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MICHELLE BARTON

TitleProfessor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
Address6767 Bertner St
Houston TX 77030-2603
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rodriguez M, Fekry B, Murphy B, Figueroa M, Cheng T, Raber M, Wartenberg L, Bell D, Triche L, Crawford K, Ma H, Allton K, Ahmed R, Tran J, Ranieri C, Konopleva M, Barton M, Nunez C, Eckel-Mahan K, Chandra J. Feasible diet and circadian interventions reduce in?vivo progression of FLT3-ITD-positive acute myeloid leukemia. Cancer Med. 2024 Jan; 13(2):e6949. PMID: 38334474; PMCID: PMC10854450.
      Citations:    Fields:    Translation:HumansAnimals
    2. Patel LR, Stratton SA, McLaughlin M, Krause P, Allton K, Rivas AL, Barbosa D, Hart T, Barton MC. Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24. iScience. 2023 Jul 21; 26(7):107126. PMID: 37426340; PMCID: PMC10329041.
      Citations:    
    3. Barton MC, Lozano G. p53 Activation Paradoxically Causes Liver Cancer. Cancer Res. 2022 08 16; 82(16):2824-2825. PMID: 35971677.
      Citations:    
    4. Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC), Merckx J, Cooke S, El Tal T, Bitnun A, Morris SK, Yeh EA, Yea C, Gill P, Papenburg J, Lefebvre MA, Scuccimarri R, Ulloa-Gutierrez R, Brenes-Chacon H, Yock-Corrales A, Ivankovich-Escoto G, Soriano-Fallas A, Mezerville MH, Dewan T, Restivo L, Nateghian A, Aski BH, Manafi A, Dwilow R, Bullard J, Lopez A, Sadarangani M, Roberts A, Barton M, Petel D, Le Saux N, Bowes J, Purewal R, Lautermilch J, Tehseen S, Bayliss A, Wong JK, Leifso K, Foo C, Robinson J. Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study. CMAJ. 2022 04 11; 194(14):E513-E523. PMID: 35410860; PMCID: PMC9001008.
      Citations:    Fields:    Translation:HumansCells
    5. Terranova CJ, Stemler KM, Barrodia P, Jeter-Jones SL, Ge Z, de la Cruz Bonilla M, Raman A, Cheng CW, Allton KL, Arslan E, Barton MC, Rai K, Piwnica-Worms H, Yilmaz ?H. Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine. Cell Rep. 2021 11 23; 37(8):110044. PMID: 34818540; PMCID: PMC8668154.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Manu SM, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC. Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nat Commun. 2021 09 10; 12(1):5389. PMID: 34508101; PMCID: PMC8433435.
      Citations: 1     Fields:    Translation:HumansAnimals
    7. English K, Barton MC. HDAC6: A Key Link Between Mitochondria and Development of Peripheral Neuropathy. Front Mol Neurosci. 2021; 14:684714. PMID: 34531721; PMCID: PMC8438325.
      Citations: 3     
    8. Kim MP, Li X, Deng J, Zhang Y, Dai B, Allton KL, Hughes TG, Siangco C, Augustine JJ, Kang Y, McDaniel JM, Xiong S, Koay EJ, McAllister F, Bristow CA, Heffernan TP, Maitra A, Liu B, Barton MC, Wasylishen AR, Fleming JB, Lozano G. Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis. Cancer Discov. 2021 08; 11(8):2094-2111. PMID: 33839689; PMCID: PMC8338884.
      Citations: 15     Fields:    Translation:HumansAnimals
    9. Joseph R, Soundararajan R, Vasaikar S, Yang F, Allton KL, Tian L, den Hollander P, Isgandarova S, Haemmerle M, Mino B, Zhou T, Shin C, Martinez-Paniagua M, Sahin AA, Rodriguez-Canales J, Gelovani J, Chang JT, Acharya G, Sood AK, Wistuba II, Gibbons DL, Solis LM, Barton MC, Varadarajan N, Rosen JM, Zhang XH, Mani SA. CD8+ T cells inhibit metastasis and CXCL4 regulates its function. Br J Cancer. 2021 07; 125(2):176-189. PMID: 33795809; PMCID: PMC8292398.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Yang DS, Saeedi A, Davtyan A, Fathi M, Sherman MB, Safari MS, Klindziuk A, Barton MC, Varadarajan N, Kolomeisky AB, Vekilov PG. Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). PMID: 33653952; PMCID: PMC7958401.
      Citations: 5     Fields:    Translation:HumansCells
    11. Jung YS, Stratton SA, Lee SH, Kim MJ, Jun S, Zhang J, Zheng B, Cervantes CL, Cha JH, Barton MC, Park JI. TMEM9-v-ATPase Activates Wnt/?-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis. Hepatology. 2021 02; 73(2):776-794. PMID: 32380568; PMCID: PMC7647947.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    12. Wasylishen AR, Sun C, Moyer SM, Qi Y, Chau GP, Aryal NK, McAllister F, Kim MP, Barton MC, Estrella JS, Su X, Lozano G. Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo. Sci Adv. 2020 08; 6(32):eaba8415. PMID: 32821827; PMCID: PMC7406367.
      Citations: 6     Fields:    Translation:AnimalsCells
    13. Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, Macfarlan T, Zhang X, Cheng X. KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. NAR Cancer. 2020 Jun; 2(2):zcaa007. PMID: 32743551; PMCID: PMC7380489.
      Citations: 2     
    14. Liang J, Wang L, Wang C, Shen J, Su B, Marisetty AL, Fang D, Kassab C, Jeong KJ, Zhao W, Lu Y, Jain AK, Zhou Z, Liang H, Sun SC, Lu C, Xu ZX, Yu Q, Shao S, Chen X, Gao M, Claret FX, Ding Z, Chen J, Chen P, Barton MC, Peng G, Mills GB, Heimberger AB. Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy. Cancer Immunol Res. 2020 07; 8(7):952-965. PMID: 32265228; PMCID: PMC8204534.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    15. Gallardo M, Malaney P, Aitken MJL, Zhang X, Link TM, Shah V, Alybayev S, Wu MH, Pageon LR, Ma H, Jacamo R, Yu L, Xu-Monette ZY, Steinman H, Lee HJ, Sarbassov D, Rapado I, Barton MC, Martinez-Lopez J, Bueso-Ramos C, Young KH, Post SM. Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas. J Natl Cancer Inst. 2020 01 01; 112(1):95-106. PMID: 31077320; PMCID: PMC7489062.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    16. Manshouri R, Coyaud E, Kundu ST, Peng DH, Stratton SA, Alton K, Bajaj R, Fradette JJ, Minelli R, Peoples MD, Carugo A, Chen F, Bristow C, Kovacs JJ, Barton MC, Heffernan T, Creighton CJ, Raught B, Gibbons DL. ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer. Nat Commun. 2019 11 12; 10(1):5125. PMID: 31719531; PMCID: PMC6851102.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    17. Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA. Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy. Cancers (Basel). 2019 May 24; 11(5). PMID: 31137625; PMCID: PMC6562947.
      Citations: 42     
    18. Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K, Ainbinder E, Furth N, Tanay A, Barton M, Oren M. Corrigendum: p53 is essential for DNA methylation homeostasis in na?ve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes Dev. 2018 10 01; 32(19-20):1358. PMID: 30275045; PMCID: PMC6169834.
      Citations:    Fields:    
    19. Jain AK, Barton MC. p53: emerging roles in stem cells, development and beyond. Development. 2018 04 13; 145(8). PMID: 29654218.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    20. Appikonda S, Thakkar KN, Shah PK, Dent SYR, Andersen JN, Barton MC. Cross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesion. J Biol Chem. 2018 05 11; 293(19):7476-7485. PMID: 29523690; PMCID: PMC5950014.
      Citations: 12     Fields:    Translation:HumansCells
    21. Xi Y, Shi J, Li W, Tanaka K, Allton KL, Richardson D, Li J, Franco HL, Nagari A, Malladi VS, Coletta LD, Simper MS, Keyomarsi K, Shen J, Bedford MT, Shi X, Barton MC, Kraus WL, Li W, Dent SYR. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC Genomics. 2018 02 20; 19(1):150. PMID: 29458327; PMCID: PMC5819162.
      Citations: 25     Fields:    Translation:HumansCells
    22. Wang H, Zhao S, Barton M, Rosengart T, Cooney AJ. Reciprocity of Action of Increasing Oct4 and Repressing p53 in Transdifferentiation of Mouse Embryonic Fibroblasts into Cardiac Myocytes. Cell Reprogram. 2018 02; 20(1):27-37. PMID: 29412738; PMCID: PMC5824656.
      Citations: 3     Fields:    Translation:AnimalsCells
    23. Franco HL, Nagari A, Malladi VS, Li W, Xi Y, Richardson D, Allton KL, Tanaka K, Li J, Murakami S, Keyomarsi K, Bedford MT, Shi X, Li W, Barton MC, Dent SYR, Kraus WL. Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis. Genome Res. 2018 02; 28(2):159-170. PMID: 29273624; PMCID: PMC5793780.
      Citations: 61     Fields:    Translation:HumansCells
    24. Wang L, Koutelou E, Hirsch C, McCarthy R, Schibler A, Lin K, Lu Y, Jeter C, Shen J, Barton MC, Dent SYR. GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation. Stem Cell Reports. 2018 01 09; 10(1):287-299. PMID: 29249668; PMCID: PMC5768892.
      Citations: 16     Fields:    Translation:AnimalsCells
    25. Bosnakovski D, Gearhart MD, Toso EA, Recht OO, Cucak A, Jain AK, Barton MC, Kyba M. p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy. Dis Model Mech. 2017 10 01; 10(10):1211-1216. PMID: 28754837; PMCID: PMC5665455.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    26. McCarthy RL, Mak DH, Burks JK, Barton MC. Rapid monoisotopic cisplatin based barcoding for multiplexed mass cytometry. Sci Rep. 2017 06 19; 7(1):3779. PMID: 28630464; PMCID: PMC5476666.
      Citations: 19     Fields:    Translation:HumansCells
    27. Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K, Ainbinder E, Furth N, Tanay A, Barton M, Oren M. p53 is essential for DNA methylation homeostasis in na?ve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes Dev. 2017 05 15; 31(10):959-972. PMID: 28607180; PMCID: PMC5495125.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    28. McCarthy RL, Duncan AD, Barton MC. Sample Preparation for Mass Cytometry Analysis. J Vis Exp. 2017 04 29; (122). PMID: 28518070; PMCID: PMC5565122.
      Citations: 4     Fields:    Translation:AnimalsCells
    29. Fiziev P, Akdemir KC, Miller JP, Keung EZ, Samant NS, Sharma S, Natale CA, Terranova CJ, Maitituoheti M, Amin SB, Martinez-Ledesma E, Dhamdhere M, Axelrad JB, Shah A, Cheng CS, Mahadeshwar H, Seth S, Barton MC, Protopopov A, Tsai KY, Davies MA, Garcia BA, Amit I, Chin L, Ernst J, Rai K. Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression. Cell Rep. 2017 04 25; 19(4):875-889. PMID: 28445736; PMCID: PMC5473172.
      Citations: 30     Fields:    Translation:HumansCells
    30. Li J, Xi Y, Li W, McCarthy RL, Stratton SA, Zou W, Li W, Dent SY, Jain AK, Barton MC. TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation. Oncogene. 2017 05 25; 36(21):2991-3001. PMID: 28068325; PMCID: PMC5760165.
      Citations: 29     Fields:    Translation:HumansCells
    31. Jain AK, Xi Y, McCarthy R, Allton K, Akdemir KC, Patel LR, Aronow B, Lin C, Li W, Yang L, Barton MC. LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56. Mol Cell. 2016 12 01; 64(5):967-981. PMID: 27912097; PMCID: PMC5137794.
      Citations: 78     Fields:    Translation:HumansCells
    32. Jain AK, Barton MC. Bromodomain Histone Readers and Cancer. J Mol Biol. 2017 06 30; 429(13):2003-2010. PMID: 27890782.
      Citations: 33     Fields:    Translation:Cells
    33. Ma L, Yuan L, An J, Barton MC, Zhang Q, Liu Z. Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer. Tumour Biol. 2016 Nov; 37(11):14803-14812. PMID: 27638829.
      Citations: 12     Fields:    Translation:HumansCells
    34. Barton MC. Cancer: Acidic shield puts a chink in p53's armour. Nature. 2016 10 06; 538(7623):45-46. PMID: 27626387.
      Citations:    Fields:    Translation:Humans
    35. Appikonda S, Thakkar KN, Barton MC. Regulation of gene expression in human cancers by TRIM24. Drug Discov Today Technol. 2016 Mar; 19:57-63. PMID: 27769359.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    36. Jain AK, Barton MC. Outside the p53 RING: Transcription Regulation by Chromatin-Bound MDM2. Mol Cell. 2016 06 16; 62(6):805-807. PMID: 27315554.
      Citations: 3     Fields:    Translation:HumansCells
    37. Patel LR, Barton MC. TRIM-ing Ligand Dependence in Castration-Resistant Prostate Cancer. Cancer Cell. 2016 06 13; 29(6):776-778. PMID: 27300431.
      Citations: 3     Fields:    Translation:HumansCells
    38. Jung KH, McCarthy RL, Zhou C, Uprety N, Barton MC, Beretta L. MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1. Stem Cells. 2016 05; 34(5):1284-96. PMID: 26731713; PMCID: PMC4860085.
      Citations: 14     Fields:    Translation:HumansCells
    39. Dhar SS, Lee SH, Chen K, Zhu G, Oh W, Allton K, Gafni O, Kim YZ, Tomoiga AS, Barton MC, Hanna JH, Wang Z, Li W, Lee MG. An essential role for UTX in resolution and activation of bivalent promoters. Nucleic Acids Res. 2016 05 05; 44(8):3659-74. PMID: 26762983; PMCID: PMC4856969.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    40. Rai K, Akdemir KC, Kwong LN, Fiziev P, Wu CJ, Keung EZ, Sharma S, Samant NS, Williams M, Axelrad JB, Shah A, Yang D, Grimm EA, Barton MC, Milton DR, Heffernan TP, Horner JW, Ekmekcioglu S, Lazar AJ, Ernst J, Chin L. Dual Roles of RNF2 in Melanoma Progression. Cancer Discov. 2015 Dec; 5(12):1314-27. PMID: 26450788; PMCID: PMC4670809.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    41. Zhan Y, Kost-Alimova M, Shi X, Leo E, Bardenhagen JP, Shepard HE, Appikonda S, Vangamudi B, Zhao S, Tieu TN, Jiang S, Heffernan TP, Marszalek JR, Toniatti C, Draetta G, Tyler J, Barton M, Jones P, Palmer WS, Geck Do MK, Andersen JN. Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery. Epigenetics Chromatin. 2015; 8:37. PMID: 26396593; PMCID: PMC4578755.
      Citations: 13     Fields:    
    42. Palmer WS, Poncet-Montange G, Liu G, Petrocchi A, Reyna N, Subramanian G, Theroff J, Yau A, Kost-Alimova M, Bardenhagen JP, Leo E, Shepard HE, Tieu TN, Shi X, Zhan Y, Zhao S, Barton MC, Draetta G, Toniatti C, Jones P, Geck Do M, Andersen JN. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25; 59(4):1440-54. PMID: 26061247; PMCID: PMC4755933.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    43. Hirsch CL, Akdemir ZC, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY. Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev. 2015 Jun 15; 29(12):1341. PMID: 26109054; PMCID: PMC4495403.
      Citations:    Fields:    
    44. Hirsch CL, Coban Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY. Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev. 2015 Apr 15; 29(8):803-16. PMID: 25877919; PMCID: PMC4403257.
      Citations: 42     Fields:    Translation:AnimalsCells
    45. Singh MM, Johnson B, Venkatarayan A, Flores ER, Zhang J, Su X, Barton M, Lang F, Chandra J. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro Oncol. 2015 Nov; 17(11):1463-73. PMID: 25795306; PMCID: PMC4648298.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    46. Jin C, Qin T, Barton MC, Jelinek J, Issa JP. Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells. Epigenetics. 2015; 10(11):1006-13. PMID: 26440216; PMCID: PMC4844212.
      Citations: 14     Fields:    Translation:HumansCells
    47. Jiang S, Minter LC, Stratton SA, Yang P, Abbas HA, Akdemir ZC, Pant V, Post S, Gagea M, Lee RG, Lozano G, Barton MC. TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice. J Hepatol. 2015 Feb; 62(2):371-9. PMID: 25281858; PMCID: PMC4772153.
      Citations: 27     Fields:    Translation:HumansAnimals
    48. Pathiraja TN, Thakkar KN, Jiang S, Stratton S, Liu Z, Gagea M, Shi X, Shah PK, Phan L, Lee MH, Andersen J, Stampfer M, Barton MC. TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene. 2015 May 28; 34(22):2836-45. PMID: 25065590; PMCID: PMC4370790.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    49. Jain AK, Allton K, Duncan AD, Barton MC. TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage. Mol Cell Biol. 2014 Jul; 34(14):2695-709. PMID: 24820418; PMCID: PMC4097665.
      Citations: 38     Fields:    Translation:HumansCells
    50. Jin C, Lu Y, Jelinek J, Liang S, Estecio MR, Barton MC, Issa JP. TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells. Nucleic Acids Res. 2014 Jun; 42(11):6956-71. PMID: 24875481; PMCID: PMC4066785.
      Citations: 68     Fields:    Translation:HumansCells
    51. Wen H, Li Y, Xi Y, Jiang S, Stratton S, Peng D, Tanaka K, Ren Y, Xia Z, Wu J, Li B, Barton MC, Li W, Li H, Shi X. ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. Nature. 2014 Apr 10; 508(7495):263-8. PMID: 24590075; PMCID: PMC4142212.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    52. Stratton SA, Barton MC. Hierarchy of a regenerative cell cycle: cyclin E1 multitasks. Hepatology. 2014 Feb; 59(2):370-1. PMID: 23913250.
      Citations: 1     Fields:    Translation:AnimalsCells
    53. Zhang X, Tanaka K, Yan J, Li J, Peng D, Jiang Y, Yang Z, Barton MC, Wen H, Shi X. Regulation of estrogen receptor a by histone methyltransferase SMYD2-mediated protein methylation. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17284-9. PMID: 24101509; PMCID: PMC3808627.
      Citations: 73     Fields:    Translation:HumansCells
    54. Akdemir KC, Jain AK, Allton K, Aronow B, Xu X, Cooney AJ, Li W, Barton MC. Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells. Nucleic Acids Res. 2014 Jan; 42(1):205-23. PMID: 24078252; PMCID: PMC3874181.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    55. Kurinna S, Stratton SA, Coban Z, Schumacher JM, Grompe M, Duncan AW, Barton MC. p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology. 2013 May; 57(5):2004-13. PMID: 23300120; PMCID: PMC3632650.
      Citations: 45     Fields:    Translation:AnimalsCells
    56. Wan M, Liang J, Xiong Y, Shi F, Zhang Y, Lu W, He Q, Yang D, Chen R, Liu D, Barton M, Songyang Z. The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells. J Biol Chem. 2013 Feb 15; 288(7):5039-48. PMID: 23239880; PMCID: PMC3576105.
      Citations: 31     Fields:    Translation:AnimalsCells
    57. Tran MN, Choi W, Wszolek MF, Navai N, Lee IL, Nitti G, Wen S, Flores ER, Siefker-Radtke A, Czerniak B, Dinney C, Barton M, McConkey DJ. The p63 protein isoform ?Np63a inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205. J Biol Chem. 2013 Feb 01; 288(5):3275-88. PMID: 23239884; PMCID: PMC3561548.
      Citations: 72     Fields:    Translation:HumansCells
    58. Jain AK, Barton MC. Unmet expectations: miR-34 plays no role in p53-mediated tumor suppression in vivo. PLoS Genet. 2012; 8(7):e1002859. PMID: 22870065; PMCID: PMC3411369.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    59. Coban Z, Barton MC. Integrative genomics: liver regeneration and hepatocellular carcinoma. J Cell Biochem. 2012 Jul; 113(7):2179-84. PMID: 22345090; PMCID: PMC3350570.
      Citations: 4     Fields:    Translation:HumansAnimals
    60. Bochkis IM, Schug J, Ye DZ, Kurinna S, Stratton SA, Barton MC, Kaestner KH. Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. PLoS Genet. 2012; 8(6):e1002770. PMID: 22737085; PMCID: PMC3380847.
      Citations: 27     Fields:    Translation:AnimalsCells
    61. Jain AK, Allton K, Iacovino M, Mahen E, Milczarek RJ, Zwaka TP, Kyba M, Barton MC. p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol. 2012; 10(2):e1001268. PMID: 22389628; PMCID: PMC3289600.
      Citations: 117     Fields:    Translation:HumansCells
    62. Stratton SA, Barton MC. p53-Mediated regulation of hepatic lipid metabolism: forging links between metabolism, atherogenesis, and cancer. J Hepatol. 2012 Mar; 56(3):518-9. PMID: 22051552.
      Citations: 2     Fields:    Translation:HumansAnimals
    63. Mani SA, Barton MC. HDAC3 at the fulcrum of an epithelial-mesenchymal balance. Mol Cell. 2011 Sep 02; 43(5):697-8. PMID: 21884971; PMCID: PMC3528183.
      Citations: 2     Fields:    
    64. Singh MM, Manton CA, Bhat KP, Tsai WW, Aldape K, Barton MC, Chandra J. Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro Oncol. 2011 Aug; 13(8):894-903. PMID: 21653597; PMCID: PMC3145466.
      Citations: 63     Fields:    Translation:HumansCells
    65. Wilson MA, Koutelou E, Hirsch C, Akdemir K, Schibler A, Barton MC, Dent SY. Ubp8 and SAGA regulate Snf1 AMP kinase activity. Mol Cell Biol. 2011 Aug; 31(15):3126-35. PMID: 21628526; PMCID: PMC3147604.
      Citations: 24     Fields:    Translation:AnimalsCells
    66. Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010 Dec 16; 468(7326):927-32. PMID: 21164480; PMCID: PMC3058826.
      Citations: 205     Fields:    Translation:HumansCells
    67. Mao CA, Tsai WW, Cho JH, Pan P, Barton MC, Klein WH. Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development. Dev Biol. 2011 Jan 01; 349(1):90-9. PMID: 20969844; PMCID: PMC2993882.
      Citations: 16     Fields:    Translation:AnimalsCells
    68. Jain AK, Barton MC. Making sense of ubiquitin ligases that regulate p53. Cancer Biol Ther. 2010 Oct 01; 10(7):665-72. PMID: 20930521; PMCID: PMC3023569.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    69. Kurinna S, Stratton SA, Tsai WW, Akdemir KC, Gu W, Singh P, Goode T, Darlington GJ, Barton MC. Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice. Hepatology. 2010 Sep; 52(3):1023-32. PMID: 20564353; PMCID: PMC3741038.
      Citations: 15     Fields:    Translation:AnimalsCells
    70. Dejosez M, Levine SS, Frampton GM, Whyte WA, Stratton SA, Barton MC, Gunaratne PH, Young RA, Zwaka TP. Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells. Genes Dev. 2010 Jul 15; 24(14):1479-84. PMID: 20581084; PMCID: PMC2904937.
      Citations: 59     Fields:    Translation:AnimalsCells
    71. Taube JH, Allton K, Duncan SA, Shen L, Barton MC. Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells. J Biol Chem. 2010 May 21; 285(21):16135-44. PMID: 20348100; PMCID: PMC2871482.
      Citations: 35     Fields:    Translation:AnimalsCells
    72. Kurinna S, Barton MC. Cascades of transcription regulation during liver regeneration. Int J Biochem Cell Biol. 2011 Feb; 43(2):189-97. PMID: 20307684; PMCID: PMC2923255.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    73. Kurinna S, Barton MC. Hierarchies of transcriptional regulation during liver regeneration. Prog Mol Biol Transl Sci. 2010; 97:201-27. PMID: 21074734.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    74. Jain AK, Barton MC. Regulation of p53: TRIM24 enters the RING. Cell Cycle. 2009 Nov 15; 8(22):3668-74. PMID: 19844164.
      Citations: 36     Fields:    Translation:AnimalsCells
    75. Gu D, Sater AK, Ji H, Cho K, Clark M, Stratton SA, Barton MC, Lu Q, McCrea PD. Xenopus delta-catenin is essential in early embryogenesis and is functionally linked to cadherins and small GTPases. J Cell Sci. 2009 Nov 15; 122(Pt 22):4049-61. PMID: 19843587; PMCID: PMC2776500.
      Citations: 19     Fields:    Translation:AnimalsCells
    76. Minard ME, Jain AK, Barton MC. Analysis of epigenetic alterations to chromatin during development. Genesis. 2009 Aug; 47(8):559-72. PMID: 19603511; PMCID: PMC2751662.
      Citations: 16     Fields:    Translation:Cells
    77. Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL, Barton MC. Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28):11612-6. PMID: 19556538; PMCID: PMC2710642.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    78. Xie Z, Zhang H, Tsai W, Zhang Y, Du Y, Zhong J, Szpirer C, Zhu M, Cao X, Barton MC, Grusby MJ, Zhang WJ. Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10859-64. PMID: 18669658; PMCID: PMC2504784.
      Citations: 52     Fields:    Translation:AnimalsCells
    79. Cirillo LA, Barton MC. Many forkheads in the road to regulation. Symposium on forkhead transcription factor networks in development, signalling and disease. EMBO Rep. 2008 Aug; 9(8):721-4. PMID: 18617889; PMCID: PMC2515216.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    80. Tsai WW, Nguyen TT, Shi Y, Barton MC. p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol. 2008 Sep; 28(17):5139-46. PMID: 18573881; PMCID: PMC2519740.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    81. Qian J, Sarnaik AA, Bonney TM, Keirsey J, Combs KA, Steigerwald K, Acharya S, Behbehani GK, Barton MC, Lowy AM, Groden J. The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus. Gastroenterology. 2008 Jul; 135(1):152-62. PMID: 18474248; PMCID: PMC2832605.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    82. Wilkinson DS, Tsai WW, Schumacher MA, Barton MC. Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol Cell Biol. 2008 Mar; 28(6):1988-98. PMID: 18212064; PMCID: PMC2268392.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    83. Johnson AB, Denko N, Barton MC. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat Res. 2008 Apr 02; 640(1-2):174-9. PMID: 18294659; PMCID: PMC2346607.
      Citations: 109     Fields:    Translation:AnimalsCells
    84. Qian J, Steigerwald K, Combs KA, Barton MC, Groden J. Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis. Oncogene. 2007 Jul 19; 26(33):4872-6. PMID: 17297457.
      Citations: 9     Fields:    Translation:HumansCells
    85. Johnson AB, Barton MC. Hypoxia-induced and stress-specific changes in chromatin structure and function. Mutat Res. 2007 May 01; 618(1-2):149-62. PMID: 17292925; PMCID: PMC1924842.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    86. Chen L, Firozi P, Barton M, Templeton NS. Widespread, exceptionally high levels of histone H3 lysine 4 trimethylation largely mediate "privileged" gene expression. Gene Expr. 2007; 13(4-5):271-82. PMID: 17605300; PMCID: PMC6032458.
      Citations: 4     Fields:    Translation:HumansCells
    87. Barton MC, Akli S, Keyomarsi K. Deregulation of cyclin E meets dysfunction in p53: closing the escape hatch on breast cancer. J Cell Physiol. 2006 Dec; 209(3):686-94. PMID: 17001684.
      Citations: 7     Fields:    Translation:HumansAnimals
    88. Barton MC. Influences along the path to maturity: regulation of cellular levels of RNA. Biochim Biophys Acta. 2006 Aug-Sep; 1759(8-9):385-7. PMID: 17007943.
      Citations:    Fields:    Translation:Cells
    89. Lu X, Zhang N, Vasquez K, Barton M, Legerski R. Repair of psoralen interstrand cross-links in Xenopus laevis egg extracts is highly mutagenic. Biochem Biophys Res Commun. 2005 Oct 14; 336(1):69-75. PMID: 16125670.
      Citations: 6     Fields:    Translation:AnimalsCells
    90. Cui R, Nguyen TT, Taube JH, Stratton SA, Feuerman MH, Barton MC. Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription. J Biol Chem. 2005 Nov 25; 280(47):39152-60. PMID: 16203738.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    91. Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD. Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. Dev Cell. 2005 Jun; 8(6):843-54. PMID: 15935774.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    92. Nguyen TT, Cho K, Stratton SA, Barton MC. Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene. Mol Cell Biol. 2005 Mar; 25(6):2147-57. PMID: 15743813; PMCID: PMC1061614.
      Citations: 32     Fields:    Translation:AnimalsCells
    93. Wilkinson DS, Ogden SK, Stratton SA, Piechan JL, Nguyen TT, Smulian GA, Barton MC. A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol Cell Biol. 2005 Feb; 25(3):1200-12. PMID: 15657445; PMCID: PMC544019.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    94. Steigerwald K, Behbehani GK, Combs KA, Barton MC, Groden J. The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Mol Cancer Res. 2005 Feb; 3(2):78-89. PMID: 15755874.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    95. Denko N, Wernke-Dollries K, Johnson AB, Hammond E, Chiang CM, Barton MC. Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. J Biol Chem. 2003 Feb 21; 278(8):5744-9. PMID: 12477712.
      Citations: 18     Fields:    Translation:HumansCells
    96. Barton MC, Stivers DN. Microarray analysis of hepatic-regulated gene expression: specific applications and nonspecific problems. Hepatology. 2002 Mar; 35(3):727-9. PMID: 11870392.
      Citations: 2     Fields:    Translation:Humans
    97. Barton MC, Crowe AJ. Chromatin alteration, transcription and replication: What's the opening line to the story? Oncogene. 2001 May 28; 20(24):3094-9. PMID: 11420725.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    98. Ogden SK, Lee KC, Barton MC. Hepatitis B viral transactivator HBx alleviates p53-mediated repression of alpha-fetoprotein gene expression. J Biol Chem. 2000 Sep 08; 275(36):27806-14. PMID: 10842185.
      Citations: 20     Fields:    Translation:HumansCells
    99. Crowe AJ, Piechan JL, Sang L, Barton MC. S-Phase progression mediates activation of a silenced gene in synthetic nuclei. Mol Cell Biol. 2000 Jun; 20(11):4169-80. PMID: 10805758; PMCID: PMC85786.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    100. Kroll SL, Paulding WR, Schnell PO, Barton MC, Conaway JW, Conaway RC, Czyzyk-Krzeska MF. von Hippel-Lindau protein induces hypoxia-regulated arrest of tyrosine hydroxylase transcript elongation in pheochromocytoma cells. J Biol Chem. 1999 Oct 15; 274(42):30109-14. PMID: 10514498.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    101. Crowe AJ, Sang L, Li KK, Lee KC, Spear BT, Barton MC. Hepatocyte nuclear factor 3 relieves chromatin-mediated repression of the alpha-fetoprotein gene. J Biol Chem. 1999 Aug 27; 274(35):25113-20. PMID: 10455192.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    102. Crowe AJ, Barton MC. Functional analysis of chromatin assembled in synthetic nuclei. Methods. 1999 Feb; 17(2):173-87. PMID: 10075895.
      Citations: 4     Fields:    Translation:AnimalsCells
    103. Lee KC, Crowe AJ, Barton MC. p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding. Mol Cell Biol. 1999 Feb; 19(2):1279-88. PMID: 9891062; PMCID: PMC116057.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    104. Crowe AJ, Barton MC. In vitro reconstitution of nuclei for replication and transcription. Methods Enzymol. 1999; 304:63-76. PMID: 10372356.
      Citations: 4     Fields:    Translation:AnimalsCells
    105. Denko N, Langland R, Barton M, Lieberman MA. Uncoupling of S-phase and mitosis by recombinant cytotoxic necrotizing factor 2 (CNF2). Exp Cell Res. 1997 Jul 10; 234(1):132-8. PMID: 9223378.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    106. Barton MC, Madani N, Emerson BM. Distal enhancer regulation by promoter derepression in topologically constrained DNA in vitro. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7257-62. PMID: 9207078; PMCID: PMC23808.
      Citations: 10     Fields:    Translation:AnimalsCells
    107. Barton MC, Emerson BM. Regulated expression of the beta-globin gene locus in synthetic nuclei. Genes Dev. 1994 Oct 15; 8(20):2453-65. PMID: 7958909.
      Citations: 20     Fields:    Translation:AnimalsCells
    108. Barton MC, Madani N, Emerson BM. The erythroid protein cGATA-1 functions with a stage-specific factor to activate transcription of chromatin-assembled beta-globin genes. Genes Dev. 1993 Sep; 7(9):1796-809. PMID: 8370527.
      Citations: 21     Fields:    Translation:AnimalsCells
    109. Shapiro DJ, Barton MC, McKearin DM, Chang TC, Lew D, Blume J, Nielsen DA, Gould L. Estrogen regulation of gene transcription and mRNA stability. Recent Prog Horm Res. 1989; 45:29-58; discussion 58-64. PMID: 2682843.
      Citations: 7     Fields:    Translation:AnimalsCells
    110. Barton MC, Shapiro DJ. Transient administration of estradiol-17 beta establishes an autoregulatory loop permanently inducing estrogen receptor mRNA. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7119-23. PMID: 3174624; PMCID: PMC282135.
      Citations: 12     Fields:    Translation:AnimalsCells
    111. McKearin DM, Barton MC, Keller MJ, Shapiro DJ. Estrogen induces transcription of the Xenopus laevis serum retinol-binding protein gene. J Biol Chem. 1987 Apr 15; 262(11):4939-42. PMID: 3558378.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    112. Hayward MA, Barton MC, Shapiro DJ. Coordinate estrogen induction of vitellogenin and a small serum protein mRNA in Xenopus laevis liver. Mol Cell Endocrinol. 1985 Feb; 39(2):91-8. PMID: 3838520.
      Citations: 1     Fields:    Translation:AnimalsCells
    113. Keller GA, Barton MC, Shapiro DJ, Singer SJ. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells. Proc Natl Acad Sci U S A. 1985 Feb; 82(3):770-4. PMID: 3883347; PMCID: PMC397128.
      Citations: 31     Fields:    Translation:AnimalsCells
    114. Clark RE, Martin GG, Barton MC, Shapiro DJ. Production and characterization of monoclonal antibodies to rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A. 1982 Jun; 79(12):3734-8. PMID: 6954516; PMCID: PMC346501.
      Citations: 4     Fields:    Translation:AnimalsCells
    115. Regulation of gene expression in human cancers by TRIM24. Drug Discovery Today: Technologies. 19:57-63.
    116. Editorial. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 618:1-2.
    117. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. Journal of Medicinal Chemistry. 59:1440-1454.
    118. Erratum. Developmental Cell. 9:305.
    119. Tissue-specific metabolism and TRIM24. Aging. 7:736-737.
    120. TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene.
    121. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro-Oncology. 17:1463-1473.
    122. An optional laboratory in molecular techniques as an aid in the teaching of medical biochemistry. Biochemical Education. 27:150-152.
    123. Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery. Epigenetics and Chromatin. 8.
    124. Cancer. Nature. 538:45-46.
    125. Bromodomain Histone Readers and Cancer. Journal of Molecular Biology.
    126. Outside the p53 RING. Molecular Cell. 62:805-807.
    127. p53. 364-373.
    128. MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1. Stem Cells. 34:1284-1296.
    129. Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells. Nucleic Acids Research. 42:205-223.
    130. LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56. Molecular Cell. 64:967-981.
    131. Dual roles of RNF2 in melanoma progression. Cancer Discovery. 5:1314-1327.
    132. An essential role for UTX in resolution and activation of bivalent promoters. Nucleic Acids Research. 44:3659-3674.
    133. TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation. Oncogene.
    134. Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells. Epigenetics. 10:1006-1013.
    135. Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer. Tumor Biology. 1-10.
    136. TRIM-ing Ligand Dependence in Castration-Resistant Prostate Cancer. Cancer Cell. 29:776-778.
    137. P53. 345-357.
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