PAX5 Transcription Factor
"PAX5 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A paired box transcription factor that is essential for CELL DIFFERENTIATION of B-LYMPHOCYTES. It functions both as a transcriptional activator and repressor to mediate B-cell commitment.
| Descriptor ID |
D051757
|
| MeSH Number(s) |
D12.776.260.645.500 D12.776.930.700.500
|
| Concept/Terms |
PAX5 Transcription Factor- PAX5 Transcription Factor
- Transcription Factor, PAX5
- B-Cell-Specific Activator Protein
- B Cell Specific Activator Protein
- Transcription Factor PAX5
- PAX5, Transcription Factor
- Paired Box 5 Protein
- B Cell-Specific Transcription Factor
- B Cell Specific Transcription Factor
- Early B Cell-Specific Binding Protein-1
- Early B Cell Specific Binding Protein 1
|
Below are MeSH descriptors whose meaning is more general than "PAX5 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "PAX5 Transcription Factor".
This graph shows the total number of publications written about "PAX5 Transcription Factor" by people in this website by year, and whether "PAX5 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2022 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "PAX5 Transcription Factor" by people in Profiles.
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PAX5 and CD70 are expressed in thymic carcinoma but not in atypical thymoma (WHO type B3 thymoma): an immunohistochemical analysis of 60 cases. J Clin Pathol. 2024 Oct 20; 77(11):761-765.
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Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia. J Clin Oncol. 2024 Oct 10; 42(29):3491-3503.
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SOX11 Is an Effective Discriminatory Marker, When Used in Conjunction With CK20 and TTF1, for Merkel Cell Carcinoma: Comparative Analysis of SOX11, CK20, PAX5, and TTF1 Expression in Merkel Cell Carcinoma and Pulmonary Small Cell Carcinoma. Arch Pathol Lab Med. 2023 07 01; 147(7):758-766.
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PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia. Sci Adv. 2022 12 14; 8(50):eadd6403.
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Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice. Cancer Res. 2022 03 15; 82(6):1098-1109.
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Delineation of a novel neurodevelopmental syndrome associated with PAX5 haploinsufficiency. Hum Mutat. 2022 04; 43(4):461-470.
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Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia. Oncogene. 2021 10; 40(43):6166-6179.
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PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia. Leukemia. 2019 08; 33(8):1895-1909.
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PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 02; 51(2):296-307.
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Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5. Clin Immunol. 2018 08; 193:80-87.