"ERG1 Potassium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of three members of the ether-a-go-go (EAG) POTASSIUM CHANNELS gene family comprising ether-a-go-go (eag), eag-like (elk) and eag-related (erg) subfamilies. Ether-a-go-go-related gene 1 (ERG1) also known as KCNH2, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel that plays an essential role in the final repolarization of ventricular action potential. Loss-of-function mutations in human hERG1 is associated with life-threatening ARRHYTHMIA.
| Descriptor ID |
D000072237
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| MeSH Number(s) |
D12.776.157.530.400.600.900.249.500 D12.776.543.550.450.750.900.249.500 D12.776.543.585.400.750.900.249.500
|
| Concept/Terms |
ERG1 Potassium Channel- ERG1 Potassium Channel
- Channel, ERG1 Potassium
- Potassium Channel, ERG1
- Potassium Voltage-Gated Channel, Subfamily H, Member 2
- Ether-A-Go-Go-Related Potassium Channel 1
- Ether A Go Go Related Potassium Channel 1
Kv11.1 Protein-Potassium Channel- Kv11.1 Protein-Potassium Channel
- Channel, Kv11.1 Protein-Potassium
- Kv11.1 Protein Potassium Channel
- Protein-Potassium Channel, Kv11.1
|
Below are MeSH descriptors whose meaning is more general than "ERG1 Potassium Channel".
Below are MeSH descriptors whose meaning is more specific than "ERG1 Potassium Channel".
This graph shows the total number of publications written about "ERG1 Potassium Channel" by people in this website by year, and whether "ERG1 Potassium Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "ERG1 Potassium Channel" by people in Profiles.
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Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk - One pharma's experience and perspective. J Pharmacol Toxicol Methods. 2022 Nov-Dec; 118:107213.
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Small Molecule Docking of DNA Repair Proteins Associated with Cancer Survival Following PCNA Metagene Adjustment: A Potential Novel Class of Repair Inhibitors. Molecules. 2019 Feb 12; 24(3).
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Sudden unexpected death in epilepsy genetics: Molecular diagnostics and prevention. Epilepsia. 2016 Jan; 57 Suppl 1:17-25.
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Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile. J Med Chem. 2012 Aug 09; 55(15):6916-33.
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Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet. 2009 Apr; 41(4):407-14.
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Structural determinants of potassium channel blockade and drug-induced arrhythmias. Handb Exp Pharmacol. 2006; (171):123-57.
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Compound mutations: a common cause of severe long-QT syndrome. Circulation. 2004 Apr 20; 109(15):1834-41.
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Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current. Circ Res. 1997 Nov; 81(5):870-8.