"Lamin Type A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.
| Descriptor ID |
D034904
|
| MeSH Number(s) |
D12.776.660.650.875.500
|
| Concept/Terms |
Lamin Type A- Lamin Type A
- Lamin A
- Type A Lamins
- Lamins, Type A
- Lamin A-C
- Lamin A C
|
Below are MeSH descriptors whose meaning is more general than "Lamin Type A".
Below are MeSH descriptors whose meaning is more specific than "Lamin Type A".
This graph shows the total number of publications written about "Lamin Type A" by people in this website by year, and whether "Lamin Type A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lamin Type A" by people in Profiles.
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DNA methylation of the Lamin A/C gene is associated with congenital heart disease. Birth Defects Res. 2024 Jul; 116(7):e2381.
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Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy. Cardiovasc Res. 2021 09 28; 117(11):2377-2394.
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Skeletal and Cardiac Muscle Disorders Caused by Mutations in Genes Encoding Intermediate Filament Proteins. Int J Mol Sci. 2021 Apr 20; 22(8).
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BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C-deficient mice. J Clin Invest. 2020 09 01; 130(9):4740-4758.
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Identification of Genes and Pathways Regulated by Lamin A in Heart. J Am Heart Assoc. 2020 08 18; 9(16):e015690.
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Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy. Circ Res. 2019 04 12; 124(8):1198-1213.
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DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations. Circ Res. 2019 03 15; 124(6):856-873.
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Amelioration of desmin network defects by aB-crystallin overexpression confers cardioprotection in a mouse model of dilated cardiomyopathy caused by LMNA gene mutation. J Mol Cell Cardiol. 2018 12; 125:73-86.
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Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies. Circ Res. 2018 03 02; 122(5):678-692.
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Non-syndromic cardiac progeria in a patient with the rare pathogenic p.Asp300Asn variant in the LMNA gene. BMC Med Genet. 2017 10 18; 18(1):116.