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KONSTANTIN TSOYI

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address6501 Fannin St
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Arokiasamy S, Balderstone MJM, Shaik F, Cristante E, Moseley TC, Madoo A, Rizzi M, Bainbridge JW, Tsoyi K, Rosas IO, Whiteford JR, De Rossi G. QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age-related macular degeneration. Br J Pharmacol. 2024 Oct 20. PMID: 39428594.
      Citations:    Fields:    
    2. Rojas-Quintero J, Ochsner SA, Lee HS, Cong C, Cohen AW, Colborg AS, Tsoyi K, Basil MC, Cantu E, Rosas IO, McKenna NJ, Est?par RS, Barjaktarevic I, Wilson AA, Polverino F. Skewed adaptive immune responses are involved in AATD emphysema. Eur Respir J. 2024 Oct 10. PMID: 39401853.
      Citations:    Fields:    
    3. Sanchez S, McDowell-Sanchez AK, Al-Meerani SB, Cala-Garcia JD, Waich Cohen AR, Ochsner SA, McKenna NJ, Celada LJ, Wu M, Assassi S, Rosas IO, Tsoyi K. PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation. PLoS One. 2024; 19(9):e0306624. PMID: 39240940; PMCID: PMC11379285.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Tsoyi K, Rosas IO. Fibroblast heterogeneity in pulmonary fibrosis: a new target for therapeutics development? Eur Respir J. 2024 Feb; 63(2). PMID: 38331439.
      Citations: 1     Fields:    Translation:HumansCells
    5. Geary B, Sun B, Tilvawala RR, Barasa L, Tsoyi K, Rosas IO, Thompson PR, Ho IC. Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA. Front Immunol. 2023; 14:1290585. PMID: 38094295; PMCID: PMC10716219.
      Citations:    Fields:    Translation:HumansAnimals
    6. Celada SI, Lim CX, Carisey AF, Ochsner SA, Arce Deza CF, Rexie P, Poli De Frias F, Cardenas-Castillo R, Polverino F, Tsoyi K, McKenna NJ, Kheradmand F, Weichhart T, Rosas IO, Van Kaer L, Celada LJ, Hengstschl?ger M. SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8+ T cells. Sci Transl Med. 2023 09 13; 15(713):eade2581. PMID: 37703351; PMCID: PMC11126869.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Tsoyi K, Rosas IO. Targeting Danger Signals to Rescue Fibrosis. Am J Respir Cell Mol Biol. 2022 05; 66(5):468-470. PMID: 35271415; PMCID: PMC9116361.
      Citations:    Fields:    Translation:HumansPHPublic Health
    8. Tsoyi K, Esposito AJ, Sun B, Bowen RG, Xiong K, Poli F, Cardenas R, Chu SG, Liang X, Ryter SW, Beeton C, Doyle TJ, Robertson MJ, Celada LJ, Romero F, El-Chemaly SY, Perrella MA, Ho IC, Rosas IO. Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts. Sci Rep. 2022 02 18; 12(1):2847. PMID: 35181688; PMCID: PMC8857282.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Han J, Shi Y, Willis G, Imani J, Kwon MY, Li G, Ayaub E, Ghanta S, Ng J, Hwang N, Tsoyi K, El-Chemaly S, Kourembanas S, Mitsialis SA, Rosas IO, Liu X, Perrella MA. Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation. FEBS J. 2022 01; 289(2):417-435. PMID: 34355516; PMCID: PMC8766882.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Tsoyi K, Liang X, De Rossi G, Ryter SW, Xiong K, Chu SG, Liu X, Ith B, Celada LJ, Romero F, Robertson MJ, Esposito AJ, Poli S, El-Chemaly S, Perrella MA, Shi Y, Whiteford J, Rosas IO. CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2021 08 01; 204(3):312-325. PMID: 33784491; PMCID: PMC8513593.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    11. Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis. Matrix Biol. 2021 08; 102:70-84. PMID: 34274450; PMCID: PMC8502204.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    12. Hettiarachchi SU, Li YH, Roy J, Zhang F, Puchulu-Campanella E, Lindeman SD, Srinivasarao M, Tsoyi K, Liang X, Ayaub EA, Nickerson-Nutter C, Rosas IO, Low PS. Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models. Sci Transl Med. 2020 10 28; 12(567). PMID: 33115948.
      Citations: 11     Fields:    Translation:AnimalsCells
    13. Zhang F, Ayaub EA, Wang B, Puchulu-Campanella E, Li YH, Hettiarachchi SU, Lindeman SD, Luo Q, Rout S, Srinivasarao M, Cox A, Tsoyi K, Nickerson-Nutter C, Rosas IO, Low PS. Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis. EMBO Mol Med. 2020 08 07; 12(8):e12034. PMID: 32597014; PMCID: PMC7411553.
      Citations: 12     Fields:    Translation:AnimalsCells
    14. Kwon MY, Ghanta S, Ng J, Tsoyi K, Lederer JA, Bronson RT, El-Chemaly S, Chung SW, Liu X, Perrella MA. Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis. Crit Care Med. 2020 05; 48(5):e409-e417. PMID: 32167490; PMCID: PMC7556326.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Chu SG, Poli De Frias S, Sakairi Y, Kelly RS, Chase R, Konishi K, Blau A, Tsai E, Tsoyi K, Padera RF, Sholl LM, Goldberg HJ, Mallidi HR, Camp PC, El-Chemaly SY, Perrella MA, Choi AMK, Washko GR, Raby BA, Rosas IO. Biobanking and cryopreservation of human lung explants for omic analysis. Eur Respir J. 2020 01; 55(1). PMID: 31699836; PMCID: PMC7066468.
      Citations: 4     Fields:    Translation:Humans
    16. Chu SG, Villalba JA, Liang X, Xiong K, Tsoyi K, Ith B, Ayaub EA, Tatituri RV, Byers DE, Hsu FF, El-Chemaly S, Kim EY, Shi Y, Rosas IO. Palmitic Acid-Rich High-Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress. Am J Respir Cell Mol Biol. 2019 12; 61(6):737-746. PMID: 31461627; PMCID: PMC6890409.
      Citations: 20     Fields:    Translation:AnimalsCells
    17. Tsoyi K, Osorio JC, Chu SG, Fernandez IE, De Frias SP, Sholl L, Cui Y, Tellez CS, Siegfried JM, Belinsky SA, Perrella MA, El-Chemaly S, Rosas IO. Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness. Am J Respir Cell Mol Biol. 2019 06; 60(6):659-666. PMID: 30562054; PMCID: PMC6543747.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    18. Tsoyi K, Chu SG, Patino-Jaramillo NG, Wilder J, Villalba J, Doyle-Eisele M, McDonald J, Liu X, El-Chemaly S, Perrella MA, Rosas IO. Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148. Am J Respir Cell Mol Biol. 2018 02; 58(2):208-215. PMID: 28886261; PMCID: PMC5805997.
      Citations: 27     Fields:    Translation:AnimalsCellsPHPublic Health
    19. Ghanta S, Tsoyi K, Liu X, Nakahira K, Ith B, Coronata AA, Fredenburgh LE, Englert JA, Piantadosi CA, Choi AM, Perrella MA. Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction. Am J Respir Cell Mol Biol. 2017 03; 56(3):300-309. PMID: 27636016; PMCID: PMC5359535.
      Citations: 25     Fields:    Translation:AnimalsCells
    20. Tsoyi K, Hall SR, Dalli J, Colas RA, Ghanta S, Ith B, Coronata A, Fredenburgh LE, Baron RM, Choi AM, Serhan CN, Liu X, Perrella MA. Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators. Crit Care Med. 2016 Dec; 44(12):e1236-e1245. PMID: 27513357; PMCID: PMC5113254.
      Citations: 33     Fields:    Translation:AnimalsCells
    21. Tsoyi K, Geldart AM, Christou H, Liu X, Chung SW, Perrella MA. Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages. J Leukoc Biol. 2015 Jan; 97(1):171-80. PMID: 25351511; PMCID: PMC4377825.
      Citations: 10     Fields:    Translation:AnimalsCells
    22. Kim YM, Tsoyi K, Jang HJ, Park EJ, Park SW, Kim HJ, Hwa JS, Chang KC. CKD712, a synthetic isoquinoline alkaloid, enhances the anti-cancer effects of paclitaxel in MDA-MB-231 cells through regulation of PTEN. Life Sci. 2014 Sep 01; 112(1-2):49-58. PMID: 25058922.
      Citations: 4     Fields:    Translation:HumansCells
    23. Park EJ, Jang HJ, Tsoyi K, Kim YM, Park SW, Kim HJ, Lee JH, Chang KC. The heme oxygenase-1 inducer THI-56 negatively regulates iNOS expression and HMGB1 release in LPS-activated RAW 264.7 cells and CLP-induced septic mice. PLoS One. 2013; 8(10):e76293. PMID: 24098466; PMCID: PMC3789711.
      Citations: 7     Fields:    Translation:AnimalsCells
    24. Jang HJ, Tsoyi K, Kim YM, Park EJ, Park SW, Kim HJ, Lee JH, Chang KC. (S)-1-a-naphthylmethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712), promotes wound closure by producing VEGF through HO-1 induction in human dermal fibroblasts and mouse skin. Br J Pharmacol. 2013 Mar; 168(6):1485-96. PMID: 23088309; PMCID: PMC3596652.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    25. Hall SR, Tsoyi K, Ith B, Padera RF, Lederer JA, Wang Z, Liu X, Perrella MA. Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils. Stem Cells. 2013 Feb; 31(2):397-407. PMID: 23132816; PMCID: PMC3572335.
      Citations: 78     Fields:    Translation:AnimalsCells
    26. Jang HJ, Kim YM, Tsoyi K, Park EJ, Lee YS, Kim HJ, Lee JH, Joe Y, Chung HT, Chang KC. Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals. Antioxid Redox Signal. 2012 Sep 15; 17(6):878-89. PMID: 22369644; PMCID: PMC3392619.
      Citations: 22     Fields:    Translation:AnimalsCells
    27. Tsoyi K, Jang HJ, Lee YS, Kim YM, Kim HJ, Seo HG, Lee JH, Kwak JH, Lee DU, Chang KC. (+)-Nootkatone and (+)-valencene from rhizomes of Cyperus rotundus increase survival rates in septic mice due to heme oxygenase-1 induction. J Ethnopharmacol. 2011 Oct 11; 137(3):1311-7. PMID: 21843620.
      Citations: 18     Fields:    Translation:AnimalsCells
    28. Tsoyi K, Jang HJ, Nizamutdinova IT, Kim YM, Lee YS, Kim HJ, Seo HG, Lee JH, Chang KC. Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice. Br J Pharmacol. 2011 Apr; 162(7):1498-508. PMID: 21091653; PMCID: PMC3057288.
      Citations: 57     Fields:    Translation:AnimalsCells
    29. Tsoyi K, Jang HJ, Kim JW, Chang HK, Lee YS, Pae HO, Kim HJ, Seo HG, Lee JH, Chung HT, Chang KC. Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction. Antioxid Redox Signal. 2011 Jun; 14(11):2057-70. PMID: 21083424.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    30. Tsoyi K, Nizamutdinova IT, Jang HJ, Mun L, Kim HJ, Seo HG, Lee JH, Chang KC. Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-?/JAK2/STAT-1/INOS/NO signaling but not COX-2 in TLR-activated macrophages. Shock. 2010 Dec; 34(6):608-14. PMID: 20442692.
      Citations: 25     Fields:    Translation:AnimalsCells
    31. Tsoyi K, Jang HJ, Nizamutdinova IT, Park K, Kim YM, Kim HJ, Seo HG, Lee JH, Chang KC. PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3?/GATA-6 signaling pathways in TNF-a-activated human endothelial cells. Atherosclerosis. 2010 Nov; 213(1):115-21. PMID: 20864106.
      Citations: 25     Fields:    Translation:HumansCells
    32. Tsoyi K, Ha YM, Kim YM, Lee YS, Kim HJ, Kim HJ, Seo HG, Lee JH, Chang KC. Activation of PPAR-gamma by carbon monoxide from CORM-2 leads to the inhibition of iNOS but not COX-2 expression in LPS-stimulated macrophages. Inflammation. 2009 Dec; 32(6):364-71. PMID: 19705266.
      Citations: 21     Fields:    Translation:AnimalsCells
    33. Tsoyi K, Kim WS, Kim YM, Kim HJ, Seo HG, Lee JH, Yun-Choi HS, Chang KC. Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells. Atherosclerosis. 2009 Dec; 207(2):412-9. PMID: 19540498.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    34. Tsoyi K, Lee TY, Lee YS, Kim HJ, Seo HG, Lee JH, Chang KC. Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo. Mol Pharmacol. 2009 Jul; 76(1):173-82. PMID: 19366789.
      Citations: 56     Fields:    Translation:AnimalsCells
    35. Tsoyi K, Park HB, Kim YM, Chung JI, Shin SC, Shim HJ, Lee WS, Seo HG, Lee JH, Chang KC, Kim HJ. Protective effect of anthocyanins from black soybean seed coats on UVB-induced apoptotic cell death in vitro and in vivo. J Agric Food Chem. 2008 Nov 26; 56(22):10600-5. PMID: 18959412.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    36. Tsoyi K, Park HB, Kim YM, Chung JI, Shin SC, Lee WS, Seo HG, Lee JH, Chang KC, Kim HJ. Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway. J Agric Food Chem. 2008 Oct 08; 56(19):8969-74. PMID: 18778065.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    37. Tsoyi K, Kim HJ, Shin JS, Kim DH, Cho HJ, Lee SS, Ahn SK, Yun-Choi HS, Lee JH, Seo HG, Chang KC. HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride. Cell Signal. 2008 Oct; 20(10):1839-47. PMID: 18634870.
      Citations: 36     Fields:    Translation:AnimalsCells
    38. Kim HJ, Tsoyi K, Heo JM, Kang YJ, Park MK, Lee YS, Lee JH, Seo HG, Yun-Choi HS, Chang KC. Regulation of lipopolysaccharide-induced inducible nitric-oxide synthase expression through the nuclear factor-kappaB pathway and interferon-beta/tyrosine kinase 2/Janus tyrosine kinase 2-signal transducer and activator of transcription-1 signaling cascades by 2-naphthylethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (THI 53), a new synthetic isoquinoline alkaloid. J Pharmacol Exp Ther. 2007 Feb; 320(2):782-9. PMID: 17108235.
      Citations: 14     Fields:    Translation:AnimalsCells
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