Proto-Oncogene Protein c-fli-1
"Proto-Oncogene Protein c-fli-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the c-ets family of transcription factors that is preferentially expressed in cells of hematopoietic lineages and vascular endothelial cells. It was originally identified as a protein that provides a retroviral integration site for integration of FRIEND MURINE LEUKEMIA VIRUS.
| Descriptor ID |
D051789
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| MeSH Number(s) |
D12.776.260.665.400 D12.776.624.664.700.175.400 D12.776.930.720.400
|
| Concept/Terms |
Proto-Oncogene Protein c-fli-1- Proto-Oncogene Protein c-fli-1
- Proto Oncogene Protein c fli 1
- c-fli-1, Proto-Oncogene Protein
- Retroviral Integration Site Protein Fli-1
- Retroviral Integration Site Protein Fli 1
- Proto-Oncogene Proteins c-fli-1
- Proto Oncogene Proteins c fli 1
- Friend Leukemia Integration 1 Transcription Factor
- fli-1 Transcription Factor
- Transcription Factor, fli-1
- fli 1 Transcription Factor
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Protein c-fli-1".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Protein c-fli-1".
This graph shows the total number of publications written about "Proto-Oncogene Protein c-fli-1" by people in this website by year, and whether "Proto-Oncogene Protein c-fli-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 2 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Proto-Oncogene Protein c-fli-1" by people in Profiles.
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Open-Label, Multicenter, Phase I/II, First-in-Human Trial of TK216: A First-Generation EWS::FLI1 Fusion Protein Antagonist in Ewing Sarcoma. J Clin Oncol. 2024 Nov; 42(31):3725-3734.
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Superficial Neurocristic EWSR1::FLI1 Fusion Tumor: A Distinctive, Clinically Indolent, S100 Protein/SOX10-Positive Neoplasm. Mod Pathol. 2024 Aug; 37(8):100537.
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Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding. Am J Hum Genet. 2023 03 02; 110(3):427-441.
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The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis. Nat Commun. 2021 02 05; 12(1):821.
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Loss of Stag2 cooperates with EWS-FLI1 to transform murine Mesenchymal stem cells. BMC Cancer. 2020 Jan 02; 20(1):3.
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Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways. Cancer Lett. 2020 01 28; 469:195-206.
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Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia Cells. PLoS One. 2016; 11(3):e0150450.
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The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease. Oncotarget. 2016 Feb 23; 7(8):8613-24.
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Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation. Circ Res. 2014 May 23; 114(11):1690-9.
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EWS-FLI-1 regulates the neuronal repressor gene REST, which controls Ewing sarcoma growth and vascular morphology. Cancer. 2014 Feb 15; 120(4):579-88.