"Collagen Type IV" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.
| Descriptor ID |
D024141
|
| MeSH Number(s) |
D12.776.860.300.250.400.100
|
| Concept/Terms |
Collagen Type IV- Collagen Type IV
- Type IV (Basement Membrane) Collagen
- Type IV Collagen
- Collagen, Type IV
|
Below are MeSH descriptors whose meaning is more general than "Collagen Type IV".
Below are MeSH descriptors whose meaning is more specific than "Collagen Type IV".
This graph shows the total number of publications written about "Collagen Type IV" by people in this website by year, and whether "Collagen Type IV" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 3 | 0 | 3 |
| 2001 | 3 | 0 | 3 |
| 2002 | 4 | 3 | 7 |
| 2003 | 2 | 2 | 4 |
| 2004 | 2 | 3 | 5 |
| 2005 | 10 | 4 | 14 |
| 2006 | 3 | 4 | 7 |
| 2007 | 1 | 3 | 4 |
| 2008 | 5 | 4 | 9 |
| 2009 | 0 | 2 | 2 |
| 2010 | 2 | 1 | 3 |
| 2011 | 1 | 2 | 3 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 3 | 3 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 3 | 3 |
| 2019 | 0 | 1 | 1 |
| 2022 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Collagen Type IV" by people in Profiles.
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Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome. Life Sci Alliance. 2024 Jun; 7(6).
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Identification of unique a4 chain structure and conserved antiangiogenic activity of a3NC1 type IV collagen in zebrafish. Dev Dyn. 2023 07; 252(7):1046-1060.
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Variants in genes coding for collagen type IV a-chains are frequent causes of persistent, isolated hematuria during childhood. Pediatr Nephrol. 2023 03; 38(3):687-695.
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Col4a3-/- Mice on Balb/C Background Have Less Severe Cardiorespiratory Phenotype and SGLT2 Over-Expression Compared to 129x1/SvJ and C57Bl/6 Backgrounds. Int J Mol Sci. 2022 Jun 15; 23(12).
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Bioinformatics analysis suggests that COL4A1 may play an important role in gastric carcinoma recurrence. J Dig Dis. 2019 Aug; 20(8):391-400.
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PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest. 2019 03 01; 129(3):1129-1151.
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Missense mutations in COL4A5 or COL4A6 genes may cause cerebrovascular fibromuscular dysplasia: Case report and literature review. Medicine (Baltimore). 2018 Jul; 97(30):e11538.
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Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation. Mol Med Rep. 2015 Aug; 12(2):2643-9.
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Post-translationally abnormal collagens of prolyl 3-hydroxylase-2 null mice offer a pathobiological mechanism for the high myopia linked to human LEPREL1 mutations. J Biol Chem. 2015 Mar 27; 290(13):8613-22.
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Loss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis in Drosophila melanogaster. Dev Dyn. 2015 Apr; 244(4):540-52.