"4-Nitroquinoline-1-oxide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage.
| Descriptor ID |
D015112
|
| MeSH Number(s) |
D02.640.820.600 D03.633.100.810.470.450 D03.661.243.500
|
| Concept/Terms |
4-Nitroquinoline-1-oxide- 4-Nitroquinoline-1-oxide
- 4 Nitroquinoline 1 oxide
- 4-Nitroquinoline-N-oxide
- 4 Nitroquinoline N oxide
|
Below are MeSH descriptors whose meaning is more general than "4-Nitroquinoline-1-oxide".
Below are MeSH descriptors whose meaning is more specific than "4-Nitroquinoline-1-oxide".
This graph shows the total number of publications written about "4-Nitroquinoline-1-oxide" by people in this website by year, and whether "4-Nitroquinoline-1-oxide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1997 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "4-Nitroquinoline-1-oxide" by people in Profiles.
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Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model. Cancer Prev Res (Phila). 2021 08; 14(8):767-778.
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Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma. Cancer Prev Res (Phila). 2021 03; 14(3):313-324.
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A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis. Int J Exp Pathol. 2020 02; 101(1-2):45-54.
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Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer. J Natl Cancer Inst. 2018 03 01; 110(3).
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PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions. Cancer Prev Res (Phila). 2017 Dec; 10(12):684-693.
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The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. Oncotarget. 2016 Jun 14; 7(24):35932-35945.
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4-nitroquinoline-1-oxide-induced mutagen sensitivity and risk of cutaneous melanoma: a case-control analysis. Melanoma Res. 2016 Apr; 26(2):181-7.
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Mutagen sensitivity as measured by induced chromatid breakage as a marker of cancer risk. Methods Mol Biol. 2014; 1105:183-92.
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Vital-dye-enhanced multimodal imaging of neoplastic progression in a mouse model of oral carcinogenesis. J Biomed Opt. 2013 Dec; 18(12):126017.
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Comparable molecular alterations in 4-nitroquinoline 1-oxide-induced oral and esophageal cancer in mice and in human esophageal cancer, associated with poor prognosis of patients. In Vivo. 2013 Jul-Aug; 27(4):473-84.