Argininosuccinate Synthase
"Argininosuccinate Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
| Descriptor ID |
D001124
|
| MeSH Number(s) |
D08.811.464.259.300
|
| Concept/Terms |
Argininosuccinate Synthase- Argininosuccinate Synthase
- Synthase, Argininosuccinate
- Argininosuccinate Synthetase
- Synthetase, Argininosuccinate
|
Below are MeSH descriptors whose meaning is more general than "Argininosuccinate Synthase".
Below are MeSH descriptors whose meaning is more specific than "Argininosuccinate Synthase".
This graph shows the total number of publications written about "Argininosuccinate Synthase" by people in this website by year, and whether "Argininosuccinate Synthase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Argininosuccinate Synthase" by people in Profiles.
-
Exogenous arginine differentially regulates inflammatory cytokine and inducible nitric oxide synthase expression in macrophages. Immunohorizons. 2025 07 14; 9(8).
-
Early prediction of phenotypic severity in Citrullinemia Type 1. Ann Clin Transl Neurol. 2019 09; 6(9):1858-1871.
-
Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer. Cancer Res. 2019 02 01; 79(3):518-533.
-
The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice, but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge. J Nutr. 2018 06 01; 148(6):844-850.
-
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 2015 Nov 19; 527(7578):379-383.
-
Improved standards for prenatal diagnosis of citrullinemia. Mol Genet Metab. 2014 Jul; 112(3):205-9.
-
Liver-directed adeno-associated virus serotype 8 gene transfer rescues a lethal murine model of citrullinemia type 1. Gene Ther. 2013 Dec; 20(12):1188-91.
-
Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction. Mol Cancer Ther. 2013 Nov; 12(11):2581-90.
-
Citrulline and arginine utility in treating nitric oxide deficiency in mitochondrial disorders. Mol Genet Metab. 2012 Nov; 107(3):247-52.
-
Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells. Cancer Res. 2012 May 15; 72(10):2622-33.