"Smad6 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitory Smad protein that negatively regulates the SIGNAL TRANSDUCTION PATHWAYS from BONE MORPHOGENETIC PROTEIN RECEPTORS. Smad6 inhibits PHOSPHORYLATION of SMAD2 PROTEIN and SMAD3 PROTEIN.
| Descriptor ID |
D051905
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| MeSH Number(s) |
D12.644.360.024.334.200.600 D12.776.157.057.170.249.600 D12.776.476.024.428.249.600 D12.776.930.806.875
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Smad6 Protein".
Below are MeSH descriptors whose meaning is more specific than "Smad6 Protein".
This graph shows the total number of publications written about "Smad6 Protein" by people in this website by year, and whether "Smad6 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Smad6 Protein" by people in Profiles.
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A genome-wide association study of LCH identifies a variant in SMAD6 associated with susceptibility. Blood. 2017 11 16; 130(20):2229-2232.
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Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGF-? Signaling Pathway. PLoS One. 2016; 11(4):e0153968.
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Genetic variants in TGF-? pathway are associated with ovarian cancer risk. PLoS One. 2011; 6(9):e25559.
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Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol Cell Biol. 2003 Dec; 23(24):9081-93.
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Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation. Surgery. 2002 Aug; 132(2):310-6.
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Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-beta in human renal epithelial cells. J Biol Chem. 2000 Dec 29; 275(52):40904-9.
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Evidence for a role of Smad6 in chick cardiac development. Dev Biol. 1999 Nov 01; 215(1):48-61.