Mutagenesis, Site-Directed
"Mutagenesis, Site-Directed" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
| Descriptor ID |
D016297
|
| MeSH Number(s) |
E05.393.420.601.575
|
| Concept/Terms |
Mutagenesis, Site-Directed- Mutagenesis, Site-Directed
- Mutagenesis, Site Directed
- Site-Specific Mutagenesis
- Site Specific Mutagenesis
- Mutagenesis, Site-Specific
- Mutageneses, Site-Specific
- Mutagenesis, Site Specific
- Site-Specific Mutageneses
- Site-Directed Mutagenesis
- Mutageneses, Site-Directed
- Site Directed Mutagenesis
- Site-Directed Mutageneses
Oligonucleotide-Directed Mutagenesis- Oligonucleotide-Directed Mutagenesis
- Oligonucleotide Directed Mutagenesis
- Mutagenesis, Oligonucleotide-Directed
- Mutageneses, Oligonucleotide-Directed
- Mutagenesis, Oligonucleotide Directed
- Oligonucleotide-Directed Mutageneses
|
Below are MeSH descriptors whose meaning is more general than "Mutagenesis, Site-Directed".
Below are MeSH descriptors whose meaning is more specific than "Mutagenesis, Site-Directed".
This graph shows the total number of publications written about "Mutagenesis, Site-Directed" by people in this website by year, and whether "Mutagenesis, Site-Directed" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 3 | 25 | 28 |
| 1995 | 0 | 17 | 17 |
| 1996 | 1 | 31 | 32 |
| 1997 | 2 | 23 | 25 |
| 1998 | 1 | 21 | 22 |
| 1999 | 0 | 26 | 26 |
| 2000 | 0 | 23 | 23 |
| 2001 | 0 | 23 | 23 |
| 2002 | 0 | 28 | 28 |
| 2003 | 2 | 34 | 36 |
| 2004 | 0 | 31 | 31 |
| 2005 | 1 | 27 | 28 |
| 2006 | 0 | 20 | 20 |
| 2007 | 2 | 15 | 17 |
| 2008 | 1 | 18 | 19 |
| 2009 | 2 | 24 | 26 |
| 2010 | 0 | 14 | 14 |
| 2011 | 1 | 12 | 13 |
| 2012 | 0 | 13 | 13 |
| 2013 | 0 | 15 | 15 |
| 2014 | 0 | 8 | 8 |
| 2015 | 0 | 7 | 7 |
| 2016 | 0 | 4 | 4 |
| 2017 | 0 | 9 | 9 |
| 2018 | 0 | 7 | 7 |
| 2019 | 0 | 2 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mutagenesis, Site-Directed" by people in Profiles.
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Recovering a Targeted Mutation in Mice from Embryonic Stem Cell Chimeras or CRISPR-Cas Founders. Cold Spring Harb Protoc. 2024 01 02; 2024(1):107959.
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PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. Cell Rep. 2021 10 05; 37(1):109767.
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Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention. JCI Insight. 2021 02 08; 6(3).
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A drug-resistant ?-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J Biol Chem. 2020 12 25; 295(52):18239-18255.
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Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice. Elife. 2020 06 15; 9.
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Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Sci Adv. 2019 10; 5(10):eaax6366.
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In vitro phosphorylation of von Willebrand factor by FAM20c enhances its ability to support platelet adhesion. J Thromb Haemost. 2019 06; 17(6):866-877.
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Structural Control of Nonnative Ligand Binding in Engineered Mutants of Phosphoenolpyruvate Carboxykinase. Biochemistry. 2018 12 04; 57(48):6688-6700.
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Broadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection. Cell Host Microbe. 2018 11 14; 24(5):717-730.e5.
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Synergistic effects of functionally distinct substitutions in ?-lactamase variants shed light on the evolution of bacterial drug resistance. J Biol Chem. 2018 11 16; 293(46):17971-17984.