"Synaptotagmin II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vesicular transport protein that was originally characterized as an inositol polyphosphate binding protein. Synaptotagmin II helps regulate EXOCYTOSIS of SYNAPTIC VESICLES and appears to serve as a calcium sensor to trigger NEUROTRANSMITTER release. It also acts as a nerve cell receptor for certain BOTULINUM TOXINS.
| Descriptor ID |
D050861
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| MeSH Number(s) |
D12.776.157.125.825.500 D12.776.543.990.850.500
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Synaptotagmin II".
Below are MeSH descriptors whose meaning is more specific than "Synaptotagmin II".
This graph shows the total number of publications written about "Synaptotagmin II" by people in this website by year, and whether "Synaptotagmin II" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 1 | 3 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Synaptotagmin II" by people in Profiles.
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Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy. Am J Hum Genet. 2014 Sep 04; 95(3):332-9.
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Synaptotagmin II and gangliosides bind independently with botulinum neurotoxin B but each restrains the other. Protein J. 2014 Jun; 33(3):278-88.
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Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses. Open Biol. 2013 Nov; 3(11):130163.
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Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells. J Biol Chem. 2009 Jul 17; 284(29):19445-51.
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Compound vesicle fusion increases quantal size and potentiates synaptic transmission. Nature. 2009 May 07; 459(7243):93-7.
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Synaptotagmin 2 couples mucin granule exocytosis to Ca2+ signaling from endoplasmic reticulum. J Biol Chem. 2009 Apr 10; 284(15):9781-7.
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The binding sites on botulinum neurotoxin B for synaptotagmin and for blocking antibodies. Biochem Biophys Res Commun. 2008 Nov 21; 376(3):631-2.
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A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature. 2007 Nov 29; 450(7170):676-82.
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Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci. 2006 Dec 27; 26(52):13493-504.
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Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. J Exp Med. 1999 May 17; 189(10):1649-58.