"Thromboxane-A Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme found predominantly in platelet microsomes. It catalyzes the conversion of PGG(2) and PGH(2) (prostaglandin endoperoxides) to thromboxane A2. EC 5.3.99.5.
| Descriptor ID |
D013930
|
| MeSH Number(s) |
D08.811.399.475.900
|
| Concept/Terms |
Thromboxane-A Synthase- Thromboxane-A Synthase
- Synthase, Thromboxane-A
- Thromboxane A2 Synthetase
- A2 Synthetase, Thromboxane
- Synthetase, Thromboxane A2
- Thromboxane Synthetase
- Synthetase, Thromboxane
- Thromboxane A Synthase
- Synthase, Thromboxane A
|
Below are MeSH descriptors whose meaning is more general than "Thromboxane-A Synthase".
Below are MeSH descriptors whose meaning is more specific than "Thromboxane-A Synthase".
This graph shows the total number of publications written about "Thromboxane-A Synthase" by people in this website by year, and whether "Thromboxane-A Synthase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thromboxane-A Synthase" by people in Profiles.
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A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A2 and exhibiting powerful anti-bleeding functions. J Cell Mol Med. 2019 12; 23(12):8343-8354.
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Bioactive lipid metabolism in platelet "first responder" and cancer biology. Cancer Metastasis Rev. 2018 09; 37(2-3):439-454.
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From the design to the clinical application of thromboxane modulators. Curr Pharm Des. 2006; 12(8):903-23.
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Solution structure of a common substrate mimetic of cyclooxygenase-downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique. Arch Biochem Biophys. 2005 Dec 15; 444(2):165-73.
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The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase. Arch Biochem Biophys. 2005 Mar 15; 435(2):372-81.
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Advance in understanding the biosynthesis of prostacyclin and thromboxane A2 in the endoplasmic reticulum membrane via the cyclooxygenase pathway. Mini Rev Med Chem. 2004 Aug; 4(6):639-47.
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New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators. Curr Med Chem. 2004 May; 11(10):1223-41.
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Structural characterization and topology of the second potential membrane anchor region in the thromboxane A2 synthase amino-terminal domain. Biochemistry. 1998 Jan 20; 37(3):822-30.
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Activated microglia are the principal glial source of thromboxane in the central nervous system. Neurochem Int. 1996 Jul; 29(1):65-76.
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Contractile effect of endothelin in human placental veins: role of endothelium prostaglandins and thromboxane. Am J Obstet Gynecol. 1993 Oct; 169(4):919-24.