"Helix-Turn-Helix Motifs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
| Descriptor ID |
D019077
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.360.360
|
| Concept/Terms |
Helix-Turn-Helix Motifs- Helix-Turn-Helix Motifs
- Helix Turn Helix Motifs
- Helix-Turn-Helix Motif
- Motif, Helix-Turn-Helix
- Motifs, Helix-Turn-Helix
- Motifs, Helix Turn Helix
- HTH Motifs
- HTH Motif
- Motif, HTH
- Motifs, HTH
|
Below are MeSH descriptors whose meaning is more general than "Helix-Turn-Helix Motifs".
Below are MeSH descriptors whose meaning is more specific than "Helix-Turn-Helix Motifs".
This graph shows the total number of publications written about "Helix-Turn-Helix Motifs" by people in this website by year, and whether "Helix-Turn-Helix Motifs" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
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Below are the most recent publications written about "Helix-Turn-Helix Motifs" by people in Profiles.
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DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair (Amst). 2007 Aug 01; 6(8):1100-15.
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Bone morphogenetic protein (BMP) family, SMAD signaling and Id helix-loop-helix proteins in the vasculature: the continuous mystery of BMPs pleotropic effects. J Mol Cell Cardiol. 2006 Jul; 41(1):4-7.
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BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science. 2002 Sep 13; 297(5588):1837-48.
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Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase. Mutat Res. 2000 Aug 30; 460(3-4):151-63.
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Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model. Cell Tissue Res. 1999 Sep; 297(3):371-82.
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Analysis of frequency (frq) clock gene homologs: evidence for a helix-turn-helix transcription factor. Mol Gen Genet. 1997 Jan 27; 253(4):401-14.