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JAN PARKER-THORNBURG

TitleAssociate Professor
InstitutionMD Anderson
DepartmentGenetics
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Parker-Thornburg J, Benavides F, Shawlot W, McBeath E. TT2022 meeting report on the 17th Transgenic Technology meeting in Helsinki, Finland. Transgenic Res. 2022 12; 31(6):677-681. PMID: 36441390; PMCID: PMC9707113.
      Citations:    Fields:    
    2. Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Manu SM, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC. Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nat Commun. 2021 09 10; 12(1):5389. PMID: 34508101; PMCID: PMC8433435.
      Citations: 1     Fields:    Translation:HumansAnimals
    3. Gurumurthy CB, O'Brien AR, Quadros RM, Adams J, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb K, Eudy JD, Gan L, Gao J, Gonzales A, Guntur A, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majeweska L, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford A, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G. Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation". Genome Biol. 2021 04 07; 22(1):99. PMID: 33827648; PMCID: PMC8025318.
      Citations: 1     Fields:    Translation:Animals
    4. Chen B, Dragomir MP, Fabris L, Bayraktar R, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, De Los Santos MC, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA, Knutsen E. The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling. Gastroenterology. 2020 12; 159(6):2146-2162.e33. PMID: 32805281; PMCID: PMC7725986.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    5. McBeath E, Parker-Thornburg J, Fujii Y, Aryal N, Smith C, Hofmann MC, Abe JI, Fujiwara K. Rapid Evaluation of CRISPR Guides and Donors for Engineering Mice. Genes (Basel). 2020 Jun 08; 11(6). PMID: 32521708; PMCID: PMC7349695.
      Citations: 1     Fields:    Translation:Animals
    6. Aryal NK, Parker-Thornburg J. Genotyping Genetically Modified (GM) Mice. Methods Mol Biol. 2020; 2066:133-148. PMID: 31512214.
      Citations:    Fields:    Translation:AnimalsCells
    7. Parker-Thornburg J. Breeding Strategies for Genetically Modified Mice. Methods Mol Biol. 2020; 2066:163-169. PMID: 31512216.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Gurumurthy CB, O'Brien AR, Quadros RM, Adams J, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G. Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol. 2019 08 26; 20(1):171. PMID: 31446895; PMCID: PMC6709553.
      Citations: 25     Fields:    Translation:Animals
    9. Kiyama T, Long Y, Chen CK, Whitaker CM, Shay A, Wu H, Badea TC, Mohsenin A, Parker-Thornburg J, Klein WH, Mills SL, Massey SC, Mao CA. Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse. Cell Rep. 2019 04 16; 27(3):900-915.e5. PMID: 30995485; PMCID: PMC6542366.
      Citations: 5     Fields:    Translation:AnimalsCells
    10. Jaramillo AM, Piccotti L, Velasco WV, Delgado ASH, Azzegagh Z, Chung F, Nazeer U, Farooq J, Brenner J, Parker-Thornburg J, Scott BL, Evans CM, Adachi R, Burns AR, Kreda SM, Tuvim MJ, Dickey BF. Different Munc18 proteins mediate baseline and stimulated airway mucin secretion. JCI Insight. 2019 03 21; 4(6). PMID: 30721150; PMCID: PMC6483006.
      Citations: 6     Fields:    Translation:AnimalsCells
    11. Aryal NK, Pant V, Wasylishen AR, Parker-Thornburg J, Baseler L, El-Naggar AK, Liu B, Kalia A, Lozano G, Arur S. Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo. Proc Natl Acad Sci U S A. 2019 01 15; 116(3):960-969. PMID: 30593561; PMCID: PMC6338878.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. Cardona SM, Kim SV, Church KA, Torres VO, Cleary IA, Mendiola AS, Saville SP, Watowich SS, Parker-Thornburg J, Soto-Ospina A, Araque P, Ransohoff RM, Cardona AE. Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant. Front Cell Neurosci. 2018; 12:365. PMID: 30386211; PMCID: PMC6199958.
      Citations: 11     
    13. Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GA. Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Res. 2018 04; 28(4):432-447. PMID: 29567676; PMCID: PMC5880235.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    14. Sutton MN, Yang H, Huang GY, Fu C, Pontikos M, Wang Y, Mao W, Pang L, Yang M, Liu J, Parker-Thornburg J, Lu Z, Bast RC. RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells. Autophagy. 2018; 14(4):637-653. PMID: 29368982; PMCID: PMC5959337.
      Citations: 15     Fields:    Translation:AnimalsCells
    15. Yang J, Joshi S, Wang Q, Li P, Wang H, Xiong Y, Xiao Y, Wang J, Parker-Thornburg J, Behringer RR, Yu D. 14-3-3? loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature. Cell Biosci. 2017; 7:58. PMID: 29118970; PMCID: PMC5667492.
      Citations: 2     
    16. Joshi S, Yang J, Wang Q, Li P, Wang H, Zhang Q, Xiong Y, Pickering BF, Parker-Thornburg J, Behringer RR, Yu D. 14-3-3? loss impedes oncogene-induced mammary tumorigenesis and metastasis by attenuating oncogenic signaling. Am J Cancer Res. 2017; 7(8):1654-1664. PMID: 28861322; PMCID: PMC5574938.
      Citations: 5     
    17. Tamowski S, Luo J, Whitelaw B, Crispo M, Doglio L, Parker-Thornburg J, Kanzler B, Jerchow B. TT2016 meeting report on the 13th Transgenic Technology meeting in Prague, Czech Republic. Transgenic Res. 2016 08; 25(4):553-9. PMID: 27277423.
      Citations:    Fields:    Translation:Humans
    18. Norton WB, Scavizzi F, Smith CN, Dong W, Raspa M, Parker-Thornburg JV. Refinements for embryo implantation surgery in the mouse: comparison of injectable and inhalant anesthesias - tribromoethanol, ketamine and isoflurane - on pregnancy and pup survival. Lab Anim. 2016 Oct; 50(5):335-43. PMID: 26566637; PMCID: PMC4865456.
      Citations: 6     Fields:    Translation:Animals
    19. Gallardo M, Lee HJ, Zhang X, Bueso-Ramos C, Pageon LR, McArthur M, Multani A, Nazha A, Manshouri T, Parker-Thornburg J, Rapado I, Quintas-Cardama A, Kornblau SM, Martinez-Lopez J, Post SM. hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies. Cancer Cell. 2015 Oct 12; 28(4):486-499. PMID: 26412324; PMCID: PMC4652598.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    20. Venkatanarayan A, Raulji P, Norton W, Chakravarti D, Coarfa C, Su X, Sandur SK, Ramirez MS, Lee J, Kingsley CV, Sananikone EF, Rajapakshe K, Naff K, Parker-Thornburg J, Bankson JA, Tsai KY, Gunaratne PH, Flores ER. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature. 2015 Jan 29; 517(7536):626-30. PMID: 25409149; PMCID: PMC4312210.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    21. Yen ST, Zhang M, Deng JM, Usman SJ, Smith CN, Parker-Thornburg J, Swinton PG, Martin JF, Behringer RR. Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes. Dev Biol. 2014 Sep 01; 393(1):3-9. PMID: 24984260; PMCID: PMC4166609.
      Citations: 142     Fields:    Translation:AnimalsCells
    22. Chakravarti D, Su X, Cho MS, Bui NH, Coarfa C, Venkatanarayan A, Benham AL, Alana J, Xiao W, Leung ML, Vin H, Chan IL, Aquino A, Wang H, Cooney AJ, Parker-Thornburg J, Tsai KY, Gunaratne PH, Flores ER, Flores Gonz?lez RE, M?ller N. Induced multipotency in adult keratinocytes through down-regulation of ?Np63 or DGCR8. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):E572-81. PMID: 24449888; PMCID: PMC3918754.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    23. Zuo X, Peng Z, Wu Y, Moussalli MJ, Yang XL, Wang Y, Parker-Thornburg J, Morris JS, Broaddus RR, Fischer SM, Shureiqi I. Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice. J Natl Cancer Inst. 2012 May 02; 104(9):709-16. PMID: 22472308; PMCID: PMC3341308.
      Citations: 18     Fields:    Translation:AnimalsCells
    24. Xiong S, Parker-Thornburg J, Lozano G. Developing genetically engineered mouse models to study tumor suppression. Curr Protoc Mouse Biol. 2012 Mar 01; 2(1):9-24. PMID: 22582146; PMCID: PMC3349200.
      Citations:    Fields:    
    25. Perez C, Parker-Thornburg J, Mikulec C, Kusewitt DF, Fischer SM, Digiovanni J, Conti CJ, Benavides F. SKHIN/Sprd, a new genetically defined inbred hairless mouse strain for UV-induced skin carcinogenesis studies. Exp Dermatol. 2012 Mar; 21(3):217-20. PMID: 22379968; PMCID: PMC3881295.
      Citations: 5     Fields:    Translation:Animals
    26. Luo C, Edison E, Palla S, Dong W, Parker-Thornburg J, Zu?iga J. Superovulation strategies for 6 commonly used mouse strains. J Am Assoc Lab Anim Sci. 2011 Jul; 50(4):471-8. PMID: 21838974; PMCID: PMC3148645.
      Citations: 35     Fields:    Translation:HumansAnimals
    27. Tian L, Peng G, Parant JM, Leventaki V, Drakos E, Zhang Q, Parker-Thornburg J, Shackleford TJ, Dai H, Lin SY, Lozano G, Rassidakis GZ, Claret FX. Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene. 2010 Nov 18; 29(46):6125-37. PMID: 20802511; PMCID: PMC3495558.
      Citations: 33     Fields:    Translation:AnimalsCells
    28. Ludes-Meyers JH, Kil H, Parker-Thornburg J, Kusewitt DF, Bedford MT, Aldaz CM. Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. PLoS One. 2009 Nov 10; 4(11):e7775. PMID: 19936220; PMCID: PMC2777388.
      Citations: 45     Fields:    Translation:HumansAnimals
    29. Parker-Thornburg J, Grabeel P, Butler M. The AALAS Learning Library and its effectiveness as a tool for technician training. Lab Anim (NY). 2009 Jun; 38(6):195-201. PMID: 19455165.
      Citations:    Fields:    Translation:HumansAnimals
    30. Singh SK, Kagalwala MN, Parker-Thornburg J, Adams H, Majumder S. REST maintains self-renewal and pluripotency of embryonic stem cells. Nature. 2008 May 08; 453(7192):223-7. PMID: 18362916; PMCID: PMC2830094.
      Citations: 158     Fields:    Translation:AnimalsCells
    31. Ludes-Meyers JH, Kil H, Conti CJ, Parker-Thornburg J, Bedford MT, Aldaz CM, Nu?ez MI. WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes Cancer. 2007 Dec; 46(12):1129-36. PMID: 17823927; PMCID: PMC4143238.
      Citations: 42     Fields:    Translation:AnimalsCells
    32. Froberg MK, Dannen D, Adams A, Parker-Thornburg J, Kolattukudy P. Murine cytomegalovirus infection markedly reduces serum MCP-1 levels in MCP-1 transgenic mice. Ann Clin Lab Sci. 2006; 36(2):179-84. PMID: 16682515.
      Citations: 2     Fields:    Translation:AnimalsCells
    33. Parker-Thornburg JV, Alana JL, Smith CN, Detry M, Rojas ML, Baskin KK. Cryopreserved morulae can be used to efficiently generate germline-transmitting chimeras by blastocyst injection. Transgenic Res. 2005 Oct; 14(5):685-90. PMID: 16245159.
      Citations: 1     Fields:    Translation:Animals
    34. Froberg MK, Adams A, Seacotte N, Parker-Thornburg J, Kolattukudy P. Cytomegalovirus infection accelerates inflammation in vascular tissue overexpressing monocyte chemoattractant protein-1. Circ Res. 2001 Dec 07; 89(12):1224-30. PMID: 11739289.
      Citations: 9     Fields:    Translation:AnimalsCells
    35. Moldovan NI, Goldschmidt-Clermont PJ, Parker-Thornburg J, Shapiro SD, Kolattukudy PE. Contribution of monocytes/macrophages to compensatory neovascularization: the drilling of metalloelastase-positive tunnels in ischemic myocardium. Circ Res. 2000 Sep 01; 87(5):378-84. PMID: 10969035.
      Citations: 79     Fields:    Translation:AnimalsCells
    36. Baader SL, Sanlioglu S, Berrebi AS, Parker-Thornburg J, Oberdick J. Ectopic overexpression of engrailed-2 in cerebellar Purkinje cells causes restricted cell loss and retarded external germinal layer development at lobule junctions. J Neurosci. 1998 Mar 01; 18(5):1763-73. PMID: 9465001; PMCID: PMC6792618.
      Citations: 25     Fields:    Translation:AnimalsCells
    37. Bumgardner GL, Heininger M, Li J, Xia D, Parker-Thornburg J, Ferguson RM, Orosz CG. A functional model of hepatocyte transplantation for in vivo immunologic studies. Transplantation. 1998 Jan 15; 65(1):53-61. PMID: 9448144.
      Citations: 31     Fields:    Translation:HumansAnimals
    38. Kolattukudy PE, Quach T, Bergese S, Breckenridge S, Hensley J, Altschuld R, Gordillo G, Klenotic S, Orosz C, Parker-Thornburg J. Myocarditis induced by targeted expression of the MCP-1 gene in murine cardiac muscle. Am J Pathol. 1998 Jan; 152(1):101-11. PMID: 9422528; PMCID: PMC1858131.
      Citations: 57     Fields:    Translation:Animals
    39. Jhiang SM, Sagartz JE, Tong Q, Parker-Thornburg J, Capen CC, Cho JY, Xing S, Ledent C. Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology. 1996 Jan; 137(1):375-8. PMID: 8536638.
      Citations: 70     Fields:    Translation:Animals
    40. Parker-Thornburg J, Bauer B, Palermo J, Robbins J. Structural and developmental analysis of two linked myosin heavy chain genes. Dev Biol. 1992 Mar; 150(1):99-107. PMID: 1371481.
      Citations: 6     Fields:    Translation:AnimalsCells
    41. Parker-Thornburg J, Bonner JJ. Mutations that induce the heat shock response of Drosophila. Cell. 1987 Dec 04; 51(5):763-72. PMID: 3119225.
      Citations: 15     Fields:    Translation:Animals
    42. Bonner JJ, Parks C, Parker-Thornburg J, Mortin MA, Pelham HR. The use of promoter fusions in Drosophila genetics: isolation of mutations affecting the heat shock response. Cell. 1984 Jul; 37(3):979-91. PMID: 6430570.
      Citations: 65     Fields:    Translation:AnimalsCells
    43. Refinements for embryo implantation surgery in the mouse. Laboratory Animals. 50:335-343.
    44. TT2016 meeting report on the 13th Transgenic Technology meeting in Prague, Czech Republic. Transgenic Research. 25:553-559.
    45. HnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies. Cancer Cell. 28:486-499.
    46. Singh et al. reply. Nature. 457.
    47. Singh et al. reply. Nature. 467.
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