PAX6 Transcription Factor
"PAX6 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A paired box transcription factor that has important functions in the development of the eye, nose, central nervous system and pancreas. Mutations in the PAX6 gene are associated with ocular disorders such as ANIRIDIA.
| Descriptor ID |
D000071841
|
| MeSH Number(s) |
D12.776.260.645.813 D12.776.930.700.813
|
| Concept/Terms |
PAX6 Transcription Factor- PAX6 Transcription Factor
- Factor, PAX6 Transcription
- Transcription Factor, PAX6
- Pax-6 Protein
- Pax 6 Protein
- Protein, Pax-6
- Paired Box Gene 6 Protein
- Oculorhombin
- Paired Box Transcription Factor 6
- Transcription Factor PAX6
- Factor PAX6, Transcription
- PAX6, Transcription Factor
- Aniridia Type II Protein
- PAX6 Protein
- Protein, PAX6
- Paired Box Protein Pax-6
- Paired Box Protein Pax 6
|
Below are MeSH descriptors whose meaning is more general than "PAX6 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "PAX6 Transcription Factor".
This graph shows the total number of publications written about "PAX6 Transcription Factor" by people in this website by year, and whether "PAX6 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 5 | 5 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 5 | 5 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 4 | 4 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "PAX6 Transcription Factor" by people in Profiles.
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Missense mutation in the PAX6 gene can cause a complex mild variable phenotype predominated by concomitant strabismus. Ophthalmic Genet. 2022 02; 43(1):88-96.
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An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate. Nat Commun. 2020 07 20; 11(1):3627.
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Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Cell. 2016 11 17; 167(5):1281-1295.e18.
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Zrf1 is required to establish and maintain neural progenitor identity. Genes Dev. 2014 Jan 15; 28(2):182-97.
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Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers. Dev Biol. 2014 Feb 01; 386(1):152-64.
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Integrated copy number and gene expression analysis detects a CREB1 association with Alzheimer's disease. Transl Psychiatry. 2012 Nov 20; 2:e192.
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Embryonic retinal tumors in SV40 T-Ag transgenic mice contain CD133+ tumor-initiating cells. Invest Ophthalmol Vis Sci. 2012 Jun 08; 53(7):3454-62.
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Mosaic deletion 11p13 in a child with dopamine beta-hydroxylase deficiency--case report and review of the literature. Am J Med Genet A. 2010 Mar; 152A(3):732-6.
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COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development. 2010 Mar; 137(5):725-34.
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Pax6 dosage requirements in iris and ciliary body differentiation. Dev Biol. 2009 Sep 01; 333(1):132-42.