"Synaptotagmin I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vesicular transport protein expressed predominately in NEURONS. Synaptotagmin helps regulate EXOCYTOSIS of SYNAPTIC VESICLES and appears to serve as a calcium sensor to trigger NEUROTRANSMITTER release. It also acts as a nerve cell receptor for certain BOTULINUM TOXINS.
| Descriptor ID |
D050863
|
| MeSH Number(s) |
D12.776.157.125.825.249 D12.776.543.990.850.249
|
| Concept/Terms |
Synaptotagmin I- Synaptotagmin I
- p65 Protein (Synaptotagmin I)
- Synaptic Vesicle Protein p65
- Synaptotagmin 1
|
Below are MeSH descriptors whose meaning is more general than "Synaptotagmin I".
Below are MeSH descriptors whose meaning is more specific than "Synaptotagmin I".
This graph shows the total number of publications written about "Synaptotagmin I" by people in this website by year, and whether "Synaptotagmin I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Synaptotagmin I" by people in Profiles.
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Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons. Cell Rep. 2021 03 16; 34(11):108842.
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SYT1-associated neurodevelopmental disorder: a case series. Brain. 2018 09 01; 141(9):2576-2591.
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The calcium sensor synaptotagmin 1 is expressed and regulated in hippocampal postsynaptic spines. Hippocampus. 2017 11; 27(11):1168-1177.
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Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. PLoS One. 2010 Sep 02; 5(9).
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Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat Struct Mol Biol. 2010 May; 17(5):568-75.
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The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. Nat Struct Mol Biol. 2008 Nov; 15(11):1160-8.
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Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol. 2007 Oct; 14(10):949-58.
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Synaptotagmin I, a Ca2+ sensor for neurotransmitter release. Trends Neurosci. 2003 Aug; 26(8):413-22.