Carbamoyl-Phosphate Synthase (Ammonia)
"Carbamoyl-Phosphate Synthase (Ammonia)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and ammonia. This enzyme is specific for arginine biosynthesis or the urea cycle. Absence or lack of this enzyme may cause CARBAMOYL-PHOSPHATE SYNTHASE I DEFICIENCY DISEASE. EC 6.3.4.16.
| Descriptor ID |
D002222
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| MeSH Number(s) |
D08.811.464.259.350
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| Concept/Terms |
Carbamoyl-Phosphate Synthase (Ammonia)- Carbamoyl-Phosphate Synthase (Ammonia)
- Carbamyl Phosphate Synthase (Ammonia)
- Carbamyl-Phosphate Synthase (Ammonia)
- Carbamoyl-Phosphate Synthetase I
- Synthetase I, Carbamoyl-Phosphate
- Carbamoyl-Phosphate Synthetase (Ammonia)
- Carbamoyl Phosphate Synthetase I
- Carbamoylphosphate Synthetase I
- Synthetase I, Carbamoylphosphate
- CP Synthase I
- Synthase I, CP
|
Below are MeSH descriptors whose meaning is more general than "Carbamoyl-Phosphate Synthase (Ammonia)".
Below are MeSH descriptors whose meaning is more specific than "Carbamoyl-Phosphate Synthase (Ammonia)".
This graph shows the total number of publications written about "Carbamoyl-Phosphate Synthase (Ammonia)" by people in this website by year, and whether "Carbamoyl-Phosphate Synthase (Ammonia)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Carbamoyl-Phosphate Synthase (Ammonia)" by people in Profiles.
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A Promising CPS1 Inhibitor Keeping Ammonia from Fueling Cancer. Cell Chem Biol. 2020 03 19; 27(3):253-254.
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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. 2017 06 01; 546(7656):168-172.
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Role of CPS1 in Cell Growth, Metabolism and Prognosis in LKB1-Inactivated Lung Adenocarcinoma. J Natl Cancer Inst. 2017 03 01; 109(3):1-9.
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Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice. J Nutr. 2015 Jun; 145(6):1227-31.
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Molecular defects in human carbamoy phosphate synthetase I: mutational spectrum, diagnostic and protein structure considerations. Hum Mutat. 2011 Jun; 32(6):579-89.
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Molecular characterization of CPS1 deletions by array CGH. Mol Genet Metab. 2011 Jan; 102(1):103-6.
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Utility of oligonucleotide array-based comparative genomic hybridization for detection of target gene deletions. Clin Chem. 2008 Jul; 54(7):1141-8.
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A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates. Metab Eng. 2004 Jan; 6(1):6-11.
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A mouse model of argininosuccinic aciduria: biochemical characterization. Mol Genet Metab. 2003 Jan; 78(1):11-6.
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Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene. Mol Cell Biol. 1998 Nov; 18(11):6305-15.