Chromatin Assembly Factor-1
"Chromatin Assembly Factor-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. It is comprised of three different subunits of 48, 60, and 150 kDa molecular size. The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling.
| Descriptor ID |
D056504
|
| MeSH Number(s) |
D12.776.580.219.200
|
| Concept/Terms |
Chromatin Assembly Factor-1- Chromatin Assembly Factor-1
- Assembly Factor-1, Chromatin
- Chromatin Assembly Factor 1
- Chromatin Assembly Complex-1
- Assembly Complex-1, Chromatin
- Chromatin Assembly Complex 1
|
Below are MeSH descriptors whose meaning is more general than "Chromatin Assembly Factor-1".
Below are MeSH descriptors whose meaning is more specific than "Chromatin Assembly Factor-1".
This graph shows the total number of publications written about "Chromatin Assembly Factor-1" by people in this website by year, and whether "Chromatin Assembly Factor-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Chromatin Assembly Factor-1" by people in Profiles.
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CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming. Adv Sci (Weinh). 2021 10; 8(19):e2005047.
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Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma. Cancer Res. 2014 Feb 01; 74(3):765-74.
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The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. EMBO Rep. 2009 Jul; 10(7):769-75.