"Trefoil Factor-3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 59 amino acid (6.6 kDa) trefoil factor that contains a single trefoil domain. It is expressed in all tissues with MUCOUS MEMBRANES, including GOBLET CELLS of the SMALL INTESTINE and LARGE INTESTINE. It associates with MUCIN-2 in the small intestine and may regulate epithelial CELL MIGRATION and WOUND HEALING.
| Descriptor ID |
D000071165
|
| MeSH Number(s) |
D12.644.937.875
|
| Concept/Terms |
Trefoil Factor-3- Trefoil Factor-3
- Trefoil Factor 3
- TFF3 Peptide
- Intestinal Trefoil Factor
- Trefoil Factor, Intestinal
- TFF3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Trefoil Factor-3".
Below are MeSH descriptors whose meaning is more specific than "Trefoil Factor-3".
This graph shows the total number of publications written about "Trefoil Factor-3" by people in this website by year, and whether "Trefoil Factor-3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Trefoil Factor-3" by people in Profiles.
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Stool and urine trefoil factor 3 levels: associations with symptoms, intestinal permeability, and microbial diversity in irritable bowel syndrome. Benef Microbes. 2018 Apr 25; 9(3):345-355.
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Urinary proteome analysis of irritable bowel syndrome (IBS) symptom subgroups. J Proteome Res. 2012 Dec 07; 11(12):5650-62.
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ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression. Neoplasia. 2010 Dec; 12(12):1031-40.
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Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Gastroenterology. 2009 Apr; 136(4):1288-96.
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Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and TFF3 mRNAs in human gastric carcinoma cells. Scand J Gastroenterol. 2008 Jan; 43(1):25-33.
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Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma. Hepatogastroenterology. 2007 Jul-Aug; 54(77):1339-44.
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Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas. Int J Oncol. 2005 Feb; 26(2):369-77.
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TIMP1 and SERPIN-A overexpression and TFF3 and CRABP1 underexpression as biomarkers for papillary thyroid carcinoma. Head Neck. 2004 Dec; 26(12):1069-83.
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Phosphorylation of beta-catenin and epidermal growth factor receptor by intestinal trefoil factor. Lab Invest. 1997 Dec; 77(6):557-63.