"Monoamine Oxidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
| Descriptor ID |
D008995
|
| MeSH Number(s) |
D08.811.682.664.750
|
| Concept/Terms |
Monoamine Oxidase- Monoamine Oxidase
- Oxidase, Monoamine
- Amine Oxidase (Flavin-Containing)
- MAO
- Tyramine Oxidase
- Oxidase, Tyramine
|
Below are MeSH descriptors whose meaning is more general than "Monoamine Oxidase".
Below are MeSH descriptors whose meaning is more specific than "Monoamine Oxidase".
This graph shows the total number of publications written about "Monoamine Oxidase" by people in this website by year, and whether "Monoamine Oxidase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Monoamine Oxidase" by people in Profiles.
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Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson's disease. Nat Med. 2024 Apr; 30(4):1096-1103.
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Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study. J Neurooncol. 2019 Nov; 145(2):287-294.
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Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1. PLoS One. 2017; 12(2):e0170301.
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Genomic analysis of pediatric cataract in Saudi Arabia reveals novel candidate disease genes. Genet Med. 2012 Dec; 14(12):955-62.
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Monoamine oxidase A expression is suppressed in human cholangiocarcinoma via coordinated epigenetic and IL-6-driven events. Lab Invest. 2012 Oct; 92(10):1451-60.
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MAO A VNTR polymorphism and amygdala volume in healthy subjects. Psychiatry Res. 2011 Feb 28; 191(2):87-91.
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Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover. Aggress Behav. 2010 May-Jun; 36(3):158-76.
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Morphological correlates of MAO A VNTR polymorphism: new evidence from cortical thickness measurement. Behav Brain Res. 2010 Jul 29; 211(1):118-24.
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Association between monoamine oxidase (MAO)-A gene variants and schizophrenia in a Chinese population. Brain Res. 2009 Sep 01; 1287:67-73.
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Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells. J Neurosci. 2006 Jun 07; 26(23):6124-30.