Ether-A-Go-Go Potassium Channels
"Ether-A-Go-Go Potassium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of voltage-gated potassium channels that are characterized by long N-terminal and C-terminal intracellular tails. They are named from the Drosophila protein whose mutation causes abnormal leg shaking under ether anesthesia. Their activation kinetics are dependent on extracellular MAGNESIUM and PROTON concentration.
| Descriptor ID |
D051638
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| MeSH Number(s) |
D12.776.157.530.400.600.900.249 D12.776.543.550.450.750.900.249 D12.776.543.585.400.750.900.249
|
| Concept/Terms |
Ether-A-Go-Go Potassium Channels- Ether-A-Go-Go Potassium Channels
- Ether A Go Go Potassium Channels
- Potassium Channels, Ether-A-Go-Go
- Eag-Related Potassium Channels
- Eag Related Potassium Channels
- Potassium Channels, Eag-Related
- Ether-A-Go-Go Related Potassium Channels
- Ether A Go Go Related Potassium Channels
- Eag Potassium Channels
- Potassium Channels, Eag
- ERG Potassium Channels
- Potassium Channels, ERG
|
Below are MeSH descriptors whose meaning is more general than "Ether-A-Go-Go Potassium Channels".
Below are MeSH descriptors whose meaning is more specific than "Ether-A-Go-Go Potassium Channels".
This graph shows the total number of publications written about "Ether-A-Go-Go Potassium Channels" by people in this website by year, and whether "Ether-A-Go-Go Potassium Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ether-A-Go-Go Potassium Channels" by people in Profiles.
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Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk - One pharma's experience and perspective. J Pharmacol Toxicol Methods. 2022 Nov-Dec; 118:107213.
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Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth. J Exp Med. 2020 05 04; 217(5).
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ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice. J Physiol. 2018 10; 596(19):4729-4752.
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Sudden unexpected death in epilepsy genetics: Molecular diagnostics and prevention. Epilepsia. 2016 Jan; 57 Suppl 1:17-25.
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EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci. 2015 Sep; 18(9):1236-46.
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Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 2012 Aug 15; 26(16):1780-96.
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Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile. J Med Chem. 2012 Aug 09; 55(15):6916-33.
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A critical assessment of combined ligand- and structure-based approaches to HERG channel blocker modeling. J Chem Inf Model. 2011 Nov 28; 51(11):2948-60.
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Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci. 2010 Sep; 13(9):1056-8.
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A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5617-21.