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HWU, PATRICK

One or more keywords matched the following items that are connected to HWU, PATRICK

Item Type	Name
Academic Article	Antitumor T-cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40.
Academic Article	Lovastatin inhibits T-cell proliferation while preserving the cytolytic function of EBV, CMV, and MART-1-specific CTLs.
Concept	Antigens, Differentiation, T-Lymphocyte
Concept	Lymphocytes
Concept	T-Lymphocytes, Cytotoxic
Concept	Lymphocyte Function-Associated Antigen-1
Concept	T-Lymphocytes, Helper-Inducer
Concept	Lymphocyte Activation
Concept	Lymphocyte Depletion
Concept	CD8-Positive T-Lymphocytes
Concept	Lymphocyte Count
Concept	B-Lymphocyte Subsets
Concept	T-Lymphocytes, Regulatory
Concept	CD4-Positive T-Lymphocytes
Concept	B-Lymphocytes
Concept	T-Lymphocyte Subsets
Concept	Epitopes, T-Lymphocyte
Concept	Lymphocytes, Tumor-Infiltrating
Concept	Lymphocyte Subsets
Concept	T-Lymphocytes
Concept	Lymphocyte Culture Test, Mixed
Concept	Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Concept	Lymphocyte Transfusion
Academic Article	Altered decamer and nonamer from an HLA-A0201-restricted epitope of Survivin differentially stimulate T-cell responses in different individuals.
Academic Article	Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice.
Academic Article	IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity.
Academic Article	Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy.
Academic Article	Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation.
Academic Article	Recognition of human colon cancer by T cells transduced with a chimeric receptor gene.
Academic Article	Human dendritic cells require multiple activation signals for the efficient generation of tumor antigen-specific T lymphocytes.
Academic Article	The immunotherapy of patients with ovarian cancer.
Academic Article	A phase I study of nonmyeloablative chemotherapy and adoptive transfer of autologous tumor antigen-specific T lymphocytes in patients with metastatic melanoma.
Academic Article	Recombinant fowlpox viruses encoding the anchor-modified gp100 melanoma antigen can generate antitumor immune responses in patients with metastatic melanoma.
Academic Article	Correspondence re R. Lapointe et al., CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells. Cancer Res 2003;63:2836-43.
Academic Article	Presentation of tumor antigens by dendritic cells genetically modified with viral and nonviral vectors.
Academic Article	IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells.
Academic Article	IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response.
Academic Article	Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients.
Academic Article	BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.
Academic Article	Minicircle DNA is superior to plasmid DNA in eliciting antigen-specific CD8+ T-cell responses.
Academic Article	In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes.
Academic Article	The use of gene-modified tumor-infiltrating lymphocytes for cancer therapy.
Academic Article	Upregulation of tumor necrosis factor-alpha production by retrovirally transduced human tumor-infiltrating lymphocytes using trans-retinoic acid.
Academic Article	The development of gene therapy for the treatment of cancer.
Academic Article	Functional and molecular characterization of tumor-infiltrating lymphocytes transduced with tumor necrosis factor-alpha cDNA for the gene therapy of cancer in humans.
Academic Article	Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases.
Academic Article	Impact of cytokine administration on the generation of antitumor reactivity in patients with metastatic melanoma receiving a peptide vaccine.
Academic Article	CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral reservoir.
Academic Article	Efficient gene transfer to human peripheral blood monocyte-derived dendritic cells using human immunodeficiency virus type 1-based lentiviral vectors.
Academic Article	Cell transfer therapy for cancer: lessons from sequential treatments of a patient with metastatic melanoma.
Academic Article	Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo.
Academic Article	Intralymphatic dendritic cell vaccination induces tumor antigen-specific, skin-homing T lymphocytes.
Academic Article	A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer.
Academic Article	Plasmacytoid dendritic cells synergize with myeloid dendritic cells in the induction of antigen-specific antitumor immune responses.
Academic Article	Antitumor activity of dual-specific T cells and influenza virus.
Academic Article	Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.
Academic Article	T helper 17 cells promote cytotoxic T cell activation in tumor immunity.
Academic Article	TGF-beta1 induces preferential rapid expansion and persistence of tumor antigen-specific CD8+ T cells for adoptive immunotherapy.
Academic Article	2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1.
Academic Article	Immunotherapy of melanoma: an update.
Academic Article	White paper on adoptive cell therapy for cancer with tumor-infiltrating lymphocytes: a report of the CTEP subcommittee on adoptive cell therapy.
Academic Article	Induction of TLR4-dependent CD8+ T cell immunity by murine ?-defensin2 fusion protein vaccines.
Academic Article	Antitumor activity mediated by CpG: the route of administration is critical.
Academic Article	Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function.
Academic Article	Impact of clinical and pathologic features on tumor-infiltrating lymphocyte expansion from surgically excised melanoma metastases for adoptive T-cell therapy.
Academic Article	BRAF(V600) inhibitor GSK2118436 targeted inhibition of mutant BRAF in cancer patients does not impair overall immune competency.
Academic Article	PD-1 blockade enhances T-cell migration to tumors by elevating IFN-? inducible chemokines.
Academic Article	Advances in the development of cancer immunotherapies.
Academic Article	Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy.
Academic Article	Persistent antigen at vaccination sites induces tumor-specific CD8? T cell sequestration, dysfunction and deletion.
Academic Article	Chemical castration of melanoma patients does not increase the frequency of tumor-specific CD4 and CD8 T cells after peptide vaccination.
Academic Article	Use of soluble recombinant TNF receptor to improve detection of TNF secretion in cultures of tumor infiltrating lymphocytes.
Academic Article	Interleukin-2-transduced lymphocytes grow in an autocrine fashion and remain responsive to antigen.
Academic Article	The genetic modification of T cells for cancer therapy: an overview of laboratory and clinical trials.
Academic Article	Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.
Academic Article	Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope.
Academic Article	Retroviral transduction of human dendritic cells with a tumor-associated antigen gene.
Academic Article	Current challenges in cancer gene therapy.
Academic Article	A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-gamma chain chimeric receptor gene recognizing a human ovarian cancer antigen.
Academic Article	Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation.
Academic Article	CD40 ligand and lipopolysaccharide enhance the in vitro generation of melanoma-reactive T-cells.
Academic Article	CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells.
Academic Article	Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma.
Academic Article	Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6.
Academic Article	Improving antitumor immune responses by circumventing immunoregulatory cells and mechanisms.
Academic Article	Immunization against MUC18/MCAM, a novel antigen that drives melanoma invasion and metastasis.
Academic Article	Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells.
Academic Article	Less yin, more yang: confronting the barriers to cancer immunotherapy.
Academic Article	Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses.
Academic Article	Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells.
Academic Article	Detection and characterization of a novel subset of CD8?CD57? T cells in metastatic melanoma with an incompletely differentiated phenotype.
Academic Article	Agonistic antibody to CD40 boosts the antitumor activity of adoptively transferred T cells in vivo.
Academic Article	Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: current status and future outlook.
Academic Article	Advances in the treatment of metastatic melanoma: adoptive T-cell therapy.
Academic Article	A new approach to simultaneously quantify both TCR a- and ?-chain diversity after adoptive immunotherapy.
Academic Article	Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma.
Academic Article	Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy.
Academic Article	Adoptive transfer of cloned melanoma-reactive T lymphocytes for the treatment of patients with metastatic melanoma.
Academic Article	Increased functional expression of transgene in primary human lymphocytes using retroviral vectors modified with IRES and splicing motifs.
Academic Article	Expression of a "self-"antigen by human tumor cells enhances tumor antigen-specific CD4(+) T-cell function.
Academic Article	Immunization of patients with metastatic melanoma using both class I- and class II-restricted peptides from melanoma-associated antigens.
Academic Article	A novel strategy for rapid and efficient isolation of human tumor-specific CD4(+) and CD8(+) T-cell clones.
Academic Article	Summary of the primer on tumor immunology and the biological therapy of cancer.
Academic Article	MART-1-specific melanoma tumor-infiltrating lymphocytes maintaining CD28 expression have improved survival and expansion capability following antigenic restimulation in vitro.
Academic Article	The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity.
Academic Article	Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity.
Academic Article	Expansion and characterization of T cells transduced with a chimeric receptor against ovarian cancer.
Academic Article	Generation of gene-modified T cells reactive against the angiogenic kinase insert domain-containing receptor (KDR) found on tumor vasculature.
Academic Article	In vivo antitumor activity of interleukin 21 mediated by natural killer cells.
Academic Article	Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer.
Academic Article	IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients.
Academic Article	Tumor-infiltrating lymphocyte therapy for melanoma: rationale and issues for further clinical development.
Academic Article	Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation.
Academic Article	Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma.
Academic Article	Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy.
Academic Article	BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma.
Academic Article	Intrathecal Administration of Tumor-Infiltrating Lymphocytes Is Well Tolerated in a Patient with Leptomeningeal Disease from Metastatic Melanoma: A Case Report.
Academic Article	Novel Treatments in Development for Melanoma.
Academic Article	STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.
Academic Article	Molecular basis of antibody binding to mucin glycopeptides in lung cancer.
Academic Article	Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.
Academic Article	The beneficial effects of a gas-permeable flask for expansion of Tumor-Infiltrating lymphocytes as reflected in their mitochondrial function and respiration capacity
Academic Article	Defective STAT1 activation associated with impaired IFN-Î· production in NK and T lymphocytes from metastatic melanoma patients treated with IL-2
Academic Article	Intrathecal Administration of Tumor-Infiltrating Lymphocytes Is Well Tolerated in a Patient with Leptomeningeal Disease from Metastatic Melanoma
Academic Article	BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties
Academic Article	The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy.
Academic Article	Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain.
Academic Article	The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression.
Academic Article	HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes.
Academic Article	Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.
Academic Article	BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties.
Academic Article	Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma.
Academic Article	Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade.
Academic Article	Defective STAT1 activation associated with impaired IFN-? production in NK and T lymphocytes from metastatic melanoma patients treated with IL-2.
Academic Article	The beneficial effects of a gas-permeable flask for expansion of Tumor-Infiltrating lymphocytes as reflected in their mitochondrial function and respiration capacity.
Academic Article	Complementing T-cell Function: An Inhibitory Role of the Complement System in T-cell-Mediated Antitumor Immunity.
Academic Article	Loss of IFN-? Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.
Academic Article	Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy.
Academic Article	Metastatic Melanoma Patient Had a Complete Response with Clonal Expansion after Whole Brain Radiation and PD-1 Blockade.
Academic Article	CpG-based immunotherapy impairs antitumor activity of BRAF inhibitors in a B-cell-dependent manner.
Academic Article	IL2 Variant Circumvents ICOS+ Regulatory T-cell Expansion and Promotes NK Cell Activation.
Academic Article	Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.
Academic Article	Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells.
Academic Article	Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma.
Academic Article	Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases.
Academic Article	4-1BB Agonist Focuses CD8+ Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer.
Academic Article	Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.
Academic Article	Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function.
Academic Article	A Novel Method to Generate and Expand Clinical-Grade, Genetically Modified, Tumor-Infiltrating Lymphocytes.
Academic Article	SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity.
Academic Article	Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter.
Academic Article	T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors.
Academic Article	Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome.
Academic Article	Utilizing T-cell Activation Signals 1, 2, and 3 for Tumor-infiltrating Lymphocytes (TIL) Expansion: The Advantage Over the Sole Use of Interleukin-2 in Cutaneous and Uveal Melanoma.
Academic Article	RNA editing derived epitopes function as cancer antigens to elicit immune responses.
Academic Article	Radiation Followed by OX40 Stimulation Drives Local and Abscopal Antitumor Effects in an Anti-PD1-Resistant Lung Tumor Model.
Academic Article	A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.
Academic Article	Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases.
Academic Article	A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2R??-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors.
Academic Article	Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3K? Inhibition in PTEN Loss Melanoma.
Academic Article	Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature.
Academic Article	Potential clinical application of tumor-infiltrating lymphocyte therapy for ovarian epithelial cancer prior or post-resistance to chemotherapy.
Academic Article	B cells and tertiary lymphoid structures promote immunotherapy response.
Academic Article	Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy.
Academic Article	Comprehensive T cell repertoire characterization of non-small cell lung cancer.
Academic Article	18F-fluorodeoxyglucose positron emission tomography correlates with tumor immunometabolic phenotypes in resected lung cancer.
Academic Article	Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02).
Academic Article	Bone morphogenetic protein 7 promotes resistance to immunotherapy.
Academic Article	Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers.
Academic Article	Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity.
Academic Article	Applications of CRISPR Genome Editing to Advance the Next Generation of Adoptive Cell Therapies for Cancer.
Academic Article	Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators.
Academic Article	Designed improvement to T-cell immunotherapy by multidimensional single cell profiling.
Academic Article	Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma.
Academic Article	Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response.
Academic Article	Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma.
Academic Article	Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy.
Academic Article	LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade.
Academic Article	CRISPR-mediated TGFBR2 knockout renders human ovarian cancer tumor-infiltrating lymphocytes resistant to TGF-? signaling.
Academic Article	Spatial PD-L1, immune-cell microenvironment, and genomic copy-number alteration patterns and drivers of invasive-disease transition in prospective oral precancer cohort.
Academic Article	Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer.
Academic Article	A novel retinoic acid receptor-? agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment.
Academic Article	Efficacy and safety of autologous tumor-infiltrating lymphocytes in recurrent or refractory ovarian cancer, colorectal cancer, and pancreatic ductal adenocarcinoma.

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Lymphocytes