HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.

HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride. Cell Signal. 2008 Oct; 20(10):1839-47.

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subject areas

Alkaloids
Animals
Cell Line
Cell Survival
Cyclooxygenase 2
Dinoprostone
Enzyme Activation
Gene Expression Regulation, Enzymologic
Gene Silencing
Heme Oxygenase-1
Janus Kinase 2
Lipopolysaccharides
Macrophage Activation
Macrophages
Mice
Mitogen-Activated Protein Kinases
Models, Biological
NF-kappa B
Nitric Oxide
Nitric Oxide Synthase Type II
Phosphorylation
Signal Transduction
STAT1 Transcription Factor
Tetrahydroisoquinolines

authors with profiles

KONSTANTIN TSOYI