Serine Peptidase Inhibitor Kazal-Type 5
"Serine Peptidase Inhibitor Kazal-Type 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.
| Descriptor ID |
D000074163
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| MeSH Number(s) |
D12.644.822.750.250 D12.776.645.688.250
|
| Concept/Terms |
Serine Peptidase Inhibitor Kazal-Type 5- Serine Peptidase Inhibitor Kazal-Type 5
- Serine Peptidase Inhibitor Kazal Type 5
- LEKTI Protein
- SPINK5 Protein
- Serine Protease Inhibitor Kazal-Type 5
- Serine Protease Inhibitor Kazal Type 5
- Lympho-Epithelial Kazal-Type Inhibitor
- Inhibitor, Lympho-Epithelial Kazal-Type
- Kazal-Type Inhibitor, Lympho-Epithelial
- Lympho Epithelial Kazal Type Inhibitor
|
Below are MeSH descriptors whose meaning is more general than "Serine Peptidase Inhibitor Kazal-Type 5".
Below are MeSH descriptors whose meaning is more specific than "Serine Peptidase Inhibitor Kazal-Type 5".
This graph shows the total number of publications written about "Serine Peptidase Inhibitor Kazal-Type 5" by people in this website by year, and whether "Serine Peptidase Inhibitor Kazal-Type 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
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Below are the most recent publications written about "Serine Peptidase Inhibitor Kazal-Type 5" by people in Profiles.
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Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants. J Med Genet. 2021 07; 58(7):442-452.
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Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI). Biol Chem. 2005 Nov; 386(11):1173-84.
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Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution. Arch Biochem Biophys. 2005 Mar 01; 435(1):89-102.
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Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice. Genes Dev. 2004 Oct 01; 18(19):2354-8.
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Expression of LEKTI domains 6-9' in the baculovirus expression system: recombinant LEKTI domains 6-9' inhibit trypsin and subtilisin A. Protein Expr Purif. 2004 May; 35(1):93-101.
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Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: a kinetic analysis. Biochemistry. 2003 Apr 08; 42(13):3874-81.