"Smad7 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitory smad protein that associates with TRANSFORMING GROWTH FACTOR BETA RECEPTORS and BONE MORPHOGENETIC PROTEIN RECEPTORS. It negatively regulates SIGNAL TRANSDUCTION PATHWAYS by inhibiting PHOSPHORYLATION of RECEPTOR-REGULATED SMAD PROTEINS.
| Descriptor ID |
D051906
|
| MeSH Number(s) |
D12.644.360.024.334.200.700 D12.776.157.057.170.249.700 D12.776.476.024.428.249.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Smad7 Protein".
Below are MeSH descriptors whose meaning is more specific than "Smad7 Protein".
This graph shows the total number of publications written about "Smad7 Protein" by people in this website by year, and whether "Smad7 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 3 | 0 | 3 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Smad7 Protein" by people in Profiles.
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Fibroblast Smad7 Induction Protects the Remodeling Pressure-Overloaded Heart. Circ Res. 2024 Jul 19; 135(3):453-469.
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The role of endogenous Smad7 in regulating macrophage phenotype following myocardial infarction. FASEB J. 2022 07; 36(7):e22400.
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Smad7 effects on TGF-? and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure. J Clin Invest. 2022 02 01; 132(3).
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Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis. Cancer Res. 2020 03 15; 80(6):1304-1315.
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Proteasome-dependent degradation of Smad7 is critical for lung cancer metastasis. Cell Death Differ. 2020 06; 27(6):1795-1806.
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REG? ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-? pathway. Cell Death Differ. 2020 02; 27(2):497-508.
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Chitinase 1 regulates pulmonary fibrosis by modulating TGF-?/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Sci Alliance. 2019 06; 2(3).
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Estrogen receptor ?, a regulator of androgen receptor signaling in the mouse ventral prostate. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):E3816-E3822.
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Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGF-? Signaling Pathway. PLoS One. 2016; 11(4):e0153968.
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Smad7 interrupts TGF-? signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis. Pediatr Res. 2016 06; 79(6):951-61.