Mutagenesis, Site-Directed
"Mutagenesis, Site-Directed" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
| Descriptor ID |
D016297
|
| MeSH Number(s) |
E05.393.420.601.575
|
| Concept/Terms |
Mutagenesis, Site-Directed- Mutagenesis, Site-Directed
- Mutagenesis, Site Directed
- Site-Specific Mutagenesis
- Site Specific Mutagenesis
- Mutagenesis, Site-Specific
- Mutageneses, Site-Specific
- Mutagenesis, Site Specific
- Site-Specific Mutageneses
- Site-Directed Mutagenesis
- Mutageneses, Site-Directed
- Site Directed Mutagenesis
- Site-Directed Mutageneses
Oligonucleotide-Directed Mutagenesis- Oligonucleotide-Directed Mutagenesis
- Oligonucleotide Directed Mutagenesis
- Mutagenesis, Oligonucleotide-Directed
- Mutageneses, Oligonucleotide-Directed
- Mutagenesis, Oligonucleotide Directed
- Oligonucleotide-Directed Mutageneses
|
Below are MeSH descriptors whose meaning is more general than "Mutagenesis, Site-Directed".
Below are MeSH descriptors whose meaning is more specific than "Mutagenesis, Site-Directed".
This graph shows the total number of publications written about "Mutagenesis, Site-Directed" by people in this website by year, and whether "Mutagenesis, Site-Directed" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 5 | 5 |
| 1996 | 0 | 17 | 17 |
| 1997 | 1 | 14 | 15 |
| 1998 | 0 | 8 | 8 |
| 1999 | 0 | 6 | 6 |
| 2000 | 0 | 8 | 8 |
| 2001 | 0 | 11 | 11 |
| 2002 | 0 | 10 | 10 |
| 2003 | 2 | 16 | 18 |
| 2004 | 0 | 18 | 18 |
| 2005 | 0 | 14 | 14 |
| 2006 | 0 | 10 | 10 |
| 2007 | 0 | 8 | 8 |
| 2008 | 1 | 9 | 10 |
| 2009 | 2 | 12 | 14 |
| 2010 | 0 | 10 | 10 |
| 2011 | 1 | 9 | 10 |
| 2012 | 0 | 7 | 7 |
| 2013 | 0 | 10 | 10 |
| 2014 | 0 | 5 | 5 |
| 2015 | 0 | 4 | 4 |
| 2016 | 0 | 5 | 5 |
| 2017 | 0 | 10 | 10 |
| 2018 | 0 | 6 | 6 |
| 2019 | 0 | 3 | 3 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mutagenesis, Site-Directed" by people in Profiles.
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Identification of Hepatic-like EPO as a Cause of Polycythemia. N Engl J Med. 2025 May 01; 392(17):1684-1697.
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Recovering a Targeted Mutation in Mice from Embryonic Stem Cell Chimeras or CRISPR-Cas Founders. Cold Spring Harb Protoc. 2024 01 02; 2024(1):107959.
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Engineering a Hyperstable Yersinia pestis Outer Membrane Protein Ail Using Thermodynamic Design. J Am Chem Soc. 2022 02 02; 144(4):1545-1555.
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PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. Cell Rep. 2021 10 05; 37(1):109767.
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Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention. JCI Insight. 2021 02 08; 6(3).
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A drug-resistant ?-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J Biol Chem. 2020 12 25; 295(52):18239-18255.
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Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice. Elife. 2020 06 15; 9.
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Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase. J Biol Chem. 2020 06 19; 295(25):8480-8491.
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Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Sci Adv. 2019 10; 5(10):eaax6366.
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Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J Biol Chem. 2019 07 05; 294(27):10428-10437.