"Trefoil Factor-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 106 amino acid (12 kDa) trefoil factor that contains two trefoil domains and associates with MUCIN-6. It is expressed in the GASTROINTESTINAL TRACT by cells of BRUNNER GLANDS; PYLORIC GLANDS and mucous neck cells. It inhibits GASTROINTESTINAL MOTILITY and GASTRIC ACID secretion and may help maintain the structural integrity of gastric mucus.
| Descriptor ID |
D000071164
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| MeSH Number(s) |
D12.644.937.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Trefoil Factor-2".
Below are MeSH descriptors whose meaning is more specific than "Trefoil Factor-2".
This graph shows the total number of publications written about "Trefoil Factor-2" by people in this website by year, and whether "Trefoil Factor-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 3 | 3 |
| 2015 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Trefoil Factor-2" by people in Profiles.
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Histological assessment of gastric pseudopyloric metaplasia: Intra- and inter-observer consistency. Dig Liver Dis. 2021 01; 53(1):61-65.
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Deficient Active Transport Activity in Healing Mucosa After Mild Gastric Epithelial Damage. Dig Dis Sci. 2020 01; 65(1):119-131.
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Calcified, top secretion only: epithelial repair in gastric organoids requires calcium mobilization. J Physiol. 2019 05; 597(10):2617-2618.
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Trefoil factor 2 activation of CXCR4 requires calcium mobilization to drive epithelial repair in gastric organoids. J Physiol. 2019 05; 597(10):2673-2690.
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Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer. Clin Chim Acta. 2015 Oct 23; 450:127-34.
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Gastric epithelial stem cells. Gastroenterology. 2011 Feb; 140(2):412-24.
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The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am J Pathol. 2010 Sep; 177(3):1514-33.
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Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer. Gastroenterology. 2010 Jun; 138(7):2207-10, 2210.e1.
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Trefoil peptides, E-cadherin, and beta-catenin expression in sporadic fundic gland polyps: further evidence toward the benign nature of these lesions. Appl Immunohistochem Mol Morphol. 2009 Oct; 17(5):431-7.
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Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Gastroenterology. 2009 Apr; 136(4):1288-96.