"PPAR alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
| Descriptor ID |
D047493
|
| MeSH Number(s) |
D12.776.826.239.500
|
| Concept/Terms |
PPAR alpha- PPAR alpha
- Peroxisome Proliferator-Activated Receptor alpha
- Peroxisome Proliferator Activated Receptor alpha
- PPARalpha
|
Below are MeSH descriptors whose meaning is more general than "PPAR alpha".
Below are MeSH descriptors whose meaning is more specific than "PPAR alpha".
This graph shows the total number of publications written about "PPAR alpha" by people in this website by year, and whether "PPAR alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 2 | 0 | 2 |
| 2008 | 1 | 0 | 1 |
| 2010 | 2 | 1 | 3 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 3 | 3 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 4 | 0 | 4 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2023 | 0 | 4 | 4 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "PPAR alpha" by people in Profiles.
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CD24 negativity reprograms mitochondrial metabolism to PPARa and NF-?B-driven fatty acid ?-oxidation in triple-negative breast cancer. Cancer Lett. 2024 Apr 10; 587:216724.
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The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2023 Nov; 17(11):e0011519.
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Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis. N Engl J Med. 2024 Feb 29; 390(9):795-805.
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Bcl-2 inhibition combined with PPARa activation synergistically targets leukemic stem cell-like cells in acute myeloid leukemia. Cell Death Dis. 2023 08 29; 14(8):573.
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Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates A? pathology in a mouse model of Alzheimer's disease. Mol Neurodegener. 2023 08 15; 18(1):56.
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Vitamin B2 enables regulation of fasting glucose availability. Elife. 2023 Jul 07; 12.
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A randomized placebo-controlled trial of elafibranor in patients with primary biliary cholangitis and incomplete response to UDCA. J Hepatol. 2021 06; 74(6):1344-1354.
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MDM2 and MDMX promote ferroptosis by PPARa-mediated lipid remodeling. Genes Dev. 2020 04 01; 34(7-8):526-543.
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NAMPT maintains mitochondria content via NRF2-PPARa/AMPKa pathway to promote cell survival under oxidative stress. Cell Signal. 2020 02; 66:109496.
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A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors. Clin Cancer Res. 2019 11 15; 25(22):6852-6867.