"beta-Lactams" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
| Descriptor ID |
D047090
|
| MeSH Number(s) |
D02.065.589.099 D02.886.108 D03.633.100.300
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "beta-Lactams".
Below are MeSH descriptors whose meaning is more specific than "beta-Lactams".
This graph shows the total number of publications written about "beta-Lactams" by people in this website by year, and whether "beta-Lactams" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 2 | 4 |
| 2019 | 1 | 1 | 2 |
| 2020 | 3 | 3 | 6 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "beta-Lactams" by people in Profiles.
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Exploiting the Carboxylate-Binding Pocket of ?-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J Med Chem. 2024 01 11; 67(1):620-642.
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Genetic determinants underlying the progressive phenotype of ?-lactam/?-lactamase inhibitor resistance in Escherichia coli. Microbiol Spectr. 2023 Dec 12; 11(6):e0222123.
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Mutagenesis and structural analysis reveal the CTX-M ?-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J Biol Chem. 2023 05; 299(5):104630.
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Antimicrobial Susceptibility Testing for Enterococci. J Clin Microbiol. 2022 09 21; 60(9):e0084321.
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New ?-Lactam-?-Lactamase Inhibitor Combinations. Clin Microbiol Rev. 2020 12 16; 34(1).
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Prolonged Versus Intermittent Infusion of ?-Lactam Antibiotics: A Systematic Review and Meta-Regression of Bacterial Killing in Preclinical Infection Models. Clin Pharmacokinet. 2020 10; 59(10):1237-1250.
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Mechanistic Insights Into the Differential Efficacy of Daptomycin Plus ?-Lactam Combinations Against Daptomycin-Resistant Enterococcus faecium. J Infect Dis. 2020 10 01; 222(9):1531-1539.
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Clinical Management of Staphylococcus aureus Bacteremia in Neonates, Children, and Adolescents. Pediatrics. 2020 09; 146(3).
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Streptococcus pyogenes With Reduced Susceptibility to ?-Lactams: How Big an Alarm Bell? Clin Infect Dis. 2020 06 24; 71(1):205-206.
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Reduced In Vitro Susceptibility of Streptococcus pyogenes to ?-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread. J Clin Microbiol. 2020 03 25; 58(4).