"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
| Descriptor ID |
D014018
|
| MeSH Number(s) |
G03.787.917 G07.690.725.949
|
| Concept/Terms |
Tissue Distribution- Tissue Distribution
- Distribution, Tissue
- Distributions, Tissue
- Tissue Distributions
|
Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".
Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".
This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 16 | 16 |
| 1995 | 0 | 17 | 17 |
| 1996 | 0 | 18 | 18 |
| 1997 | 0 | 22 | 22 |
| 1998 | 0 | 15 | 15 |
| 1999 | 0 | 34 | 34 |
| 2000 | 0 | 42 | 42 |
| 2001 | 0 | 40 | 40 |
| 2002 | 0 | 37 | 37 |
| 2003 | 0 | 30 | 30 |
| 2004 | 0 | 24 | 24 |
| 2005 | 0 | 30 | 30 |
| 2006 | 0 | 28 | 28 |
| 2007 | 0 | 16 | 16 |
| 2008 | 0 | 15 | 15 |
| 2009 | 0 | 12 | 12 |
| 2010 | 0 | 15 | 15 |
| 2011 | 0 | 15 | 15 |
| 2012 | 0 | 27 | 27 |
| 2013 | 0 | 20 | 20 |
| 2014 | 0 | 16 | 16 |
| 2015 | 0 | 15 | 15 |
| 2016 | 0 | 3 | 3 |
| 2017 | 0 | 9 | 9 |
| 2018 | 0 | 5 | 5 |
| 2019 | 0 | 24 | 24 |
| 2020 | 0 | 11 | 11 |
| 2021 | 0 | 8 | 8 |
| 2022 | 0 | 4 | 4 |
| 2023 | 0 | 3 | 3 |
| 2024 | 0 | 4 | 4 |
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Below are the most recent publications written about "Tissue Distribution" by people in Profiles.
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Bone-targeted ultrasound-responsive nanobubbles for siRNA delivery to treat osteoporosis in mice. Biomater Adv. 2025 Jan; 166:214078.
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MALDI Imaging Mass Spectrometry Visualizes the Distribution of Antidepressant Duloxetine and Its Major Metabolites in Mouse Brain, Liver, Kidney, and Spleen Tissues. Drug Metab Dispos. 2024 Jun 17; 52(7):673-680.
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Harnessing RNA Technology to Advance Therapeutic Vaccine Antigens against Chagas Disease. ACS Appl Mater Interfaces. 2024 Apr 03; 16(13):15832-15846.
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Somatostatin Receptor Subtype-2 Targeting System for Specific Delivery of Temozolomide. J Med Chem. 2024 02 22; 67(4):2425-2437.
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SPIONs: Superparamagnetic iron oxide-based nanoparticles for the delivery of microRNAi-therapeutics in cancer. Biomed Microdevices. 2024 02 07; 26(1):16.
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Development of a novel UPLC-MS/MS method for the simultaneous quantification of mycophenolic mofetil, mycophenolic acid, and its major metabolites: Application to pharmacokinetic and tissue distribution study in rats. J Pharm Biomed Anal. 2023 Sep 20; 234:115504.
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Development of a Novel Tool To Demystify Drug Distribution at Tissue-Blood Barriers. Chembiochem. 2023 07 03; 24(13):e202200804.
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A phase I/II study of preoperative letrozole, everolimus, and carotuximab in stage 2 and 3 hormone receptor-positive and Her2-negative breast cancer. Breast Cancer Res Treat. 2023 Apr; 198(2):217-229.
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Accuracy and Safety of Scout Dose Resin Yttrium-90 Microspheres for Radioembolization Therapy Treatment Planning: A Prospective Single-Arm Clinical Trial. J Vasc Interv Radiol. 2022 12; 33(12):1578-1587.e5.
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A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer. Nat Commun. 2022 08 17; 13(1):4829.