Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.
| Descriptor ID |
D020875
|
| MeSH Number(s) |
D12.644.400.575.281.075 D12.776.631.650.575.281.075
|
| Concept/Terms |
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- 2-Ala-4-MePhe-5-Gly-Enkephalin
- 2 Ala 4 MePhe 5 Gly Enkephalin
- Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin
- DAGO
- DAMGE
- D-Ala2-NMe-Phe4-Gly-ol Enkephalin
- D Ala2 NMe Phe4 Gly ol Enkephalin
- Enkephalin, D-Ala2-NMe-Phe4-Gly-ol
- DAGOL
- Tyr-Ala-Gly-(NMe)Phe-Gly-ol
- Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-
- D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin
- DAMGO
|
Below are MeSH descriptors whose meaning is more general than "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-".
Below are MeSH descriptors whose meaning is more specific than "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-".
This graph shows the total number of publications written about "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" by people in this website by year, and whether "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 1 | 3 | 4 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" by people in Profiles.
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Brief Opioid Exposure Paradoxically Augments Primary Afferent Input to Spinal Excitatory Neurons via a2d-1-Dependent Presynaptic NMDA Receptors. J Neurosci. 2022 12 14; 42(50):9315-9329.
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Opioid-induced long-term potentiation in the spinal cord is a presynaptic event. J Neurosci. 2010 Mar 24; 30(12):4460-6.
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A functional link between T-type calcium channels and mu-opioid receptor expression in adult primary sensory neurons. J Neurochem. 2009 May; 109(3):867-78.
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Sustained inhibition of neurotransmitter release from nontransient receptor potential vanilloid type 1-expressing primary afferents by mu-opioid receptor activation-enkephalin in the spinal cord. J Pharmacol Exp Ther. 2008 Nov; 327(2):375-82.
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The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. J Neurochem. 2007 Oct; 103(1):77-87.
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Loss of TRPV1-expressing sensory neurons reduces spinal mu opioid receptors but paradoxically potentiates opioid analgesia. J Neurophysiol. 2006 May; 95(5):3086-96.
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Mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/1.2 channels. J Neurophysiol. 2006 Apr; 95(4):2032-41.
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Mu-opioid-mediated inhibition of glutamate synaptic transmission in rat central amygdala neurons. Neuroscience. 2005; 133(1):97-103.
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Effect of the {mu} opioid on excitatory and inhibitory synaptic inputs to periaqueductal gray-projecting neurons in the amygdala. J Pharmacol Exp Ther. 2005 Feb; 312(2):441-8.
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Differential sensitivity of N- and P/Q-type Ca2+ channel currents to a mu opioid in isolectin B4-positive and -negative dorsal root ganglion neurons. J Pharmacol Exp Ther. 2004 Dec; 311(3):939-47.