"Receptors, Interleukin-4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Receptors present on a wide variety of hematopoietic and non-hematopoietic cell types that are specific for INTERLEUKIN-4. They are involved in signaling a variety of immunological responses related to allergic INFLAMMATION including the differentiation of TH2 CELLS and the regulation of IMMUNOGLOBULIN E production. Two subtypes of receptors exist and are referred to as the TYPE I INTERLEUKIN-4 RECEPTOR and the TYPE II INTERLEUKIN-4 RECEPTOR. Each receptor subtype is defined by its unique subunit composition.
| Descriptor ID |
D019948
|
| MeSH Number(s) |
D12.776.543.750.705.852.420.360
|
| Concept/Terms |
Receptors, Interleukin-4- Receptors, Interleukin-4
- Receptors, Interleukin 4
- IL-4 Receptors
- IL 4 Receptors
- Receptors, IL-4
- Receptors, IL 4
- IL4 Receptors
- Receptors, IL4
- Interleukin 4 Receptor
- Receptor, Interleukin 4
- Interleukin-4 Receptors
- Interleukin 4 Receptors
- IL-4 Receptor
- IL 4 Receptor
- Receptor, IL-4
- IL4 Receptor
- Receptor, IL4
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Interleukin-4".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Interleukin-4".
This graph shows the total number of publications written about "Receptors, Interleukin-4" by people in this website by year, and whether "Receptors, Interleukin-4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptors, Interleukin-4" by people in Profiles.
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Unneutral neutrophils in patients with late-phase allergic reactions. J Allergy Clin Immunol. 2019 07; 144(1):46-48.
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Interleukin-4/interleukin-13 versus interleukin-5: a comparison of molecular targets in biologic therapy for the treatment of severe asthma. Curr Opin Allergy Clin Immunol. 2019 02; 19(1):30-37.
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Targeting the interleukin-4 and interleukin-13 pathways in severe asthma: current knowledge and future needs. Curr Opin Pulm Med. 2018 01; 24(1):50-55.
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IgE and eosinophils as therapeutic targets in asthma. Curr Opin Allergy Clin Immunol. 2017 Feb; 17(1):42-49.
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Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25; 58(22):8970-84.
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Regulation of IL-4 receptor signaling by STUB1 in lung inflammation. Am J Respir Crit Care Med. 2014 Jan 01; 189(1):16-29.
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Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis. Arthritis Res Ther. 2010; 12(3):R75.
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Redox regulation of interleukin-4 signaling. Immunity. 2008 Oct 17; 29(4):551-64.
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Polymorphisms in the interleukin-4 receptor gene are associated with better survival in patients with glioblastoma. Clin Cancer Res. 2008 Oct 15; 14(20):6640-6.
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Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma. Cancer Res. 2007 Oct 15; 67(20):9903-12.