"beta-Arrestin 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A beta-arrestin that functions similarly to BETA-ARRESTIN 1 in regulating signaling by G-PROTEIN-COUPLED RECEPTORS. It is expressed at high levels in the central nervous system where it may regulate signaling by SYNAPTIC RECEPTORS.
| Descriptor ID |
D000071560
|
| MeSH Number(s) |
D12.644.360.024.098.525.750 D12.776.157.057.005.525.750 D12.776.476.024.104.525.750 D12.776.543.090.525.750
|
| Concept/Terms |
beta-Arrestin 2- beta-Arrestin 2
- beta Arrestin 2
- ARRB2 Protein
- Arrestin, beta 2
- beta 2 Arrestin
- Arrestin-3
- Arrestin 3
|
Below are MeSH descriptors whose meaning is more general than "beta-Arrestin 2".
Below are MeSH descriptors whose meaning is more specific than "beta-Arrestin 2".
This graph shows the total number of publications written about "beta-Arrestin 2" by people in this website by year, and whether "beta-Arrestin 2" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "beta-Arrestin 2" by people in Profiles.
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Competing Engagement of ?-arrestin Isoforms Balances IGF1R/p53 Signaling and Controls Melanoma Cell Chemotherapeutic Responsiveness. Mol Cancer Res. 2023 12 01; 21(12):1288-1302.
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Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling. Sci Signal. 2018 08 28; 11(545).
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Phosphorylation of ?-arrestin2 at Thr383 by MEK underlies ?-arrestin-dependent activation of Erk1/2 by GPCRs. Elife. 2017 02 07; 6.
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Occupancy of human EPCR by protein C induces ?-arrestin-2 biased PAR1 signaling by both APC and thrombin. Blood. 2016 10 06; 128(14):1884-1893.
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Gene dosage-dependent negative regulatory role of ?-arrestin-2 in polymicrobial infection-induced inflammation. Infect Immun. 2013 Aug; 81(8):3035-44.
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Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells. Mol Cancer Res. 2009 Jul; 7(7):1064-77.
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Beta-arrestin 2 is required for lysophosphatidic acid-induced NF-kappaB activation. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17085-90.
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Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. J Biol Chem. 2006 Mar 17; 281(11):7684-92.
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Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2449-54.
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beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1601-6.