Item Type | Name |
Academic Article
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Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells.
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Academic Article
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A multicenter phase II study of tgDCC-E1A for the intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma.
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Academic Article
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beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma.
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Academic Article
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Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
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Academic Article
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External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator.
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Academic Article
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Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.
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Academic Article
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Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy.
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Academic Article
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Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer.
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Academic Article
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Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.
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Academic Article
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Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin.
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Academic Article
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Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer.
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Academic Article
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Expanding the arsenal: metformin for the treatment of triple-negative breast cancer?
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Academic Article
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SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.
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Academic Article
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14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival.
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Academic Article
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Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation.
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Academic Article
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Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer.
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Concept
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Biliary Tract Neoplasms
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Concept
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Mammary Neoplasms, Experimental
|
Concept
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Tumor Burden
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Concept
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Esophageal Neoplasms
|
Concept
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Brain Neoplasms
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Concept
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Lung Neoplasms
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Concept
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Rectal Neoplasms
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Concept
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Tumor Suppressor Protein p14ARF
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Concept
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Tumor Suppressor Protein p53
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Concept
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Prostatic Neoplasms
|
Concept
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Neoplasm Metastasis
|
Concept
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Genes, Tumor Suppressor
|
Concept
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Mammary Neoplasms, Animal
|
Concept
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Biomarkers, Tumor
|
Concept
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Antigens, Neoplasm
|
Concept
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Ovarian Neoplasms
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Concept
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Nasopharyngeal Neoplasms
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Concept
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DNA, Neoplasm
|
Concept
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Receptors, Tumor Necrosis Factor, Type I
|
Concept
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Prostatic Intraepithelial Neoplasia
|
Concept
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Neoplasms, Experimental
|
Concept
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Colorectal Neoplasms
|
Concept
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Pancreatic Neoplasms
|
Concept
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Neoplasm Proteins
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Concept
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Neoplasm Staging
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Concept
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Tumor Escape
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Concept
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Kidney Neoplasms
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Concept
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Drug Resistance, Neoplasm
|
Concept
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Neoplasm Transplantation
|
Concept
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Mouth Neoplasms
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Concept
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Breast Neoplasms
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Concept
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Bone Neoplasms
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Concept
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Tumor Stem Cell Assay
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Concept
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Tumor Cells, Cultured
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Concept
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Head and Neck Neoplasms
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Concept
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Lymphocytes, Tumor-Infiltrating
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Concept
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Oropharyngeal Neoplasms
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Concept
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Neoplasms, Hormone-Dependent
|
Concept
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Tumor Necrosis Factor-alpha
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Concept
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Von Hippel-Lindau Tumor Suppressor Protein
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Concept
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Neoplasms
|
Concept
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Skin Neoplasms
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Concept
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Receptors, Tumor Necrosis Factor
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Concept
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Retinal Neoplasms
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Concept
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Colonic Neoplasms
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Concept
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Cell Line, Tumor
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Concept
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Tumor Suppressor Proteins
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Concept
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Neoplasm Recurrence, Local
|
Concept
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RNA, Neoplasm
|
Concept
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Liver Neoplasms
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Concept
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Uterine Cervical Neoplasms
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Concept
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Soft Tissue Neoplasms
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Concept
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Liver Neoplasms, Experimental
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Concept
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Neoplasm Invasiveness
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Academic Article
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IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway.
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Academic Article
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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
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Academic Article
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Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer.
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Academic Article
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Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol.
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Academic Article
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RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus.
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Academic Article
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Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation.
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Academic Article
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Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells.
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Academic Article
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Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.
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Academic Article
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Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells.
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Academic Article
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EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors.
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Academic Article
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APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.
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Academic Article
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TRIM24 links a non-canonical histone signature to breast cancer.
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Academic Article
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A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer.
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Academic Article
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Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis.
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Academic Article
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The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis.
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Academic Article
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Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-?-dependent cancer metastasis.
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Academic Article
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miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion.
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Academic Article
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Molecular mechanisms in Barrett's metaplasia and its progression.
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Academic Article
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Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.
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Academic Article
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Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties.
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Academic Article
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Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer.
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Academic Article
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ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1.
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Academic Article
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Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.
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Academic Article
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Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer.
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Academic Article
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lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
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Academic Article
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14-3-3? turns TGF-?'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
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Academic Article
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Length of the linking domain of human pro-tumor necrosis factor determines the cleavage processing.
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Academic Article
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Inhibition of intratracheal lung cancer development by systemic delivery of E1A.
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Academic Article
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Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo.
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Academic Article
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High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma.
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Academic Article
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Systemic tumor suppression by the proapoptotic gene bik.
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Academic Article
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HER2/neu in the management of invasive breast cancer.
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Academic Article
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Strategies to target HER2/neu overexpression for cancer therapy.
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Academic Article
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Dysregulation of cellular signaling by HER2/neu in breast cancer.
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Academic Article
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Determinants of rapamycin sensitivity in breast cancer cells.
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Academic Article
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A delayed chemically induced tumorigenesis in Brca2 mutant mice.
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Academic Article
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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
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Academic Article
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Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.
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Academic Article
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Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
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Academic Article
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Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.
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Academic Article
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Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis.
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Academic Article
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Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant.
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Academic Article
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EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization.
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Academic Article
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Cytoplasmic/nuclear shuttling and tumor progression.
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Academic Article
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AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model.
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Academic Article
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The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells.
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Academic Article
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Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer.
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Academic Article
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MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation.
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Academic Article
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Clinical biology of esophageal adenocarcinoma after surgery is influenced by nuclear factor-kappaB expression.
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Academic Article
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Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition.
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Academic Article
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Kr?ppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.
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Academic Article
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Breast cancer brain metastases.
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Academic Article
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Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
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Academic Article
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GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
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Academic Article
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IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance.
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Academic Article
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Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice.
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Academic Article
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A new fork for clinical application: targeting forkhead transcription factors in cancer.
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Academic Article
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Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
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Academic Article
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Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation.
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Academic Article
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Molecular predictors of response to trastuzumab and lapatinib in breast cancer.
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Academic Article
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Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents.
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Academic Article
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Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein?
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Academic Article
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COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport.
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Academic Article
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Vimentin is a novel AKT1 target mediating motility and invasion.
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Academic Article
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The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus.
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Academic Article
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Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumab.
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Academic Article
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BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment.
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Academic Article
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Identification of a GaG??, AKT and PKCa signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition.
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Academic Article
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Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer.
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Academic Article
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In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.
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Academic Article
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Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells.
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Academic Article
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Signaling cross-talk in the resistance to HER family receptor targeted therapy.
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Academic Article
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Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.
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Academic Article
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RASAL2: wrestling in the combat of Ras activation.
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Academic Article
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miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression.
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Academic Article
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Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.
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Academic Article
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Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms.
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Academic Article
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Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol.
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Academic Article
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Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties.
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Academic Article
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Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis.
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Academic Article
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Expression profile of tyrosine kinases in breast cancer.
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Academic Article
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Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.
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Academic Article
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Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis.
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Academic Article
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Adenovirus type 5 E1A sensitizes hepatocellular carcinoma cells to gemcitabine.
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Academic Article
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Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway.
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Academic Article
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The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells.
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Academic Article
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A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells.
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Academic Article
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Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.
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Academic Article
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HER-2/Neu signaling and therapeutic approaches in breast cancer.
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Academic Article
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Significant differences in nipple aspirate fluid protein expression between healthy women and those with breast cancer demonstrated by time-of-flight mass spectrometry.
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Academic Article
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Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
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Academic Article
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Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth.
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Academic Article
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Signaling intricacies take center stage in cancer cells.
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Academic Article
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E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation.
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Academic Article
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When all colonies are blue.
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Academic Article
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Cancer-specific gene therapy.
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Academic Article
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Improved peak detection and quantification of mass spectrometry data acquired from surface-enhanced laser desorption and ionization by denoising spectra with the undecimated discrete wavelet transform.
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Academic Article
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Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells.
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Academic Article
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An attenuated Salmonella oral DNA vaccine prevents the growth of hepatocellular carcinoma and colon cancer that express alpha-fetoprotein.
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Academic Article
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Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model.
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Academic Article
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Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death.
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Academic Article
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Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
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Academic Article
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ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.
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Academic Article
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Novel approaches for chemosensitization of breast cancer cells: the E1A story.
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Academic Article
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Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma.
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Academic Article
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Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells.
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Academic Article
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Advances in targeting IKK and IKK-related kinases for cancer therapy.
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Academic Article
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Induction of Akt activity by chemotherapy confers acquired resistance.
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Academic Article
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The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.
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Academic Article
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EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation.
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Academic Article
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A novel hTERT promoter-driven E1A therapeutic for ovarian cancer.
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Academic Article
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KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
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Academic Article
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Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer.
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Academic Article
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Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.
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Academic Article
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CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.
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Academic Article
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Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.
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Academic Article
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Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase.
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Academic Article
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Hepatitis B virus X protein induces IKKa nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells.
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Academic Article
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Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycin.
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Academic Article
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Mesenchymal stem cells promote formation of colorectal tumors in mice.
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Academic Article
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Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients.
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Academic Article
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CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.
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Academic Article
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FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization.
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Academic Article
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RAC1 activation mediates Twist1-induced cancer cell migration.
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Academic Article
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The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells.
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Academic Article
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Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776.
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Academic Article
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Targeting the IKK?/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer.
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Academic Article
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On mammary gland growth factors: roles in normal development and in cancer.
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Academic Article
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Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis.
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Academic Article
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Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells.
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Academic Article
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Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.
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Academic Article
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Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis.
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Academic Article
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Deubiquitylation and stabilization of PTEN by USP13.
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Academic Article
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Epigenetic regulation of the miR142-3p/interleukin-6 circuit in glioblastoma.
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Academic Article
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Block-Cell-Printing for live single-cell printing.
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Academic Article
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MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis.
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Academic Article
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Human pro-tumor necrosis factor is a homotrimer.
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Academic Article
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Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains.
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Academic Article
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Mapping of adenovirus 5 E1A domains responsible for suppression of neu-mediated transformation via transcriptional repression of neu.
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Academic Article
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Safety study and characterization of E1A-liposome complex gene-delivery protocol in an ovarian cancer model.
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Academic Article
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Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202.
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Academic Article
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Chemo-signal therapy, an emerging new approach to modify drug resistance in breast cancer.
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Academic Article
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Adenovirus-mediated N5 gene transfer inhibits tumor cell proliferation by induction of apoptosis.
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Academic Article
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Overexpression of ErbB2 in cancer and ErbB2-targeting strategies.
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Academic Article
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E1A is an oncogene and may immortalize normal cells, especially in combination with other oncoproteins.
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Academic Article
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The adenoviral E1A induces p21WAF1/CIP1 expression in cancer cells.
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Academic Article
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Prostate-specific antitumor activity by probasin promoter-directed p202 expression.
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Academic Article
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Quality control and peak finding for proteomics data collected from nipple aspirate fluid by surface-enhanced laser desorption and ionization.
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Academic Article
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STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis.
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Academic Article
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Delivery of DNA to tumor cells using cationic liposomes.
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Academic Article
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Enhanced paclitaxel cytotoxicity and prolonged animal survival rate by a nonviral-mediated systemic delivery of E1A gene in orthotopic xenograft human breast cancer.
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Academic Article
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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.
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Academic Article
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Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53.
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Academic Article
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Finding the bEST routes to cancer.
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Academic Article
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Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.
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Academic Article
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Inefficient proteasomal-degradation pathway stabilizes AP-2alpha and activates HER-2/neu gene in breast cancer.
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Academic Article
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Bcl-2 antisense oligonucleotide overcomes resistance to E1A gene therapy in a low HER2-expressing ovarian cancer xenograft model.
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Academic Article
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Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.
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Academic Article
|
Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells.
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Academic Article
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Role of IkappaB kinase in tumorigenesis.
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Academic Article
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Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1.
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Academic Article
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Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer.
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Academic Article
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Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.
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Academic Article
|
Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy.
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Academic Article
|
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization.
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Academic Article
|
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.
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Academic Article
|
Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.
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Academic Article
|
Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents.
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Academic Article
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A new mutational AKTivation in the PI3K pathway.
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Academic Article
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Rapamycin regulates the phosphorylation of rictor.
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Academic Article
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Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
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Academic Article
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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
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Academic Article
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Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer.
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Academic Article
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Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.
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Academic Article
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Regulation of breast cancer metastasis by atypical chemokine receptors.
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Academic Article
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Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation.
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Academic Article
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14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.
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Academic Article
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Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues.
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Academic Article
|
Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.
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Academic Article
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Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies.
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Academic Article
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Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.
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Academic Article
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Downregulation of microRNA miR-520h by E1A contributes to anticancer activity.
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Academic Article
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Regulation of tumor angiogenesis by EZH2.
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Academic Article
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Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer.
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Academic Article
|
Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis.
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Academic Article
|
EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-?-catenin signaling.
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Academic Article
|
CARMA3 is crucial for EGFR-Induced activation of NF-?B and tumor progression.
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Academic Article
|
Protein localization in disease and therapy.
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Academic Article
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IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression.
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Academic Article
|
Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.
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Academic Article
|
The crosstalk of mTOR/S6K1 and Hedgehog pathways.
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Academic Article
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Targeted expression of BikDD eliminates breast cancer with virtually no toxicity in noninvasive imaging models.
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Academic Article
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Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.
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Academic Article
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Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion.
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Academic Article
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Dysregulation of microRNAs in cancer.
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Academic Article
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Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
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Academic Article
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Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides.
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Academic Article
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EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
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Academic Article
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Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.
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Academic Article
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Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis.
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Academic Article
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Characterization of BRCA2: temperature sensitivity of detection and cell-cycle regulated expression.
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Academic Article
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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
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Academic Article
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HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.
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Academic Article
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Transcriptional upregulation and activation of p55Cdc via p34(cdc2) in Taxol-induced apoptosis.
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Academic Article
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The NH(2)-terminal and conserved region 2 domains of adenovirus E1A mediate two distinct mechanisms of tumor suppression.
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Academic Article
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Localizing the EGF receptor.
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Academic Article
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Inhibition of cancer cell growth by BRCA2.
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Academic Article
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Enhancement of Bik antitumor effect by Bik mutants.
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Academic Article
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Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast.
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Academic Article
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P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells.
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Academic Article
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Cancer-specific activation of the survivin promoter and its potential use in gene therapy.
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Academic Article
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Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.
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Academic Article
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Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
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Academic Article
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Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model.
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Academic Article
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Characterization of a novel tripartite nuclear localization sequence in the EGFR family.
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Academic Article
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All roads lead to mTOR: integrating inflammation and tumor angiogenesis.
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Academic Article
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Survival of cancer cells is maintained by EGFR independent of its kinase activity.
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Academic Article
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Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
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Academic Article
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Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity.
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Academic Article
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p53 acetylation is crucial for its transcription-independent proapoptotic functions.
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Academic Article
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ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells.
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Academic Article
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Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors.
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Academic Article
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ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
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Academic Article
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Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
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Academic Article
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Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
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Academic Article
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Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent.
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Academic Article
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Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells.
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Academic Article
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Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors.
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Academic Article
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Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth.
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Academic Article
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Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer.
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Academic Article
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p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.
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Academic Article
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Deciphering the role of forkhead transcription factors in cancer therapy.
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Academic Article
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The role of EZH2 in tumour progression.
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Academic Article
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Epithelial-mesenchymal transition induced by TNF-a requires NF-?B-mediated transcriptional upregulation of Twist1.
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Academic Article
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KrasG12D-induced IKK2/?/NF-?B activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.
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Academic Article
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Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2.
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Academic Article
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LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker.
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Academic Article
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Beyond NF-?B activation: nuclear functions of I?B kinase a.
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Academic Article
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TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase.
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Academic Article
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KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.
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Academic Article
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EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.
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Academic Article
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Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu.
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Academic Article
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Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells.
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Academic Article
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Association between ductal fluid proteomic expression profiles and the presence of lymph node metastases in women with breast cancer.
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Academic Article
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A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.
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Academic Article
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Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1.
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Academic Article
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TNFalpha induces HIF-1alpha expression through activation of IKKbeta.
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Academic Article
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CXCR4 expression in early breast cancer and risk of distant recurrence.
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Academic Article
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The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.
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Academic Article
|
Emerging molecular targets in esophageal cancers.
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Academic Article
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The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines.
|
Academic Article
|
Complex regulation of the adenovirus e2 promoter by the viral oncoproteins e1a and e7 and tumor-suppressor rb.
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Academic Article
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Mechanisms of deregulated her2/neu expression in breast-cancer cell-lines.
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Academic Article
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Her2 Neu overexpression counteracts the growth effects of C-myc in breast-cancer cells.
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Academic Article
|
Growth suppression of low HER-2/neu-expressing breast cancer cell line MDA-MB-435 by tyrosine kinase inhibitor emodin.
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Academic Article
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Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer.
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Academic Article
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The anti-tumor activity of E1A and its implications in cancer therapy.
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Academic Article
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IKKa restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation.
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Academic Article
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Targeted BikDD expression kills androgen-dependent and castration-resistant prostate cancer cells.
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Academic Article
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Regulation and Role of EZH2 in Cancer.
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Academic Article
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EZH2 expression correlates with locoregional recurrence after radiation in inflammatory breast cancer.
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Academic Article
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ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway.
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Academic Article
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MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
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Academic Article
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S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer.
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Academic Article
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E1A-mediated inhibition of HSPA5 suppresses cell migration and invasion in triple-negative breast cancer.
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Academic Article
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De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells.
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Academic Article
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HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.
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Academic Article
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Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response.
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Academic Article
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Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.
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Academic Article
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Signaling-mediated regulation of MicroRNA processing.
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Academic Article
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The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer.
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Academic Article
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Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer.
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Academic Article
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Modeling familial cancer with induced pluripotent stem cells.
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Academic Article
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Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis.
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Academic Article
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The ZNF304-integrin axis protects against anoikis in cancer.
|
Academic Article
|
Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination.
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Academic Article
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Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma.
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Academic Article
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Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers.
|
Academic Article
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miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin.
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Academic Article
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Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.
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Academic Article
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The effect of ephrin-A1 on resistance to Photofrin-mediated photodynamic therapy in esophageal squamous cell carcinoma cells.
|
Academic Article
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Erythropoietin Stimulates Tumor Growth via EphB4.
|
Academic Article
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FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer.
|
Academic Article
|
PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.
|
Academic Article
|
Non-canonical signaling mode of the epidermal growth factor receptor family.
|
Academic Article
|
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype.
|
Academic Article
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JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis.
|
Academic Article
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AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation.
|
Academic Article
|
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.
|
Academic Article
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Altered Expression and Splicing of ESRP1 in Malignant Melanoma Correlates with Epithelial-Mesenchymal Status and Tumor-Associated Immune Cytolytic Activity.
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Academic Article
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Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.
|
Academic Article
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A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.
|
Academic Article
|
TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1.
|
Academic Article
|
The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to?hyperactivate AKT?and confer resistance to AKT?inhibitors.
|
Academic Article
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Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma.
|
Academic Article
|
Erratum
|
Academic Article
|
Cancer
|
Academic Article
|
HER2/neu overexpression counteracts the growth effects of c-myc in breast cancer cells
|
Academic Article
|
The hippo coactivator YAP1 mediates EGFR overexpression and confers chemoresistance in esophageal cancer
|
Academic Article
|
Regulation of therapeutic resistance in cancers by receptor tyrosine kinases
|
Academic Article
|
Regulation and role of EZH2 in cancer
|
Academic Article
|
Breast cancer gene therapy
|
Academic Article
|
Activation of keap1/nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells
|
Academic Article
|
Sodium/glucose co-transporter 1 expression increases in human diseased prostate
|
Academic Article
|
P27kip1 down-regulation is associated with trastuzumab resistance in breast cancer cells (Cancer Research (June 1, 2004) 64 (3981-3986))
|
Academic Article
|
Preclinical and clinical study of HER-2/neu-targeting cancer gene therapy
|
Academic Article
|
Powering Tumor Metastasis with Recycled Fuel
|
Academic Article
|
Deubiquitination and Stabilization of PD-L1 by CSN5
|
Academic Article
|
Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis
|
Academic Article
|
AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent twist1 degradation
|
Academic Article
|
Tumor suppression activity of adenovirus 5 E1A in prostate cancer
|
Academic Article
|
Erratum
|
Academic Article
|
Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression
|
Academic Article
|
Nanofluidic Strategies for Cancer Research
|
Academic Article
|
Altered expression and splicing of ESRP1 in malignant melanoma correlates with epithelial- mesenchymal status and Tumor-Associated immune cytolytic activity
|
Academic Article
|
Safety and efficacy of quadrapeutics versus chemoradiation in head and neck carcinoma xenograft model
|
Academic Article
|
The VEGF-C/Flt-4 Axis Promotes Invasion and Metastasis of Cancer Cells (DOI
|
Academic Article
|
APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis (Journal of Clinical Investigation (2012) 122, 1 (419) DOI
|
Academic Article
|
Role of cancer stem cells in brain tumors
|
Academic Article
|
PTEN key to Herceptin response in Her2-positive breast cancer
|
Academic Article
|
Cancer Gene Therapy by Viral and Non-viral Vectors
|
Academic Article
|
MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Cα-based triple-negative breast cancer cells
|
Academic Article
|
Severe hepatitis promotes hepatocellular carcinoma recurrence via NF-κb pathway-mediated epithelial-mesenchymal transition after resection
|
Academic Article
|
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer
|
Academic Article
|
Novel signaling pathways in breast cancer
|
Academic Article
|
ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5
|
Academic Article
|
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
|
Academic Article
|
FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
|
Academic Article
|
A perspective on anti-EGFR therapies targeting triple-negative breast cancer
|
Academic Article
|
JARID1D is a suppressor and prognostic marker of prostate cancer invasion and metastasis
|
Academic Article
|
Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells
|
Academic Article
|
Erythropoietin Stimulates Tumor Growth via EphB4
|
Academic Article
|
Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy
|
Academic Article
|
The expression patterns of ER, PR, HER2, CK5/6, EGFR, KI-67 and AR by immunohistochemical analysis in breast cancer cell lines
|
Academic Article
|
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
|
Academic Article
|
Non-canonical signaling mode of the epidermal growth factor receptor family
|
Academic Article
|
Oncogenic functions of Gli1 in pancreatic adenocarcinoma are supported by its PRMT1-mediated methylation
|
Academic Article
|
High level of STK-15 expression in primary breast tumors correlates with nuclear grade
|
Academic Article
|
EGFR signaling enhances aerobic glycolysis in triple-negative breast cancer cells to promote tumor growth and immune escape
|
Academic Article
|
Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer
|
Academic Article
|
Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promoters
|
Academic Article
|
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
|
Academic Article
|
Complex regulation of the adenovirus E2 promoter by the viral oncoproteins E1A and E7 and tumor suppressor Rb
|
Academic Article
|
STK15/BTAK/aurora-A expression in ductal carcinoma in situ of the breast
|
Academic Article
|
Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells
|
Academic Article
|
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors
|
Academic Article
|
Growth inhibition of breast cancer cells by celecoxib
|
Academic Article
|
GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers
|
Academic Article
|
Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway
|
Academic Article
|
Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer
|
Academic Article
|
Dicer elicits paclitaxel chemosensitization and suppresses cancer stemness in breast cancer by repressing AXL
|
Academic Article
|
Aurora A kinase activates YAP signaling in triple-negative breast cancer
|
Academic Article
|
S6k1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer
|
Academic Article
|
The VEGF-C/Flt-4 Axis Promotes Invasion and Metastasis of Cancer Cells (DOI
|
Academic Article
|
Efficient systemic DNA delivery to the tumor by self-assembled nanoparticle
|
Academic Article
|
The ZNF304-integrin axis protects against anoikis in cancer
|
Academic Article
|
Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo
|
Academic Article
|
Mechanisms of deregulated HER2/neu expression in breast cancer cell lines
|
Academic Article
|
Advances in Liposome-Based Targeted Gene Therapy of Cancer
|
Academic Article
|
A novel alteration in the epidermal growth factor receptor gene is frequently detected in human non-small cell lung cancer
|
Academic Article
|
Phosphorylation of ezh2 at t416 by cdk2 contributes to the malignancy of triple negative breast cancers
|
Academic Article
|
Signal transduction of HER-2/neu receptor tyrosine kinase
|
Academic Article
|
Structural and Functional Impacts of ER Coactivator Sequential Recruitment.
|
Academic Article
|
JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.
|
Academic Article
|
TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation.
|
Academic Article
|
Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.
|
Academic Article
|
ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer.
|
Academic Article
|
Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.
|
Academic Article
|
Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.
|
Academic Article
|
The LINK-A lncRNA activates normoxic HIF1a signalling in triple-negative breast cancer.
|
Academic Article
|
EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape.
|
Academic Article
|
Safety and efficacy of quadrapeutics versus chemoradiation in head and neck carcinoma xenograft model.
|
Academic Article
|
Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo.
|
Academic Article
|
Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells.
|
Academic Article
|
Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis.
|
Academic Article
|
Severe Hepatitis Promotes Hepatocellular Carcinoma Recurrence via NF-?B Pathway-Mediated Epithelial-Mesenchymal Transition after Resection.
|
Academic Article
|
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
|
Academic Article
|
Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells.
|
Academic Article
|
Upregulation of lactate dehydrogenase a by 14-3-3? leads to increased glycolysis critical for breast cancer initiation and progression.
|
Academic Article
|
Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway.
|
Academic Article
|
Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL.
|
Academic Article
|
A Positive TGF-?/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer.
|
Academic Article
|
Inhibition of VEGF165/VEGFR2-dependent signaling by LECT2 suppresses hepatocellular carcinoma angiogenesis.
|
Academic Article
|
A perspective on anti-EGFR therapies targeting triple-negative breast cancer.
|
Academic Article
|
Regulation of therapeutic resistance in cancers by receptor tyrosine kinases.
|
Academic Article
|
GSK3? inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers.
|
Academic Article
|
Aurora A kinase activates YAP signaling in triple-negative breast cancer.
|
Academic Article
|
Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation.
|
Academic Article
|
Linking genomic reorganization to tumor initiation via the giant cell cycle.
|
Academic Article
|
Deubiquitination and Stabilization of PD-L1 by CSN5.
|
Academic Article
|
Lymphotoxin-? Interacts with Methylated EGFR to Mediate Acquired Resistance to Cetuximab in Head and Neck Cancer.
|
Academic Article
|
Powering Tumor Metastasis with Recycled Fuel.
|
Academic Article
|
Corrigendum: Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
|
Academic Article
|
ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.
|
Academic Article
|
Segmentation of 3D Trajectories Acquired by TSUNAMI Microscope: An Application to EGFR Trafficking.
|
Academic Article
|
A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1a activation, tumorigenesis and?metastasis.
|
Academic Article
|
MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Ca-based triple-negative breast cancer cells.
|
Academic Article
|
Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy.
|
Academic Article
|
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer.
|
Academic Article
|
Erratum: Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells.
|
Academic Article
|
Metastasis regulation by PPARD expression in cancer cells.
|
Academic Article
|
POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells.
|
Academic Article
|
Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases.
|
Academic Article
|
A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma.
|
Academic Article
|
The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells.
|
Academic Article
|
Erratum to: E1A-Mediated Inhibition of HSPA5 Suppresses Cell Migration and Invasion in Triple-Negative Breast Cancer.
|
Academic Article
|
A UBE2O-AMPKa2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.
|
Academic Article
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PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.
|
Academic Article
|
Rational combination of immunotherapy for triple negative breast cancer treatment.
|
Academic Article
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EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.
|
Academic Article
|
Intracaecal Orthotopic Colorectal Cancer Xenograft Mouse Model.
|
Academic Article
|
Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with ?-blockers.
|
Academic Article
|
Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly.
|
Academic Article
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Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice.
|
Academic Article
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The role of T-cell immunoglobulin mucin-3 and its ligand galectin-9 in antitumor immunity and cancer immunotherapy.
|
Academic Article
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HIF-1a promotes autophagic proteolysis of Dicer and enhances tumor metastasis.
|
Academic Article
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Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment.
|
Academic Article
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Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing.
|
Academic Article
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Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.
|
Academic Article
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A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing.
|
Academic Article
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Single oral dose acute and subacute toxicity of a c-MET tyrosine kinase inhibitor and CDK 4/6 inhibitor combination drug therapy.
|
Academic Article
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YY1 and HDAC9c transcriptionally regulate p38-mediated mesenchymal stem cell differentiation into osteoblasts.
|
Academic Article
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Activation of phagocytosis by immune checkpoint blockade.
|
Academic Article
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Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non-Small Cell Lung Cancer.
|
Academic Article
|
Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
|
Academic Article
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BAP1 links metabolic regulation of ferroptosis to tumour suppression.
|
Academic Article
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Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression.
|
Academic Article
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A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues.
|
Academic Article
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Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth.
|
Academic Article
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Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.
|
Academic Article
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Deglycosylation of PD-L1 by 2-deoxyglucose reverses PARP inhibitor-induced immunosuppression in triple-negative breast cancer.
|
Academic Article
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STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.
|
Academic Article
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Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing.
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The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells.
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CDK4/6 inhibitors in hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer: Are we at the finish line?
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Long noncoding RNA MALAT1 suppresses breast cancer metastasis.
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Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma.
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Palmitoylation stabilizes PD-L1 to promote breast tumor growth.
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PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression.
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Expression and Clinical Significance of Protein Kinase RNA-Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2a in Pancreatic Ductal Adenocarcinoma.
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An essential role of PRMT1-mediated EGFR methylation in EGFR activation by ribonuclease 5.
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EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma.
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MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.
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Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis.
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Posttranslational Modifications of PD-L1 and Their Applications in Cancer Therapy.
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Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications.
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Targeting PKCd as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer.
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Assessing metastatic potential of breast cancer cells based on EGFR dynamics.
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Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade.
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Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma.
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Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells.
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H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism.
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Concept
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Tumor Suppressor p53-Binding Protein 1
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Concept
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Tumor Protein p73
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Concept
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Inflammatory Breast Neoplasms
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Concept
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Tumor Microenvironment
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Concept
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Neoplasm Grading
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Concept
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Prostatic Neoplasms, Castration-Resistant
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Concept
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Triple Negative Breast Neoplasms
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Activation of Aurora A kinase increases YAP stability via blockage of autophagy.
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Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
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IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
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Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy.
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BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.
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A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics.
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Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling.
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Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells.
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New Approaches on Cancer Immunotherapy.
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Mechanisms Controlling PD-L1 Expression in Cancer.
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ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis.
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CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer.
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Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer.
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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
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Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2.
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The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors.
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Author Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer.
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ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis.
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Inhibition of c-MET upregulates PD-L1 expression in lung adenocarcinoma.
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Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer.
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Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity.
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SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway.
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Academic Article
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The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
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Academic Article
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Inhibition of CDK2 reduces EZH2 phosphorylation and reactivates ERa expression in high-grade serous ovarian carcinoma.
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Academic Article
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Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases.
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Academic Article
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Hepatoma cell-intrinsic TLR9 activation induces immune escape through PD-L1 upregulation in hepatocellular carcinoma.
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Nuclear receptor tyrosine kinase transport and functions in cancer.
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Academic Article
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The impact of PD-L1?N-linked glycosylation on cancer therapy and clinical diagnosis.
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Principles and treatment strategies for the use of Chinese herbal medicine in patients at different stages of coronavirus infection.
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Cancer Cell Metabolism Bolsters Immunotherapy Resistance by Promoting an Immunosuppressive Tumor Microenvironment.
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Academic Article
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Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.
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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
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Structural basis of SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug.
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The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.
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Academic Article
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TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer.
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Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma.
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Academic Article
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Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
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Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression.
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High RPS3A expression correlates with low tumor immune cell infiltration and unfavorable prognosis in hepatocellular carcinoma patients.
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Erratum: The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.
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Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC.
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RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse.
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Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease.
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PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
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The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1.
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Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy.
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Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells.
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Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment.
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TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis.
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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade.
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Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation.
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Glycosylation of Siglec15 promotes immunoescape and tumor growth.
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Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer.
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Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture.
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NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation.
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AMBRA1 Promotes TGF? Signaling via Nonproteolytic Polyubiquitylation of Smad4.
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Academic Article
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Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA.
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Academic Article
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Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity.
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Academic Article
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Suppression of breast cancer cells resistant to a pure anti-estrogen with CAR-transduced natural killer cells.
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Academic Article
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Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance.
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Academic Article
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Development and validation of a radiopathomics model to predict pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a multicentre observational study.
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Endoscopic ultrasound-guided fine-needle biopsy as a tool for studying the intra-tumoral microbiome in pancreatic ductal adenocarcinoma: a pilot study.
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Ferroptosis: a promising target for cancer immunotherapy.
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De-glycosylated membrane PD-L1 in tumor tissues as a biomarker for responsiveness to atezolizumab (Tecentriq) in advanced breast cancer patients.
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Academic Article
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Exploiting induced vulnerability to overcome PARPi resistance and clonal heterogeneity in BRCA mutant triple-negative inflammatory breast cancer.
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Academic Article
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Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics.
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Academic Article
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Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer.
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Academic Article
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Development and characterization of anti-galectin-9 antibodies that protect T cells from galectin-9-induced cell death.
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Academic Article
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Endothelial p130cas confers resistance to anti-angiogenesis therapy.
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Academic Article
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PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy.
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Academic Article
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An optimized protocol for PD-L1 pathological assessment with patient sample deglycosylation to improve correlation with therapeutic response.
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Academic Article
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Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies.
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Academic Article
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Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function.
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Academic Article
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Shedding light on triple-negative breast cancer with Trop2-targeted antibody-drug conjugates.
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Academic Article
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Targeting 2-oxoglutarate dehydrogenase for cancer treatment.
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Academic Article
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Prospects of the potential strategies to improve the efficacy of anti-PD-1/PD-L1 therapy.
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Academic Article
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ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer.
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Academic Article
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PD-L1 deficiency sensitizes tumor cells to DNA-PK inhibition and enhances cGAS-STING activation.
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Academic Article
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Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis.
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Academic Article
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Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex.
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Academic Article
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Combination treatment of arsenic trioxide and osimertinib in recurrent and metastatic head and neck squamous cell carcinoma.
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Academic Article
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Disulfiram blocked cell entry of SARS-CoV-2 via inhibiting the interaction of spike protein and ACE2.
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Academic Article
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GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism.
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Academic Article
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Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis.
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Academic Article
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Structural insights into EphA4 unconventional activation from prediction of the EphA4 and its complex with ribonuclease 1.
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Academic Article
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Snail induces dormancy in disseminated luminal type A breast cancer through Src inhibition.
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Academic Article
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DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0.
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Academic Article
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Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis.
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Academic Article
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EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression.
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Academic Article
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Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors.
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Academic Article
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Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion.
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Academic Article
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Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity.
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Academic Article
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Disruption of SLFN11 Deficiency-Induced CCL2 Signaling and Macrophage M2 Polarization Potentiates Anti-PD-1 Therapy Efficacy in Hepatocellular Carcinoma.
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Academic Article
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Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation.
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Academic Article
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IRG1/Itaconate induces metabolic reprogramming to suppress ER-positive breast cancer cell growth.
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Academic Article
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Highly Mimetic Ex Vivo Lung-Cancer Spheroid-Based Physiological Model for Clinical Precision Therapeutics.
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Academic Article
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Detection of Gasdermin C-Mediated Cancer Cell Pyroptosis.
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Academic Article
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RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse.
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Academic Article
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Nuclear export signal mutation of epidermal growth factor receptor enhances malignant phenotypes of cancer cells.
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Academic Article
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Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma.
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Academic Article
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Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal.
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Academic Article
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Ribonuclease 1 Enhances Antitumor Immunity against Breast Cancer by Boosting T cell Activation.
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Academic Article
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ZRANB1 is an NBS1 deubiquitinase and a potential target to overcome radioresistance and PARP inhibitor resistance in triple-negative breast cancer.
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Academic Article
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PD-L1 and CD58 co-regulated by CMTM6 play yin and yang to shape anti-tumor immunity.
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Academic Article
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Gasdermins and cancers.
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Academic Article
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PD-1 blockade in combination with dasatinib potentiates induction of anti-acute lymphocytic leukemia immunity.
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Academic Article
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Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity.
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Academic Article
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Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models.
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Academic Article
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Development of triazole-based PKC-inhibitors to overcome resistance to EGFR inhibitors in EGFR-mutant lung cancers.
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Academic Article
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DriverDBv4: a multi-omics integration database for cancer driver gene research.
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MRCK as a Potential Target for Claudin-Low Subtype of Breast Cancer.
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Academic Article
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Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer.
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Academic Article
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Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.
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Academic Article
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Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma.
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Academic Article
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CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma.
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Academic Article
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DDX3 regulates cancer immune surveillance via 3' UTR-mediated cell-surface expression of PD-L1.
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Academic Article
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Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer.
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Academic Article
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BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers.
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Academic Article
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Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
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