"Oncogene Proteins v-erbA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.
| Descriptor ID |
D018774
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| MeSH Number(s) |
D12.776.624.664.520.750.882 D12.776.964.700.750.882 D12.776.964.775.750.882
|
| Concept/Terms |
Oncogene Proteins v-erbA- Oncogene Proteins v-erbA
- Oncogene Proteins v erbA
- v-erbA Proteins
- v erbA Proteins
- erbA Oncogene Proteins
- Oncogene Products v-erbA
- Oncogene Products v erbA
|
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This graph shows the total number of publications written about "Oncogene Proteins v-erbA" by people in this website by year, and whether "Oncogene Proteins v-erbA" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
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Below are the most recent publications written about "Oncogene Proteins v-erbA" by people in Profiles.
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Specific mutations in the ligand binding domain selectively abolish the silencing function of human thyroid hormone receptor beta. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11691-5.
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Kindred S thyroid hormone receptor is an active and constitutive silencer and a repressor for thyroid hormone and retinoic acid responses. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10633-7.
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Structural organization and regulation of the chicken estrogen receptor. Mol Endocrinol. 1987 Jan; 1(1):25-35.