"Desipramine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
| Descriptor ID |
D003891
|
| MeSH Number(s) |
D03.633.300.240.281
|
| Concept/Terms |
Desipramine- Desipramine
- Desmethylimipramine
- Demethylimipramine
|
Below are MeSH descriptors whose meaning is more general than "Desipramine".
Below are MeSH descriptors whose meaning is more specific than "Desipramine".
This graph shows the total number of publications written about "Desipramine" by people in this website by year, and whether "Desipramine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 2 | 0 | 2 |
| 1999 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 2 | 0 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Desipramine" by people in Profiles.
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Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. J Hepatol. 2005 Jun; 42(6):880-7.
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Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response. Am J Addict. 2005 Jan-Feb; 14(1):8-17.
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Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron. 2004 Oct 28; 44(3):439-51.
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S-nitroso-l-cysteine releases norepinephrine in rat spinal synaptosomes. Brain Res. 2000 Jul 28; 872(1-2):301-7.
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Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone. Arch Gen Psychiatry. 1999 Sep; 56(9):812-20.
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Desipramine versus phenelzine in recurrent unipolar depression: clinical characteristics and treatment response. J Clin Psychopharmacol. 1997 Apr; 17(2):78-83.
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Desipramine, amantadine, or fluoxetine in buprenorphine-maintained cocaine users. J Subst Abuse Treat. 1995 Nov-Dec; 12(6):423-8.
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Gender differences in cocaine use and treatment response. J Subst Abuse Treat. 1993 Jan-Feb; 10(1):63-6.
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Clinical and research perspectives on cocaine abuse: the pharmacotherapy of cocaine abuse. NIDA Res Monogr. 1993; 135:48-56.
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Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine. Arch Gen Psychiatry. 1992 Nov; 49(11):894-8.