Argininosuccinate Synthase
"Argininosuccinate Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
| Descriptor ID |
D001124
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| MeSH Number(s) |
D08.811.464.259.300
|
| Concept/Terms |
Argininosuccinate Synthase- Argininosuccinate Synthase
- Synthase, Argininosuccinate
- Argininosuccinate Synthetase
- Synthetase, Argininosuccinate
|
Below are MeSH descriptors whose meaning is more general than "Argininosuccinate Synthase".
Below are MeSH descriptors whose meaning is more specific than "Argininosuccinate Synthase".
This graph shows the total number of publications written about "Argininosuccinate Synthase" by people in this website by year, and whether "Argininosuccinate Synthase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 3 | 4 |
| 2011 | 0 | 1 | 1 |
| 2012 | 2 | 2 | 4 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 2 | 1 | 3 |
| 2016 | 2 | 0 | 2 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Argininosuccinate Synthase" by people in Profiles.
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Phase 1 trial of ADI-PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors. Cancer Med. 2022 01; 11(2):340-347.
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Early prediction of phenotypic severity in Citrullinemia Type 1. Ann Clin Transl Neurol. 2019 09; 6(9):1858-1871.
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Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer. Cancer Res. 2019 02 01; 79(3):518-533.
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The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice, but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge. J Nutr. 2018 06 01; 148(6):844-850.
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Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1a Degradation at the ASS1 promoter for ASS1 Derepression. Sci Rep. 2017 09 07; 7(1):10814.
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Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma. PLoS One. 2017; 12(2):e0171985.
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Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1a, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. Oncotarget. 2016 Dec 13; 7(50):82658-82670.
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Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy. Cancer Lett. 2017 03 01; 388:54-63.
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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 2015 Nov 19; 527(7578):379-383.
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Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin. Oncotarget. 2015 Mar 20; 6(8):6295-309.