"Smad7 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitory smad protein that associates with TRANSFORMING GROWTH FACTOR BETA RECEPTORS and BONE MORPHOGENETIC PROTEIN RECEPTORS. It negatively regulates SIGNAL TRANSDUCTION PATHWAYS by inhibiting PHOSPHORYLATION of RECEPTOR-REGULATED SMAD PROTEINS.
| Descriptor ID |
D051906
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| MeSH Number(s) |
D12.644.360.024.334.200.700 D12.776.157.057.170.249.700 D12.776.476.024.428.249.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Smad7 Protein".
Below are MeSH descriptors whose meaning is more specific than "Smad7 Protein".
This graph shows the total number of publications written about "Smad7 Protein" by people in this website by year, and whether "Smad7 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Smad7 Protein" by people in Profiles.
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Chitinase 1 regulates pulmonary fibrosis by modulating TGF-?/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Sci Alliance. 2019 06; 2(3).
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Smad7 interrupts TGF-? signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis. Pediatr Res. 2016 06; 79(6):951-61.
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Renal inflammation is modulated by potassium in chronic kidney disease: possible role of Smad7. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1123-30.
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Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol. 2007 Jun; 27(12):4488-99.
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Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev Cell. 2006 Sep; 11(3):301-12.
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Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney. Am J Pathol. 2005 Mar; 166(3):761-71.
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Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol Cell Biol. 2003 Dec; 23(24):9081-93.
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Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues. EMBO J. 2002 Jun 03; 21(11):2580-90.
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Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6397-402.
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SMAD genes in juvenile polyposis. Genes Chromosomes Cancer. 1999 Sep; 26(1):54-61.