"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
| Descriptor ID |
D014018
|
| MeSH Number(s) |
G03.787.917 G07.690.725.949
|
| Concept/Terms |
Tissue Distribution- Tissue Distribution
- Distribution, Tissue
- Distributions, Tissue
- Tissue Distributions
|
Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".
Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".
This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 7 | 7 |
| 1997 | 0 | 8 | 8 |
| 1998 | 0 | 7 | 7 |
| 1999 | 0 | 14 | 14 |
| 2000 | 0 | 19 | 19 |
| 2001 | 0 | 15 | 15 |
| 2002 | 0 | 23 | 23 |
| 2003 | 0 | 9 | 9 |
| 2004 | 0 | 10 | 10 |
| 2005 | 0 | 11 | 11 |
| 2006 | 0 | 15 | 15 |
| 2007 | 0 | 7 | 7 |
| 2008 | 0 | 4 | 4 |
| 2009 | 0 | 5 | 5 |
| 2010 | 0 | 5 | 5 |
| 2011 | 0 | 6 | 6 |
| 2012 | 0 | 10 | 10 |
| 2013 | 0 | 6 | 6 |
| 2014 | 0 | 5 | 5 |
| 2015 | 0 | 6 | 6 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 7 | 7 |
| 2018 | 0 | 6 | 6 |
| 2019 | 0 | 12 | 12 |
| 2020 | 0 | 9 | 9 |
| 2021 | 0 | 3 | 3 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 4 | 4 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tissue Distribution" by people in Profiles.
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A comprehensive atlas of AAV tropism in the mouse. Mol Ther. 2025 Mar 05; 33(3):1282-1299.
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The role of patient-specific variables in protein corona formation and therapeutic efficacy in nanomedicine. J Nanobiotechnology. 2024 Nov 15; 22(1):714.
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Effect of Ibuprofen as an Albumin Binder on Melanoma-Targeting Properties of 177Lu-Labeled Ibuprofen-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides. Mol Pharm. 2024 Aug 05; 21(8):4004-4011.
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MALDI Imaging Mass Spectrometry Visualizes the Distribution of Antidepressant Duloxetine and Its Major Metabolites in Mouse Brain, Liver, Kidney, and Spleen Tissues. Drug Metab Dispos. 2024 Jun 17; 52(7):673-680.
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Harnessing RNA Technology to Advance Therapeutic Vaccine Antigens against Chagas Disease. ACS Appl Mater Interfaces. 2024 Apr 03; 16(13):15832-15846.
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Effects of Polyethylene Glycol and 8-Aminooctanoic Acid Linkers on Melanoma Uptake of [99mTc]Tc-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized a-MSH Peptides. Bioconjug Chem. 2023 05 17; 34(5):934-940.
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A phase I/II study of preoperative letrozole, everolimus, and carotuximab in stage 2 and 3 hormone receptor-positive and Her2-negative breast cancer. Breast Cancer Res Treat. 2023 Apr; 198(2):217-229.
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A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer. Nat Commun. 2022 08 17; 13(1):4829.
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Novel 64Cu-Labeled NOTA-Conjugated Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptides with Enhanced Tumor to Kidney Uptake Ratios. Mol Pharm. 2022 07 04; 19(7):2535-2541.
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The Effect of Albumin-Binding Moiety on Tumor Targeting and Biodistribution Properties of 67Ga-Labeled Albumin Binder-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides. Cancer Biother Radiopharm. 2022 Feb; 37(1):47-55.