-14. PMID: 3322810; PMCID: PMC553810.
      Citations: 118     Fields:    Translation:AnimalsCells
    155. Draetta G, Brizuela L, Potashkin J, Beach D. Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell. 1987 Jul 17; 50(2):319-25. PMID: 3297353.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    156. Porta R, De Santis A, Esposito C, Draetta GF, Di Donato A, Illiano G. Inhibition of adenylate cyclase by transglutaminase-catalyzed reactions in pigeon erythrocyte ghosts. Biochem Biophys Res Commun. 1986 Jul 31; 138(2):596-603. PMID: 2874804.
      Citations: 1     Fields:    Translation:AnimalsCells
    157. Putkey JA, Draetta GF, Slaughter GR, Klee CB, Cohen P, Stull JT, Means AR. Genetically engineered calmodulins differentially activate target enzymes. J Biol Chem. 1986 Jul 25; 261(21):9896-903. PMID: 3460991.
      Citations: 12     Fields:    Translation:AnimalsCells
    158. Klee CB, Ni WC, Draetta GF, Newton DL. Different modes of interaction of calmodulin with its target enzymes. J Cardiovasc Pharmacol. 1986; 8 Suppl 8:S52-6. PMID: 2433526.
      Citations:    Fields:    Translation:AnimalsCells
    159. Di Donato A, Draetta GF, Illiano G, Tufano MA, Sommese L, Galdiero F. Do porins inhibit the macrophage phagocyting activity by stimulating the adenylate cyclase? J Cyclic Nucleotide Protein Phosphor Res. 1986; 11(2):87-97. PMID: 2426319.
      Citations: 10     Fields:    Translation:AnimalsCells
    160. Illiano G, Galderisi R, Di Donato A, Paolisso G, Draetta GF. The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium. Gen Pharmacol. 1985; 16(2):115-9. PMID: 2987079.
      Citations:    Fields:    Translation:AnimalsCells
    161. Brotzu G, Carta M, Cherchi R, D'Alia G, Deriu IP, Diaz G, Draetta G, Montisci R, Savona G, Testa Riva F. The stereomorphologic disposition of the muscular capillary network. Experimental research into the effect of training, age, arterial insufficiency and chronic treatment with EPL. J Sports Med Phys Fitness. 1984 Mar; 24(1):1-12. PMID: 6471832.
      Citations:    Fields:    Translation:AnimalsCells
    162. Illiano G, Chiosi E, Draetta GF, Laurenza A. Relationship between the fluidity of the membrane lipids and the activity of the membrane-bound proteins: the effects of lidocaine on the adenylate cyclase activity of rat myocardium. Gen Pharmacol. 1983; 14(6):669-72. PMID: 6662347.
      Citations: 1     Fields:    Translation:Animals
    163. Pisano M, Draetta G, Valdes E, Serra FA, Versace R, Furcas S, Desogus AI. [Hamartochondromas of the lung. Case reports]. Pathologica. 1982 Sep-Oct; 74(1033):623-30. PMID: 7167275.
      Citations:    Fields:    Translation:Humans
    164. Utili R, Di Donato A, Draetta G, Paolisso G, Abernathy CO, Illiano G. Endotoxin inhibits the fluoride-stimulated adenylate cyclase activity of rat liver membranes enriched with bile canaliculi. Experientia. 1982 Jul 15; 38(7):831-3. PMID: 7049721.
      Citations:    Fields:    Translation:AnimalsCells
    165. Faa G, Dessy E, Bucarelli A, Frau G, Zucca G, Draetta G. [Experimental research on the toxicity of PVC administered orally]. Boll Soc Ital Biol Sper. 1981 Apr 30; 57(8):926-8. PMID: 7272069.
      Citations: 1     Fields:    Translation:Animals
    166. Illiano G, Draetta GF, Laurenza A, Spina A, Paolisso G. The effects of polyamines on the cyclic AMP efflux and metabolism in E. coli B cells. Int J Biochem. 1981; 13(6):701-5. PMID: 6266892.
      Citations: 1     Fields:    Translation:Cells
    167. Draetta G, Pintus ML, Santa Cruz G, Pinto G. [Malignant mesenchymal tumors of the larynx]. Pathologica. 1980 Nov-Dec; 72(1022):821-32. PMID: 6270622.
      Citations:    Fields:    Translation:Humans
    168. Zucca G, Dessy E, Faa G, Draetta G. [Tumors of the large intestine. Statistical research and histopathological findings]. Minerva Med. 1980 Mar 17; 71(10):709-13. PMID: 6244519.
      Citations:    Fields:    Translation:Humans
    169. Genetics and biology of pancreatic ductal adenocarcinoma. Genes and Development. 30:355-385.
    170. Metabolic features of cancer treatment resistance. 135-156.
    171. The behaviour of cyclic AMP in the plasma and urine of psoriatic patients. (Preliminary note). Annali Italiani di Dermatologia Clinica e Sperimentale. 33:11-16.
    172. Antiangiogenic therapy. Molecular Medicine Today. 6:188-189.
    173. Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery. Epigenetics and Chromatin. 8.
    174. Biology of the Cell. 76:213.
    175. Correlation between the membrane physical state and the post-translational covalent modifications of membrane bound proteins. Italian Journal of Biochemistry. 33.
    176. Identification of potent and selective MTH1 inhibitors. Bioorganic and Medicinal Chemistry Letters. 26:1503-1507.
    177. Activation of rat myocardial adenylate cyclase activity by sulfate anions. Bulletin of Molecular Biology and Medicine. 3:42-53.
    178. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Reports. 16:133-147.
    179. Tumors and mitochondrial respiration. Cancer Research. 75:3687-3691.
    180. The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF-mutant cancers. Cancer Research. 75:3865-3878.
    181. Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer. Antioxidants and Redox Signaling. 23:15-29.
    182. The cdc25 Phosphatase. Advances in Molecular and Cell Biology. 13:151-164.
    183. Chapter 25. Cell Cycle Control and Cancer. Annual Reports in Medicinal Chemistry. 31:241-248.
    184. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. Journal of Medicinal Chemistry. 59:1440-1454.
    185. Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair. Cell Reports. 14:1555-1566.
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