"Dantrolene" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
| Descriptor ID |
D003620
|
| MeSH Number(s) |
D03.383.129.308.432.555.287
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dantrolene".
Below are MeSH descriptors whose meaning is more specific than "Dantrolene".
This graph shows the total number of publications written about "Dantrolene" by people in this website by year, and whether "Dantrolene" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dantrolene" by people in Profiles.
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Ryanodine receptor 1-mediated Ca2+ signaling and mitochondrial reprogramming modulate uterine serous cancer malignant phenotypes. J Exp Clin Cancer Res. 2022 Aug 11; 41(1):242.
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Calcium ions trigger the exposure of phosphatidylserine on the surface of necrotic cells. PLoS Genet. 2021 02; 17(2):e1009066.
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CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72.
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Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor. PLoS One. 2013; 8(6):e66634.
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Dantrolene sodium for the treatment of aldesleukin-induced rigors in a melanoma patient. Ann Pharmacother. 2012 May; 46(5):e11.
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Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation. J Immunol. 2008 Apr 01; 180(7):5017-27.
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Successful treatment of an episode of malignant hyperthermia using a large dose of dantrolene. J Clin Anesth. 1993 Jan-Feb; 5(1):69-72.
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Spasticity: medical and surgical treatment. Neurology. 1980 Jul; 30(7 Pt 2):19-27.